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公开(公告)号：US20080071076A1
公开(公告)日：2008-03-20
申请号：US11855558
申请日：2007-09-14
申请人： Sinuhe Hahn , Wolfgang Holzgreve , Bernhard Zimmermann , Ying Li
发明人： Sinuhe Hahn , Wolfgang Holzgreve , Bernhard Zimmermann , Ying Li
IPC分类号： C07H1/06
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q2600/156 , C12Q2565/125
摘要： Blood plasma of pregnant women contains fetal and (generally>90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains .Itoreq.500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of .Itoreq.500 base pairs results in separation of fetal from maternal DNA. A fraction of a blood plasma or serum sample of a pregnant woman containing, due to size separation (e.g. by chromatography, density gradient centrifugation or nanotechnological methods), extracellular DNA substantially comprising .Itoreq.500 base pairs is useful for non-invasive detection of fetal genetic traits (including the fetal RhD gene in pregnancies at risk for HDN; fetal Y chromosome-specific sequences in pregnancies at risk for X chromosome-linked disorders; chromosomal aberrations; hereditary Mendelian genetic disorders and corresponding genetic markers; and traits decisive for paternity determination) by e.g. PCR, ligand chain reaction or probe hybridization techniques, or nucleic acid arrays.
摘要翻译： 孕妇的血浆含有胎儿和（一般> 90％）母体循环细胞外DNA。 大多数所述胎儿DNA含有大约0.500个碱基对，所述母体DNA具有更大的尺寸。 分离的循环细胞外DNA，它们的碱基对，导致胎儿与母体DNA的分离。 由于尺寸分离（例如通过色谱法，密度梯度离心或纳米技术方法），怀孕妇女血浆或血清样品的一小部分含有基本上包含0.5个碱基对的细胞外DNA，可用于非侵入性检测 胚胎遗传特征（包括胎儿RhD基因在HDN风险的怀孕中;胎儿Y染色体特异性序列在X染色体相关疾病风险的怀孕中;染色体畸变;遗传性孟德尔遗传疾病和相应的遗传标记;性状决定性的亲子鉴定 确定） PCR，配体链反应或探针杂交技术或核酸阵列。
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22.发明申请AMIDE SUBSTITUTED IMIDAZOPYRIDINES, IMIDAZOQUINOLINES, AND IMIDAZONAPHTHYRIDINES 有权酰胺取代的咪唑吡啶，咪唑啉和咪唑并吡啶公开(公告)号：US20070219196A1
公开(公告)日：2007-09-20
申请号：US10599159
申请日：2005-03-24
申请人： Larry Krepski , Joseph Dellaria Jr. , Daniel Duffy , David Amos , Bernhard Zimmermann , William Moser
发明人： Larry Krepski , Joseph Dellaria Jr. , Daniel Duffy , David Amos , Bernhard Zimmermann , William Moser
IPC分类号： A61K31/4353 , A61K31/5377 , C07D413/14 , C07D471/02 , C07D471/12
CPC分类号： C07D471/04 , C07D413/14 , C07D471/02 , C07D471/12 , C07D471/14
摘要： Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having an amide substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物，其在1-位具有酰胺基取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。
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公开(公告)号：US20070178602A1
公开(公告)日：2007-08-02
申请号：US10560426
申请日：2004-06-09
IPC分类号： G01N21/76
CPC分类号： G01N21/6458 , G01N21/6402 , G01N2021/6417 , G02B21/0024 , G02B21/16
摘要： A method using fluorescence microscopy for image evaluation using a laser scanning microscope in which an at least partially spectrally resolved detection of the fluorescence spectrum occurs. Reference spectra are used for spectral demixing. Temporally and/or spectrally variable dyes and/or dye combinations are employed for recording of the reference spectra. Finally, the recorded reference spectra are inspected for image evaluation.
