摘要:
An innovative pharmaceutical form for controlled drug release relates to systems obtained by the assembly of individual release modules, of which the capacity to release the drug in time and in space depends on the way in which the modules have been assembled. The modular structure offers high reproducibility of manufacture and flexibility of release.
摘要:
A pressure sensor device comprises a casing (2a, 3 a) defining a chamber (20) and an inlet passage (14a, 14b) of the chamber. Accommodated in the chamber (20) is a pressure sensor (17) having a sensor body with a cavity and a membrane capable of deformation under pressure action of a fluid present in the inlet passage (14a, 14b). The device further comprises a circuit arrangement (26, 27, 30) to which the pressure sensor (17) is electrically connected, the circuit arrangement including a circuit support at least partially accommodated in the chamber (20). The sensor body is not rigidly associated to the casing (2a, 3 a) and/or to other parts of the device (26, 27, 30, 35), i.e. it is mounted elastically or in a moveable manner with respect to the casing (2a, 3 a) and/or to said other parts (26, 27, 30, 35) inside the chamber (20).
摘要:
A pressure-sensor device (1) comprises: —a pressure-sensitive component (9) having a body, defined in which is a blind cavity, and having a membrane portion (9a), operatively associated to which is a detection element (R); and —a connection structure (2), which has a duct in communication with the cavity of the pressure-sensitive component (9) and is to receive a fluid, a pressure of which is to be detected. The connection structure (2) comprises a supporting body (2a) of the pressure-sensitive component (9), which defines a respective passage (2b), and a compressible element (12, 18) that is designed to be in contact with the fluid and is configured for compensating possible variations of volume thereof. The compressible element (12, 18) is positioned at least in part within the cavity (11) of the pressure-sensitive component (9) and/or in a stretch of the passage (2b) of the supporting body (2a) that is close to the cavity (11) of the pressure-sensitive component (9).
摘要:
A module which is destroyed in the presence of water solution, composed of a compressed powdery mixture, the said powdery mixture comprising a matrix building component, suitable to release an optionally included active substance into a surrounding aqueous liquid, and one or more tabletting aids chosen from the group consisting of lubricants, glidants, and anti-adherent agents, the said module being provided with particular male topological features allowing its connection to a corresponding female module, giving raise to an assembly that can be safely handled on industrial scale, wherein, in the composition of the male module, the percentage ratio between the tabletting aid and the matrix building component is comprised between 1:2.5 and 1:999. The module can be employed to convey pharmaceuticals, nutraceuticals, agrochemicals or other active principles to the intended site of action.
摘要:
The invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, nonagglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%).
摘要:
A system for protecting the battery of a vehicle includes a device (1) for electrically disconnecting of connecting the battery (BA) with respect to an electric load (CS). The device (1) includes a switch (20, 21) and a microprocessor control circuit (15). The control circuit (15) includes a unit for calculating a mean value of the voltage of the battery (BA) and comparing it with a threshold value, in order to control the switch (20, 21). The threshold value is variable as a function of the ambient temperature and the time of inactivity of the motor. The switch includes a bistable electromagnetic arrangement, capable of passing from a first to a second stable condition following a pulse generated by the control circuit (15).
摘要:
The present invention relates to hypoallergenic variants of ns-LTPs allergens, to pharmaceutical compositions comprising them and to the use of such variants for the preparation of medicaments suitable in the treatment and in the prevention of the allergic forms associated with an ns-LTP allergen, in particular to the allergen corresponding to the variant used.
摘要:
The invention relates to laminated films and articles of manufacture based on such films and having improved resistance to heat treatment, wherein said films comprise a heat sealing layer of copolyamide obtained by random copolymerization of precursor monomers of at least two different polyamides. Said laminated films, or the articles of manufacture formed therefrom, such as bags or preformed containers, are useful for packaging applications, particularly in connection with food products.
摘要:
A gas supply control device for an apparatus, particularly a coking apparatus, includes timing means (20) and a first command means (12) for manually setting a an opening time interval of a safety valve of a gas tap (1), equipped with a second command means (6). In an installed condition of the control device (10), the command means (6, 12) are operable from outside the structure (7) of the apparatus, with the first command means (12) and the second command means (6) substantially rotating around one same axis, one independent from the other. The timing means (20) of the control device (10) belong to a functional unit (10a) which is coupled or configured for coupling with a portion of the body of the tap (2) which portion, in the above mentioned installed conditions, is located inside the structure (7) of the apparatus. The functional unit (10a) includes switch means (22), controllable by timing means for cutting off the electric current to a solenoid of the tap (1) at the end of a time interval set through the first command means (6), and hence causing the passage of the valve to the respective closed condition.
摘要:
A pharmaceutical composition is described comprising sucralfate gel, PVA and optionally a vegetable product comprising tocotrienols and tocopherols. In particular, this composition proved to be suitable for being sprayed, and is advantageously used in the treatment of skin lesions, even deep lesions, such as second-degree burns.