利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

73 条记录 (耗时 0.035 秒)

    1,3,4-thiadiazoles
    21.
    发明授权
    1,3,4-thiadiazoles 失效
    1,3,4-噻二唑

    公开(公告)号：US4927822A

    公开(公告)日：1990-05-22

    申请号：US901048

    申请日：1986-08-27

    申请人： Roger C. Brown ,  John Dixon ,  David H. Robinson

    发明人： Roger C. Brown ,  John Dixon ,  David H. Robinson

    IPC分类号： A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/54 ,  A61K38/00 ,  A61P9/12 ,  A61P43/00 ,  C07D249/12 ,  C07D253/06 ,  C07D271/10 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D285/16 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07K5/02 ,  C07K5/068 ,  C12N9/99

    CPC分类号： C07D253/06 ,  C07D271/10 ,  C07D285/12 ,  C07D285/135 ,  C07D285/16 ,  C07D417/04 ,  C07K5/0222 ,  C07K5/06086 ,  A61K38/00

    摘要： There are described compounds of formula I, ##STR1## in which Y is S, O or NR.sub.9,n is 0 or 1,R.sub.9 is hydrogen or alkyl C 1 to 10,R.sub.3 is hydrogen, alkyl C 1 to 10, cycloalkyl C3 to 10, CF.sub.3, SR.sub.10, a 5 or 6 membered heterocyclic group containing one or more S, O or N atoms, NR.sub.4 R.sub.5, phenyl or phenylalkyl C7 to 12, the phenyl, phenylalkyl and heterocyclic groups optionally being fused to a further phenyl group, the heterocyclic group and any phenyl group optionally being substituted by alkyl C 1 to 6, halogen, alkoxy C 1 to 6, nitro, nitrile, CF.sub.3, SR.sub.6, NR.sub.7 R.sub.11 or hydroxy,R.sub.6, R.sub.7 and R.sub.11, which may be the same or different, are each hydrogen or alkyl C 1 to 10,R.sub.4 and R.sub.5, which may be the same or different, are each hydrogen, alkyl C 1 to 10 or phenyl,R.sub.10 is alkyl C 1 to 10,X.sub.1 is S or O, andA is a chain comprising from 2-16 atoms, which chain carries an O or S containing substitutent at a position 2-6 atoms away from the group C=X.sub.1,and pharmaceutically acceptable salts, esters and amides thereof, p1 there are also described method of making the compounds and pharmaceutical formulations, e.g. for the treatment of hypertension, containing them.

    摘要翻译： 描述了式I的化合物，其中Y是S，O或NR9，n是0或1，R9是氢或烷基C1至10，R3是氢，烷基C1至10，环烷基C3 至10，CF 3，SR 10，含有一个或多个S，O或N原子的5或6元杂环基，NR 4 R 5，苯基或苯基烷基C 7至12，任选地与另外的苯基稠合的苯基，苯基烷基和杂环基， 杂环基和任选被烷基C 1-6取代的任何苯基，卤素，烷氧基C 1至6，硝基，腈，CF 3，SR 6，NR 7 R 11或羟基，R 6，R 7和R 11可以相同或不同 各自为氢或烷基C 1至10，R 4和R 5可以相同或不同，各自为氢，烷基C 1至10或苯基，R 10为烷基C 1至10，X 1为S或O，以及 A是包含2-16个原子的链，该链在距离基团C = X1的2-6个原子的位置上携带含有O或S的取代基，以及药学上可接受的盐，酯和酰胺 除此之外，还描述了制备化合物和药物制剂的方法，例如， 用于治疗高血压，包含它们。

    Locking toy vehicle
    23.
    发明授权
    Locking toy vehicle 失效
    锁定玩具车

    公开(公告)号：US4533336A

    公开(公告)日：1985-08-06

    申请号：US490235

    申请日：1983-04-29

    申请人： John Dixon ,  Peter Manning

    发明人： John Dixon ,  Peter Manning

    IPC分类号： A63H17/26 ,  A63H17/273 ,  A63H17/00

    CPC分类号： A63H17/26

    摘要： A toy vehicle has hinged and lockable doors, trunk lid, and hood, each with an internal U-shaped shackle, clevis, or claw projecting inwardly. A single locking plate is slidably positioned inside the vehicle. The plate has an integral sliding bolt at each position which is adjacent a shackle, clevis, or claw. The internal hub of each wheel has an integral, cam shaped member formed thereon to be captured or released by detents on the locking plate. A key fits through a key hole in the bottom of the vehicle in order to slide the plate forward or aft, as the key turns. As it so slides, a bolt or detent on the plate slides through or out of each shackle, clevis, or claw and engages or disengages the cam members, thereby locking or unlocking the doors and wheels.

