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    SINGLE USE SLURRYING AND CHROMATOGRAPHY SYSTEMS
    21.
    发明申请
    SINGLE USE SLURRYING AND CHROMATOGRAPHY SYSTEMS 审中-公开
    单一使用浆料和色谱系统

    公开(公告)号：US20130186834A1

    公开(公告)日：2013-07-25

    申请号：US13825829

    申请日：2011-09-23

    申请人： John J. Vicalvi ,  Joseph Makowiecki ,  Joseph D. Crowell ,  Parrish M. Galliher

    发明人： John J. Vicalvi ,  Joseph Makowiecki ,  Joseph D. Crowell ,  Parrish M. Galliher

    IPC分类号： B01D15/22

    CPC分类号： B01D15/22 ,  B01F7/00141 ,  B01F7/00858 ,  B01F7/161 ,  B01F7/162 ,  B01F7/1695 ,  B01F7/22 ,  B01F13/0211 ,  B01F13/065 ,  B01F13/0827 ,  B01F15/00162 ,  B01F15/00175 ,  B01F15/0022 ,  B01F15/00227 ,  B01F15/0085 ,  B01F15/065 ,  G01N30/50 ,  G01N30/56 ,  G01N30/6017 ,  G01N30/603 ,  G01N2030/565

    摘要： Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium, such as a chromatography resin. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion during use while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration. Alternatively, the agitator in the lowered position permits the chromatography resin packing material to operate in a mixed, slurry configuration.

    摘要翻译： 公开了用于层析的方法和系统，其采用配置成装配在支撑结构内并适于接收过滤或吸收介质如色谱树脂的柔性容器。 柔性容器可以包括至少一个入口，至少一个出口和周边地密封在容器内的分离屏障，以将容器分离成树脂容纳部分和排出部分。 挡板可以构造成在使用期间将树脂材料从排水部分排除，同时允许流体通过。 一次性色谱系统还可以包括设置在柔性容器内的一个或多个搅拌器，并可调节地构造成在柔性容器中升高或降低。 当搅拌器处于升起位置时，树脂包装材料可以以沉降的填充床构型运行。 或者，处于降低位置的搅拌器允许色谱树脂包装材料以混合的浆料配置运行。

    Process for producing heparinase
    22.
    发明授权
    Process for producing heparinase 失效
    生产肝素酶的方法

    公开(公告)号：US4443545A

    公开(公告)日：1984-04-17

    申请号：US337910

    申请日：1982-01-08

    申请人： Robert S. Langer, Jr. ,  Robert Linhardt ,  Charles L. Cooney ,  Parrish M. Galliher

    发明人： Robert S. Langer, Jr. ,  Robert Linhardt ,  Charles L. Cooney ,  Parrish M. Galliher

    IPC分类号： C12N9/88

    CPC分类号： C12N9/88

    摘要： Heparinase is produced by growing the bacterium, Flavobacterium heparinum in an improved defined medium consisting of a carbon source, two or more amino acids and several salts in the absence of protein. The carbon source concentration is specifically kept below a certain level to promote improved heparinase production. The sulfate source concentration is also specifically kept below a certain level to promote improved heparinase synthesis. Heparinase can be produced in this medium with or without the addition of an inducer compound.

    摘要翻译： 通过在不存在蛋白质的情况下，在由碳源，两种或更多种氨基酸和几种盐组成的改进的限定培养基中生长细菌，肝素黄杆菌来生产肝素酶。 碳源浓度特别保持在一定水平以促进肝素酶的产生。 硫酸根源浓度也被特异地保持在一定水平以促进改善的肝素酶合成。 肝素酶可以在该培养基中产生或不加入诱导剂化合物。