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公开(公告)号：US20110125089A1
公开(公告)日：2011-05-26
申请号：US12935114
申请日：2009-03-26
申请人： Richard I. Senderoff , Jeffrey D. Meyer , Emily N. Rollins , Steven D. Hughes , Richard M. Garcoa , Paul D. Bishop , Gerald W. Lasser
发明人： Richard I. Senderoff , Jeffrey D. Meyer , Emily N. Rollins , Steven D. Hughes , Richard M. Garcoa , Paul D. Bishop , Gerald W. Lasser
CPC分类号： A61K47/42 , A61K9/0024 , A61K9/06 , A61K38/4833 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , C12Y304/21005 , Y10T428/2982
摘要： Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked gelatin microspheres with pores. In another embodiment, the hemostatic composition comprises an additive such as a wetting agent, a suspending agent, or both. The hemostatic compositions may also include a hemostatic agent such as thrombin, and may include a high concentration of thrombin. The hemostatic compositions may also include plasma. Also provided herein are devices for dispersing said hemostatic compositions in a diluent, and delivering said dispersed hemostatic composition. The hemostatic compositions may also fabricated with a selected geometry as administration suggests.
摘要翻译： 本文提供止血组合物。 在一个实施方案中，止血组合物包括交联聚合物微球体，例如具有孔的交联明胶微球体。 在另一个实施方案中，止血组合物包含添加剂，例如润湿剂，悬浮剂或两者。 止血组合物还可以包括止血剂如凝血酶，并且可以包括高浓度的凝血酶。 止血组合物还可以包括血浆。 本文还提供了用于将所述止血组合物分散在稀释剂中并递送所述分散的止血组合物的装置。 止血组合物也可以按照给药方式制备具有所选择的几何形状。
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公开(公告)号：US07691585B2
公开(公告)日：2010-04-06
申请号：US11549241
申请日：2006-10-13
申请人： Paul O. Sheppard , Paul D. Bishop
发明人： Paul O. Sheppard , Paul D. Bishop
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides polypeptides and compositions comprising amino acid residues 23 to 108 of SEQ ID NO: 2, polypeptides and compositions comprising amino acid residues 28 to 108 of SEQ ID NO: 2, including affinity tags and the like, useful for stimulating gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis.
摘要翻译： 本发明提供了包含SEQ ID NO：2的氨基酸残基23至108的多肽和组合物，包含SEQ ID NO：2的氨基酸残基28至108的多肽和组合物，包括用于刺激胃肠收缩力的亲和标签等 ，胃排空，肠道运输和治疗胃轻瘫。
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公开(公告)号：US20080194484A1
公开(公告)日：2008-08-14
申请号：US12009230
申请日：2008-01-16
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.
摘要翻译： 本发明涉及用于标记为TML肽的新型肽片段的多核苷酸，肽，变体及其用途。 肽片段的结合已显示在肾脏和小肠中。 本发明还包括激动剂，拮抗剂，变体，抗体，表达编码新型TML肽的cDNA的宿主细胞和使用新型TML肽增加消化蛋白和激素的胃动力和分泌的方法。
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公开(公告)号：US20080181904A1
公开(公告)日：2008-07-31
申请号：US11678904
申请日：2007-02-26
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to polynucleotide and polypeptide molecules for zacrp2, a novel member of the family of proteins bearing a collagen-like domain and a Clq domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp2 polypeptides.
摘要翻译： 本发明涉及用于zacrp2的多核苷酸和多肽分子，其是具有胶原样结构域和Clq结构域的蛋白家族的新成员。 编码它们的多肽和多核苷酸参与二聚化或低聚反应，并可用于其研究。 本发明还包括针对zacrp2多肽的抗体。
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公开(公告)号：US07135317B2
公开(公告)日：2006-11-14
申请号：US09809617
申请日：2001-03-15
IPC分类号： C12N9/00
CPC分类号： C12N9/6489 , C07K14/47
摘要： The present invention relates to human polynucleotide and polypeptide molecules for zdint1, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are believed to be cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the zdint1 polypeptides.