    摘要翻译： 玩具车具有铰链和可锁定的门，行李箱盖和罩，每个具有向内突出的内部U形钩环，U形夹或爪。 单个锁定板可滑动地定位在车辆内部。 该板在每个位置具有一个整体滑动螺栓，该滑动螺栓与钩环，U形夹或爪相邻。 每个车轮的内部轮毂具有形成在其上的整体的凸轮形构件，以通过锁定板上的棘爪来捕获或释放。 一个钥匙通过车辆底部的一个钥匙孔装配，以便在钥匙转动时向前或向后滑动车板。 当它滑动时，板上的螺栓或棘爪滑动或滑出每个钩环，U形夹或爪，并接合或脱离凸轮构件，从而锁定或解锁门和车轮。

    System and method for reducing drag on hulls of marine crafts thereby increasing fluid dynamic efficiencies
    24.
    发明授权
    System and method for reducing drag on hulls of marine crafts thereby increasing fluid dynamic efficiencies 有权

    公开(公告)号：US12097932B2

    公开(公告)日：2024-09-24

    申请号：US18119324

    申请日：2023-03-09

    申请人： John Dixon

    发明人： John Dixon

    IPC分类号： B63B1/38 ,  B63B59/04

    CPC分类号： B63B1/38 ,  B63B59/04 ,  B63B2001/387

    摘要： The present invention seeks to reduce the frictional resistance of a vessel through enhanced air lubrication by creating and sustaining a superaerophilic surface underneath the vessel. Air is supplied by two different means: through vents near the bow of the vessel and through the perforated superaerophilic surface underneath the vessel. The air delivered through the perforations in the superaerophilic surface prohibits wetting of microscopic structures on the surface, maintaining the superaerophilic properties of it. Since the superaerophilic surface attracts air close to the hull surface, this invention greatly increases the ratio of air from the bow vents within the boundary layer, improving the efficiency and effectiveness of the air lubrication system. Aerophilic effects are enhanced by carbon, which is captured, filtered, and mixed in with the air supplied to the plastron.

    SYSTEM AND METHOD FOR REDUCING DRAG ON HULLS OF MARINE CRAFTS THEREBY INCREASING FLUID DYNAMIC EFFICIENCIES
    25.
    发明公开
    SYSTEM AND METHOD FOR REDUCING DRAG ON HULLS OF MARINE CRAFTS THEREBY INCREASING FLUID DYNAMIC EFFICIENCIES 审中-公开

    公开(公告)号：US20240166305A1

    公开(公告)日：2024-05-23

    申请号：US18119324

    申请日：2023-03-09

    申请人： John Dixon

    发明人： John Dixon

    IPC分类号： B63B1/38 ,  B63B59/04

    CPC分类号： B63B1/38 ,  B63B59/04 ,  B63B2001/387

    摘要： The present invention seeks to reduce the frictional resistance of a vessel through enhanced air lubrication by creating and sustaining a superaerophilic surface underneath the vessel. Air is supplied by two different means: through vents near the bow of the vessel and through the perforated superaerophilic surface underneath the vessel. The air delivered through the perforations in the superaerophilic surface prohibits wetting of microscopic structures on the surface, maintaining the superaerophilic properties of it. Since the superaerophilic surface attracts air close to the hull surface, this invention greatly increases the ratio of air from the bow vents within the boundary layer, improving the efficiency and effectiveness of the air lubrication system. Aerophilic effects are enhanced by carbon, which is captured, filtered, and mixed in with the air supplied to the plastron.

    Combination
    26.
    发明申请
    Combination 审中-公开
    组合

    公开(公告)号：US20060247257A1

    公开(公告)日：2006-11-02

    申请号：US10545972

    申请日：2004-02-16

    申请人： John Dixon

    发明人： John Dixon

    IPC分类号： A61K31/495 ,  A61K31/4412 ,  A61K31/44 ,  A61K31/4709 ,  A61K31/4172 ,  A61K31/165

    CPC分类号： A61K45/06 ,  A61K31/166 ,  A61K31/167 ,  A61K31/47 ,  A61K2300/00

    摘要： The invention provides a pharmaceutical composition, pharmaceutical product or kit comprising a first active ingredient which is a P2X7 receptor antagonist, and a second active ingredient which is an inhibitor of proTNFα; convertase enzyme (TACE), for use in the treatment of inflammatory disorders.

