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21.发明授权公开(公告)号：US08551512B2
公开(公告)日：2013-10-08
申请号：US10807546
申请日：2004-03-22
Applicant: Syed Faiyaz Ahmed Hossainy , Yiwen Tang , Homayon Askaryar , Qing Lin , Thierry Glauser
Inventor： Syed Faiyaz Ahmed Hossainy , Yiwen Tang , Homayon Askaryar , Qing Lin , Thierry Glauser
IPC: A61F2/82
CPC classification number: B05D5/00 , A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/02
Abstract: Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
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公开(公告)号：US20100093086A1
公开(公告)日：2010-04-15
申请号：US12561107
申请日：2009-09-16
Applicant: Qing Lin , Mike Madden
Inventor： Qing Lin , Mike Madden
CPC classification number: C07K1/045 , C07K1/107 , C07K1/1136
Abstract: A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.
Abstract translation: 一种制备缝合肽的方法。 根据光化学方法[3 + 2]环加成反应制备包装螺旋缝合肽的缝合肽。 螺旋缝合肽表现出增加的螺旋度，热稳定性和细胞渗透性。
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23.发明申请Gene Engineering Recombinant Anti-CEA, Anti-CD3, And Anti-CD28 Single-Chain Tri-Specific Antibody 审中-公开基因工程重组抗CEA，抗CD3和抗CD28单链三特异性抗体公开(公告)号：US20090117108A1
公开(公告)日：2009-05-07
申请号：US10594908
申请日：2005-03-29
Applicant: Xiangbin Wang , Hualiang Huang , Baofeng Zhao , Qi Zhao , Jinhua Piao , Qing Lin
Inventor： Xiangbin Wang , Hualiang Huang , Baofeng Zhao , Qi Zhao , Jinhua Piao , Qing Lin
CPC classification number: C07K16/00 , A61K2039/505 , C07K16/2809 , C07K16/2818 , C07K16/3007 , C07K2317/34 , C07K2317/626 , C07K2317/73
Abstract: The invention is related to a recombinant single-chain tri-specific antibody made from anti-Tumor Associated Antigen (TAA) antibody, FC interlinker, anti-CD3 antibody, HSA interlinker and anti-CD28 antibody in turn. Particularly, the invention relates to an anti-CEA, anti-CD3, anti-CD28 recombinant single-chain tri-specific antibody, CEA-scTsAb, which was constructed with three tandem antibody fragments (anti-CEA scFv, anti-CD3 scFv and anti-CD28 single-domain antibody) linked by two interlinkers (FC interlinker, HSA interlinker), and could be appended by C myc tag or histidine tag ((His)6-tag) at the C terminal. It also concerns a method for construction, expression and purification of the antibody. It also offers the encoded DNA sequence of the antibody, expression vectors and host cells for the vectors.
Abstract translation: 本发明涉及由抗肿瘤相关抗原（TAA）抗体，FC连接子，抗CD3抗体，HSA互连体和抗CD28抗体依次制备的重组单链三特异性抗体。 特别地，本发明涉及用三个串联抗体片段（抗CEA scFv，抗CD3 scFv和构建体）构建的抗CEA，抗CD3，抗CD28重组单链三特异性抗体CEA-scTsAb 抗CD28单结构域抗体）通过两个连接子（FC连接子，HSA连接子）连接，并可以通过C末端标签或组氨酸标签（（His）6-标签）附加。 它还涉及抗体的构建，表达和纯化的方法。 它还提供抗体的编码DNA序列，载体的表达载体和宿主细胞。
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公开(公告)号：US20090046606A1
公开(公告)日：2009-02-19
申请号：US11994491
申请日：2005-07-01
Applicant: Lei Wan , Lars Robert Loostrom , Qing Lin
Inventor： Lei Wan , Lars Robert Loostrom , Qing Lin
IPC: H04J3/00
CPC classification number: H04L47/36 , H04J3/0682 , H04L1/0007 , H04L47/10
Abstract: The present invention relates to an arrangement for point-to-point transmission over links between first and second link (end) terminals in a system implementing time division duplex (TDD) and wherein information is sent over the links in frames divided into time slots. It is adapted to determine the lengths of the frames on a per link basis using one or more link parameters, the frame length hence being variable.
