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公开(公告)号：US09061973B2
公开(公告)日：2015-06-23
申请号：US14076302
申请日：2013-11-11
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07C271/22 , C07D207/263 , C07D207/36
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及生产NEP抑制剂或其前药的新方法，特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
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22.发明申请Manufacture process for the preparation of an iron containing phosphate adsorbent 审中-公开制备含铁磷酸盐吸附剂的制备方法公开(公告)号：US20130316018A1
公开(公告)日：2013-11-28
申请号：US13955433
申请日：2013-07-31
申请人： Daniel Kaufmann , Nicole Bieri , Ulrich Meier , Ranjit Thakur , Zdenek Zencak , Christa Hartmann , Andreas Meyer
发明人： Daniel Kaufmann , Nicole Bieri , Ulrich Meier , Ranjit Thakur , Zdenek Zencak , Christa Hartmann , Andreas Meyer
IPC分类号： B01J20/04
CPC分类号： B01J20/048 , A61K33/26 , A61M1/3486 , A61M1/3679 , B01J20/0229 , B01J20/06 , B01J20/24 , B01J2220/46 , B01J2220/4825 , B33Y80/00 , C01G49/06
摘要： The present invention relates to a new manufacture process for producing an iron containing phosphate adsorbent, in particular to a process for manufacturing and isolating an iron(III)-based phosphate adsorbent which exhibits valuable pharmacological properties.
摘要翻译： 本发明涉及一种用于生产含铁磷酸盐吸附剂的新制造方法，特别涉及一种制备和分离具有有价值的药理学性质的基于铁（III）的磷酸盐吸附剂的方法。
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23.发明申请Manufacture process for the preparation of an iron containing phosphate adsorbent 审中-公开制备含铁磷酸盐吸附剂的制备方法公开(公告)号：US20110086097A1
公开(公告)日：2011-04-14
申请号：US12997447
申请日：2009-06-12
申请人： Daniel Kaufmann , Nicole Bieri , Ulrich Meier , Ranjit Thakur , Zdenek Zencak , Christa Hartmann , Andreas Meyer
发明人： Daniel Kaufmann , Nicole Bieri , Ulrich Meier , Ranjit Thakur , Zdenek Zencak , Christa Hartmann , Andreas Meyer
CPC分类号： B01J20/048 , A61K33/26 , A61M1/3486 , A61M1/3679 , B01J20/0229 , B01J20/06 , B01J20/24 , B01J2220/46 , B01J2220/4825 , B33Y80/00 , C01G49/06
摘要： The present invention relates to a new manufacture process for producing an iron containing phosphate adsorbent, in particular to a process for manufacturing and isolating an iron(III)-based phosphate adsorbent which exhibits valuable pharmacological properties.
摘要翻译： 本发明涉及一种用于生产含铁磷酸盐吸附剂的新制造方法，特别涉及一种制备和分离具有有价值的药理学性质的基于铁（III）的磷酸盐吸附剂的方法。
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公开(公告)号：US20110046397A1
公开(公告)日：2011-02-24
申请号：US12863213
申请日：2009-01-16
申请人： David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Phillippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Phillippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D403/06 , C07D207/38 , C07C229/34
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及生产NEP抑制剂或其前药的新方法，特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
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公开(公告)号：US09403766B2
公开(公告)日：2016-08-02
申请号：US14939513
申请日：2015-11-12
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D207/26 , C07D207/38 , C07D207/263 , C07D207/36 , C07D403/06 , C07C271/22
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及生产NEP抑制剂或其前药的新方法，特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
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公开(公告)号：US09227934B2
公开(公告)日：2016-01-05
申请号：US14715129
申请日：2015-05-18
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D207/38
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
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公开(公告)号：US08580974B2
公开(公告)日：2013-11-12
申请号：US12863213
申请日：2009-01-16
申请人： David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D207/38 , C07D207/26
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及用于产生NEP抑制剂或其前药的新方法，特别是包含γ-氨基-Δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
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公开(公告)号：US20120126440A1
公开(公告)日：2012-05-24
申请号：US13365349
申请日：2012-02-03
申请人： Michael Ambühl , Corine Gessier-Vial , Christa Hartmann , Daniel Kaufmann , Ernst Küsters , Ulrich Meier , Andreas Meyer , Nabila Sekkat
发明人： Michael Ambühl , Corine Gessier-Vial , Christa Hartmann , Daniel Kaufmann , Ernst Küsters , Ulrich Meier , Andreas Meyer , Nabila Sekkat
IPC分类号： B29B9/12
CPC分类号： A61K33/26 , B01J20/223 , B01J20/2803 , C01G49/0018 , C01G49/02
摘要： The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.
摘要翻译： 本发明涉及一种新的含磷磷酸盐吸附剂及其用途。 用于治疗高磷血症。
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公开(公告)号：US20080145410A1
公开(公告)日：2008-06-19
申请号：US12001132
申请日：2007-12-10
申请人： Michael Ambuhl , Corine Gessier-Vial , Christa Hartmann , Daniel Kaufmann , Ernst Kusters , Ulrich Meier , Andreas Meyer , Nabila Sekkat
发明人： Michael Ambuhl , Corine Gessier-Vial , Christa Hartmann , Daniel Kaufmann , Ernst Kusters , Ulrich Meier , Andreas Meyer , Nabila Sekkat
IPC分类号： A61K33/26 , B01D11/00 , C01G49/06 , A61P5/18 , A61K9/14 , A61K9/00 , A61P7/00 , A61P19/08 , A61K9/20 , A61P9/00 , B01J20/06 , B27N3/18
CPC分类号： A61K33/26 , B01J20/223 , B01J20/2803 , C01G49/0018 , C01G49/02
摘要： The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.
摘要翻译： 本发明涉及一种新的含磷磷酸盐吸附剂及其用途。 用于治疗高磷血症。
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公开(公告)号：US20140243546A1
公开(公告)日：2014-08-28
申请号：US14076302
申请日：2013-11-11
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07C271/22
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及生产NEP抑制剂或其前药的新方法，特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
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