    摘要翻译： 本发明提供药物组合物，药物产品或试剂盒，其包含P2X 7受体拮抗剂的第一活性成分和作为proTNFα的抑制剂的第二活性成分; 转化酶（TACE），用于治疗炎症性疾病。

    Polymerisation of olefinic compounds
    29.
    发明申请
    Polymerisation of olefinic compounds 失效
    烯烃化合物的聚合

    公开(公告)号：US20060020091A1

    公开(公告)日：2006-01-26

    申请号：US11130106

    申请日：2005-05-17

    申请人： Kevin Blann ,  Deon De Wet-Roos ,  Dawid Joubert ,  Esna Killian ,  John Dixon ,  Nonhlanhla Phelembe ,  Aletta Toit

    发明人： Kevin Blann ,  Deon De Wet-Roos ,  Dawid Joubert ,  Esna Killian ,  John Dixon ,  Nonhlanhla Phelembe ,  Aletta Toit

    IPC分类号： C08F4/44

    CPC分类号： B01J31/2204 ,  B01J31/18 ,  B01J31/188 ,  B01J31/2409 ,  B01J2231/12 ,  B01J2231/20 ,  B01J2531/46 ,  B01J2531/56 ,  B01J2531/62 ,  C08F110/02 ,  C08F2410/04 ,  C08F2500/08 ,  C08F2500/02 ,  C08F2500/23 ,  C08F2500/17 ,  C08F2500/20 ,  C08F4/69146 ,  C08F4/6497

    摘要： This invention relates to a process for producing a polymeric product by the polymerisation of at least one olefinic compound in the form of an olefin or a compound including an olefinic moiety by contacting the at least one olefinic compound with a polymerisation catalyst. The catalyst comprises the combination of a source of a Group IV to VI transition metal; and a ligating compound of the formula (R1)mX1(Y)X2(R2)n. The process is characterised therein that when R1 and R2 are independently a hydrocarbyl group or a heterohydrocarbyl group which contains at least one non-polar substituent, the olefinic compound is contacted with the polymerisation catalyst at a reaction temperature from and above 70° C.; and where R1 and R2 are independently a hydrocarbyl group or a heterohydrocarbyl group which contains no substituent, the olefinic compound is contacted with the polymerisation catalyst at a reaction temperature from and above 90° C.

    摘要翻译： 本发明涉及通过使烯烃或包含烯属部分的化合物的形式聚合至少一种烯烃化合物来生产聚合产物的方法，该方法包括使至少一种烯烃化合物与聚合催化剂接触。 催化剂包括IV-VI族过渡金属源的组合; 和式<？in-line-formula description =“In-line Formulas”的连接化合物end =“lead”？（R 1） （Y）X 2（R 2）N 2。 <？in-line-formula description =“In-line Formulas”end =“tail”？>该过程的特征在于当R 1和R 2独立地为 烃基或含有至少一个非极性取代基的杂烃基，该烯烃化合物在70℃以上的反应温度下与聚合催化剂接触; 并且其中R 1和R 2独立地是不含取代基的烃基或杂烃基，所述烯烃化合物与所述聚合催化剂在反应温度下 高于90°C

    Rear seat for a vehicle
    30.
    发明授权
    Rear seat for a vehicle 失效
    车后座

    公开(公告)号：US06629729B2

    公开(公告)日：2003-10-07

    申请号：US10034479

    申请日：2002-01-04

    申请人： Michael Wiedeman ,  Michael Tsay ,  Mami Endo ,  John Dixon ,  John A. Frye ,  Frank D. Moburg

    发明人： Michael Wiedeman ,  Michael Tsay ,  Mami Endo ,  John Dixon ,  John A. Frye ,  Frank D. Moburg

    IPC分类号： A47C1500

    CPC分类号： B60N2/3011 ,  B60N2/3043 ,  B60N2/3052

    摘要： A pair of foldable rear seats for a motor vehicle includes a support stub fixed to the vehicle and a pair elongated support arms pivotally connected to the support stub. A pair of seat bottoms are pivotally connected to each of the respective support arms, such that each seat bottom is pivotable between a vertical folded position and a horizontal open position. Further, a pair of seat backs are each pivotally connected to a rear portion of each respective seat bottom in order to fold into the respective seat bottom from an open position. A headrest is slidably disposed on each seat back. Furthermore, a pair of seat legs are each pivotally connected to the seat bottom at an outer portion thereof so that when the seat bottom is in the open state, the seat leg, in its open position, extends from the seat bottom to the vehicle floor.

    摘要翻译： 用于机动车辆的一对可折叠后座椅包括固定到车辆的支撑短柱和枢转地连接到支撑短柱的一对细长支撑臂。 一对座椅底部枢转地连接到每个相应的支撑臂，使得每个座椅底部可在垂直折叠位置和水平打开位置之间枢转。 此外，一对座椅靠背各自枢转地连接到每个相应座椅底部的后部，以便从打开位置折叠到相应的座椅底部。 头枕可滑动地设置在每个座椅靠背上。 此外，一对座椅腿在其外侧各自枢转地连接到座椅底部，使得当座椅底部处于打开状态时，座椅腿处于其打开位置，从座椅底部延伸到车辆地板 。