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公开(公告)号：US4749691A
公开(公告)日：1988-06-07
申请号：US37470
申请日：1987-04-13
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
CPC分类号： C07C243/00 , C07K5/0215 , C07K5/06017 , C07K5/06026 , C07K5/06052 , C07K5/06078 , C07K5/06104 , C07K9/005 , C12R1/465 , A61K38/00 , Y02P20/55
摘要： The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R.sup.1 is hydroxyalkanoyl,R.sup.2 and R.sup.q are each hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR2## wherein R.sub.a.sup.2 is mono- or di-carboxy (or protected carboxy) lower alkyl or ar(carboxy or protected carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy, R.sup. 2 is hydrogen or lower alkyl; R.sup.p is hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy or a group of the formula: ##STR3## wherein R.sub.a.sup.2 and R.sub.b.sup.2 are each as defined above; R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3;or its pharmaceutically acceptable salt.
摘要翻译： 本发明涉及增强的药理活性的新肽，其具有下式：其中R 1是羟基烷酰基，R 2和R q各自是氢，羧基，被保护的羧基或下式的基团：其中Ra 2是单 - 或 二羧基（或被保护的羧基）低级烷基或芳基部分可以被羟基取代的芳（羧基或被保护的羧基）低级烷基，R 2是氢或低级烷基; Rp是氢，羧基，受保护的羧基，条件是当R 2和R q中的一个是氢时，另一个是羧基或保护的羧基或下式的基团：其中Ra2和Rb2各自如上所定义; Rr为氢或氨基保护基; m为整数1〜3; 或其药学上可接受的盐。
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公开(公告)号：US4539155A
公开(公告)日：1985-09-03
申请号：US515590
申请日：1983-07-21
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
IPC分类号： A61K38/00 , C07K5/02 , C07K7/02 , C07K9/00 , C07C103/52 , C07C69/74 , C07C101/20 , C07C101/30
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00
摘要： The invention relates to compounds and salts of compounds which are diaminopimelyl peptides, N-acetoxypropionyl or N-t-butoxycarbonyl-amino-acid - (.alpha.-OBzl) glutamic acid peptides or N-acylated derivatives of (.alpha.-OBzl) glytamic acid or of (.alpha.-OBzl) aminoadipic acid.The compounds and their salts are starting materials for the preparation of pharmacologically active peptides.
摘要翻译： 本发明涉及化合物和化合物的盐，它们是二氨基辛基肽，N-乙酰氧基丙酰基或N-叔丁氧基羰基 - 氨基酸 - （α-Boc z）谷氨酸肽或（α-Boc z）谷氨酸的N-酰化衍生物或（ α-OBzl）氨基己二酸。 化合物及其盐是制备药理活性肽的起始原料。
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公开(公告)号：US4458078A
公开(公告)日：1984-07-03
申请号：US377841
申请日：1982-05-13
申请人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto , Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
CPC分类号： C07C243/00 , C07K5/0215 , C07K9/005 , C12R1/465 , A61K38/00 , Y02P20/55 , Y10S930/19
摘要： The invention relates to novel intermediates for the preparation of peptides of pharmacological activity, said intermediates being of the formulas: ##STR1## wherein R.sub.2.sup.r is amino protective group andY is hydrogen or amino protective group; and : ##STR2##
摘要翻译： 本发明涉及用于制备药理学活性肽的新型中间体，所述中间体具有下式：其中R2r为氨基保护基，Y为氢或氨基保护基; 和：
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公开(公告)号：US4414328A
公开(公告)日：1983-11-08
申请号：US283962
申请日：1981-07-16
申请人： Hiroshi Imanaka , Toshio Miyoshi , Toshio Konomi , Yoshiaki Kubochi , Seiziro Hattori , Takeshi Kawakita
发明人： Hiroshi Imanaka , Toshio Miyoshi , Toshio Konomi , Yoshiaki Kubochi , Seiziro Hattori , Takeshi Kawakita
CPC分类号： C12P35/06 , C12N9/18 , Y10S435/911
摘要： Deacetylcephalosporin C is converted to cephalosporin C by contact with an acetylesterase produced by Aureobasidium pullanans strain 1F0 4466.
