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    Crystalline α-D-glucosyl α-D-galactoside, saccharide composition comprising the same, process for producing the same, and uses thereof
    21.
    发明授权
    Crystalline α-D-glucosyl α-D-galactoside, saccharide composition comprising the same, process for producing the same, and uses thereof 有权
    结晶α-D-葡糖基α-D-半乳糖苷，包含其的糖组合物，其制备方法及其用途

    公开(公告)号：US07163711B2

    公开(公告)日：2007-01-16

    申请号：US10455730

    申请日：2003-06-06

    申请人： Tomoyuki Nishimoto ,  Michio Kubota ,  Shigeharu Fukuda

    发明人： Tomoyuki Nishimoto ,  Michio Kubota ,  Shigeharu Fukuda

    IPC分类号： A23G3/00

    CPC分类号： C07H3/04 ,  A23L2/52 ,  A23L27/33 ,  A61K8/60 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/10

    摘要： A crystalline α-D-glucosyl α-D-galactoside which has a melting point of 119–123° C.; a saccharide composition comprising the same; a process for producing the same or the saccharide composition comprising the same, which comprises (i) crystallizing α-D-glucosyl α-D-galactoside from its solution and (ii) collecting the grown crystalline α-D-glucosyl α-D-galactoside; a method for converting amorphous α-D-glucosyl α-D-galactoside to crystalline α-D-glucosyl α-D-galactoside in the presence of moisture; and a composition comprising the crystalline α-D-glucosyl α-D-galactoside or the saccharide composition comprising the same.

    摘要翻译： 结晶α-D-葡糖基α-D-半乳糖苷，其熔点为119-123℃。 包含其的糖组合物; 其制备方法或包含其的糖组合物，其包括（i）从其溶液中结晶α-D-葡糖基α-D-半乳糖苷和（ii）收集生长的结晶α-D-葡萄糖基α-D- 半乳糖苷 在水分存在下将无定形α-D-葡糖基α-D-半乳糖苷转化成结晶α-D-葡糖基α-D-半乳糖苷的方法; 以及包含结晶α-D-葡糖基α-D-半乳糖苷或包含其的糖组合物的组合物。

    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    23.
    发明申请
    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
    生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US20140178943A9

    公开(公告)日：2014-06-26

    申请号：US13980223

    申请日：2012-03-07

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/18

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    25.
    发明申请
    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
    生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US20130295618A1

    公开(公告)日：2013-11-07

    申请号：US13980223

    申请日：2012-03-07

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/18

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    PARTICULATE COMPOSITION CONTAINING ANHYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PROCESS FOR PRODUCING THE SAME, AND USES THEREOF
    27.
    发明申请
    PARTICULATE COMPOSITION CONTAINING ANHYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PROCESS FOR PRODUCING THE SAME, AND USES THEREOF 有权
    包含无水晶体2-O-α-D-葡糖醛酸-L-抗坏血酸的颗粒组合物，其生产方法及其用途

    公开(公告)号：US20110091726A1

    公开(公告)日：2011-04-21

    申请号：US12875786

    申请日：2010-09-03

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： B32B5/00 ,  C07H19/01 ,  C12P19/60

    CPC分类号： C12P19/60 ,  A23L33/10 ,  A23L33/15 ,  A61K8/0241 ,  A61K8/676 ,  A61K8/732 ,  A61K31/7048 ,  A61K2800/57 ,  A61K2800/654 ,  A61Q19/02 ,  C07H17/04 ,  Y10T428/2982

    摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, when calculated based on a profile of powder X-ray diffraction analysis of the particulate composition, and a dynamic vapor sorption level of 0.01% by weight or lower, when kept at 25° C. under a relative humidity of 35% by weight for 12 hours after removal water in the particulate composition under nitrogen gas stream; and by providing a process for producing the same and uses thereof.

    摘要翻译： 本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。 本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上时，基于颗粒组合物的粉末X射线衍射分析曲线和动态蒸气 当在氮气流下除去颗粒组合物中的水后，在25℃相对湿度35重量％下保持12小时，吸附水平为0.01重量％以下; 并提供其制造方法及其用途。

    Kojibiose phosphorylase glucosyl-saccharides produced by transglycosylation
    29.
    发明授权
    Kojibiose phosphorylase glucosyl-saccharides produced by transglycosylation 有权
    通过转糖基化产生的糖基二糖磷酸化葡糖基糖

    公开(公告)号：US06204377B1

    公开(公告)日：2001-03-20

    申请号：US09281259

    申请日：1999-03-30

    申请人： Tomoyuki Nishimoto ,  Michio Kubota ,  Hiroto Chaen ,  Toshio Miyake

    发明人： Tomoyuki Nishimoto ,  Michio Kubota ,  Hiroto Chaen ,  Toshio Miyake

    IPC分类号： C07H100

    CPC分类号： A61K8/60 ,  A61K38/00 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/02 ,  C12N9/1051 ,  C12P19/18

    摘要： A kojibiose phosphorylase which hydrolyzes kojibiose in the presence of an inorganic phosphoric acid to form D-glucose and &bgr;-D-glucose-1-phosphoric acid, forms kojibiose and an inorganic phosphoric acid from &bgr;-D-glucose-1-phosphoric acid, and catalyzes the transfer reaction of glucosyl group to other saccharides using &bgr;-D-glucose-1-phosphoric acid as a saccharide donor. The enzyme is obtainable from natural sources such as microorganisms of the genus Thermoanaerobium, and obtainable by recombinant technology. Kojibiose phosphorylase is used to transfer glucose from glucose-1-phosphate to acceptor saccharides to produce &agr;-D-glucosyl-1(1→5)-L-sorbose, kojibiosylglucose, kojibiosylglucoside and kojibiosylfructoside.

    摘要翻译： 在无机磷酸存在下水解曲霉糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸的曲霉糖磷酸化酶，从β-D-葡萄糖-1-磷酸形成曲酸和无机磷酸， 并使用β-D-葡萄糖-1-磷酸作为糖供体催化葡糖基转移至其他糖类。 该酶可从天然来源例如Thermoanaerobium属的微生物获得，可通过重组技术获得。 葡萄糖磷酸化酶用于将葡萄糖从葡萄糖-1-磷酸转移到受体糖以产生α-D-葡糖基-1（1-> 5）-L-山梨糖，茉莉基糖基葡萄糖，猕猴糖基葡萄糖苷和猕猴桃糖苷果糖苷。