摘要翻译： 本发明涉及用于zdint1的人多核苷酸和多肽分子，其是解聚酶蛋白酶的新成员。 多肽和编码它们的多核苷酸被认为是细胞 - 细胞相互作用调节，并可用于递送和治疗。 本发明还包括针对zdint1多肽的抗体。
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公开(公告)号：US06897286B2
公开(公告)日：2005-05-24
申请号：US09853253
申请日：2001-05-10
IPC分类号： A61K38/00 , C07K14/575 , C07K14/63 , C12N9/00 , C12N15/00
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to peptides related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33肽相关的肽，包括激动剂，拮抗剂和抗体。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US06756479B2
公开(公告)日：2004-06-29
申请号：US10212201
申请日：2002-08-02
申请人： Paul O. Sheppard , Paul D. Bishop
发明人： Paul O. Sheppard , Paul D. Bishop
IPC分类号： C07K1400
CPC分类号： C07K14/52 , A61K38/00 , C07K14/4702 , C07K2319/00 , C12Q1/6888 , C12Q2600/158
摘要： The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
摘要翻译： 本发明提供了两个称为“Zven”的人类蛋白质家族的成员。 位于人染色体3p21.1-3p14.3中的Zven1基因在睾丸组织和外周血淋巴细胞中表达。
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公开(公告)号：US5965389A
公开(公告)日：1999-10-12
申请号：US747108
申请日：1996-11-08
IPC分类号： C12N15/09 , C07K1/18 , C07K1/22 , C12N1/19 , C12N9/04 , C12N9/08 , C12N9/50 , C12N9/88 , C12N15/81 , C12P21/02 , C12R1/84
CPC分类号： C12N9/0065 , C12N15/815 , C12N9/0006 , C12N9/50 , C12N9/88
摘要： Methylotrophic yeast are used for high-level expression of GAD65 that makes the production of GAD65 feasible on an industrial scale. A methanol-inducible promoter from, for example, an alcohol oxidase gene, such as Pichia pastoris AOX1, can be used to regulate GAD65 expression. The recombinant GAD65 has high specific activity and retains antigenic characteristics of the native molecule that are essential to immunological assays and therapeutic protocols.
摘要翻译： 甲基营养酵母用于GAD65的高水平表达，使GAD65的生产在工业规模上可行。 来自例如醇氧化酶基因如巴斯德毕赤酵母（AOX1）的甲醇诱导型启动子可用于调节GAD65表达。 重组GAD65具有高比活性，并保留了对免疫学测定和治疗方案至关重要的天然分子的抗原特征。
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公开(公告)号：US09597062B2
公开(公告)日：2017-03-21
申请号：US12988353
申请日：2009-04-27
CPC分类号： A61B17/00234 , A61B17/00491 , A61B2017/00004 , A61B2017/00473 , A61B2017/00495 , A61B2017/0065 , A61B2017/00654 , A61B2017/320044 , A61B2090/3966
摘要： Provided is a surgical applicator and applicator tip configured to attach in fluid communication, for the delivery of beneficial fluids. The applicator tip may also be configured to reversibly attach, in fluid communication, with a pledget. For example, the applicator tip may include male or female threads, and the pledget has threads that are complementary to the thread configuration of the tip. The applicator tip may further comprise at least one fluid transfer lumen for transfer of a fluid from the tip to the pledget. In one embodiment of the invention, the tip includes male threads and the pledget includes a pledget attachment portion. There are also provided methods for connecting the tip to the pledget. In one embodiment, a tip comprising male threads is attached to the pledget, comprising a pledget attachment portion, by tapping or pressing the tip into the pledget attachment portion. There are also provided methods of use for the attached tip and pledget, including debridement, tissue translocation, delivery of fluid substances, absorption of fluid substances and combinations thereof. In a particular embodiment, the applicator places a thrombin solution into the attached pledget for delivery of an active hemostatic agent to a tissue site.
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公开(公告)号：US20090270333A1
公开(公告)日：2009-10-29
申请号：US12075821
申请日：2008-03-13
申请人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
发明人： Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop , Stephen R. Jaspers , Virender M. Labroo
IPC分类号： A61K38/10 , C07H21/04 , C12N15/63 , C12N5/10 , C07K7/08 , C07K14/00 , C07K16/00 , C12P21/00 , A61P1/00
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.
摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。
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