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公开(公告)号：US06660499B1
公开(公告)日：2003-12-09
申请号：US09762960
申请日：2001-02-14
申请人： Aris N. Economides , Neil Stahl
发明人： Aris N. Economides , Neil Stahl
IPC分类号： C12P2106
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/02
摘要： DCR5, a protein related to DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and related nucleic acids are provided. Included are natural DCR5 homologs from several species and proteins comprising a DCR5 domain having specific activity, particularly the ability to antagonize a bone morphogenetic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译： 提供了与DAN相关的蛋白质（神经母细胞瘤中的差异筛选选择基因Aberrative）和相关核酸的DCR5。 包括来自几种物种的天然DCR5同源物和包含具有比活性的DCR5结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。 蛋白质可以用受试核酸从转化的宿主细胞重组产生。 还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。
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公开(公告)号：US20050197293A1
公开(公告)日：2005-09-08
申请号：US11056730
申请日：2005-02-11
申请人： Scott Mellis , Neil Stahl , Allen Radin , Steven Weinstein , Denise Calaprice , Margaret Karow , Joanne Papadopoulos
发明人： Scott Mellis , Neil Stahl , Allen Radin , Steven Weinstein , Denise Calaprice , Margaret Karow , Joanne Papadopoulos
CPC分类号： C07H21/04 , A61K38/00 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： Methods of treating, inhibiting, or ameliorating arthritis, including rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, or juvenile rheumatoid arthritis, in a human subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein arthritis inhibited, or ameliorated. The IL-1 antagonist is an IL-1-specific fusion protein comprising an IL-1 binding portion of the extracellular domain of human II-1RAcP, an IL-1 binding portion of the extracellular domain of human IL-1RI, and a multimerizing component antagonist, preferably comprising a sequence selected from the group consisting of SEQ ID NO:4, 6, 8, 10, 12,14, 16, 18, 20, 22, 24, 26, or a substantially identical sequence.
摘要翻译： 在有需要的人类受试者中治疗，抑制或改善关节炎，包括类风湿性关节炎，骨关节炎，银屑病关节炎，强直性脊柱炎或幼年型类风湿性关节炎的方法，包括向需要治疗的受试者施用治疗量的白介素1（ IL-1）拮抗剂，其中关节炎被抑制或改善。 IL-1拮抗剂是IL-1特异性融合蛋白，其包含人II-1RAcP的细胞外结构域的IL-1结合部分，人IL-1RI细胞外结构域的IL-1结合部分和多聚化 优选包含选自SEQ ID NO：4,6,8,10,12,14,16,18,20,22,24,26的序列，或基本相同的序列。
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公开(公告)号：US20050186623A1
公开(公告)日：2005-08-25
申请号：US11099158
申请日：2005-04-05
申请人： James Fandl , Neil Stahl , Gang Chen , George Yancopoulos
发明人： James Fandl , Neil Stahl , Gang Chen , George Yancopoulos
IPC分类号： A01K67/027 , C07K14/315 , C07K14/52 , C07K16/28 , C12N5/10 , C12N15/09 , C40B30/04 , G01N33/569 , G01N33/68 , C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： C40B30/04 , A01K2217/05 , A01K2267/01 , C07K14/315 , C07K14/52 , C07K16/2863 , C07K2317/77 , C07K2319/00 , C12N15/1051 , G01N33/56966 , G01N33/6845 , G01N2500/10
摘要： A method for identifying and isolating cells which produce secreted proteins. This method is based upon a specific characteristic or the expression level of the secreted protein by transiently capturing the secreted protein on the surface of an individual cell, allowing selection of rare cell clones from a heterogeneous population. Also provided is the use of this method to generate cells which produce a desired level of secreted protein or secreted protein of a particular characteristic(s), and organisms which possess such cells. In particular, the method allows rapid isolation of high expression recombinant antibody-producing cell lines, or may be applied directly to rapid isolation of specific hybridomas, or to the isolation of antibody-producing transgenic animals. This method is applicable for any cell which secretes protein.
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公开(公告)号：US5360740A
公开(公告)日：1994-11-01
申请号：US907680
申请日：1992-07-02
申请人： Nancy Y. Ip , Peter S. DiStefano , Neil Stahl
发明人： Nancy Y. Ip , Peter S. DiStefano , Neil Stahl
IPC分类号： G01N33/50 , G01N33/53 , G01N33/561 , G01N33/68 , G01N33/536 , G01N33/543 , G01N33/566
CPC分类号： G01N33/6896 , G01N33/6872 , G01N2800/2878 , G01N2800/52 , Y10S436/811
摘要： An assay system useful for detecting denervated or degenerating muscle by measuring the amount of soluble ciliary neurotrophic factor receptor in body fluids is described.
