公开(公告)号：US20230201426A1

公开(公告)日：2023-06-29

申请号：US17926924

申请日：2021-06-16

Applicant: TOPPAN INC. ,  Osaka University

Inventor： Shiro KITANO ,  Michiya MATSUSAKI ,  Hidehiro SAKURAI ,  Yuta UETAKE

IPC: A61L27/52 ,  A61L27/04 ,  A61L27/24 ,  A61L27/36

CPC classification number: A61L27/52 ,  A61L27/047 ,  A61L27/24 ,  A61L27/3633

Abstract: The present invention relates to a gel composition containing at least one selected from the group consisting of an extracellular matrix component and a fragmented extracellular matrix component, and an ion of a metal element.

公开(公告)号：US20230110381A1

公开(公告)日：2023-04-13

申请号：US17908283

申请日：2021-03-04

Applicant: OSAKA UNIVERSITY ,  TOPPAN INC.

Inventor： Michiya MATSUSAKI ,  Naoko SASAKI ,  Shiro KITANO ,  Shinji IRIE

IPC: A61L27/50 ,  A61L27/36 ,  A61L27/24 ,  A61L27/38 ,  C12N5/00

Abstract: Disclosed is a method for controlling the Young’s modulus of a three-dimensional tissue containing cells and an extracellular matrix by adjusting the average diameter of an extracellular matrix in production of the three-dimensional tissue.

公开(公告)号：US20220341918A1

公开(公告)日：2022-10-27

申请号：US17642608

申请日：2020-08-27

Applicant: TOPPAN INC. ,  Osaka University

Inventor： Shiro KITANO ,  Shinji IRIE ,  Michiya MATSUSAKI ,  Naoko SASAKI ,  Atsuo AMANO ,  Hiroki TAKEUCHI

IPC: G01N33/50 ,  C12N5/071

Abstract: Provided is a cell structure including: a connective tissue structure; and an epithelial structure placed on the connective tissue structure, in which the connective tissue structure contains a fragmented extracellular matrix component and first cells including mesenchymal cells, at least a part of the fragmented extracellular matrix component is placed between the first cells, and the epithelial structure contains epithelial cells.

公开(公告)号：US20220170911A1

公开(公告)日：2022-06-02

申请号：US17600348

申请日：2020-03-19

Applicant: TOPPAN INC. ,  OSAKA UNIVERSITY ,  Kyoto Prefectural Public University Corporation

Inventor： Shiro KITANO ,  Shinji IRIE ,  Michiya MATSUSAKI ,  Fiona LOUIS ,  Yoshihiro SOWA

IPC: G01N33/50 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/071 ,  A61K35/35

Abstract: Disclosed is a cell structure comprising: a fragmented extracellular matrix component; and cells, wherein the cell structure comprises an intercellular vascular network, and the cells comprise at least adipocytes and vascular endothelial cells.

公开(公告)号：US20210238542A1

公开(公告)日：2021-08-05

申请号：US17050731

申请日：2019-05-07

Applicant: TOPPAN PRINTING CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Shiro KITANO ,  Shinji IRIE ,  Michiya MATSUSAKI

IPC: C12N5/00

Abstract: The present invention relates to an extracellular-matrix-containing composition comprising: a fragmented extracellular matrix component, wherein at least a part of the fragmented extracellular matrix component is crosslinked.

公开(公告)号：US20170333598A1

公开(公告)日：2017-11-23

申请号：US15533724

申请日：2015-12-07

Applicant: OSAKA UNIVERSITY ,  TOHOKU UNIVERSITY

Inventor： Mitsuru AKASHI ,  Michiya MATSUSAKI ,  Michiaki UNNO ,  Naoaki SAKATA ,  Gumpei YOSHIMATSU

IPC: A61L27/38 ,  A61K35/28 ,  A61L27/60 ,  C12N5/00

Abstract: An artificial tissue containing pancreatic islet cells, fibroblasts and/or cells capable of differentiating, extracellular matrix, and vascular endothelial cells, in which the fibroblasts and/or the cells capable of differentiating, the extracellular matrix, and the vascular endothelial cells constitute a three-dimensional tissue structure in which a vascular network structure has been formed, and in which the three-dimensional tissue structure contains pancreatic islets constituted by aggregating ten or more of the pancreatic islet cells.