摘要翻译： 使用激光扫描显微镜使用荧光显微镜进行图像评估的方法，其中发生荧光光谱的至少部分光谱分辨检测。 参考光谱用于光谱分层。 使用时间和/或光谱变化的染料和/或染料组合来记录参考光谱。 最后，对记录的参考光谱进行图像评估。
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24.发明申请Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines 有权羟胺和肟取代的咪唑并喹啉，咪唑并吡啶和咪唑并吡啶类公开(公告)号：US20070099901A1
公开(公告)日：2007-05-03
申请号：US10595895
申请日：2004-11-24
申请人： Larry Krepski , Joseph Dellaria , Daniel Duffy , David Amos , Bernhard Zimmermann , David Squire , Gregory Marszalek , Philip Heppner , Tushar Kshirsagar
发明人： Larry Krepski , Joseph Dellaria , Daniel Duffy , David Amos , Bernhard Zimmermann , David Squire , Gregory Marszalek , Philip Heppner , Tushar Kshirsagar
IPC分类号： A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-quinoline, -pyridine, and -naphthyridine ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 在1-位取代的咪唑并喹啉，吡啶和萘啶环体系，含有这些化合物的化合物，中间体和使用方法作为免疫调节剂的药物组合物，用于在动物中诱导细胞因子生物合成和治疗疾病，包括 公开了病毒和肿瘤疾病。
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公开(公告)号：US20070006786A1
公开(公告)日：2007-01-11
申请号：US11423187
申请日：2006-06-09
申请人： Bernhard Zimmermann
发明人： Bernhard Zimmermann
CPC分类号： F23H9/02 , F23H1/02 , F23H3/02 , F23H2900/03021
摘要： A grate covering for a roller grate of an incineration furnace has a furnace space, the grate covering includes a plurality of metallic grate bars arranged on a carrying structure of the roller grate such that they form an outer surface of the roller grate and are exposed directly to the furnace space. The grate bars have a cavity configured to receive a liquid coolant. In addition, a roller grate having such grate bars is provided.
摘要翻译： 用于焚烧炉的辊式炉排的炉篦具有炉膛空间，炉篦覆盖物包括布置在辊篦的承载结构上的多个金属篦棒，使得它们形成辊篦的外表面并且直接暴露 到炉膛。 格栅条具有构造成接收液体冷却剂的空腔。 此外，提供了具有这种格栅条的滚轮格栅。
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公开(公告)号：US20110251076A1
公开(公告)日：2011-10-13
申请号：US13029995
申请日：2011-02-17
申请人： Sinuhe Hahn , Wolfgang Holzgreve , Bernhard Zimmermann , Ying Li
发明人： Sinuhe Hahn , Wolfgang Holzgreve , Bernhard Zimmermann , Ying Li
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q2600/156 , C12Q2565/125
摘要： Blood plasma of pregnant women contains fetal and (generally >90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains ≦500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of
摘要翻译： 孕妇的血浆含有胎儿和（一般> 90％）母体循环细胞外DNA。 大多数所述胎儿DNA含有nlE; 500个碱基对，所述母体DNA具有更大的尺寸。 分离<500碱基对的循环细胞外DNA导致胎儿与母体DNA分离。 由于尺寸分离（例如通过色谱法，密度梯度离心或纳米技术方法），怀孕妇女的血浆或血清样品的一小部分含有基本上包含500个碱基对的细胞外DNA，可用于非侵入性检测胎儿 遗传性状（包括胎儿RhD基因在妊娠中存在HDN风险;胎儿Y染色体特异性序列在怀孕中存在X染色体相关疾病风险;染色体异常;遗传性孟德尔遗传疾病及相应的遗传标记;以及决定亲子鉴定的特征 ）通过例如 PCR，配体链反应或探针杂交技术或核酸阵列。
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公开(公告)号：US20110245482A1
公开(公告)日：2011-10-06
申请号：US13029999
申请日：2011-02-17
申请人： Sinuhe Hahn , Wolfgang Holzgreve , Bernhard Zimmermann , Ying Li
发明人： Sinuhe Hahn , Wolfgang Holzgreve , Bernhard Zimmermann , Ying Li
IPC分类号： G01N33/50 , C07H1/08 , C25B7/00 , G01N27/447 , B82Y5/00
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q2600/156 , C12Q2565/125
摘要： Blood plasma of pregnant women contains fetal and (generally>90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains ≦500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of
