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42 条记录 (耗时 0.03 秒)

    Fat-Derived Progenitor Cell and Use Thereof
    25.
    发明申请
    Fat-Derived Progenitor Cell and Use Thereof 审中-公开
    脂肪来源的祖细胞及其用途

    公开(公告)号：US20080317720A1

    公开(公告)日：2008-12-25

    申请号：US11911466

    申请日：2006-04-14

    申请人： Noritoshi Nagaya ,  Kunio Miyatake ,  Kenji Kangawa ,  Masaharu Kataoka

    发明人： Noritoshi Nagaya ,  Kunio Miyatake ,  Kenji Kangawa ,  Masaharu Kataoka

    IPC分类号： A61K35/12 ,  C12N5/06 ,  A61P9/00

    CPC分类号： A61L27/3843 ,  A61K35/12 ,  A61L27/3804 ,  C12N5/0667 ,  C12N2501/165 ,  C12N2501/34 ,  C12N2533/90

    摘要： An objective of the present invention is to provide methods for producing progenitor cells which show a high proliferation ability ex vivo and promote neovascularization or myocardium regeneration, by culturing pluripotent cells in a medium containing adrenomedullin (AM) and/or vascular endothelial growth factor (VEGF). Moreover, another objective of the present invention is to provide the progenitor cells and uses thereof. In order to solve the above problems, the inventors of the present application have successfully developed a novel culture technique for producing progenitor cells from adipose tissues more efficiently compared to the conventional techniques, by using adrenomedullin (AM) and/or vascular endothelial growth factor (VEGF). The progenitor cells produced by the present inventors are specialized cells having a potent proliferation ability, a revascularization ability, and a myocardium regeneration ability, and have the property of not differentiating into adipocytes even if subjected to differentiation induction into adipocytes. Therefore, the progenitor cells of the present invention can be effective pharmaceutical agents for intractable diseases in the brain, lung, liver, kidney and the like.

    摘要翻译： 本发明的目的是提供通过在含有肾上腺髓质素（AM）和/或血管内皮生长因子（VEGF）的培养基中培养多能细胞来产生离体显示高增殖能力并促进新生血管形成或心肌再生的祖细胞的方法 ）。 此外，本发明的另一个目的是提供祖细胞及其用途。 为了解决上述问题，本申请的发明人通过使用肾上腺髓质素（AM）和/或血管内皮生长因子（AM）和/或血管内皮生长因子（AM），成功地开发了一种新型的培养技术，用于与常规技术相比更有效地从脂肪组织产生祖细胞 VEGF）。 由本发明人生产的祖细胞是具有有效增殖能力，血运重建能力和心肌再生能力的特殊细胞，即使进行脂肪细胞分化诱导，也具有不分化成脂肪细胞的性质。 因此，本发明的祖细胞可以是脑，肺，肝，肾等中难治性疾病的有效药剂。

    Porcine CNP gene and precursor protein
    26.
    发明授权
    Porcine CNP gene and precursor protein 失效
    猪CNP基因和前体蛋白

    公开(公告)号：US6020168A

    公开(公告)日：2000-02-01

    申请号：US728220

    申请日：1991-07-12

    申请人： Hisayuki Matsuo ,  Kenji Kangawa ,  Naoto Minamino ,  Shoji Tanaka ,  Kayoko Fuchimura ,  Yasunori Tawaragi

    发明人： Hisayuki Matsuo ,  Kenji Kangawa ,  Naoto Minamino ,  Shoji Tanaka ,  Kayoko Fuchimura ,  Yasunori Tawaragi

    IPC分类号： C12N15/09 ,  A61K38/00 ,  C07H21/04 ,  C07K14/575 ,  C07K14/58 ,  C12N15/16 ,  C12P21/02 ,  C12R1/19 ,  C12P21/06 ,  C07H17/00 ,  C07K14/00

    CPC分类号： C07K14/58 ,  A61K38/00

    摘要： The gene and cDNA of a procine derived CNP (C-type natriuretic peptide), and a procine derived CNP precursor protein and derivatives thereof are disclosed. The proceine derivative CNP precursor is represented by the following amino acid sequence:Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Gly Glu Glu Val - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu His - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser These derivatives are novel and have natriuretic and hypotensive activities.

