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公开(公告)号：US20120129237A1
公开(公告)日：2012-05-24
申请号：US13336371
申请日：2011-12-23
申请人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
发明人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
CPC分类号： C07K16/40 , A61K38/00 , C07K2317/41 , C07K2317/76 , C12N9/6424 , C12Y302/01008 , C12Y304/21061 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US08105804B2
公开(公告)日：2012-01-31
申请号：US12903658
申请日：2010-10-13
申请人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
发明人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
CPC分类号： C07K16/40 , A61K38/00 , C07K2317/41 , C07K2317/76 , C12N9/6424 , C12Y302/01008 , C12Y304/21061 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07056737B2
公开(公告)日：2006-06-06
申请号：US10075846
申请日：2002-02-13
申请人： John N. Feder , Liana Lee , Jian Chen , Nathan O. Siemers , Han Chang
发明人： John N. Feder , Liana Lee , Jian Chen , Nathan O. Siemers , Han Chang
IPC分类号： C12N5/00
CPC分类号： C07K14/705 , A61K2039/53
摘要： The present invention provides novel polynucleotides encoding HGRA4 polypeptides, fragments and homologues thereof. The present invention also provides novel polynucleotides encoding a HGRA4 splice variant, HGRA4sv. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGRA4 and HGRA4sv polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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公开(公告)号：US20100003736A1
公开(公告)日：2010-01-07
申请号：US12456798
申请日：2009-06-23
申请人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
发明人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
CPC分类号： C07K16/40 , A61K38/00 , C07K2317/41 , C07K2317/76 , C12N9/6424 , C12Y302/01008 , C12Y304/21061 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US07034134B2
公开(公告)日：2006-04-25
申请号：US10133797
申请日：2002-04-26
申请人： Shujian Wu , Jian Chen
发明人： Shujian Wu , Jian Chen
CPC分类号： C12N9/6489
摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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26.发明申请公开(公告)号：US20070071743A1
公开(公告)日：2007-03-29
申请号：US11601407
申请日：2006-11-17
申请人： Liana Lee , John Feder , Shujian Wu , Jian Chen
发明人： Liana Lee , John Feder , Shujian Wu , Jian Chen
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K14/705 , C07K16/42
CPC分类号： C07K14/705 , A61K38/00 , C07K14/70503
摘要： The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码BGS-19多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将新型BGS-19多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US20060105379A1
公开(公告)日：2006-05-18
申请号：US11313356
申请日：2005-12-21
申请人： Shujian Wu , Jian Chen , John Feder , Liana Lee , Stanley Krystek
发明人： Shujian Wu , Jian Chen , John Feder , Liana Lee , Stanley Krystek
CPC分类号： C12N9/6489
摘要： The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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公开(公告)号：US07598348B2
公开(公告)日：2009-10-06
申请号：US12148669
申请日：2008-04-21
申请人： Jian Chen , Ning Lee , Dong Cheng
发明人： Jian Chen , Ning Lee , Dong Cheng
IPC分类号： C07K14/72
CPC分类号： C07K14/72
摘要： The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1 polypeptides, rat AdipoR1 polypeptides, rat AdipoR2 polypeptides, to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽，其片段及其同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新的人AdipoR2v1多肽，小鼠AdipoR2v1多肽，人AdipoR3多肽，人AdipoR2v2多肽，人AdipoR3v1多肽，大鼠AdipoR1多肽，大鼠AdipoR2多肽应用于诊断，治疗和/或治疗的诊断和治疗方法。 预防与这些多肽相关的各种疾病和/或病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US20200032191A1
公开(公告)日：2020-01-30
申请号：US16586989
申请日：2019-09-29
申请人： Jian Chen
发明人： Jian Chen
摘要： The shock tube comprises a tube, a first electrode, a second electrode and a stopple, wherein the tube is internally provided with a cavity for accommodating a target liquid sample. The first electrode is arranged at one end of the tube. The second electrode is arranged in the stopple, and the outer end of the second electrode can be electrically connected with the exterior via an opening of the stopple. The stopple is internally provided with an elastic piece connected with the second electrode. The outer side of the elastic piece is connected with the stopple, and the inner side of the elastic piece is connected with the second electrode. The invention further provides a cell electroporation device where the shock tube can be placed.
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30.发明授权公开(公告)号：US10392634B2
公开(公告)日：2019-08-27
申请号：US15472003
申请日：2017-03-28
申请人： Jingwen Zhou , Jian Chen , Yongkun Lv , Guocheng Du
发明人： Jingwen Zhou , Jian Chen , Yongkun Lv , Guocheng Du
摘要： The present invention provides a method for high-efficiency production of pinoresinol by use of an H2O2 auto-scavenging enzymatic cascade. It uses eugenol as the substrate, which is relatively inexpensive and is industrially available. It uses an enzymatic cascade to remove H2O2 produced in the process of pinoresinol synthesis, thereby reducing its inhibitory effect on the enzyme activity. In addition, the present invention uses whole cells as a catalyst, which can continuously regenerate cofactors needed by the enzyme, thus eliminating the need for exogenous addition of expensive cofactors during the reaction. The yield of the present invention can reach 7.12 g/L and the conversion rate is 61.55%.
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