公开(公告)号：US07001729B2

公开(公告)日：2006-02-21

申请号：US09811131

申请日：2001-03-14

申请人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

发明人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC分类号： G01N29/00 ,  G01N33/573 ,  C12N11/00

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06906175B2

公开(公告)日：2005-06-14

申请号：US09809889

申请日：2001-03-16

申请人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

发明人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC分类号： G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

摘要翻译： 提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。 还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

公开(公告)号：US06902908B2

公开(公告)日：2005-06-07

申请号：US09811094

申请日：2001-03-14

申请人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

发明人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC分类号： G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C12N15/00 ,  C07H21/04 ,  C12N15/63

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

摘要翻译： 提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。 还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

公开(公告)号：US06887670B2

公开(公告)日：2005-05-03

申请号：US09811132

申请日：2001-03-14

申请人： Christen M. Anderson ,  Robert E. Davis ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

发明人： Christen M. Anderson ,  Robert E. Davis ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC分类号： G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K1/14 ,  C07K1/16 ,  C07K17/00

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06906174B2

公开(公告)日：2005-06-14

申请号：US09809827

申请日：2001-03-16

申请人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley

发明人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley

IPC分类号： G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00

CPC分类号： C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06906173B2

公开(公告)日：2005-06-14

申请号：US09185904

申请日：1998-11-03

申请人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley

发明人： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley

IPC分类号： C07K14/47 ,  C12N5/02 ,  C12N15/62 ,  C07K1/00 ,  C07K14/00

CPC分类号： C12N15/62 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N2799/021

摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06498191B2

公开(公告)日：2002-12-24

申请号：US09733271

申请日：2000-12-07

申请人： Soumitra S. Ghosh ,  Scott W. Miller ,  Robert E. Davis ,  Walter H. Moos

发明人： Soumitra S. Ghosh ,  Scott W. Miller ,  Robert E. Davis ,  Walter H. Moos

IPC分类号： A61K31225

CPC分类号： A61K31/155 ,  A61K31/00 ,  A61K31/05 ,  A61K31/06 ,  A61K31/136 ,  C07C39/08 ,  C07C39/11 ,  C07C39/19 ,  C07C69/017 ,  C07C215/78 ,  C07C215/80 ,  C07C217/84 ,  C07C279/18 ,  C07D215/20 ,  C07D311/72

摘要： The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contain a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases which may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus, Parkinson's Disease, neuronal and cardiac ischemia, Huntington's disease and stroke.

摘要翻译： 本发明一般涉及用于治疗线粒体功能障碍导致组织变性的线粒体保护剂，更具体地涉及与其相关的化合物，组合物和方法。 本发明的方法涉及向有需要的温血动物施用药学有效量的线粒体保护剂，本发明的组合物含有与药学上可接受的载体或稀释剂组合的线粒体保护剂。 可以通过本发明治疗的线粒体相关疾病包括（但不限于）阿尔茨海默氏病，糖尿病，帕金森病，神经元和心脏缺血，亨廷顿病和中风。

公开(公告)号：US06511966B2

公开(公告)日：2003-01-28

申请号：US09933911

申请日：2001-08-20

申请人： Soumitra S. Ghosh ,  Scott W. Miller ,  Robert E. Davis ,  Walter H. Moos

发明人： Soumitra S. Ghosh ,  Scott W. Miller ,  Robert E. Davis ,  Walter H. Moos

IPC分类号： A01N4304

CPC分类号： A61K31/155 ,  A61K31/00 ,  A61K31/05 ,  A61K31/06 ,  A61K31/136 ,  C07C39/08 ,  C07C39/11 ,  C07C39/19 ,  C07C69/017 ,  C07C215/78 ,  C07C215/80 ,  C07C217/84 ,  C07C279/18 ,  C07D215/20 ,  C07D311/72

摘要： The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contain a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases which may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus. Parkinson's Disease, neuronal and cardiac ischemia. Huntington's disease and stroke.

公开(公告)号：US06900197B2

公开(公告)日：2005-05-31

申请号：US10020867

申请日：2001-12-14

申请人： Tomas R. Szabo ,  Soumitra S. Ghosh ,  Robert E. Davis

发明人： Tomas R. Szabo ,  Soumitra S. Ghosh ,  Robert E. Davis

IPC分类号： A61K31/409 ,  A61K33/24 ,  A61P3/04 ,  C07D487/22 ,  C07F15/06 ,  A61K31/555 ,  A61K31/40 ,  A61K31/415

CPC分类号： C07D487/22

摘要： Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.

公开(公告)号：US06562563B1

公开(公告)日：2003-05-13

申请号：US09434354

申请日：1999-11-03

申请人： Anne N. Murphy ,  William Clevenger ,  Sandra Eileen Wiley ,  Alexander Y. Andreyev ,  Luciano G. Frigeri ,  Gonul Velecelebi ,  Robert E. Davis

发明人： Anne N. Murphy ,  William Clevenger ,  Sandra Eileen Wiley ,  Alexander Y. Andreyev ,  Luciano G. Frigeri ,  Gonul Velecelebi ,  Robert E. Davis

IPC分类号： C12N500

CPC分类号： G01N33/5079 ,  C07K14/43595 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/50 ,  C07K2319/60 ,  C12N9/90 ,  C12N15/62 ,  G01N33/542

摘要： Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.

摘要翻译： 提供组合物和方法用于鉴定改变线粒体膜通透性转换的药剂。 筛选方法通常检测改变线粒体腺嘌呤核苷酸转运体和亲环蛋白D之间的相互作用的试剂。这种试剂可用于例如治疗与线粒体功能改变相关的多种病症。