    摘要翻译： 公开了源自CNP（C型利尿钠肽）的基因和cDNA，以及源自CNP前体蛋白及其衍生物的衍生物。 程序衍生物CNP前体由以下氨基酸序列表示： - Met His Leu Ser Gln Leu Leu Ala Cys Ala - - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - - Val Pro Arg Thr Pro Pro Gly Glu Glu Val - - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - - Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly - - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - - Ser Arg Ala Ala Trp Ala Arg Leu Leu His - - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - - Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser - - Met Ser Gly Leu Gly Cys。 - 这些衍生物是新颖的，具有钠尿和降血压活性。

    Rat CNP complementary DNA and precursor protein
    27.
    发明授权
    Rat CNP complementary DNA and precursor protein 失效
    大鼠CNP互补DNA和前体蛋白

    公开(公告)号：US5973134A

    公开(公告)日：1999-10-26

    申请号：US757606

    申请日：1991-09-11

    申请人： Hisayuki Matsuo ,  Masayasu Kojima ,  Kenji Kangawa ,  Naoto Minamito

    发明人： Hisayuki Matsuo ,  Masayasu Kojima ,  Kenji Kangawa ,  Naoto Minamito

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/22 ,  A61P7/10 ,  A61P9/12 ,  C07H21/04 ,  C07K14/00 ,  C07K14/575 ,  C07K14/58 ,  C12N15/12 ,  C12P21/02 ,  C07H17/00

    CPC分类号： C07K14/58 ,  A61K38/00

    摘要： A cDNA coding for a rat derived CNP (rCNP: C-type natriuretic pepteide), and a rat derived CNP precursor protein and derivatives thereof are disclosed.The rat derived CNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly CysThe rCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.

    摘要翻译： 公开了编码大鼠衍生的CNP（rCNP：C型利尿钠蛋白酶）的cDNA和大鼠衍生的CNP前体蛋白及其衍生物。 大鼠衍生的CNP前体由以下氨基酸序列表示。 Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys rCNP前体及其衍生物是新颖的，具有钠尿和降血压活性。

    Preventives or Remedies for Hepatopathy
    29.
    发明申请
    Preventives or Remedies for Hepatopathy 审中-公开
    预防或治疗肝病

    公开(公告)号：US20070219114A1

    公开(公告)日：2007-09-20

    申请号：US10554875

    申请日：2004-04-30

    申请人： Kenji Kangawa ,  Hiroshi Hosoda

    发明人： Kenji Kangawa ,  Hiroshi Hosoda

    IPC分类号： A61K38/02

    CPC分类号： A61K31/00 ,  A61K38/25

    摘要： The present invention relates to a preventive or a therapeutic agent for hepatopathy, comprising, as an effective ingredient, a polypeptide derivative having an activity of binding to growth hormone secretagogue receptor and thus elevating intracellular calcium ion concentration, and having one amino acid sequence selected from the group consisting of amino acid sequences represented by SEQ ID NOS: 1 to 22, or an amino acid sequence in which one to several amino acids are deleted, substituted or added at the amino acid residues other that the first to forth amino acid residues from the amino-terminus in the said amino acid sequence, or a pharmacologically acceptable salt thereof. The preventive or the therapeutic agent for hepatopathy in accordance with the present invention is useful as a drug suitable for treating or preventing hepatic diseases such as hepatitis, liver cirrhosis and hepatic insufficiency. Further, the preventive or the therapeutic agent for hepatopathy in accordance with the present invention is also useful as an agent of promoting hepatic regeneration and hepatic function recovery after hepatectomy.

    摘要翻译： 本发明涉及用于肝病的预防或治疗剂，其包含作为有效成分的具有与生长激素促分泌素受体结合的活性的多肽衍生物，从而提高细胞内钙离子浓度，并且具有一个选自以下的氨基酸序列 由SEQ ID NO：1至22表示的氨基酸序列组成的组，或其中一至几个氨基酸缺失，氨基酸残基取代或加入的氨基酸序列，其中第一至第四氨基酸残基来自 所述氨基酸序列中的氨基末端或其药理学上可接受的盐。 根据本发明的肝病预防或治疗剂可用作适合于治疗或预防肝病，肝硬化和肝功能不全等肝病的药物。 此外，根据本发明的肝病的预防或治疗剂也可用作肝切除术后促进肝再生和肝功能恢复的药剂。