公开(公告)号：US20190316206A1

公开(公告)日：2019-10-17

申请号：US16347778

申请日：2017-11-07

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services

发明人： Shashankkumar J. Patel ,  Nicholas P. Restifo

IPC分类号： C12Q1/6886

摘要： Disclosed are methods of selecting a therapy for a cancer patient and methods of treating cancer in the patient. The methods comprise detecting a mutation in one or more genes in a cancer cell from the patient, wherein the one or more genes is selected from the group consisting of PTCD2, TWF1, DEFB134, BBS1, SOX10, APLNR, CD58, COL17A1, CRKL, hsa-mir-101-2, hsa-mir-548s, MAD2L1, MLANA, PSMB5, RNPS1, RPL10A, RPL23, SRP54, TAF3, TAP1, TAP2, TAPBP, TBXAS1, GMIP, OTOA, LAIR1, CLEC1, GPSM3, TRAF1, JAK2, TAPBPL, ICAM1, LILRA1, LILRA3, STAT1, and HLA-F. Also disclosed are methods of screening for one or more genes, the mutation of which confers resistance to T cell-mediated cytolytic activity.

公开(公告)号：US09522948B2

公开(公告)日：2016-12-20

申请号：US14106031

申请日：2013-12-13

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Nicholas P. Restifo ,  Lydie Cassard ,  Zhiya Yu ,  Steven A. Rosenberg

IPC分类号： C07H21/02 ,  C12N15/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/30 ,  C12N15/85 ,  C12N15/86 ,  G01N33/574 ,  A61K38/00

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/7051 ,  C07K16/30 ,  C12N15/85 ,  C12N15/86 ,  G01N33/57492

摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.

公开(公告)号：US20220105133A1

公开(公告)日：2022-04-07

申请号：US17481404

申请日：2021-09-22

申请人： Regents of the University of Minnesota ,  Intima Bioscience, Inc. ,  The U.S.A., as Represented by the Secretary, Department of Health and Human Service

发明人： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC分类号： A61K35/17 ,  C12N15/113 ,  C07K14/705 ,  C07K14/47 ,  A61P31/00 ,  A61P35/00 ,  A61K9/00 ,  C07K14/725 ,  C07K14/715 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/79 ,  C12N15/90

摘要： Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.

公开(公告)号：US11154574B2

公开(公告)日：2021-10-26

申请号：US16885874

申请日：2020-05-28

申请人： Regents of the University of Minnesota ,  Intima Bioscience, Inc. ,  The U.S.A., as Represented by the Secretary, Department of Health and Human Services

发明人： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC分类号： A61K35/17 ,  C12N15/113 ,  C07K14/705 ,  C07K14/47 ,  A61P31/00 ,  A61P35/00 ,  A61K9/00 ,  C07K14/725 ,  C07K14/715 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/79 ,  C12N15/90 ,  A61K45/06

摘要： Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.

公开(公告)号：US20200306310A1

公开(公告)日：2020-10-01

申请号：US16900372

申请日：2020-06-12

申请人： Regents of the University of Minnesota ,  Intima Bioscience, Inc. ,  The U.S.A., as Represented by the Secretary, Department of Health and Human Services

发明人： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC分类号： A61K35/17 ,  C07K14/715 ,  C12N15/113 ,  C07K14/47 ,  C07K14/725 ,  C12N5/0783 ,  C07K14/705 ,  C12N15/90 ,  C12N9/22 ,  C12N9/96

摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

公开(公告)号：US20200330517A1

公开(公告)日：2020-10-22

申请号：US16889914

申请日：2020-06-02

申请人： Regents of the University of Minnesota ,  Intima Bioscience, Inc. ,  The U.S.A., as Represented by the Secretary, Department of Health and Human Services

发明人： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC分类号： A61K35/17 ,  C12N15/113 ,  C07K14/705 ,  C07K14/47 ,  A61P31/00 ,  A61P35/00 ,  A61K9/00 ,  C07K14/725 ,  C07K14/715 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/79 ,  C12N15/90

摘要： Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.

公开(公告)号：US11903966B2

公开(公告)日：2024-02-20

申请号：US16180867

申请日：2018-11-05

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  INTIMA BIOSCIENCE, INC. ,  The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC分类号： C12N15/00 ,  A61K35/17 ,  A61P35/00 ,  C07K14/715 ,  C12N15/113 ,  C07K14/47 ,  C07K14/725 ,  C12N5/0783 ,  C07K14/705 ,  C12N15/90 ,  C12N9/22 ,  C12N9/96 ,  C12N15/87

CPC分类号： A61K35/17 ,  C07K14/4718 ,  C07K14/7051 ,  C07K14/70503 ,  C07K14/7158 ,  C12N5/0636 ,  C12N9/22 ,  C12N9/96 ,  C12N15/113 ,  C12N15/907 ,  C12N15/87 ,  C12N2310/20 ,  C12N2510/00

摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

公开(公告)号：US20220125843A1

公开(公告)日：2022-04-28

申请号：US17478615

申请日：2021-09-17

申请人： Regents of the University of Minnesota ,  Intima Bioscience, Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  R. Scott McIvor ,  David Largaespada ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC分类号： A61K35/17 ,  C07K14/47 ,  C12N9/22 ,  C12N9/96 ,  C07K14/725 ,  C12N15/90 ,  C07K14/715 ,  C12N15/113 ,  C07K14/705 ,  C12N5/0783 ,  C12N15/87

摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

公开(公告)号：US11583556B2

公开(公告)日：2023-02-21

申请号：US17003081

申请日：2020-08-26

申请人： Regents of the University of Minnesota ,  Intima Bioscience, Inc. ,  The U.S.A., as represented by the Secretary, Department of Health and Human Services

发明人： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  R. Scott McIvor ,  David Largaespada ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC分类号： C12N5/00 ,  A61K35/17 ,  C07K14/715 ,  C12N15/113 ,  C07K14/47 ,  C07K14/725 ,  C12N5/0783 ,  C07K14/705 ,  C12N15/90 ,  C12N9/22 ,  C12N9/96 ,  C12N15/87

摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

公开(公告)号：US11266692B2

公开(公告)日：2022-03-08

申请号：US16900372

申请日：2020-06-12

申请人： Regents of the University of Minnesota ,  Intima Bioscience, Inc. ,  The U.S.A., as Represented by the Secretary, Department of Health and Human Services

发明人： Branden Moriarity ,  Beau Webber ,  Modassir Choudhry ,  Steven A. Rosenberg ,  Douglas C. Palmer ,  Nicholas P. Restifo

IPC分类号： A61K35/17 ,  C12N5/0783 ,  C07K14/715 ,  C12N15/113 ,  C07K14/47 ,  C07K14/725 ,  C07K14/705 ,  C12N15/90 ,  C12N9/22 ,  C12N9/96 ,  C12N15/87

摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.