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公开(公告)号：US20090062213A1
公开(公告)日：2009-03-05
申请号：US12167852
申请日：2008-07-03
CPC分类号： G01N33/6896 , A61K38/06 , C12Q1/26 , G01N33/88 , G01N2500/00
摘要： The present invention relates to compositions for use in the modulation of PDZ domain interactions with cognate ligands. Methods of assessing and characterizing PDZ domain interactions from various polypeptides also are provided.
摘要翻译： 本发明涉及用于调节与同源配体的PDZ结构域相互作用的组合物。 还提供了评估和表征各种多肽的PDZ结构域相互作用的方法。
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公开(公告)号：US20090036376A1
公开(公告)日：2009-02-05
申请号：US12165983
申请日：2008-07-01
申请人： Andrew Tasker , Tracy Doucette , Michael Tymianski , Kenneth Mendoza , Michael P. Belmares , David Garman , Peter S. Lu
发明人： Andrew Tasker , Tracy Doucette , Michael Tymianski , Kenneth Mendoza , Michael P. Belmares , David Garman , Peter S. Lu
CPC分类号： A61K38/1787 , A61K38/07
摘要： The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective regime of an agent that inhibits specific binding of PSD95 to an NMDA receptor is administered to a patient.
摘要翻译： 本发明提供了治疗或预防患有或有发生焦虑症状的患者的方法，其中向患者施用抑制PSD95与NMDA受体的特异性结合的药剂的有效方案。
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公开(公告)号：US07312041B2
公开(公告)日：2007-12-25
申请号：US10630590
申请日：2003-07-29
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
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公开(公告)号：US08633160B2
公开(公告)日：2014-01-21
申请号：US12167852
申请日：2008-07-03
CPC分类号： G01N33/6896 , A61K38/06 , C12Q1/26 , G01N33/88 , G01N2500/00
摘要： The present invention relates to compositions for use in the modulation of PDZ domain interactions with cognate ligands. Methods of assessing and characterizing PDZ domain interactions from various polypeptides also are provided.
摘要翻译： 本发明涉及用于调节与同源配体的PDZ结构域相互作用的组合物。 还提供了评估和表征各种多肽的PDZ结构域相互作用的方法。
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25.发明申请Treating Stroke and Other Diseases Without Inhibiting N-Type Calcium Channels 审中-公开治疗中风和其他疾病，不抑制N型钙通道公开(公告)号：US20130172230A1
公开(公告)日：2013-07-04
申请号：US13620438
申请日：2012-09-14
申请人： Michael P. Belmares , Jonathan David Garman , Peter S. Lu , Michael W. Salter , Michael Tymianski
发明人： Michael P. Belmares , Jonathan David Garman , Peter S. Lu , Michael W. Salter , Michael Tymianski
CPC分类号： A61K47/48246 , A61K38/00 , A61K47/645 , C07K7/06 , C07K14/70571 , C07K2319/10
摘要： The invention provides methods for treating stroke and compositions for use in the same. The methods employ a chimeric peptide of an active peptide and an internalization peptide. The internalization peptide is a tat variant that promotes uptake of itself and a linked active peptide into a cell without substantial binding to N-type calcium channels. Use of the tat variant allows treating of stroke free of certain side effects associated with binding to N-type calcium channels. Tat variant peptides can also be linked to other active agent for use in treating other diseases.
摘要翻译： 本发明提供了治疗中风和组合物的方法。 该方法采用活性肽和内化肽的嵌合肽。 内化肽是一种tat变体，其促进其自身的摄取和连接的活性肽进入细胞，而不与N型钙通道基本结合。 使用tat变体允许治疗与结合N-型钙通道相关的某些副作用。 Tat变体肽也可以连接到其他活性剂以用于治疗其它疾病。
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公开(公告)号：US08008253B2
公开(公告)日：2011-08-30
申请号：US12165983
申请日：2008-07-01
申请人： Andrew Tasker , Tracy Doucette , Michael Tymianski , Kenneth Mendoza , Michael P. Belmares , David Garman , Peter S. Lu
发明人： Andrew Tasker , Tracy Doucette , Michael Tymianski , Kenneth Mendoza , Michael P. Belmares , David Garman , Peter S. Lu
IPC分类号： A61K38/04
CPC分类号： A61K38/1787 , A61K38/07
摘要： The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective regime of an agent that inhibits specific binding of PSD95 to an NMDA receptor is administered to a patient.
