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公开(公告)号：US08008437B2
公开(公告)日：2011-08-30
申请号：US12099513
申请日：2008-04-08
IPC分类号： C07K5/00
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。 根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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公开(公告)号：US07829083B2
公开(公告)日：2010-11-09
申请号：US12013346
申请日：2008-01-11
IPC分类号： A61K39/395 , C12N5/10 , C12N5/12 , G01N33/53
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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公开(公告)号：US07344838B2
公开(公告)日：2008-03-18
申请号：US11007517
申请日：2004-12-07
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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24.发明申请Use of KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development 审中-公开使用KIAA0172基因治疗和诊断疾病以及药物开发公开(公告)号：US20070128645A1
公开(公告)日：2007-06-07
申请号：US11606148
申请日：2006-11-30
申请人： Ryoichi Kiyama , Keisuke Kitajima , Shinobu Oguchi , Michio Oishi , Osamu Ohara , Takahiro Nagase
发明人： Ryoichi Kiyama , Keisuke Kitajima , Shinobu Oguchi , Michio Oishi , Osamu Ohara , Takahiro Nagase
CPC分类号： C12Q1/6886 , C07K14/47 , C12Q2600/154 , C12Q2600/172 , G01N33/505
摘要： An object of the present invention is to provide use of the KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development. An agent for treating cancer which comprises as an active ingredient a polypeptide encoded by the KIAA0172 gene, a partial sequence thereof or a variant thereof; an agent for treating cancer which comprises as an active ingredient an oligonucleotide including the KIAA0172 gene sequence; an agent for detecting cancer which comprises an antibody which recognizes polypeptide encoded by the KIAA0172 gene; an agent for detecting cancer which comprises an oligonucleotide including the KIAA0172 gene sequence; a composition for treating cancer which comprises said agent for treating cancer and a pharmaceutically acceptable carrier; and a composition for detecting cancer which comprises said agent for detecting cancer and a pharmaceutically acceptable carrier.
摘要翻译： 本发明的目的是提供KIAA0172基因在疾病和药物开发的治疗和诊断中的用途。 一种用于治疗癌症的药物，其包含作为活性成分的由KIAA0172基因编码的多肽，其部分序列或其变体; 一种治疗癌症的药物，其包含作为活性成分的包含KIAA0172基因序列的寡核苷酸; 用于检测癌症的试剂，其包含识别由KIAA0172基因编码的多肽的抗体; 用于检测癌症的试剂，其包含含有KIAA0172基因序列的寡核苷酸; 用于治疗癌症的组合物，其包含所述治疗癌症的药物和药学上可接受的载体; 和用于检测癌症的组合物，其包含所述用于检测癌症的药物和药学上可接受的载体。
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25.发明申请Method of efficiently recombining orf encoded by cdna and template vector, trap vector and primer to be used therein 审中-公开由cdna和模板载体有效重组或编码的方法，其中使用的捕获载体和引物公开(公告)号：US20050106719A1
公开(公告)日：2005-05-19
申请号：US10491192
申请日：2003-12-04
申请人： Takahiro Nagase , Daisuke Nakajima , Osamu Ohara
发明人： Takahiro Nagase , Daisuke Nakajima , Osamu Ohara
摘要： The object of the present invention is to solve the problems in excising a DNA region (or gene) with conventional restriction enzymes, or in amplification of the DNA region by PCR. The present invention provides a method for precisely, quickly and simply cloning a target ORF, for example the target ORF encoding a protein, particularly the target ORF encoding a long-chain ORF comprising bases as many as several thousand bp in cDNA, and means such as various vectors used for the cloning method,
摘要翻译： 本发明的目的是解决用常规限制酶切除DNA区域（或基因）或通过PCR扩增DNA区域的问题。 本发明提供了精确，快速和简单地克隆靶ORF的方法，例如编码蛋白质的靶ORF，特别是编码包含cDNA多达数千bp的碱基的长链ORF的靶ORF， 作为用于克隆方法的各种载体，
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公开(公告)号：US20050079539A1
公开(公告)日：2005-04-14
申请号：US11007517
申请日：2004-12-07
CPC分类号： C07K14/705
摘要： A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of the cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ binding motif.