摘要翻译： 孕妇的血浆含有胎儿和（一般> 90％）母体循环细胞外DNA。 大多数所述胎儿DNA含有nlE; 500个碱基对，所述母体DNA具有更大的尺寸。 分离<500碱基对的循环细胞外DNA导致胎儿与母体DNA分离。 由于尺寸分离（例如通过色谱法，密度梯度离心或纳米技术方法），怀孕妇女的血浆或血清样品的一小部分含有基本上包含500个碱基对的细胞外DNA，可用于非侵入性检测胎儿 遗传性状（包括胎儿RhD基因在妊娠中存在HDN风险;胎儿Y染色体特异性序列在怀孕中存在X染色体连锁障碍的风险;染色体畸变;遗传性孟德尔遗传疾病和相应的遗传标记;以及决定亲子鉴定的性状 ）通过例如 PCR，配体链反应或探针杂交技术或核酸阵列。
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28.发明申请公开(公告)号：US20070287724A1
公开(公告)日：2007-12-13
申请号：US11570707
申请日：2005-06-17
申请人： Doris Stoermer , Joseph Dellaria , David Amos , Bernhard Zimmermann , Luke Dressel , Jason Bonk , Matthew Radmer
发明人： Doris Stoermer , Joseph Dellaria , David Amos , Bernhard Zimmermann , Luke Dressel , Jason Bonk , Matthew Radmer
IPC分类号： A61K31/4745 , A61K31/437 , A61P31/12 , A61P35/00 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, 1,5-naphthyridines, 1,5-tetrahydronaphthyridines) substituted at the 1-position with a cyclic substituent, pharmaceutical compositions containing the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 咪唑并喹啉，吡啶和萘啶环体系（特别是在1位被环状取代基取代的喹啉，四氢喹啉，吡啶，1,5-萘啶，1,5-四氢萘并吡啶），含有这些化合物的药物组合物和 公开了这些化合物作为免疫调节剂的用途，用于在动物中诱导细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病的方法。
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公开(公告)号：US20060213405A1
公开(公告)日：2006-09-28
申请号：US11207215
申请日：2005-08-19
申请人： Bernhard Zimmermann
发明人： Bernhard Zimmermann
CPC分类号： F27D5/0006 , C21D9/0025 , F23G5/002 , F23H9/02 , F23H17/12
摘要： A grate covering for an incineration grate of an incineration furnace having a combustion chamber, includes a plurality of metal grate bars, each having a surface facing the combustion chamber that includes a layer made of a temperature-resistant, corrosion-resistant and abrasion-resistant non-metallic material, wherein a thickness of the layer is minimally sufficient to bear pressure and thrust loading. The thickness of the layer is about 10 mm to 15 mm. For a forward feed grate, the layer on each metal grate bar is present only in a zone of contact with an adjacent metal grate bar, and for a roller grate, and wherein the layer is present on the entire surface facing the combustion chamber.
摘要翻译： 具有燃烧室的焚化炉的焚烧炉的炉篦包括多个金属炉排棒，每个金属炉排条具有面向燃烧室的表面，该表面包括由耐温，耐腐蚀和耐磨的层 非金属材料，其中该层的厚度最小地足以承受压力和推力载荷。 该层的厚度为约10mm至15mm。 对于正向进料格栅，每个金属格栅条上的层仅存在于与相邻金属格栅条和与辊格栅接触的区域中，并且其中该层存在于面向燃烧室的整个表面上。
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公开(公告)号：US10017812B2
公开(公告)日：2018-07-10
申请号：US13300235
申请日：2011-11-18
申请人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
发明人： Matthew Rabinowitz , George Gemelos , Milena Banjevic , Allison Ryan , Zachary Demko , Matthew Hill , Bernhard Zimmermann , Johan Baner
IPC分类号： G01N33/48 , G01N31/00 , G06G7/48 , G06G7/58 , C12Q1/6869 , C12Q1/6827 , G06F19/18 , C12Q1/6883 , C12Q1/6862 , G06F19/24
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6827 , C12Q1/686 , C12Q1/6862 , C12Q1/6874 , C12Q1/6883 , C12Q2600/156 , C12Q2600/16 , G06F19/34 , G16B20/00 , G16B40/00 , C12Q2537/161 , C12Q2537/165 , C12Q2537/143
摘要： The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
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