Expandable sheath for introducing an endovascular delivery device into a body
    21.
    发明授权
    Expandable sheath for introducing an endovascular delivery device into a body 有权
    用于将血管内输送装置引入体内的可扩展护套

    公开(公告)号:US08790387B2

    公开(公告)日:2014-07-29

    申请号:US13312739

    申请日:2011-12-06

    IPC分类号: A61F2/06 A61F2/24 A61B19/00

    摘要: Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.

    摘要翻译: 可扩张护套的实施例可以与导管组件一起使用以将诸如心脏瓣膜的假体装置引入患者体内。 这样的实施例可以通过允许引导器护套的一部分临时膨胀以适应输送装置来最小化对容器的创伤,然后一旦假肢装置通过就恢复到原始直径。 一些实施例可以包括具有内层和外层的护套,其中内层的折叠部分延伸穿过外层中的狭缝,并且外层的一部分与内层的折叠部分重叠。 一些实施例包括位于外层外部的弹性外盖。 本发明的可扩张护套的实施例可以避免需要多次插入用于扩张容器,从而提供优于现有技术的导引器护套的优点。

    Synthesis of Site Specifically-Linked Ubiquitin
    22.
    发明申请
    Synthesis of Site Specifically-Linked Ubiquitin 审中-公开
    场地特异性连接的泛素的合成

    公开(公告)号:US20130065272A1

    公开(公告)日:2013-03-14

    申请号:US13636618

    申请日:2011-03-23

    摘要: The invention relates to a method of modifying a specific lysine residue in a polypeptide comprising at least two lysine residues, said method comprising (a) providing a polypeptide comprising a target lysine residue protected by a first protecting group, and at least one further lysine residue; (b) treating the polypeptide to protect said further lysine residue(s), wherein the protecting group for said further lysine residues is different to the protecting group for the target lysine residue; (c) selectively deprotecting the target lysine residue; and (d) modifying the deprotected lysine residue of (c).

    摘要翻译: 本发明涉及一种修饰包含至少两个赖氨酸残基的多肽中的特定赖氨酸残基的方法,所述方法包括(a)提供包含被第一保护基团保护的靶赖氨酸残基的多肽和至少一种赖氨酸残基 ; (b)处理多肽以保护所述另外的赖氨酸残基,其中所述另外的赖氨酸残基的保护基与靶赖氨酸残基的保护基不同; (c)选择性脱保护目标赖氨酸残基; 和(d)修饰(c)的去保护的赖氨酸残基。

    Paper products softening process using amphoteric surfactants
    29.
    发明申请
    Paper products softening process using amphoteric surfactants 审中-公开
    造纸产品使用两性表面活性剂的软化工艺

    公开(公告)号:US20050153866A1

    公开(公告)日:2005-07-14

    申请号:US11013079

    申请日:2004-12-15

    IPC分类号: B01F17/04 D21H21/24 C11D17/00

    CPC分类号: C07C233/35 D21H21/24

    摘要: Provided herein are amphoteric surfactants derived from ethyleneamines, and processes for using such surfactants in the treatment of paper, fibers, textiles, hair, and human skin, to impart softness-to-the-touch properties to these and other substrates.

    摘要翻译: 本文提供了衍生自乙撑胺的两性表面活性剂,以及使用这种表面活性剂处理纸,纤维,纺织品,毛发和人皮肤的方法,以赋予这些和其它基材柔软的触感性质。

    Minimally invasive medical device deployment and retrieval system
    30.
    发明申请
    Minimally invasive medical device deployment and retrieval system 有权
    微创医疗器械部署和检索系统

    公开(公告)号:US20050090857A1

    公开(公告)日:2005-04-28

    申请号:US10989787

    申请日:2004-11-16

    IPC分类号: A61F2/01 A61B17/22 A61M29/00

    摘要: The present invention provides a medical device retrieval system comprising a working element carried by a flexible, elongate shaft, the working element having a proximal profile and the shaft extending proximally from the working element and a retrieval cover slidable carried along the shaft of the medical device, the cover having a deployed configuration and being capable of being compressed into a compressed configuration for deployment, yet resiliently substantially return to the deployed configuration; the cover in its deployed configuration having a radially reduced proximal portion, a distally open distal end defining a distal opening having a maximum dimension at least as great as the maximum dimension of the proximal profile of the working element of the medical device, and an elongate internal recess defined between the proximal portion and the distal end.

    摘要翻译: 本发明提供了一种医疗装置检索系统,其包括由柔性细长轴承载的工作元件,所述工作元件具有近端轮廓,并且所述轴从所述工作元件向近侧延伸;以及可沿着所述医疗装置的轴 ,所述盖具有展开配置并且能够被压缩成用于展开的压缩配置,但是弹性地基本上返回到展开配置; 其展开构型中的盖具有径向缩小的近端部分,限定远端开口的远侧开口远端具有至少与医疗装置的工作元件的近端轮廓的最大尺寸至少相同的最大尺寸, 限定在近端部分和远端之间的内部凹部。