摘要翻译： 通过构建人大脑中表达的mRNA的大小为4kb或以上的cDNA文库，并通过霰弹枪法分析所述文库中所含的cDNA的结构，已经成功地分离了显然编码跨膜糖蛋白的新基因。 该新基因显示脑特异性表达，由该基因编码的蛋白具有典型的PDZ结合基序。
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公开(公告)号：US20050037347A1
公开(公告)日：2005-02-17
申请号：US10451000
申请日：2001-12-21
IPC分类号： A61P13/08 , A61P15/00 , A61P35/00 , C07K14/47 , C12N15/12 , C12Q1/68 , C07H21/04 , C07K14/72 , C07K16/30 , G01N33/574
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with an amino acid sequence represented by SEQ ID No. 1 or No. 2, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No. 1 or No. 2 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a). The present invention is further related to an antibody binding to the polypeptide or protein, an anti-cancer agent comprising the antibody, a method of screening a substance that binds to the protein or a peptide fragment thereof, and a polynucleotide having at least 15 bases and hybridizing with the DNA according to the present invention under stringent conditions, and a method of detecting cancer with the use of said polynucleotide. The DNA according to the present invention is a cancer-associated gene, and that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）由与SEQ ID NO：1所示氨基酸序列相同或基本相同的氨基酸序列组成的多肽 1或2，（b）由SEQ ID No.1或No.2所示的氨基酸序列组成的多肽，其中部分氨基酸被缺失，取代或添加并且具有基本上相同的生物活性 作为多肽（a）的功能。 本发明还涉及与多肽或蛋白质结合的抗体，包含抗体的抗癌剂，筛选与蛋白质结合的物质或其肽片段的方法，以及具有至少15个碱基的多核苷酸 并且在严格条件下与根据本发明的DNA杂交，以及使用所述多核苷酸检测癌症的方法。 根据本发明的DNA是癌相关基因，并且可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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28.发明授权Formation/elongation of axon by inhibiting the expression or function of Singar and application to nerve regeneration 有权通过抑制Singar的表达或功能并应用于神经再生来形成/延伸轴突公开(公告)号：US08076307B2
公开(公告)日：2011-12-13
申请号：US12084242
申请日：2006-10-26
申请人： Naoyuki Inagaki , Tatsuya Mori , Osamu Ohara , Takahiro Nagase
发明人： Naoyuki Inagaki , Tatsuya Mori , Osamu Ohara , Takahiro Nagase
CPC分类号： G01N33/5058 , C12N15/113 , C12N2310/14 , G01N2500/00
摘要： Singar is identified as a novel molecule, whose expression is varied before and after the polarization of a nerve cell, and occurs in the tip of an elongating axon, called a growth cone, which is important for the formation or elongation of an axon. Singar is expressed specifically in the brain and the amount of Singar expression is largely increased in an individual during periods where the formation of axons is increased. It is observed that Singar is highly enriched in the growth cone at the tip of an axon. When the expression of Singar is inhibited in nerve cells in culture, the formation of multiple axons is induced. Thus, the inhibition of Singar can induce axon formation. Therefore, by inhibiting the expression or activity of Singar, it becomes possible to induce or promote the formation or elongation of an axon in a nerve cell.
摘要翻译： Singar被鉴定为一种新颖的分子，其表达在神经细胞的极化之前和之后是变化的，并且发生在延伸轴突的尖端，称为生长锥，其对于轴突的形成或延伸是重要的。 Singar在脑中特异性表达，并且在轴突形成增加期间个体中Singar表达量大大增加。 观察到，Singar在轴突末端的生长锥中高度富集。 当培养中神经细胞中Singar的表达被抑制时，诱导多个轴突的形成。 因此，Singar的抑制可以诱导轴突形成。 因此，通过抑制Singar的表达或活性，可以诱导或促进神经细胞中轴突的形成或延伸。
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公开(公告)号：US07375199B2
公开(公告)日：2008-05-20
申请号：US10451000
申请日：2001-12-21
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。 根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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公开(公告)号：US20060063152A1
公开(公告)日：2006-03-23
申请号：US10204639
申请日：2001-12-20
申请人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima
发明人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima
CPC分类号： C07K14/47 , A61K2039/505
摘要： Novel DNAs containing the regions which encode proteins have been directly cloned from cDNA libraries derived from the human adult whole brain, the human adult hippocampus and the human embryonic whole brain, the nucleotide sequences thereof have been determined, and their functions have been identified. The present invention provides DNA which comprises the nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide comprising an amino acid sequence which is identical or substantially identical to an amino acid sequence represented by any one of SEQ ID NOS: 1 to 70; (b) a polypeptide comprising an amino acid sequence derived from the amino acid sequence represented by any one of SEQ ID NOS: 1 to 70 by deletion, substitution or addition of a section of amino acids, and having biological activity which is substantially the same characteristic with the function of the polypeptide of (a); a recombinant polypeptide, which is encoded by the above DNA; and a protein containing the polypeptide.
摘要翻译： 含有编码蛋白质的区域的新DNA已经从源自人成年全脑，人成年海马和人胚胎全脑的cDNA文库直接克隆，其核苷酸序列已被确定，其功能已被鉴定。 本发明提供包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）包含与SEQ ID NO：1中任一项所示的氨基酸序列相同或基本相同的氨基酸序列的多肽 NOS：1〜70; （b）通过缺失，取代或添加一部分氨基酸，并且具有基本相同的生物活性的多肽，其包含衍生自SEQ ID NO：1至70中任一个所示氨基酸序列的氨基酸序列的多肽 具有（a）的多肽的功能的特征; 由上述DNA编码的重组多肽; 和含有多肽的蛋白质。
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