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43 条记录 (耗时 0.024 秒)

    Delivery of Active Agents
    21.
    发明申请
    Delivery of Active Agents 有权
    交付活动代理

    公开(公告)号：US20090111749A1

    公开(公告)日：2009-04-30

    申请号：US12258341

    申请日：2008-10-24

    申请人： Peter Richardson ,  Robert A. Baughman ,  Andrea Leone-Bay ,  Donald Costello

    发明人： Peter Richardson ,  Robert A. Baughman ,  Andrea Leone-Bay ,  Donald Costello

    IPC分类号： A61K38/00

    CPC分类号： A61K9/0075 ,  A61K9/1617 ,  A61K9/1688 ,  A61K31/495 ,  A61K38/26

    摘要： A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.

    摘要翻译： 本文公开了将生理活性剂引入哺乳动物的循环系统中的方法。 该方法利用快速的药物递送系统，其防止正在施用给需要治疗的患者的活性剂的失活或降解。 特别地，药物递送系统被设计用于肺部药物递送，例如通过吸入，用于以治疗有效的方式将活性剂（例如蛋白质和肽）递送至肺循环，从而避免在外周和血管组织中的活性剂的降解， 到达目标网站。

    Identification of therapeutic compounds
    23.
    发明申请
    Identification of therapeutic compounds 审中-公开
    鉴定治疗化合物

    公开(公告)号：US20070059773A1

    公开(公告)日：2007-03-15

    申请号：US10547462

    申请日：2004-03-05

    申请人： Peter Richardson

    发明人： Peter Richardson

    IPC分类号： G01N33/567 ,  G01N33/53

    CPC分类号： G01N33/9406 ,  G01N2500/02

    摘要： Methods for identifying potential therapeutic agents involve determining the affinity and/or efficacy of a test compound for an adensoine receptor at a relatively high pH and at a relatively low pH. Compounds with greater affinity and/or efficacy at the low pH are identified as potential therapeutic agents, in particular for the treatment of pain or inflammation.

    摘要翻译： 用于鉴定潜在治疗剂的方法包括在相对较高的pH和相对低的pH下测定受试化合物对于Adensoine受体的亲和性和/或功效。 在低pH下具有更高亲和力和/或功效的化合物被鉴定为潜在的治疗剂，特别是用于治疗疼痛或炎症。

    Variable flow and pressure ventilation system
    24.
    发明授权
    Variable flow and pressure ventilation system 有权
    可变流量和压力通风系统

    公开(公告)号：US06279574B1

    公开(公告)日：2001-08-28

    申请号：US09206113

    申请日：1998-12-04

    申请人： Peter Richardson ,  Jeffrey L. Orth ,  J. Bert Bunnell

    发明人： Peter Richardson ,  Jeffrey L. Orth ,  J. Bert Bunnell

    IPC分类号： A61M1600

    CPC分类号： A61M16/204 ,  A61M16/0051 ,  A61M16/0096 ,  A61M16/024 ,  A61M16/0808 ,  A61M16/085 ,  A61M16/0858 ,  A61M16/1095 ,  A61M16/161 ,  A61M2016/1025

    摘要： A ventilation system supplies a gas mixture that is humidified and heated through a proportional valve which is a fail closed and normally closed servo control valve positioned proximate a patient. The proportional valve is operated by a controller that regulates the pressure and the mode (e.g., high frequency, normal respiration, combinations) gas is delivered to the patient through a nozzle connected to the endotracheal tube. The nozzle has an exhaust connected to it and a pressure sensor through a pressure sensing port. The exhaust is a capped corrugated tube that is heated and perforated to allow air to escape, to muffle gas and respiration noises, and to trap moisture.

    摘要翻译： 通风系统提供通过比例阀加湿和加热的气体混合物，比例阀是位于病人附近的故障闭合和常闭伺服控制阀。 比例阀由调节压力的控制器操作，并且通过连接到气管内管的喷嘴将气体输送到患者的模式（例如，高频率，正常呼吸，组合）。 喷嘴具有与其连接的排气口和通过压力感测端口的压力传感器。 排气是加热和穿孔的带盖波纹管，允许空气逸出，消除气体和呼吸噪音，并吸收水分。

    Use of spongosine for the treatment of pain
    26.
    发明授权
    Use of spongosine for the treatment of pain 失效
    使用海绵体治疗疼痛

    公开(公告)号：US08252766B2

    公开(公告)日：2012-08-28

    申请号：US10537564

    申请日：2003-12-09

    申请人： Peter Richardson

    发明人： Peter Richardson

    IPC分类号： A61K31/70

    CPC分类号： A61K31/197 ,  A61K31/52 ,  A61K31/7076 ,  Y02A50/411 ,  A61K2300/00

    摘要： The compound spongosine (2-methoxyadenosine), of the class of adenosines, is useful as an analgesic, particularly in a method of preventing, treating, or ameliorating pain which comprises administering spongosine (2-methoxyadenosine) to a subject in need of such prevention, treatment, or amelioration.

