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    Broad-band, low frequency, high-amplitude, long time duration, oscillating airway pressure breathing apparatus and method utilizing bubbles
    1.
    发明授权
    Broad-band, low frequency, high-amplitude, long time duration, oscillating airway pressure breathing apparatus and method utilizing bubbles 有权
    宽带，低频，高振幅，长时间，振荡气道呼吸器和利用气泡的方法

    公开(公告)号：US08381723B2

    公开(公告)日：2013-02-26

    申请号：US12899323

    申请日：2010-10-06

    申请人： Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    发明人： Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    IPC分类号： A62B7/00 ,  A62B9/00

    CPC分类号： A61M16/0006 ,  A61M16/021 ,  A61M16/04 ,  A61M16/0465 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/1045 ,  A61M16/202 ,  A61M16/204 ,  A61M16/205 ,  A61M16/208 ,  A61M16/209 ,  A61M2016/003 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/025 ,  A61M2202/0266 ,  A61M2205/3331 ,  A61M2205/3348 ,  A61M2205/3365 ,  A61M2205/50 ,  A61M2205/70

    摘要： It has been discovered that high amplitude, low frequency, broadband spectrum pressure oscillations of sufficient time duration can help stabilize lung volumes and improve gas exchange in a patient receiving ventilation assistance by helping to recruit and stabilize alveoli. A novel device is presented which can produce pressure oscillations having high amplitudes, a low broad-band frequency spectrum and long time duration. Additionally, the device can maintain a patient's mean airway pressure at one or more controlled levels. The device can control the oscillatory amplitude, frequency range and composition, time duration, and mean airway pressure levels by adjusting certain device parameters, such as the angle and depth of the device in a fluid. A device and mechanical system for remotely adjusting and measuring the angle of the device in a fluid are also disclosed. Furthermore, a device and system are disclosed that can deliver pressure oscillations having high amplitudes, a low broad-band frequency spectrum, long time duration, and multiple mean airway inspiratory and expiratory pressure levels. The device and system also provide means for controlling respiration timing in a patient, including: breaths per minute, inspiratory time, and the ratio of inspiratory to expiratory time.

    摘要翻译： 已经发现，具有足够持续时间的高振幅，低频，宽带频谱压力振荡可以帮助稳定肺容积并通过帮助招募和稳定肺泡来改善患者接受通气辅助的气体交换。 提出了一种可以产生具有高幅度，低宽带频谱和长时间持续时间的压力振荡的新型装置。 另外，该装置可以将患者的平均气道压力维持在一个或多个受控水平。 该设备可以通过调整某些设备参数（例如流体中的设备的角度和深度）来控制振荡幅度，频率范围和组成，持续时间和平均气道压力水平。 还公开了用于远程调节和测量流体中装置的角度的装置和机械系统。 此外，公开了一种可以提供具有高幅度，低宽带频谱，长时间持续时间和多个平均气道吸气和呼气压力水平的压力振荡的装置和系统。 该装置和系统还提供用于控制患者呼吸时间的装置，包括：每分钟呼吸，吸气时间以及吸气与呼气时间的比例。

    BROAD-BAND, LOW FREQUENCY, HIGH-AMPLITUDE, LONG TIME DURATION, OSCILLATING AIRWAY PRESSURE BREATHING APPARATUS AND METHOD UTILIZING BUBBLES
    2.
    发明申请
    BROAD-BAND, LOW FREQUENCY, HIGH-AMPLITUDE, LONG TIME DURATION, OSCILLATING AIRWAY PRESSURE BREATHING APPARATUS AND METHOD UTILIZING BUBBLES 有权
    宽带，低频，高功率，长时间，振荡气道呼吸装置和使用泡沫的方法

    公开(公告)号：US20110073112A1

    公开(公告)日：2011-03-31

    申请号：US12899177

    申请日：2010-10-06

    申请人： Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    发明人： Robert M. DiBlasi ,  Jay C. Zignego ,  Thomas N. Hansen ,  Charles V. Smith ,  Peter Richardson

    IPC分类号： A61M16/20

    CPC分类号： A61M16/0006 ,  A61M16/021 ,  A61M16/04 ,  A61M16/0465 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/1045 ,  A61M16/202 ,  A61M16/204 ,  A61M16/205 ,  A61M16/208 ,  A61M16/209 ,  A61M2016/003 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/025 ,  A61M2202/0266 ,  A61M2205/3331 ,  A61M2205/3348 ,  A61M2205/3365 ,  A61M2205/50 ,  A61M2205/70

    摘要： It has been discovered that high amplitude, low frequency, broadband spectrum pressure oscillations of sufficient time duration can help stabilize lung volumes and improve gas exchange in a patient receiving ventilation assistance by helping to recruit and stabilize alveoli. A novel device is presented which can produce pressure oscillations having high amplitudes, a low broad-band frequency spectrum and long time duration. Additionally, the device can maintain a patient's mean airway pressure at one or more controlled levels. The device can control the oscillatory amplitude, frequency range and composition, time duration, and mean airway pressure levels by adjusting certain device parameters, such as the angle and depth of the device in a fluid. A device and mechanical system for remotely adjusting and measuring the angle of the device in a fluid are also disclosed. Furthermore, a device and system are disclosed that can deliver pressure oscillations having high amplitudes, a low broad-band frequency spectrum, long time duration, and multiple mean airway inspiratory and expiratory pressure levels. The device and system also provide means for controlling respiration timing in a patient, including: breaths per minute, inspiratory time, and the ratio of inspiratory to expiratory time.