摘要翻译： 描述了通过测量体液中可溶性睫状神经营养因子受体的量来检测去神经支配或退化肌肉的测定系统。
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公开(公告)号：US07241739B2
公开(公告)日：2007-07-10
申请号：US10465474
申请日：2003-06-19
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： Human Cerberus proteins and related nucleic acids are provided. Included are proteins comprising a human cerberus domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译： 提供人Cerberus蛋白和相关核酸。 包括包含具有比活性的人类cerberus结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。 蛋白质可以用受试核酸从转化的宿主细胞重组产生。 还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。
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公开(公告)号：US20070037748A1
公开(公告)日：2007-02-15
申请号：US11502736
申请日：2006-08-11
申请人： Neil Stahl , George Yancopoulos , Eric Furfine , Jesse Cedarbaum
发明人： Neil Stahl , George Yancopoulos , Eric Furfine , Jesse Cedarbaum
IPC分类号： A61K38/17
CPC分类号： A61K38/179
摘要： A method of reducing or preventing hypertension associated with administration of a vascular endothelial growth factor (VEGF) antagonist in a human subjects suffering from a disease or condition treatable with a VEGF antagonist in which is it desirable to reduce or prevent hypertension. The method is particularly useful for treatment of patients unresponsive to treatment with a VEGF inhibitor administered intravenously.
摘要翻译： 在患有可用VEGF拮抗剂治疗的疾病或病症的人类受试者中降低或预防与血管内皮生长因子（VEGF）拮抗剂的给药相关的高血压的方法，其中希望减少或预防高血压。 该方法对于治疗对用静脉内施用的VEGF抑制剂治疗无反应的患者特别有用。
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公开(公告)号：US20060234311A1
公开(公告)日：2006-10-19
申请号：US11434403
申请日：2006-05-15
申请人： James Fandl , Neil Stahl , Gang Chen , George Yancopoulos
发明人： James Fandl , Neil Stahl , Gang Chen , George Yancopoulos
CPC分类号： C40B30/04 , A01K2217/05 , A01K2267/01 , C07K14/315 , C07K14/52 , C07K16/2863 , C07K2317/77 , C07K2319/00 , C12N15/1051 , G01N33/56966 , G01N33/6845 , G01N2500/10
摘要： A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.
摘要翻译： 一种检测和分离产生任何分泌的感兴趣蛋白质（POI）的细胞的方法，包括：a）通过用核酸转染细胞系来构建瞬时或稳定表达结合POI的细胞表面捕获分子的细胞系 编码这种细胞表面捕获分子; b）同时或随后用编码POI的第二核酸同时转染所述细胞，其中所述POI被分泌; c）通过使细胞与结合POI的检测分子接触来检测表面显示的POI; 和d）基于检测分子分离细胞。
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28.发明申请公开(公告)号：US20050074855A1
公开(公告)日：2005-04-07
申请号：US10610452
申请日：2003-06-30
申请人： Neil Stahl , George Yancopoulos
发明人： Neil Stahl , George Yancopoulos
IPC分类号： C07K14/715 , C07K16/24 , C07K16/46 , C12N15/62 , C12P21/04 , C07H21/04 , C07K14/52 , C12N5/06 , C12P21/02
CPC分类号： C12N15/62 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K16/248 , C07K16/468 , C07K2317/622 , C07K2317/92 , C07K2318/10 , C07K2318/20 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： High affinity fusion proteins (“trapbodies”), capable of binding and inhibiting the activity of soluble, interacting proteins (“SIPs”) are described. The trapbodies are multimers, preferably dimers, of SIP-specific fusion polypeptides which comprise SIP binding domains derived from SIP targets and/or anti-SIP immunoglobulins, as well as multimerizing components.
摘要翻译： 描述了能够结合和抑制可溶性相互作用蛋白（“SIP”）活性的高亲和力融合蛋白（“陷阱”）。 所述捕获体是SIP特异性融合多肽的多聚体，优选二聚体，其包含衍生自SIP靶标和/或抗-Iss免疫球蛋白的SIP结合结构域，以及多聚化组分。
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29.发明申请High affinity fusion proteins and therapeutic and diagnostic methods for use 审中-公开高亲和力融合蛋白和治疗和诊断方法使用公开(公告)号：US20050032175A1
公开(公告)日：2005-02-10
申请号：US10879994
申请日：2004-06-29
申请人： Neil Stahl , George Yancopoulos , Margaret Karow , Eric Smith
发明人： Neil Stahl , George Yancopoulos , Margaret Karow , Eric Smith
IPC分类号： C07K14/715 , C07K16/24 , C07K16/46 , C12N15/62 , C12P21/04 , C07H21/04 , C07K16/40 , C12N9/64
CPC分类号： C12N15/62 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K16/248 , C07K16/468 , C07K2317/622 , C07K2317/92 , C07K2318/10 , C07K2318/20 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： High affinity fusion proteins capable of binding and inhibiting the activity of soluble, interacting proteins (“SIPs”) are described. In specific embodiments the fusion proteins are multimers, preferably dimers, of SIP-specific fusion polypeptides which comprise SIP binding domains derived from SIP targets and/or anti-SIP immunoglobulin domains, as well as multimerizing components.
摘要翻译： 描述了能够结合和抑制可溶性相互作用蛋白（“SIP”）活性的高亲和力融合蛋白。 在具体实施方案中，融合蛋白是SIP特异性融合多肽的多聚体，优选二聚体，其包含衍生自SIP靶标和/或抗SIP免疫球蛋白结构域的SIP结合结构域，以及多聚化组分。
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公开(公告)号：US06610510B1
公开(公告)日：2003-08-26
申请号：US09423029
申请日：1999-11-16
IPC分类号： C12P2100
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： Human Cerberus proteins and related nucleic acids are provided. Included are proteins comprising a human cerberus domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译： 提供人Cerberus蛋白和相关核酸。 包括包含具有比活性的人类cerberus结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。 蛋白质可以用受试核酸从转化的宿主细胞重组产生。 还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。
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