摘要翻译： 本发明提供了治疗或预防患有或有发生焦虑症状的患者的方法，其中向患者施用抑制PSD95与NMDA受体的特异性结合的药剂的有效方案。
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公开(公告)号：US20110039758A1
公开(公告)日：2011-02-17
申请号：US12779501
申请日：2010-05-13
CPC分类号： C07K5/081 , C07K5/1016 , C07K5/1021 , C07K14/47 , C07K14/705 , C07K2319/00
摘要： Inhibitors that disrupt binding between a PDZ protein and cognate ligands such as N-methyl-D-aspartate (NMDA) receptors that are involved in various neurological disorders are provided. Pharmaceutical compositions containing such inhibitors and their use in treating neurological diseases such as stroke and ischemia are also disclosed. Screening methods to identify additional inhibitors of specific protein ligand interactions with PDZ proteins are also described.
摘要翻译： 提供了破坏参与各种神经系统疾病的PDZ蛋白和类同体配体如N-甲基-D-天冬氨酸（NMDA）受体之间的结合的抑制剂。 还公开了含有这些抑制剂的药物组合物及其在治疗神经系统疾病如中风和缺血中的用途。 还描述了鉴定与PDZ蛋白特异性蛋白质配体相互作用的其他抑制剂的筛选方法。
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公开(公告)号：US20100028855A1
公开(公告)日：2010-02-04
申请号：US12298133
申请日：2006-10-21
申请人： Peter S. Lu , Michael P. Belmares , Johannes Schweizer , Jon Silver , Jon Silver
发明人： Peter S. Lu , Michael P. Belmares , Johannes Schweizer , Jon Silver , Jon Silver
IPC分类号： C12Q1/70
CPC分类号： C07K16/1018 , G01N33/56983 , G01N2333/11
摘要： The invention provides methods for detecting influenza B from its NS1 protein. The NS1 protein is present in detectable levels in clinical samples and can be detected using antibodies that are panspecific for influenza B without binding to influenza A or other viruses.
摘要翻译： 本发明提供从其NS1蛋白检测流感B的方法。 NS1蛋白以临床样品中可检测的水平存在，并且可以使用针对乙型流感病毒而不与A型流感病毒或其他病毒结合的特异性抗体进行检测。
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公开(公告)号：US07595152B2
公开(公告)日：2009-09-29
申请号：US11698798
申请日：2007-01-26
申请人： Peter S. Lu , Michael P. Belmares , Dave Garman
发明人： Peter S. Lu , Michael P. Belmares , Dave Garman
IPC分类号： C12Q1/70 , G01N33/53 , G01N33/542 , G01N33/00 , C12M1/34
CPC分类号： G01N33/56983 , G01N2333/11 , G01N2500/02 , Y02A50/53 , Y02A50/60
摘要： The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or influenza B and PDZ domains in combination with panspecific antibodies to influenza A to distinguish pathogenic and seasonal influenza A subtypes.
摘要翻译： 本申请描述了用于检测甲型和（或）乙型流感和/或区分病原性和季节性流感A亚型的方法。 这些优选形式中的许多使用泛特异性抗体（即，与流感类型内的全部或至少多个菌株反应）以检测A型流感和/或B型流感和PDZ结构域与甲型流感病毒的特异性抗体的存在 区分致病性和季节性流感A亚型。
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公开(公告)号：US20080124702A1
公开(公告)日：2008-05-29
申请号：US11881724
申请日：2007-07-27
CPC分类号： G01N33/56983 , A61K38/00 , C07K14/705 , C07K16/084 , C07K2319/70 , C12Q1/42 , C12Q1/485 , G01N33/564 , G01N33/566 , G01N33/57411 , G01N33/5748 , G01N33/6872 , G01N2333/025 , G01N2333/726 , G01N2500/02 , G01N2800/52 , Y10S435/975
摘要： The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.
摘要翻译： 本发明提供用于检测人类样品中病原体感染的试剂和方法。 该检测利用特异性蛋白质来检测病原体蛋白质的存在或病原体感染引起的人类蛋白质的异常表达。 本文公开了用于在临床样品中检测致癌人乳头状瘤病毒E6蛋白的具体方法，组合物和试剂盒。
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