-
公开(公告)号：US20110046397A1
公开(公告)日：2011-02-24
申请号：US12863213
申请日：2009-01-16
申请人： David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Phillippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Phillippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D403/06 , C07D207/38 , C07C229/34
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及生产NEP抑制剂或其前药的新方法，特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
-
公开(公告)号：US08580974B2
公开(公告)日：2013-11-12
申请号：US12863213
申请日：2009-01-16
申请人： David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernhard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D207/38 , C07D207/26
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及用于产生NEP抑制剂或其前药的新方法，特别是包含γ-氨基-Δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
-
公开(公告)号：US20140243546A1
公开(公告)日：2014-08-28
申请号：US14076302
申请日：2013-11-11
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07C271/22
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及生产NEP抑制剂或其前药的新方法，特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
-
公开(公告)号：US09061973B2
公开(公告)日：2015-06-23
申请号：US14076302
申请日：2013-11-11
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07C271/22 , C07D207/263 , C07D207/36
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及生产NEP抑制剂或其前药的新方法，特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
-
公开(公告)号：US20160060217A1
公开(公告)日：2016-03-03
申请号：US14939513
申请日：2015-11-12
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D207/38 , C07D403/06
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
-
公开(公告)号：US20150246881A1
公开(公告)日：2015-09-03
申请号：US14715129
申请日：2015-05-18
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D207/38
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及生产NEP抑制剂或其前药的新方法，特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
-
公开(公告)号：US09403766B2
公开(公告)日：2016-08-02
申请号：US14939513
申请日：2015-11-12
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D207/26 , C07D207/38 , C07D207/263 , C07D207/36 , C07D403/06 , C07C271/22
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
摘要翻译： 本发明涉及生产NEP抑制剂或其前药的新方法，特别是包含γ-氨基-δ-联苯基-α-甲基链烷酸或酸酯主链的NEP抑制剂。 具体而言，根据本发明的新方法最终涉及制备上述NEP抑制剂的中间体的合成，即根据式（1）的化合物或其盐，其中R 1和R 2各自独立地 另一个是氢或氮保护基，R3是羧基或酯基，优选羧基或烷基酯。
-
公开(公告)号：US09227934B2
公开(公告)日：2016-01-05
申请号：US14715129
申请日：2015-05-18
申请人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
发明人： David Hook , Bernard Riss , Daniel Kaufmann , Matthias Napp , Erhard Bappert , Philippe Polleux , Jonathan Medlock , Antonio Zanotti-Gerosa
IPC分类号： C07D207/38
CPC分类号： C07D207/38 , C07C271/22 , C07D207/26 , C07D207/263 , C07D207/36 , C07D403/06 , Y02P20/55
摘要： The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
-
9.发明申请公开(公告)号：US20080081930A1
公开(公告)日：2008-04-03
申请号：US11719478
申请日：2005-11-01
IPC分类号： C07C49/15 , B01J31/12 , C07C311/16
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译： 描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2， 或者Z是C1-C10烷基，环烷基，烷芳基，芳烷基或烷氧基取代基。 手性二胺可用于制备适用于转移氢化反应的催化剂。
-
公开(公告)号：US08431741B2
公开(公告)日：2013-04-30
申请号：US13104114
申请日：2011-05-10
申请人： Dario Veghini , Markus Bicker , Miguel Angel Caraucán Dávila , Golo Heckmann , Thomas Ward , Christophe Malan , Julien Pierron , Antonio Zanotti-Gerosa , Hans Nedden , Laleh Jafarpour
发明人： Dario Veghini , Markus Bicker , Miguel Angel Caraucán Dávila , Golo Heckmann , Thomas Ward , Christophe Malan , Julien Pierron , Antonio Zanotti-Gerosa , Hans Nedden , Laleh Jafarpour
IPC分类号： C07C229/00
CPC分类号： C07C227/32 , C07B2200/07 , C07C67/31 , C07C69/675 , C07C229/22
摘要： The invention relaters to a process for the production of an (S)- or (R)-4-halo-3-hydroxybutyrate, comprising reacting a 4-haloacetoacetate with hydrogen in the presence ofa solvent, the solvent being a solvent mixture, which comprises a first solvent and a second solvent, wherein the first solvent is an aliphatic alcohol, preferably methanol, ethanol or propanol, and the second solvent is aprotic and comprises at least one oxygen atom; and a catalyst of the formula [RuXYZ]X, wherein X is halogen, preferably Cl or Br, or OAc, acetoacetate, allyl or ClO4, Y is a bidentate organic ligand having two phosphine groups, and Z is an arene, preferably cymene, benzene, xylene or toluene, or a polyene, preferably a diene, or an alkene.
摘要翻译： 本发明涉及制备（S） - 或（R）-4-卤代-3-羟基丁酸酯的方法，包括在溶剂存在下使4-卤代乙酰乙酸酯与氢气反应，溶剂为溶剂混合物， 其包括第一溶剂和第二溶剂，其中所述第一溶剂是脂族醇，优选甲醇，乙醇或丙醇，所述第二溶剂是非质子性的，并且包含至少一个氧原子; 和具有式[RuXYZ] X的催化剂，其中X是卤素，优选Cl或Br，或OAc，乙酰乙酸酯，烯丙基或ClO 4，Y是具有两个膦基的二齿有机配体，Z是芳烃，优选为异丙基苯， 苯，二甲苯或甲苯，或多烯，优选二烯或烯烃。
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.046 秒)
