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公开(公告)号：US20090155921A1
公开(公告)日：2009-06-18
申请号：US12333219
申请日：2008-12-11
申请人： Peter S. Lu , Joseph Byerly , Christopher Kepner , Thomas M. Sherlock , Michael P. Belmares , Johannes Schweizer
发明人： Peter S. Lu , Joseph Byerly , Christopher Kepner , Thomas M. Sherlock , Michael P. Belmares , Johannes Schweizer
CPC分类号： G01N21/8483 , G01N21/274 , G01N21/276 , G01N2201/12792
摘要： The present invention provides a method and apparatus for reading test strips such as lateral flow test strips as used for the testing of various chemicals in humans and animals. A compact and portable device is provided that may be battery powered when used remotely from the laboratory and, may store test data until it can be downloaded to another database. Motive power during scanning of the test strip is by means of a spring and damper that is wound by the operator during the insertion of a test strip cassette holder prior to test.
摘要翻译： 本发明提供一种用于读取测试条的方法和装置，例如用于测试人和动物中的各种化学物质的横向流动测试条。 提供了一种紧凑型便携式设备，可在实验室远程使用电池供电，并可存储测试数据，直到可以下载到另一个数据库。 在测试条扫描期间的动力是借助于弹簧和阻尼器，其在测试之前插入测试条带盒座期间由操作者缠绕。
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公开(公告)号：US07399467B2
公开(公告)日：2008-07-15
申请号：US11021949
申请日：2004-12-23
申请人： Peter S. Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter S. Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
IPC分类号： A61K39/395
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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23.发明申请CODON MODIFIED POLYNUCLEOTIDE SEQUENCES FOR ENHANCED EXPRESSION IN A HOST SYSTEM 审中-公开用于在主机系统中增强表达的CODON修饰的多核苷酸序列公开(公告)号：US20130017572A1
公开(公告)日：2013-01-17
申请号：US12919684
申请日：2010-04-30
CPC分类号： C12P21/02
摘要： Synthetic DNA molecules encoding various HPV proteins are provided. The codons of the synthetic molecules are designed so as to use the codons that preferentially increase expression of the polypeptide in the host cell, which in preferred embodiments is a human cell. The codons are modified in order to minimize, decrease or eliminate cellular destruction of the polypeptide construct.
摘要翻译： 提供编码各种HPV蛋白质的合成DNA分子。 设计合成分子的密码子以便使用优先增加宿主细胞中多肽表达的密码子，其在优选的实施方案中是人细胞。 修饰密码子以最小化，减少或消除多肽构建体的细胞破坏。
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公开(公告)号：US20120052484A1
公开(公告)日：2012-03-01
申请号：US13212991
申请日：2011-08-18
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US08048676B2
公开(公告)日：2011-11-01
申请号：US11650455
申请日：2007-01-05
IPC分类号： G01N33/53
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US07972774B2
公开(公告)日：2011-07-05
申请号：US11881724
申请日：2007-07-27
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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27.发明申请Methods of Identifying Modulators of Interaction Between PDZ Domain Proteins and PL Proteins 审中-公开识别PDZ结构域蛋白与PL蛋白相互作用的调节剂的方法公开(公告)号：US20090149339A1
公开(公告)日：2009-06-11
申请号：US12194408
申请日：2008-08-19
IPC分类号： C40B30/04
CPC分类号： G01N33/566 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , B01J2219/00659 , B01J2219/00725 , C07K14/705 , C07K2319/00 , C12N2310/315 , C40B40/10 , Y02A90/26 , Y10S436/809
摘要： The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in hematopoietic cells and other cells involved in the mediation of an immune response. Reagents and methods provided are useful for treatment of a variety of diseases and conditions mediated by immune system cells.
摘要翻译： 本发明提供了用于抑制或增强造血细胞中的蛋白质与涉及免疫应答中介的其它细胞之间的相互作用的试剂和方法。 提供的试剂和方法可用于治疗由免疫系统细胞介导的多种疾病和病症。
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公开(公告)号：US20090075377A1
公开(公告)日：2009-03-19
申请号：US11833848
申请日：2007-08-03
IPC分类号： C12N5/08
CPC分类号： C12N5/0636 , A61K38/1709 , C12N2501/998 , C12N2501/999
摘要： The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in cells, particularly interactions between a PDZ protein and a PL protein. Reagents and methods that are provided are useful for treatment of a variety of diseases and conditions in a variety of cell types.
摘要翻译： 本发明提供用于抑制或增强细胞中蛋白质之间的相互作用的试剂和方法，特别是PDZ蛋白和PL蛋白之间的相互作用。 提供的试剂和方法可用于治疗各种细胞类型中的各种疾病和病症。
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公开(公告)号：US06942981B1
公开(公告)日：2005-09-13
申请号：US09688017
申请日：2000-10-13
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705 , C12Q1/68 , C40B40/10 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/566 , G06F19/00
CPC分类号： G01N33/566 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , B01J2219/00659 , B01J2219/00725 , C07K14/705 , C07K2319/00 , C12N2310/315 , C40B40/10 , Y02A90/26 , Y10S436/809
摘要： Methods are provided for determining interactions between multiple PDZ-domain polypeptides and PDZ Ligand Proteins.
摘要翻译： 提供了用于确定多个PDZ结构域多肽和PDZ配体蛋白之间的相互作用的方法。
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公开(公告)号：US20100028855A1
公开(公告)日：2010-02-04
申请号：US12298133
申请日：2006-10-21
申请人： Peter S. Lu , Michael P. Belmares , Johannes Schweizer , Jon Silver , Jon Silver
发明人： Peter S. Lu , Michael P. Belmares , Johannes Schweizer , Jon Silver , Jon Silver
IPC分类号： C12Q1/70
CPC分类号： C07K16/1018 , G01N33/56983 , G01N2333/11
摘要： The invention provides methods for detecting influenza B from its NS1 protein. The NS1 protein is present in detectable levels in clinical samples and can be detected using antibodies that are panspecific for influenza B without binding to influenza A or other viruses.
摘要翻译： 本发明提供从其NS1蛋白检测流感B的方法。 NS1蛋白以临床样品中可检测的水平存在，并且可以使用针对乙型流感病毒而不与A型流感病毒或其他病毒结合的特异性抗体进行检测。
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