摘要:
Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
摘要:
Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
摘要:
Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
摘要:
A fire extinguishing access port includes a port and nozzle assembly where the nozzle has a plurality of radial outlets defining a pattern of dispersal for a fire extinguishing agent. According to a presently preferred embodiment, the port and nozzle assembly is dimensioned to be mounted in an existing mounting hole (e.g. a switch mounting hole) of an aircraft electrical panel with the nozzle residing in the rear of the panel and the port residing on the front of the panel. A plurality of different nozzles are provided for different electrical panels, each nozzle having a different pattern of dispersal. A fire extinguisher access port kit includes a plurality of threaded nozzles, each with different dispersal patterns, a plurality of threaded ports which mate with the nozzles, and a plurality of different length threaded tubes which mate with the nozzles and the ports. According to the presently preferred embodiment, the nozzles are provided with a plurality if radial slots which deflect the flow of fire extinguishing agent substantially perpendicular to the direction of entry through the port. This provides excellent dispersal of fire extinguishing agent throughout the electrical compartment and also provides two unexpected advantages, prevents foreign objects from passing through the port and potentially causing a short circuit, and eliminates the possibility of blowback.
摘要:
A streamfeeder for the untrimmed, folded cover signatures includes an uphill streamfeeder with the cover signatures disposed between a pair of conveyor belts with a jogger being on the side of the folded signatures opposite the long tail. The preferred cutter for the long tail, cover signatures comprises a rotating, slitting wheel and an opposing, rotating anvil. The slitting wheel is preferably a rotating disc with a beveled, cutting edge that cooperates with a resilient insert on the anvil. Herein, the cutting wheel is mounted on a rotary shaft and rotated by a variable speed drive.
摘要:
The present invention relates to improved diagnostic methods for early detection of a risk for developing type 2 diabetes mellitus in humans, and screening assays for therapeutic agents useful in the treatment of type 2 diabetes mellitus, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.
摘要:
Certain N-substituted 1-(1,2,3,6-tetrahydro-3-pyridinyl)oximes and N-substituted 1-(1,2,3,6-tetrahydro-4-pyridinyl)oximes are useful as sigma binding agents for the treatment of depression, psychoses and/or inflammatory diseases.
摘要:
A power combustion device comprising an elongate combustion chamber having an inlet for a combustible mixture and an unvalved outlet for combustion gases; an open flow valve distributor member mounted in fixed relation in a wall of the combustion chamber which has a first side in communication with the combustion chamber and a second side in communication with a controlled supply of pressurized combustible mixture with a pluralilty of ports through the valve distributor member directing the combustible mixture along the periphery of the combustion chamber, a pump for premixing and supplying a controlled pressurized combustible mixture to the second side of the floating valve member, and an ignition system for igniting and combusting the combustible mixture in the combustion chamber. The power combustion device provides premixing of fuel and oxidizing gas to form a combustible mixture thereby allowing sealed combustion with respect to the surrounding atmosphere.
摘要:
In a log-periodic monopole antenna array of the type described in U.S. Pat. No. 3,286,268, each antenna of the array having active elements spaced over the top surface of a ground structure and grounded parasitic elements interspersed between the active elements, the improvement of means for mechanically and electrically connecting the parasitic elements to a non-solderable ground structure comprising an elongated block compressed into a correspondingly shaped groove in the structure. Screw means threadedly engage the ground structure in a direction transversely of the top surface thereof and abut against the block. The lower strip portion of the parasitic elements is disposed in the groove between the block and a groove side wall and is compressed therebetween when the screw means is tightened into the structure and against the block. In one embodiment, one side of the block and the adjacent side of the groove are tapered toward the opposite side of the groove so as to force the block against the strip when the screw means is tightened. In another embodiment the block abutting surface of the head of the screw means is tapered and forces the block against the strip when the screw means is tightened. A tight mechanical and electrical connection of the parasitic element strip portions in the array of antennas is thus achieved in a minimum of space.
摘要:
A pulsing combustion device including a combustion chamber having an inlet for combustible mixture and an unvavled outlet open to the atmosphere for combustion gases, a floating valve member mounted in reciprocation relation in the wall of the combustion chamber, the reciprocation of the floating valve closing and opening communication through ports between the supply of combustible mixture and the combustion chamber. The floating valve may be annular shaped with an ignition means extending through a central portion of the end of the combustion chamber. The pulsing combustion device may be used as an air heater by providing an exhaust manifold passing the combustion gases through a closed heat exchanger over which treatment air is passed through an air treatment duct. The pulsing combustion device may be provided with a pressurized combustion air flow regulator providing higher pressure combustion air to a lower pressure combustible mixing chamber to which fuel gas is added.