公开(公告)号：US20190046635A1

公开(公告)日：2019-02-14

申请号：US16074907

申请日：2017-02-01

Applicant: NITTO DENKO CORPORATION

Inventor： Daisuke ASARI ,  Takuya SHISHIDO ,  Kyohei MATSUSHITA ,  Mitsuhiko HORI

IPC: A61K39/39 ,  A61K9/00 ,  A61P37/00

Abstract: The present invention aims to provide a composition for immunity induction promotion and a vaccine pharmaceutical composition each universally usable for induction of cellular immunity and/or humoral immunity against various antigens and exerting a high effect of inducing cellular immunity and/or humoral immunity. Provided is a composition for immunity induction promotion, containing a first immunity induction promoter, the first immunity induction promoter being an ion channel drug that affects an ion channel or an ion pump.

公开(公告)号：US20180169227A1

公开(公告)日：2018-06-21

申请号：US15932118

申请日：2016-08-03

Applicant: NITTO DENKO CORPORATION

Inventor： Kyohei MATSUSHITA ,  Daisuke ASARI ,  Takuya SHISHIDO ,  Mitsuhiko HORI

IPC: A61K39/39 ,  A61K45/00 ,  A61K9/00 ,  A61P37/04

CPC classification number: A61K39/39 ,  A61K9/0019 ,  A61K39/00 ,  A61K45/00 ,  A61K2039/55511 ,  A61P37/04

Abstract: The present invention provides an immunity induction-promoting composition which has a track record of use as a medicine or medicinal additive and is capable of safely and effectively inducing cellular immune response, and a vaccine pharmaceutical composition containing the immunity induction-promoting composition. The present invention relates to an immunity induction-promoting composition containing an immunity induction promoter whose active ingredient is an antimicrobial drug.

公开(公告)号：US20170360908A1

公开(公告)日：2017-12-21

申请号：US15507443

申请日：2015-09-02

Applicant: NITTO DENKO CORPORATION

Inventor： Takuya SHISHIDO ,  Daisuke ASARI ,  Mitsuhiko HORI

IPC: A61K39/00 ,  A61K31/047 ,  A61K33/00 ,  A61K31/7048 ,  A61K31/685 ,  A61K31/675 ,  A61K31/663 ,  A61K31/635 ,  A61K31/616 ,  A61K31/5415 ,  A61K31/4745 ,  A61K31/421 ,  A61K31/4192 ,  A61K31/4184 ,  A61K31/407 ,  A61K31/405 ,  A61K31/375 ,  A61K31/37 ,  A61K31/355 ,  A61K31/353 ,  A61K31/352 ,  A61K31/235 ,  A61K31/216 ,  A61K31/198 ,  A61K31/194 ,  A61K31/09 ,  A61K31/085 ,  A61K31/05 ,  A61K33/04 ,  A61K38/10

CPC classification number: A61K39/0005 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/7023 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/047 ,  A61K31/05 ,  A61K31/085 ,  A61K31/09 ,  A61K31/12 ,  A61K31/19 ,  A61K31/192 ,  A61K31/194 ,  A61K31/196 ,  A61K31/198 ,  A61K31/216 ,  A61K31/235 ,  A61K31/352 ,  A61K31/353 ,  A61K31/355 ,  A61K31/37 ,  A61K31/375 ,  A61K31/405 ,  A61K31/407 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/5415 ,  A61K31/616 ,  A61K31/635 ,  A61K31/663 ,  A61K31/675 ,  A61K31/685 ,  A61K31/7048 ,  A61K33/00 ,  A61K33/04 ,  A61K38/00 ,  A61K38/10 ,  A61K39/00 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention aims to provide a vaccine pharmaceutical composition universally usable for induction of cellular immunity against various antigens and exerting a high cellular immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition for inducing cellular immunity, containing: an antigen; and a first cellular immunity induction promoter that is a bisphosphonate.

公开(公告)号：US20170281759A1

公开(公告)日：2017-10-05

申请号：US15507525

申请日：2015-09-02

Applicant: NITTO DENKO CORPORATION

Inventor： Takuya SHISHIDO ,  Daisuke ASARI ,  Mitsuhiko HORI

IPC: A61K39/395

CPC classification number: A61K39/395 ,  A61K31/663 ,  A61K39/00 ,  A61K39/39 ,  A61K47/548 ,  A61K2039/55511 ,  A61K2039/58

Abstract: The present invention aims to provide a vaccine pharmaceutical composition universally usable for induction of humoral immunity against various antigens and exerting a high antibody production inducing effect. The present invention relates to a vaccine pharmaceutical composition for inducing humoral immunity, including: an antigen; and an immunity induction promoter that is a bisphosphonate.

公开(公告)号：US20170216429A1

公开(公告)日：2017-08-03

申请号：US15501271

申请日：2015-08-04

Applicant: NITTO DENKO CORPORATION

Inventor： Takuya SHISHIDO ,  Daisuke ASARI ,  Kyohei MATSUSHITA ,  Mitsuhiko HORI

IPC: A61K39/39

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/55511 ,  A61K2039/575 ,  Y02A50/388 ,  Y02A50/39

Abstract: The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.

公开(公告)号：US20140220100A1

公开(公告)日：2014-08-07

申请号：US14166952

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION

Inventor： Katsuyuki OKUBO ,  Yoshiki MAEDA ,  Takuya SHISHIDO ,  Daisuke ASARI ,  Arimichi OKAZAKI ,  Kyohei MATSUSHITA ,  Wenjing LI ,  Mitsuhiko HORI ,  Haruo SUGIYAMA

IPC: A61K39/00

CPC classification number: A61K39/0005 ,  A61K39/0011 ,  A61K2039/54

Abstract: The invention provides a cancer vaccine composition for transdermal administration for inducing cellular immunity comprising (i) HER2/neu E75 peptide and/or a modified HER2/neu E75 peptide; and (ii) a first cellular immunity induction promoter.

Abstract translation: 本发明提供了用于诱导细胞免疫的透皮给药的癌症疫苗组合物，其包含（i）HER2 / neu E75肽和/或经修饰的HER2 / neu E75肽; 和（ii）第一细胞免疫诱导启动子。

公开(公告)号：US20140220058A1

公开(公告)日：2014-08-07

申请号：US14166959

申请日：2014-01-29

Applicant: NITTO DENKO CORPORATION

Inventor： Yoshiki MAEDA ,  Katsuyuki OKUBO ,  Daisuke ASARI ,  Arimichi OKAZAKI ,  Takuya SHISHIDO ,  Kyohei MATSUSHITA ,  Wenjing LI ,  Mitsuhiko HORI ,  Haruo SUGIYAMA

IPC: A61K9/00 ,  A61K31/739 ,  A61K31/4745 ,  A61K39/00 ,  A61K38/10

CPC classification number: A61K9/0014 ,  A61K9/006 ,  A61K31/4745 ,  A61K31/739 ,  A61K38/10 ,  A61K39/0011 ,  A61K39/12 ,  A61K2039/54 ,  A61K2039/541 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55572 ,  C12N2770/24234

Abstract: The invention provides a vaccine composition for transdermal or transmucosal administration for inducing cellular immunity, comprising (i) an antigen; and (ii) a pharmacologically acceptable acid or a pharmacologically acceptable salt thereof as a first cellular immunity induction promoter.

Abstract translation: 本发明提供了用于诱导细胞免疫的透皮或经粘膜给药的疫苗组合物，其包含（i）抗原; 和（ii）药理学上可接受的酸或其药理学上可接受的盐作为第一细胞免疫诱导启动子。