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    Control compositions and methods of use for coagulation tests
    2.
    发明授权
    Control compositions and methods of use for coagulation tests 有权
    控制组合物和凝血试验的使用方法

    公开(公告)号：US06746872B2

    公开(公告)日：2004-06-08

    申请号：US10055788

    申请日：2002-01-16

    申请人： Xiang Yang Zheng ,  Brian Earp ,  Herbert Chow ,  Christa Hartmann

    发明人： Xiang Yang Zheng ,  Brian Earp ,  Herbert Chow ,  Christa Hartmann

    IPC分类号： G01N3386

    CPC分类号： G01N33/86 ,  Y10T436/10 ,  Y10T436/106664

    摘要： Compositions, methods, devices and kits for use in the calibration of coagulation tests. The control compositions include particles capable of aggregating in plasma and calcium ions which, when mixed with plasma, simulate the behavior of whole blood in a coagulation test. The methods include providing calcium ions and particles capable of aggregating in plasma, combining the particles and calcium ions with plasma to form a control composition, and applying the control composition to a coagulation test. The devices include a container having at least two compartments, with one compartment including particles that promote or induce aggregation of a protein or proteins in plasma, and the other compartment includes a solution of calcium ions. The kits include a control composition including a container of calcium ions, a container of particles capable of inducing aggregation of proteins in plasma, and one or more coagulation test devices.

    摘要翻译： 用于校准凝血试验的组合物，方法，装置和试剂盒。 对照组合物包括能够在血浆和钙离子中聚集的颗粒，当与血浆混合时，模拟凝血试验中全血的行为。 所述方法包括提供能够在血浆中聚集的钙离子和颗粒，将颗粒和钙离子与血浆组合以形成对照组合物，并将对照组合物施用于凝血试验。 这些装置包括具有至少两个隔室的容器，其中一个隔室包括促进或诱导血浆中蛋白质或蛋白质聚集的颗粒，另一隔室包括钙离子溶液。 试剂盒包括包含钙离子容器的控制组合物，能够诱导血浆中的蛋白质聚集的颗粒的容器和一个或多个凝固测试装置。