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公开(公告)号：US20100120700A1
公开(公告)日：2010-05-13
申请号：US12606905
申请日：2009-10-27
申请人： Peter S. Lu , Christoph Peter Bagowski , Johannes Schweizer , Chamorro Somoza Diaz-Sarmiento , Jonathan David Garman , Michael P. Belmares
发明人： Peter S. Lu , Christoph Peter Bagowski , Johannes Schweizer , Chamorro Somoza Diaz-Sarmiento , Jonathan David Garman , Michael P. Belmares
CPC分类号： C07K14/005 , A61K38/00 , C07K14/47 , C07K14/705 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02
摘要： The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid sequence of a particular PDZ domain from the cellular protein MAGI-1. The invention provides methods to treat diseases associated with expression of pathogen proteins by modulating their interactions with MAGI-1, and a number of isolated peptides useful in such methods. Also provided are kits for performing the subject methods.
摘要翻译： 本发明提供了用于治疗病原体感染，特别是人乳头瘤病毒感染的方法和组合物。 具体地，本发明提供了一种筛选方法，其涉及确定候选试剂对来自HPV的致癌菌株的E6蛋白与含有来自细胞蛋白MAGI-1的特定PDZ结构域的氨基酸序列的多肽的结合的影响 。 本发明提供了通过调节与MAGI-1的相互作用来治疗与病原体蛋白表达相关的疾病的方法，以及在这些方法中有用的许多分离的肽。 还提供了用于执行主题方法的套件。
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2.发明申请CODON MODIFIED POLYNUCLEOTIDE SEQUENCES FOR ENHANCED EXPRESSION IN A HOST SYSTEM 审中-公开用于在主机系统中增强表达的CODON修饰的多核苷酸序列公开(公告)号：US20130017572A1
公开(公告)日：2013-01-17
申请号：US12919684
申请日：2010-04-30
CPC分类号： C12P21/02
摘要： Synthetic DNA molecules encoding various HPV proteins are provided. The codons of the synthetic molecules are designed so as to use the codons that preferentially increase expression of the polypeptide in the host cell, which in preferred embodiments is a human cell. The codons are modified in order to minimize, decrease or eliminate cellular destruction of the polypeptide construct.
摘要翻译： 提供编码各种HPV蛋白质的合成DNA分子。 设计合成分子的密码子以便使用优先增加宿主细胞中多肽表达的密码子，其在优选的实施方案中是人细胞。 修饰密码子以最小化，减少或消除多肽构建体的细胞破坏。
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公开(公告)号：US20120052484A1
公开(公告)日：2012-03-01
申请号：US13212991
申请日：2011-08-18
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US08048676B2
公开(公告)日：2011-11-01
申请号：US11650455
申请日：2007-01-05
IPC分类号： G01N33/53
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US07972774B2
公开(公告)日：2011-07-05
申请号：US11881724
申请日：2007-07-27
IPC分类号： C12Q1/70
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US07399467B2
公开(公告)日：2008-07-15
申请号：US11021949
申请日：2004-12-23
申请人： Peter S. Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
发明人： Peter S. Lu , Jonathan David Garman , Michael P. Belmares , Chamorro Somoza Diaz-Sarmiento , Johannes Schweizer
IPC分类号： A61K39/395
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , C07K2317/92 , G01N33/56983 , G01N33/57411 , G01N33/5748 , G01N2333/025
摘要： The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.
摘要翻译： 本发明提供了结合来自至少三种致癌菌株的HPV的E6蛋白质的抗体，包括多克隆和单克隆抗体。 通常，抗体结合不同HPV株的E6蛋白之间保守的氨基酸基序，特别是HPV 16和18。本发明的抗体可用于检测样品中的HPV E6蛋白，因此，抗体 可用于各种诊断应用，包括诊断癌症的方法。 还提供了用于进行受试方法并含有目标抗体的试剂盒。
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公开(公告)号：US07312041B2
公开(公告)日：2007-12-25
申请号：US10630590
申请日：2003-07-29
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
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公开(公告)号：US20080124702A1
公开(公告)日：2008-05-29
申请号：US11881724
申请日：2007-07-27
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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公开(公告)号：US20100215677A1
公开(公告)日：2010-08-26
申请号：US12770682
申请日：2010-04-29
IPC分类号： A61K39/00 , G01N33/53 , C12N5/07 , A61P37/00 , A61P3/10 , A61P19/02 , A61P17/06 , A61P35/02 , A61P35/00 , A61P1/00 , C07K2/00 , C07K14/00
CPC分类号： G01N33/564 , G01N33/566 , G01N2500/02
摘要： Methods for modulating immune cell signaling are provided. In general such methods involve modulating an interaction between a PDZ protein and a PDZ ligand protein whose interaction affects the composition and/or distribution of lipid rafts in an immune cell. Modulators that enhance or inhibit such interactions are also disclosed, as well as methods of screening for such modulators.
摘要翻译： 提供了调节免疫细胞信号传导的方法。 通常，这种方法涉及调节PDZ蛋白和PDZ配体蛋白之间的相互作用，其相互作用影响免疫细胞中脂筏的组成和/或分布。 还公开了增强或抑制这种相互作用的调节剂，以及筛选这种调节剂的方法。
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公开(公告)号：US20080166736A1
公开(公告)日：2008-07-10
申请号：US11674034
申请日：2007-02-12
申请人： Peter S. Lu , Chamorro Somoza Diaz-Sarmiento , Brian Seed , Ramnik Xavier , Brayan Allen Irving
发明人： Peter S. Lu , Chamorro Somoza Diaz-Sarmiento , Brian Seed , Ramnik Xavier , Brayan Allen Irving
CPC分类号： G01N33/564 , G01N33/566 , G01N2500/02
摘要： Methods for modulating immune cell signaling are provided. In general such methods involve modulating an interaction between a PDZ protein and a PDZ ligand protein whose interaction affects the composition and/or distribution of lipid rafts in an immune cell. Modulators that enhance or inhibit such interactions are also disclosed, as well as methods of screening for such modulators.
摘要翻译： 提供了调节免疫细胞信号传导的方法。 通常，这种方法涉及调节PDZ蛋白和PDZ配体蛋白之间的相互作用，其相互作用影响免疫细胞中脂筏的组成和/或分布。 还公开了增强或抑制这种相互作用的调节剂，以及筛选这种调节剂的方法。
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