公开(公告)号：US20060228792A1

公开(公告)日：2006-10-12

申请号：US10568754

申请日：2004-08-19

申请人： Kohei Oda ,  Yoshiharu Kimura ,  Kazumi Hiraga ,  Yasuhito Maeda ,  Kiyotsuna Toyohara ,  Hiroyoshi Minematsu

发明人： Kohei Oda ,  Yoshiharu Kimura ,  Kazumi Hiraga ,  Yasuhito Maeda ,  Kiyotsuna Toyohara ,  Hiroyoshi Minematsu

IPC分类号： C12N1/12 ,  C12N1/20

CPC分类号： C08J11/18 ,  C08J2367/02 ,  C12R1/41 ,  Y02W30/706

摘要： A microorganism which belongs to the genus Rhizobium and has the ability of degrading an aromatic polyester, and a method of degrading an aromatic polyester by using the microorganism. According to this method, the aromatic polyester can be degraded safely and relatively swiftly at a low cost.

摘要翻译： 属于根瘤菌属并具有降解芳族聚酯的能力的微生物，以及使用该微生物降解芳香族聚酯的方法。 根据该方法，芳香族聚酯可以以低成本安全且相对迅速地降解。

公开(公告)号：US06235393B1

公开(公告)日：2001-05-22

申请号：US09526492

申请日：2000-03-15

申请人： Yoshiharu Kimura ,  Yoji Hori

发明人： Yoshiharu Kimura ,  Yoji Hori

IPC分类号： D01F800

CPC分类号： D01F8/14 ,  Y10T428/2924 ,  Y10T428/2929 ,  Y10T428/2931

摘要： A biodegradable complex fiber which retains excellent biodegradability and hydrolyzability and has high strength and high melting temperature suitable for practical use and a method for producing the biodegradable complex fiber are provided. The biodegradable complex fiber comprises at least one polymer material selected from the group consisting of a polyglycolic acid, a poly(glycolic acid-co-lactic acid) and polylactic acid as a core component or as a shell component and a polymer material of poly(3-hydroxybutyric acid) groups or a polymer material of an aliphatic polyester consisting of a dibasic acid and a diol as a shell component or as a core component. The method comprises producing the biodegradable complex fiber by melt spinning.

公开(公告)号：US06007857A

公开(公告)日：1999-12-28

申请号：US98547

申请日：1998-06-17

申请人： Yoshiharu Kimura ,  Masakazu Terauchi

发明人： Yoshiharu Kimura ,  Masakazu Terauchi

IPC分类号： A23G1/00 ,  A23G1/04 ,  A23G1/56

CPC分类号： A23G1/047 ,  A23G1/56 ,  A23G2200/06

摘要： A process for producing granular cocoa which comprises granulating cocoa powder in a fluidized bed while spraying with a liquid binder prepared by heating cocoa powder and/or cacao extract with or without water to obtain granules having a water content of 15 to 40% by weight, and then drying the granules with hot air in a fluidized bed. The resulting granular cocoa easily dissolves in warm milk or warm water without preliminary kneading.

摘要翻译： 一种生产颗粒状可可粉的方法，包括将可可粉在流化床中粒化，同时喷雾通过加热可可粉和/或可可粉提取物制备的液体粘合剂，其中含有或不含有水，得到含水量为15-40重量％的颗粒， 然后在流化床中用热空气干燥颗粒。 所得到的颗粒状可可粉容易溶解在温热的牛奶或温水中而无需预先捏合。

公开(公告)号：US5272221A

公开(公告)日：1993-12-21

申请号：US863085

申请日：1992-04-03

申请人： Toshio Kitao ,  Yoshiharu Kimura ,  Hideki Yamane ,  Hiroki Nakata ,  Hosei Shinoda

发明人： Toshio Kitao ,  Yoshiharu Kimura ,  Hideki Yamane ,  Hiroki Nakata ,  Hosei Shinoda

IPC分类号： A61L31/04 ,  C08L77/00 ,  C08G69/48

CPC分类号： A61L31/041 ,  C08L77/00 ,  Y10S525/937

摘要： The present invention provides a nylon composition having increased hydrolyzability which is obtained by physically mixing 100 parts by weight of a nylon with 1 to 50 parts by weight of at least one polymer selected from the group consisting of polylactic acid, polyglycolic acid and a copolymer containing 50 mol % or more of a lactic acid unit or a glycolic acid unit as a repeating unit in its chain; and a method for increasing the hydrolyzability of a nylon by preparing such a composition. High hydrolyzability can be imparted to the nylon inherently having extremely low hydrolyzability without impairing its original mechanical strength. Therefore, various molded articles made from the nylon can be hydrolyzed under natural circumstances, and thus the wastes are not stored.