    摘要翻译： 腺苷类化合物的海绵体（2-甲氧基腺苷）可用作止痛剂，特别是在预防，治疗或改善疼痛的方法中，其包括向需要这种预防的受试者施用棉球蛋白（2-甲氧基腺苷） ，治疗或改善。

    BROAD-BAND, LOW FREQUENCY, HIGH-AMPLITUDE, LONG TIME DURATION, OSCILLATING AIRWAY PRESSURE BREATHING APPARATUS AND METHOD UTILIZING BUBBLES
    29.
    发明申请
    BROAD-BAND, LOW FREQUENCY, HIGH-AMPLITUDE, LONG TIME DURATION, OSCILLATING AIRWAY PRESSURE BREATHING APPARATUS AND METHOD UTILIZING BUBBLES 有权
    宽带，低频，高功率，长时间，振荡气道呼吸装置和使用泡沫的方法

    公开(公告)号：US20110073112A1

    公开(公告)日：2011-03-31

    申请号：US12899177

    申请日：2010-10-06

    申请人： Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    发明人： Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    IPC分类号： A61M16/20

    CPC分类号： A61M16/0006 ,  A61M16/021 ,  A61M16/04 ,  A61M16/0465 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/1045 ,  A61M16/202 ,  A61M16/204 ,  A61M16/205 ,  A61M16/208 ,  A61M16/209 ,  A61M2016/003 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/025 ,  A61M2202/0266 ,  A61M2205/3331 ,  A61M2205/3348 ,  A61M2205/3365 ,  A61M2205/50 ,  A61M2205/70

    摘要： It has been discovered that high amplitude, low frequency, broadband spectrum pressure oscillations of sufficient time duration can help stabilize lung volumes and improve gas exchange in a patient receiving ventilation assistance by helping to recruit and stabilize alveoli. A novel device is presented which can produce pressure oscillations having high amplitudes, a low broad-band frequency spectrum and long time duration. Additionally, the device can maintain a patient's mean airway pressure at one or more controlled levels. The device can control the oscillatory amplitude, frequency range and composition, time duration, and mean airway pressure levels by adjusting certain device parameters, such as the angle and depth of the device in a fluid. A device and mechanical system for remotely adjusting and measuring the angle of the device in a fluid are also disclosed. Furthermore, a device and system are disclosed that can deliver pressure oscillations having high amplitudes, a low broad-band frequency spectrum, long time duration, and multiple mean airway inspiratory and expiratory pressure levels. The device and system also provide means for controlling respiration timing in a patient, including: breaths per minute, inspiratory time, and the ratio of inspiratory to expiratory time.

    摘要翻译： 已经发现，具有足够持续时间的高振幅，低频，宽带频谱压力振荡可以帮助稳定肺容积并通过帮助招募和稳定肺泡来改善患者接受通气辅助的气体交换。 提出了一种可以产生具有高幅度，低宽带频谱和长时间持续时间的压力振荡的新型装置。 另外，该装置可以将患者的平均气道压力维持在一个或多个受控水平。 该设备可以通过调整某些设备参数（例如流体中的设备的角度和深度）来控制振荡幅度，频率范围和组成，持续时间和平均气道压力水平。 还公开了用于远程调节和测量流体中装置的角度的装置和机械系统。 此外，公开了一种可以提供具有高幅度，低宽带频谱，长时间持续时间和多个平均气道吸气和呼气压力水平的压力振荡的装置和系统。 该装置和系统还提供用于控制患者呼吸时间的装置，包括：每分钟呼吸，吸气时间以及吸气与呼气时间的比例。

    METHOD OF PREVENTING ADVERSE EFFECTS BY GLP-1
    30.
    发明申请
    METHOD OF PREVENTING ADVERSE EFFECTS BY GLP-1 有权
    通过GLP-1预防不良反应的方法

    公开(公告)号：US20090110647A1

    公开(公告)日：2009-04-30

    申请号：US12258340

    申请日：2008-10-24

    申请人： Peter Richardson ,  Robert A. Baughman ,  Donald Costello

    发明人： Peter Richardson ,  Robert A. Baughman ,  Donald Costello

    IPC分类号： A61K9/14 ,  A61K38/00 ,  A61P3/10 ,  A61K38/28

    CPC分类号： A61K45/06 ,  A61K31/495 ,  A61K38/26 ,  A61K38/28 ,  A61M15/00 ,  A61K2300/00

    摘要： A method for preventing or reducing adverse effects such as profuse sweating, nausea and vomiting, which normally are associated with subcutaneous and intravenous administration of glucagon-like peptide 1 (GLP-1) therapy is provided. In particular, the method comprises the rapid administration of a GLP-1 formulation into the pulmonary circulation such as by inhalation, directly into pulmonary alveolar capillaries using a dry powder drug delivery system.

    摘要翻译： 提供了通常与皮下和静脉内施用胰高血糖素样肽1（GLP-1）治疗相关的预防或减少诸如大量出汗，恶心和呕吐的不良反应的方法。 特别地，该方法包括使用干粉药物递送系统将GLP-1制剂快速施用于肺循环，例如通过吸入，直接进入肺泡毛细血管。