摘要:
Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.
摘要:
The invention relates to a method of modifying a specific lysine residue in a polypeptide comprising at least two lysine residues, said method comprising (a) providing a polypeptide comprising a target lysine residue protected by a first protecting group, and at least one further lysine residue; (b) treating the polypeptide to protect said further lysine residue(s), wherein the protecting group for said further lysine residues is different to the protecting group for the target lysine residue; (c) selectively deprotecting the target lysine residue; and (d) modifying the deprotected lysine residue of (c).
摘要:
The present invention relates to sulphone-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.
摘要:
The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.
摘要:
The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as antiinflammatory agents.
摘要:
The invention relates to alkylidene-tetrahydronaphthalene derivatives of general formula (I), process for their production, and their use as anti-inflammatory agents.
摘要:
Provided herein are amphoteric surfactants derived from ethyleneamines, and processes for using such surfactants in the treatment of paper, fibers, textiles, hair, and human skin, to impart softness-to-the-touch properties to these and other substrates.
摘要:
The present invention provides a medical device retrieval system comprising a working element carried by a flexible, elongate shaft, the working element having a proximal profile and the shaft extending proximally from the working element and a retrieval cover slidable carried along the shaft of the medical device, the cover having a deployed configuration and being capable of being compressed into a compressed configuration for deployment, yet resiliently substantially return to the deployed configuration; the cover in its deployed configuration having a radially reduced proximal portion, a distally open distal end defining a distal opening having a maximum dimension at least as great as the maximum dimension of the proximal profile of the working element of the medical device, and an elongate internal recess defined between the proximal portion and the distal end.