摘要翻译： 本发明提供了具有增加的水解性的尼龙组合物，其通过将100重量份的尼龙与1至50重量份的至少一种选自聚乳酸，聚乙醇酸和含有 50重量％以上的乳酸单元或乙醇酸单元作为其链中的重复单元; 以及通过制备这种组合物来提高尼龙的水解性的方法。 可以将高水解性赋予固有地具有极低水解性的尼龙，而不损害其原始的机械强度。 因此，由尼龙制成的各种成型体在自然条件下可以水解，因此不会将废物进行储存。

公开(公告)号：US5225514A

公开(公告)日：1993-07-06

申请号：US812824

申请日：1991-12-24

申请人： Yoshiharu Kimura ,  Soonih Kim ,  Akio Nishiura

发明人： Yoshiharu Kimura ,  Soonih Kim ,  Akio Nishiura

IPC分类号： A61K9/48 ,  A61K9/50 ,  C08G18/38

CPC分类号： C08G18/3836 ,  A61K9/4891 ,  A61K9/5031 ,  A61K9/5078 ,  C08G2230/00

摘要： A polyurethane (I) of 1000 to 100,000 in average molecular weight, comprising plural segments, which are each structural units of A-B, A-C and A-D of the formulae: ##STR1## the proportion of the said segments of A-B, A-C and A-D, i.e. x:y:z is in the molar ratio 0.01 to 0.8:0 to 0.80:0 to 0.99, provided that the sum of x, y and z is 1.0; each segment being produced by combining with repeat units of A, B, C and D of the formulae: ##STR2## wherein R.sup.1 is a skeleton of a diisocyanate and the three R.sup.1 's in each of segments A-B, A-C and A-D can be the same or different; aza is a group of the formula: ##STR3## wherein Y.sup.1 and Y.sup.2 which can be the same or different, are oxygen, imino(--NH--) or a group of the formula:*R.sup.6 --O, *R.sup.6 --NH, O--R.sup.6 --O, *NHCO--R.sup.6 --NH or *CONH--R.sup.6 --NH;whereinR.sup.6 is alkylene and an atom or the end of the group, marked by * is bonded to phenyl ring;R.sup.4 and R.sup.5 each are, independently, hydrogen, halogen, nitro or phenyl;R.sup.2 is polyalkylene glycol residue;Z is oxygen or imino and the two Z's are the same;R.sup.3 is alkylene or a group of the formula: ##STR4## wherein R.sup.7 and R.sup.8 which can be the same or different, are alkylene; andR.sup.9 is alkyl;each segment of the polyurethane being contained in the aforementioned proportion of x, y and z, is combined by block-type, random-type or a combination thereof, is degraded specifically in the large intestine. Therefore, by using the polyurethane as pharmaceutical adjuvants, the medicament can be delivered specifically to the large intestine and at a high concentration with hardly any degradation and absorption in the small intestine, after oral administration.

摘要翻译： 平均分子量为1000至100,000的聚氨酯（I），包含多个片段，其各自为AB，AC和AD的结构单元，其分子式如下： AB AC和 AD 所述AB，AC和AD的区段，即x：y：z的摩尔比为0.01至0.8:0至0.80:0至0.99，条件是x，y和z的和为1.0; 每个片段通过与下式的A，B，C和D的重复单元组合来产生：A -aza-，BZR2Z和C OR3O; D其中R1是二异氰酸酯的骨架，并且段A-B，A-C和A-D中的每一个中的三个R 1可以相同或不同; 氮杂是下式的基团：其中可以相同或不同的Y1和Y2是氧，亚氨基（-NH-）或下式的基团：R6 -O，* R6-NH，O-R6-O，* NHCO-R6-NH或* CONH-R6-NH; 其中R6是亚烷基，并且由*标记的基团的原子或末端键合到苯环上; R4和R5各自独立地为氢，卤素，硝基或苯基; R2是聚亚烷基二醇残基; Z是氧或亚氨基，两个Z相同; R 3是亚烷基或下式的基团：其中可以相同或不同的R 7和R 8是亚烷基; 并且R 9为烷基; 以上述比例的x，y和z包含的聚氨酯的各段通过嵌段型，无规型或其组合组合在大肠中特异性降解。 因此，通过使用聚氨酯作为药物佐剂，可以在口服给药后，将药物特异性递送至大肠，高浓度，几乎不会在小肠中降解和吸收。