Abstract translation: 本发明涉及一种在实现时分双工（TDD）的系统中的第一和第二链路（终端）终端之间的链路上的点对点传输的装置，并且其中信息通过划分为时隙的帧中的链路发送。 其适于使用一个或多个链路参数在每个链路的基础上确定帧的长度，因此帧长度是可变的。
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公开(公告)号：US20080241223A1
公开(公告)日：2008-10-02
申请号：US12113434
申请日：2008-05-01
Applicant: Thierry NIVAGGIOLI , Jane Guo Shiah , Qing Lin
Inventor： Thierry NIVAGGIOLI , Jane Guo Shiah , Qing Lin
CPC classification number: A61K9/0051 , A61K9/204 , A61K31/57 , A61K31/573 , A61K47/34
Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
Abstract translation: 尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。 植入物以治疗有效量提供活性剂的延长释放一段时间在50天至1年或更长时间之间。
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Patent Agency Ranking
公开(公告)号：US07262276B2
公开(公告)日：2007-08-28
申请号：US10478345
申请日：2002-05-23
Applicant: Hualiang Huang , Xin Jiang , Min Fang , Xiaocong Yu , Jie Feng , Ping Zhou , Qing Lin
Inventor： Hualiang Huang , Xin Jiang , Min Fang , Xiaocong Yu , Jie Feng , Ping Zhou , Qing Lin
IPC: C07K16/30
CPC classification number: C07K16/2809 , C07K16/3069 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622
Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
Abstract translation: 本发明提供了抗卵巢癌双特异性抗体。 所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或 其Fab片段，单CDR抗体或scFv。 本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。
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公开(公告)号：US09814553B1
公开(公告)日：2017-11-14
申请号：US11870394
申请日：2007-10-10
Applicant: Lothar Walter Kleiner , Yiwen Tang , Syed Faiyaz Ahmed Hossainy , Florencia Lim , Michael Ngo , Mikael Trollsas , Qing Lin
Inventor： Lothar Walter Kleiner , Yiwen Tang , Syed Faiyaz Ahmed Hossainy , Florencia Lim , Michael Ngo , Mikael Trollsas , Qing Lin
IPC: A61F2/00
CPC classification number: A61F2/00 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , C08L67/04
Abstract: The present invention provides a semi-crystalline polymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.
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公开(公告)号：US20120272352A1
公开(公告)日：2012-10-25
申请号：US13504846
申请日：2010-10-12
Applicant: Shouyi Chen , Jinsong Zhang , Shouqiang Ouyang , Sijie He , Wanke Zhang , Biao Ma , Qing Lin
Inventor： Shouyi Chen , Jinsong Zhang , Shouqiang Ouyang , Sijie He , Wanke Zhang , Biao Ma , Qing Lin
CPC classification number: C12N15/8273 , C12N9/90
Abstract: Compositions and methods for conferring drought and salt tolerance to plants using tocopherol cyclase (TC) genes, including polynucleotides, polypeptides, vectors, cells and plants.
Abstract translation: 使用生育酚环化酶（TC）基因（包括多核苷酸，多肽，载体，细胞和植物）赋予对植物的干旱和耐盐性的组合物和方法。
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29.发明申请Plant Stress Tolerance Related Protein GmSIK1 and Encoding Gene and Use Thereof 审中-公开植物胁迫耐受相关蛋白GmSIK1和编码基因及其用途公开(公告)号：US20120266325A1
公开(公告)日：2012-10-18
申请号：US13503163
申请日：2010-10-15
Applicant: Shouyi Chen , Jinsong Zhang , Peng Liu , Wanke Zhang , Sijie He , Qing Lin
Inventor： Shouyi Chen , Jinsong Zhang , Peng Liu , Wanke Zhang , Sijie He , Qing Lin
CPC classification number: C07K14/415 , C12N15/8273
Abstract: Provided are a plant stress tolerance related protein GmSIK1 and encoding gene and use thereof. The GmSIK1 protein has the amino acid sequence as shown in SEQ ID NO: 2. The transgenic plant with enhanced stress tolerance such as drought tolerance and/or salt tolerance can be obtained from introducing the encoding gene of GmSIK1 protein into plant cell.
Abstract translation: 提供植物胁迫耐受相关蛋白GmSIK1和编码基因及其用途。 GmSIK1蛋白具有如SEQ ID NO：2所示的氨基酸序列。通过将GmSIK1蛋白的编码基因导入植物细胞，可以获得具有增强的胁迫耐受性如耐旱性和/或耐盐性的转基因植物。
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公开(公告)号：US20120196796A1
公开(公告)日：2012-08-02
申请号：US13364250
申请日：2012-02-01
Applicant: Christopher J. Soares , Michael R. Hanley , Diana Yvonne Lewis , David Geoffrey Parkes , Carolyn Marie Jodka , Kathryn S. Prickett , Soumitra Ghosh , Christine Marie Mack , Qing Lin
Inventor： Christopher J. Soares , Michael R. Hanley , Diana Yvonne Lewis , David Geoffrey Parkes , Carolyn Marie Jodka , Kathryn S. Prickett , Soumitra Ghosh , Christine Marie Mack , Qing Lin
IPC: A61K38/16 , A61P5/50 , A61P3/04 , A61P3/10 , A61P9/12 , A61K38/26 , A61P9/00 , A61P25/00 , A61P35/00 , A61P19/02 , A61K38/23 , A61P3/00 , A61P3/06
CPC classification number: C07K14/575
Abstract: The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.
Abstract translation: 本发明涉及在胰岛淀粉样多肽家族中具有肽功能的新化合物，相关核酸，表达构建体，宿主细胞，并且处理化合物的生产。 本发明的化合物包括一个或多个氨基酸序列修饰。 此外，公开了治疗和预防代谢紊乱如肥胖，糖尿病和增加的心血管风险的方法和组合物。
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