摘要翻译： 脱乙酰头孢菌素C通过与由Aureobasidium pullanans菌株1F04466产生的乙酰酯酶接触而转化为头孢菌素C.
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公开(公告)号：US4110166A
公开(公告)日：1978-08-29
申请号：US742013
申请日：1976-11-15
申请人： Shigeru Mori , Shigeyoshi Ohsawa , Hatsuo Aoki , Hiroshi Imanaka
发明人： Shigeru Mori , Shigeyoshi Ohsawa , Hatsuo Aoki , Hiroshi Imanaka
CPC分类号： C12P17/10 , C07D205/085 , Y10S435/872
摘要： Nocardicin A is produced by culturing a Nocardicin A producing microorganism in a medium containing at least one of shikimic acid, a hydroxy phenyl carboxylic acid, glycine, alanine, serine, homoserine, .alpha.aminobutyric acid, .alpha., .beta.-diaminoproprionic acid and their ester, acid amide and hydrazide derivatives in a concentration of 2-0.001% by weight.
摘要翻译： 通过在含有莽草酸，羟基苯基羧酸，甘氨酸，丙氨酸，丝氨酸，高丝氨酸，α氨基丁酸，α，β-二氨基丙酸及其酯中的至少一种的培养基中培养含有产生诺卡氏菌素A的微生物来产生诺卡氏菌素A， 浓度为2-0.001重量％的酰胺和酰肼衍生物。
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公开(公告)号：US4268570A
公开(公告)日：1981-05-19
申请号：US55434
申请日：1979-07-06
申请人： Hiroshi Imanaka , Yoshihiko Kijima
发明人： Hiroshi Imanaka , Yoshihiko Kijima
IPC分类号： B32B15/095 , B32B15/04 , B32B15/09 , B44C1/14 , C08J7/04 , C08L33/06 , C08L55/02 , C08L63/00 , C08L67/00 , C08L67/02 , C23C14/20 , B32B15/08 , C08L67/06
CPC分类号： C08J7/045 , B44C1/14 , C08L33/062 , C08L55/02 , C08L67/00 , C08L67/02 , C08L67/025 , C23C14/20 , C08L63/00 , Y10T428/24975 , Y10T428/31576 , Y10T428/31587 , Y10T428/31605 , Y10T428/31681 , Y10T428/31699 , Y10T428/31786 , Y10T428/31928 , Y10T428/31935
摘要： Metal-coated plastic product which comprises a molded product of a mixture of 95 to 20% by weight of a polyester block copolymer and 5 to 80% by weight of a copolymer comprising an acrylic monomer, butadiene and styrene and a layer of a metallic coating which is provided optionally via a layer of an adhesive, and optionally a layer of a top coating. Said metal-coated plastic product has excellent properties such as excellent stiffness, plasticity, processability, and further beautiful and gloss appearance and is useful as a substitute of metallic products.
摘要翻译： 金属包覆的塑料制品，其包含95至20重量％的聚酯嵌段共聚物和5至80重量％的包含丙烯酸单体，丁二烯和苯乙烯的共聚物和金属涂层的混合物的模塑产品 其任选地通过粘合剂层提供，并且任选地提供顶层涂层。 所述金属涂覆的塑料制品具有优异的性能，例如优异的刚度，可塑性，可加工性，以及更美观和光泽的外观，并且可用作金属产品的替代物。
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公开(公告)号：US4146536A
公开(公告)日：1979-03-27
申请号：US738144
申请日：1976-11-02
申请人： Junji Hosoda , Hatsuo Aoki , Hiroshi Imanaka
发明人： Junji Hosoda , Hatsuo Aoki , Hiroshi Imanaka
IPC分类号： A61K31/395 , A61K31/397 , A61P31/04 , C07D205/08 , C07D205/085 , C12P17/10 , A01N9/22 , C12D9/22
CPC分类号： C12P17/10
摘要： This invention relates to new compounds having antibacterial activity.More particularly, it relates to new antibiotics, Nocardicin E and F and to a process for production of the same by fermentation.