公开(公告)号：US4624920A

公开(公告)日：1986-11-25

申请号：US673249

申请日：1984-11-20

申请人： Shigeo Inoue ,  Yoshiharu Kimura ,  Shigehito Adachi

发明人： Shigeo Inoue ,  Yoshiharu Kimura ,  Shigehito Adachi

IPC分类号： C12P7/44 ,  C12R1/32 ,  C12N1/20

CPC分类号： C12P7/44 ,  Y10S435/863

摘要： A process for the preparation of a dicarboxylic acid using a thermophilic croorganism, and the microorganism used. The process involves cultivating a microorganism belonging to the genus Mycobacterium which produces a dicarboxylic acid at high temperatures in a medium to which a substrate selected from among normal paraffins, fatty acids, and their derivatives, each containing 6 to 22 carbon atoms, has been added, so that a dicarboxylic acid containing 6 to 22 carbon atoms is formed and accumulated in the medium, and collecting the dicarboxylic acid.

摘要翻译： 使用嗜热微生物制备二羧酸的方法和使用的微生物。 该方法包括培养属于分枝杆菌属的微生物，该微生物在高温下在加入了选自其中含有6-22个碳原子的正链烷烃，脂肪酸及其衍生物的底物的培养基中产生二羧酸 ，使得含有6-22个碳原子的二羧酸形成并积聚在介质中，并收集二羧酸。

公开(公告)号：US4215213A

公开(公告)日：1980-07-29

申请号：US962693

申请日：1978-11-21

申请人： Shigeo Inoue ,  Yoshiharu Kimura ,  Manzo Kinta

发明人： Shigeo Inoue ,  Yoshiharu Kimura ,  Manzo Kinta

IPC分类号： A61K8/60 ,  B01F17/00 ,  B01F17/56 ,  C07H15/04 ,  C11B5/00 ,  C11D3/22 ,  C07H15/06 ,  C07H3/04

CPC分类号： C11D3/226 ,  C07H15/04

摘要： A process for producing a glycolipid ester represented by the formula, ##STR1## wherein R.sub.3 represents a hydrogen atom or a methyl group, R.sub.4 represents a saturated or unsaturated hydrocarbon group having 12 to 16 carbon atoms when R.sub.3 is a hydrogen atom, R.sub.4 represents a saturated or unsaturated hydrocarbon group having 11 to 15 carbon atoms when R.sub.3 is a methyl group, and R represents a saturated or unsaturated alkyl group having 2 to 20 carbon atoms, which comprises subjecting Sophorolipid to methanolysis and methylation reactions by reaction with methanol in the presence of a strong acid to produce methyl 1-[(2'-O-.beta.-D-glucopyranosyl-.beta.-D-glucopyranosyl)oxy]-alkanoate and -alkenoate, and subjecting the resulting mixture to ester interchange by reaction with an alcohol represented by the formula,ROHwherein R is the same as defined above.

摘要翻译： 一种由式表示的糖脂酯的方法，其中R 3表示氢原子或甲基，R 4表示当R 3为氢原子时具有12至16个碳原子的饱和或不饱和烃基，R 4表示 R 3为甲基时为11〜15个碳原子的饱和或不饱和烃基，R为碳原子数为2〜20的饱和或不饱和的烷基，其包括在存在下通过与甲醇反应进行甲醇分解和甲基化反应 的强酸产生1 - [（2'-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基）氧基] - 烷酸酯和 - 烯丙酸甲酯，并通过与所代表的醇反应将所得混合物进行酯交换 通式ROH其中R与上述定义相同。

公开(公告)号：US4195177A

公开(公告)日：1980-03-25

申请号：US962664

申请日：1978-11-21

申请人： Shigeo Inoue ,  Yoshiharu Kimura ,  Manzo Kinta

发明人： Shigeo Inoue ,  Yoshiharu Kimura ,  Manzo Kinta

IPC分类号： B01F17/56 ,  A61K8/60 ,  A61K9/06 ,  A61K31/25 ,  C07H3/04 ,  C07H15/04 ,  C07H15/08 ,  C07H15/10 ,  C12P19/12 ,  C07H13/04

CPC分类号： A61K8/60 ,  A61Q19/00 ,  C07H15/10 ,  C07H3/04 ,  C12P19/12

摘要： A hydroxyalkyl-etherified glycolipid ester represented by the formula (I), ##STR1## wherein R.sup.1 represents a methyl group or a hydrogen atom, R.sup.2 represents a saturated or unsaturated hydrocarbon group having 11 to 15 carbon atoms when R.sup.1 is a methyl group, R.sup.2 represents a saturated or unsaturated hydrocarbon group having 12 to 16 carbon atoms when R.sup.1 is a hydrogen atom, R.sup.3 represents a saturated or unsaturated hydrocarbon group having 1 to 20 carbon atoms, A represents --CH.sub.2 --CH.sub.2 --O-- or ##STR2## and a,b,c,d,e,f and g represent integers from 1 to 60 in the sum total.