    摘要翻译： 已经发现，具有足够持续时间的高振幅，低频，宽带频谱压力振荡可以帮助稳定肺容积并通过帮助招募和稳定肺泡来改善患者接受通气辅助的气体交换。 提出了一种可以产生具有高幅度，低宽带频谱和长时间持续时间的压力振荡的新型装置。 另外，该装置可以将患者的平均气道压力维持在一个或多个受控水平。 该设备可以通过调整某些设备参数（例如流体中的设备的角度和深度）来控制振荡幅度，频率范围和组成，持续时间和平均气道压力水平。 还公开了用于远程调节和测量流体中装置的角度的装置和机械系统。 此外，公开了一种可以提供具有高幅度，低宽带频谱，长时间持续时间和多个平均气道吸气和呼气压力水平的压力振荡的装置和系统。 该装置和系统还提供用于控制患者呼吸时间的装置，包括：每分钟呼吸，吸气时间以及吸气与呼气时间的比例。

    Use of adenosine receptor agonists in therapy
    7.
    发明申请
    Use of adenosine receptor agonists in therapy 失效
    腺苷受体激动剂在治疗中的应用

    公开(公告)号：US20060234975A1

    公开(公告)日：2006-10-19

    申请号：US10547454

    申请日：2004-03-05

    申请人： Peter Richardson

    发明人： Peter Richardson

    IPC分类号： A61K31/7076

    CPC分类号： A61K31/7076 ,  Y02A50/411

    摘要： Use of compounds of formula: (I) wherein R is C1-4 alkoxy and X is H or OH; for the prevention, treatment, or amelioration of cancer, inflammation, auto-immune disease, ischemia-reperfusion injury, epilepsy, sepsis, septic shock, neurode-generation (including Alzheimer's Disease), muscle fatigue or muscle cramp is described. The compounds are effective at very low doses, and so can be administered at doses at which serious side effects are not observed.

    摘要翻译： 使用式（I）的化合物，其中R是C 1-4烷氧基，X是H或OH; 描述了预防，治疗或改善癌症，炎症，自身免疫疾病，缺血再灌注损伤，癫痫，败血症，败血症休克，神经发生（包括阿尔茨海默病），肌肉疲劳或肌肉抽筋的预防，治疗或改善。 这些化合物在非常低的剂量下是有效的，因此可以在没有观察到严重副作用的剂量下给药。

    Ventilator system
    8.
    发明授权
    Ventilator system 失效
    呼吸机系统

    公开(公告)号：US5752506A

    公开(公告)日：1998-05-19

    申请号：US700840

    申请日：1996-08-21

    申请人： Peter Richardson

    发明人： Peter Richardson

    IPC分类号： A61M16/00 ,  A61M16/04 ,  A61M16/08 ,  A61H31/00

    CPC分类号： A61M16/0463 ,  A61M16/0096 ,  A61M16/0858 ,  A61M2016/0027

    摘要： A ventilation system for use in ventilating a patient includes a source of pressurized gas, a primary delivery conduit to communicate and transmit the pressurized gas, an endotracheal tube for insertion into the patient's mouth and throat, and an adapter. The adapter includes a first side aperture and a second side aperture, coupled between the primary delivery conduit and the endotracheal tube for communication pressurized gas therebetween. A pressure detector is connected to the first side aperture to detect and generate signals reflective of the pressure of gas in the adapter. An indicator associated with the pressure detector receives the signals and visually displays an indication of the detected pressure of the gas in the adapter. The second side aperture receives and communicates pulses of pressurized gas from the source of pressurized gas to the endotracheal tube. The side apertures are connected to channels that angle toward the second part. The adapter may be formed from a separate base and top joined together. A source of lung therapy material may also be included in the system.

    摘要翻译： 用于通气患者的通气系统包括加压气体源，用于连通和传送加压气体的主要输送导管，用于插入患者口腔和喉部的气管插管，以及适配器。 适配器包括第一侧孔和第二侧孔，联接在主输送导管和气管内管之间，用于在其间连通加压气体。 压力检测器连接到第一侧孔以检测并产生反映适配器中气体压力的信号。 与压力检测器相关联的指示器接收信号并且在视觉上显示检测到的适配器中气体压力的指示。 第二侧孔口将加压气体的脉冲从加压气体源传送到气管内管。 侧孔连接到与第二部分成角度的通道。 适配器可以由连接在一起的单独的基座和顶部形成。 肺部治疗材料的来源也可能包括在系统中。