摘要翻译： 本发明涉及具有抗菌活性的新化合物。
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公开(公告)号：US3936661A
公开(公告)日：1976-02-03
申请号：US511472
申请日：1974-10-01
IPC分类号： C08L67/00 , B23Q1/00 , B23Q3/08 , C08G63/00 , C08G63/16 , C08G63/181 , C08G63/672 , E01B9/68 , E01D19/04 , E01D101/40 , E02D35/00 , E04B1/36 , F16M7/00 , H05B3/34
CPC分类号： B23Q1/0054 , B23Q3/08 , C08G63/16 , C08G63/672 , E01B9/68 , E01B9/688 , E02D35/00 , E04B1/36 , F16M7/00 , E01B2204/01 , E01B2204/06 , E01B9/681
摘要： An electrothermally deformable levelling pad utilizable in padding, levelling or aligning girders, rails or any other constructional or structural elements. The levelling pad comprises at least one thermoplastic plate member and an electric heater for heating the thermoplastic plate member to soften or melt to cause the overall thickness of the pad to reduce to a value sufficient to bring an article or machine to a predetermined level. The plate member is made of a thermoplastic random-copolymerized polyester which comprises an acid component and a glycol component.
摘要翻译： 可用于填充，调平或对准桁材，导轨或任何其他结构或结构元件的电热可变形调平垫。 调平垫包括至少一个热塑性板构件和电加热器，用于加热热塑性板构件以软化或熔化以使垫的总体厚度减小到足以使物品或机器达到预定水平的值。 板构件由包含酸组分和二醇组分的热塑性无规共聚聚酯制成。
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29.发明授权Production of antibiotics WS-3442 A, B, C, D and E, and their acyl derivatives 失效生产抗生素WS-3442A，B，C，D和E及其酰基衍生物
公开(公告)号：US4283492A
公开(公告)日：1981-08-11
申请号：US915215
申请日：1978-06-13
申请人： Hiroshi Imanaka , Junzi Hosoda , Kazuyoshi Jomon , Heiichi Sakai , Ikuo Ueda , Daizou Morino
发明人： Hiroshi Imanaka , Junzi Hosoda , Kazuyoshi Jomon , Heiichi Sakai , Ikuo Ueda , Daizou Morino
CPC分类号： C12P35/06 , C12P35/08 , Y10S435/886
摘要： Production of antibiotic WS-3442 A, B, C, D and E, and their acyl derivatives thereof, the production of antibiotic WS-3442 A, B, C, D and E being a new method by culturing a new species of Streptomyces and their acyl derivatives of said antibiotics being prepared by acylating said antibiotics with an acylating agent. The acyl derivative of antibiotic WS-3442 A, B, C, D and E has antimicrobiological activity and is also useful for intermediate for preparing Cephalosporin derivatives having antimicrobiological activity.
摘要翻译： 生产抗生素WS-3442A，B，C，D和E及其酰基衍生物，生产抗生素WS-3442A，B，C，D和E是一种新方法，通过培养新品种的链霉菌和 所述抗生素的酰基衍生物通过用酰化剂酰化所述抗生素来制备。 抗生素WS-3442A，B，C，D和E的酰基衍生物具有抗微生物活性，也可用于制备具有抗微生物活性的头孢菌素衍生物的中间体。
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公开(公告)号：US4092411A
公开(公告)日：1978-05-30
申请号：US806147
申请日：1977-06-13
申请人： Hatsuo Aoki , Toyozi Nishiura , Hiroshi Imanaka
发明人： Hatsuo Aoki , Toyozi Nishiura , Hiroshi Imanaka
IPC分类号： A61K31/395 , A61K31/42 , A61P31/04 , A61P31/06 , C07D261/04 , A61K35/00
CPC分类号： A61K31/42
摘要： Antibacterial synergistic mixture of Nocardicin A and cycloserine or their respective pharmaceutically acceptable salts.
摘要翻译： 诺卡氏菌素A和环丝氨酸的抗菌协同混合物或其各自的药学上可接受的盐。
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