摘要翻译： 由式（I）表示的羟烷基醚化糖脂酯，其中R1表示甲基或氢原子，R2表示当R1是甲基时，具有11至15个碳原子的饱和或不饱和烃基 基团，当R1是氢原子时，R2代表具有12-16个碳原子的饱和或不饱和烃基，R3代表具有1-20个碳原子的饱和或不饱和烃基，A代表-CH2-CH2-O-或和a，b，c，d，e，f和g表示总和中从1到60的整数。

公开(公告)号：US20100258770A1

公开(公告)日：2010-10-14

申请号：US12755751

申请日：2010-04-07

申请人： Yutaka NISHITSUJI ,  Yoshiharu Kimura

发明人： Yutaka NISHITSUJI ,  Yoshiharu Kimura

IPC分类号： B66F3/08

CPC分类号： G01B11/24

摘要： A synchronous moving device includes: a device body; a movable portion which is provided in the device body; a feed screw shaft which is supported on the device body; a nut member which is thread-engaged with the feed screw shaft; a coupler which couples the movable portion and the nut member; and a cable binder which supports and guides a cable wired into the movable portion, wherein: the coupler includes a first member fixed to the movable portion, a second member fixed to the nut member, and an intermediate member interposed between the first and second members for absorbing deflecting motion of the feed screw shaft; and an end portion of the cable binder on a side of wiring of the cable into the movable portion is connected to the second member through a connection member and moved in synchronization with the movable portion.

摘要翻译： 同步移动装置包括：装置主体; 设置在所述装置主体中的可动部; 进给螺杆轴，其被支撑在装置主体上; 与进给螺杆轴螺纹接合的螺母构件; 联接所述可动部和所述螺母构件的联接器; 以及电缆固定件，其支撑并引导布线到所述可动部中的电缆，其中：所述耦合器包括固定到所述可动部的第一构件，固定到所述螺母构件的第二构件，以及插入在所述第一构件和所述第二构件之间的中间构件 用于吸收进给丝杠轴的偏转运动; 并且所述电缆固定件的所述电缆的布线的一侧的端部通过连接构件连接到所述第二构件，并且与所述可动部分同步地移动。

公开(公告)号：US20100056751A1

公开(公告)日：2010-03-04

申请号：US12526456

申请日：2008-02-06

申请人： Kiyotsuna Toyohara ,  Midori Ikegame ,  Hideki Yamane ,  Yoshiharu Kimura ,  Daisuke Masaki ,  Shin To

发明人： Kiyotsuna Toyohara ,  Midori Ikegame ,  Hideki Yamane ,  Yoshiharu Kimura ,  Daisuke Masaki ,  Shin To

IPC分类号： C08G63/08

CPC分类号： D01F6/625 ,  C08G63/08 ,  C08G63/88 ,  C08G63/912 ,  C08J3/005 ,  C08J2367/04 ,  D01F6/92

摘要： It is an object of the present invention to produce a polylactic acid having a high molecular weight such as a weight average molecular weight (Mw) of more than 100,000 from which only a stereocomplex crystal is grown even by repeating melting and crystallization. The present invention is a process of producing a polylactic acid, including the steps of: (i) obtaining a solid by kneading together poly(L-lactic acid) and poly(D-lactic acid) at a temperature of 160 to 225° C. and crystallizing the kneaded product; and (ii) melt kneading the obtained solid.

摘要翻译： 本发明的目的是制备具有高分子量的重均分子量（Mw）超过100,000的聚乳酸，即使通过重复熔融和结晶也仅生长立体络合物晶体。 本发明是一种制备聚乳酸的方法，包括以下步骤：（i）通过在160-225℃的温度下将聚（L-乳酸）和聚（D-乳酸）捏合在一起获得固体 并使捏合产物结晶; 和（ii）熔融捏合所得固体。