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公开(公告)号：US07897781B2
公开(公告)日：2011-03-01
申请号：US11746318
申请日：2007-05-09
申请人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
发明人： Raymond W. Colburn , Scott L. Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark A. Youngman
IPC分类号： C07F9/28
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US07575882B2
公开(公告)日：2009-08-18
申请号：US11589340
申请日：2006-10-30
申请人： Ning Qin , Yi Liu , Christopher M. Flores , Tasha Hutchinson , Michael P. Neeper
发明人： Ning Qin , Yi Liu , Christopher M. Flores , Tasha Hutchinson , Michael P. Neeper
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： G01N33/6872 , A61K31/05 , A61K31/352 , G01N33/5058 , G01N33/948 , G01N2500/02
摘要： It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.
摘要翻译： 现在已经发现某些大麻素特异性地激活TRPV2通道活性。 基于发现，用于筛选，鉴定和表征增加或降低TRPV2生物活性的化合物的新型组合物和方法。
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23.发明申请CANINE TRANSIENT RECEPTOR POTENTIAL V2 (CTRPV2) AND METHODS OF SCREENING FOR TRPV2 CHANNEL MODULATORS 有权可能的瞬态受体电位V2（CTRPV2）和TRPV2通道调制器的筛选方法公开(公告)号：US20090165151A1
公开(公告)日：2009-06-25
申请号：US12042016
申请日：2008-03-04
CPC分类号： C07K14/705 , G01N33/6872 , G01N2500/10 , G01N2800/2842
摘要： A recombinant canine TRPV2 channel which has been prepared by cDNA cloning and polymerase chain reaction techniques is disclosed. Expression systems for these channels and an assay using the expression systems are also disclosed. The recombinant TRPV2 channel can be used in assays to evaluate compounds which directly or indirectly interact with or bind to TRPV2 channel.
摘要翻译： 公开了通过cDNA克隆和聚合酶链反应技术制备的重组犬TRPV2通道。 还公开了这些通道的表达系统和使用表达系统的测定法。 重组TRPV2通道可用于测定直接或间接与TRPV2通道相互作用或结合TRPV2通道的化合物。
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公开(公告)号：US20070105086A1
公开(公告)日：2007-05-10
申请号：US11589340
申请日：2006-10-30
申请人： Ning Qin , Yi Liu , Christopher Flores , Tasha Hutchinson , Michael Neeper
发明人： Ning Qin , Yi Liu , Christopher Flores , Tasha Hutchinson , Michael Neeper
CPC分类号： G01N33/6872 , A61K31/05 , A61K31/352 , G01N33/5058 , G01N33/948 , G01N2500/02
摘要： It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.
摘要翻译： 现在已经发现某些大麻素特异性地激活TRPV2通道活性。 基于发现，用于筛选，鉴定和表征增加或降低TRPV2生物活性的化合物的新型组合物和方法。
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公开(公告)号：US20060014246A1
公开(公告)日：2006-01-19
申请号：US11099855
申请日：2005-04-06
申请人： Christopher Flores , Yi Liu , Mary Lubin , Ning Qin
发明人： Christopher Flores , Yi Liu , Mary Lubin , Ning Qin
IPC分类号： A61K38/17 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays and screening assays.
摘要翻译： 本发明提供描述新型犬冷和薄荷醇敏感受体的核酸和多肽序列，本文命名为犬CMR1（cCMR1）。 本发明的分离的核酸或多肽分子可用于检测测定和筛选测定。
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公开(公告)号：US08399201B2
公开(公告)日：2013-03-19
申请号：US11590503
申请日：2006-10-31
申请人： Ning Qin , Christopher M. Flores
发明人： Ning Qin , Christopher M. Flores
CPC分类号： C07K14/705 , G01N33/6872 , G01N2333/4727 , G01N2500/02
摘要： The present invention discovered that a mammalian TRPM8 binds to calmodulin. The present invention provides a polypeptide complex comprising a cold-menthol receptor (TRPM8) or an active fragment or derivative of TRPM8 and a calmodulin or an active fragment or derivative of calmodulin, and the uses of the polypeptide complex.
摘要翻译： 本发明发现哺乳动物TRPM8与钙调蛋白结合。 本发明提供了包含冷薄荷醇受体（TRPM8）或TRPM8的活性片段或衍生物和钙调蛋白或钙调素的活性片段或衍生物的多肽复合物，以及多肽复合物的用途。
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公开(公告)号：US20120190674A1
公开(公告)日：2012-07-26
申请号：US13407251
申请日：2012-02-28
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/381 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61P9/12 , A61P25/00 , A61P29/00 , A61P25/22 , A61P25/24 , A61P9/00 , C07D333/66 , A61K31/541
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US07375203B2
公开(公告)日：2008-05-20
申请号：US11099855
申请日：2005-04-06
申请人： Christopher M. Flores , Yi Liu , Mary Lou Lubin , Ning Qin
发明人： Christopher M. Flores , Yi Liu , Mary Lou Lubin , Ning Qin
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays and screening assays.
摘要翻译： 本发明提供描述新型犬冷和薄荷醇敏感受体的核酸和多肽序列，本文命名为犬CMR1（cCMR1）。 本发明的分离的核酸或多肽分子可用于检测测定和筛选测定。
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公开(公告)号：US20080027029A1
公开(公告)日：2008-01-31
申请号：US11746318
申请日：2007-05-09
申请人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
发明人： Raymond Colburn , Scott Dax , Christopher Flores , Jay Matthews , Ning Qin , Laura Reany , Christopher Teleha , Mark Youngman
IPC分类号： A61K31/67 , A61K31/665 , A61K31/675 , A61P25/00 , A61P29/00 , A61P9/00 , A61P9/12 , C07D495/00 , C07F9/572 , C07F9/655 , C07F9/6553
CPC分类号： C07F9/655354 , C07F9/5728 , C07F9/65517 , C07F9/65586 , C07F9/6561
摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及式（I）的TRPM8拮抗剂。 更具体地说，本发明涉及某些新化合物，制备化合物，组合物，中间体及其衍生物的方法和治疗TRPM8介导的病症的方法。 还描述了使用本发明化合物治疗疼痛和各种其它疾病状态或病症的药物和兽医组合物和方法。
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