公开(公告)号：US08034000B2

公开(公告)日：2011-10-11

申请号：US12510962

申请日：2009-07-28

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina V. Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina V. Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/04

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

公开(公告)号：US08000780B2

公开(公告)日：2011-08-16

申请号：US11426835

申请日：2006-06-27

申请人： Ramesh Wariar ,  Veerichetty Kadhiresan ,  Richard Fogoros

发明人： Ramesh Wariar ,  Veerichetty Kadhiresan ,  Richard Fogoros

IPC分类号： A61B5/04

CPC分类号： A61B5/02 ,  A61B5/0402 ,  A61B5/0535 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3702

摘要： A system including a plurality of implantable sensors, a processor, and a response circuit. Each sensor produces an electrical sensor signal related to physiologic cardiovascular events of a subject. The processor includes an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of a subject and a decision module. The time-wise cascade includes at least first, second, and third physiologic cardiovascular events. The decision module declares whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events. The response circuit provides a specified response if the ischemic event is declared.

摘要翻译： 一种包括多个可植入传感器，处理器和响应电路的系统。 每个传感器产生与受试者的生理心血管事件相关的电传感器信号。 该处理器包括事件序列检测器，以允许实时检测与受试者和决策模块的心肌缺血相关的生理心血管事件的时间顺序级联。 时间级联包括至少第一，第二和第三生理心血管事件。 决策模块声明是否使用至少应用于第一，第二和第三生理心血管事件的时间关系的规则来发生缺血事件。 如果声明缺血事件，则响应电路提供指定的响应。

公开(公告)号：US07963926B2

公开(公告)日：2011-06-21

申请号：US12220710

申请日：2008-07-28

申请人： Krzysztof Z. Siejko ,  Richard Fogoros

发明人： Krzysztof Z. Siejko ,  Richard Fogoros

IPC分类号： A61B5/02

CPC分类号： A61N1/36514 ,  A61B7/023 ,  A61N1/3627

摘要： Described is an implantable device configured to monitor for changes in the intensity and/or duration of a systolic murmur such as mitral regurgitation by means of an acoustic sensor. Such changes may be taken to indicate a change in a patient's heart failure status. Upon detection of a worsening in the patient's heart failure statue, the device may be programmed to alert clinical personnel over a patient management network and/or make appropriate adjustments to pacing therapy.

摘要翻译： 描述了被配置为通过声学传感器监测收缩期杂音如二尖瓣反流的强度和/或持续时间的变化的可植入装置。 可以采取这种改变来指示患者心力衰竭状态的变化。 当检测到患者的心力衰竭雕像恶化时，该装置可以被编程以通过患者管理网络警告临床人员和/或对起搏治疗进行适当的调整。

公开(公告)号：US07922669B2

公开(公告)日：2011-04-12

申请号：US11148107

申请日：2005-06-08

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

公开(公告)号：US07869877B2

公开(公告)日：2011-01-11

申请号：US11852845

申请日：2007-09-10

申请人： Veerichetty Kadhiresan ,  Donald Hopper ,  Richard Fogoros ,  Lemont Baker

发明人： Veerichetty Kadhiresan ,  Donald Hopper ,  Richard Fogoros ,  Lemont Baker

IPC分类号： A61N1/365

CPC分类号： A61N1/365 ,  A61B5/0205 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3702

摘要： An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's heart rate response. Such evaluation may be performed by computing a heart rate response slope, defined as the ratio of an incremental change in intrinsic heart rate to an incremental change in measured activity level. The heart rate response slope may then be compared with a normal range to assess the patient's functional status.

摘要翻译： 可植入心脏装置被配置和编程以通过评估患者的心率响应来评估患者的心肺功能。 可以通过计算定义为内在心率的增量变化与测量的活动水平的增量变化的比率的心率响应斜率来执行这种评估。 然后将心率反应斜率与正常范围进行比较以评估患者的功能状态。

公开(公告)号：US20090287106A1

公开(公告)日：2009-11-19

申请号：US12510962

申请日：2009-07-28

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

公开(公告)号：US07613514B2

公开(公告)日：2009-11-03

申请号：US11109603

申请日：2005-04-19

申请人： Richard Fogoros ,  Jiang Ding ,  Yinghong Yu

发明人： Richard Fogoros ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and system for calculating an atrio-ventricular delay interval based upon an inter-atrial delay exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may optimize the stroke volume exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may be blended with another atrio-ventricular delay interval that may optimize another performance characteristic, such as left ventricular contractility. Such blending may include finding an arithmetic mean, geometric mean, or weighted mean of two or more proposed atrio-ventricular delay intervals.

摘要翻译： 一种用于根据患者心脏表现的心房间延迟来计算心房延迟间隔的方法和系统。 上述的心室延迟间隔可以优化患者心脏展示的搏动量。 上述房室延迟间隔可以与可以优化另一性能特征（例如左心室收缩力）的另一心房延迟间隔混合。 这种混合可以包括找到两个或更多个提出的心房延迟间隔的算术平均值，几何平均值或加权平均值。

公开(公告)号：US20080004668A1

公开(公告)日：2008-01-03

申请号：US11852845

申请日：2007-09-10

申请人： Veerichetty Kadhiresan ,  Donald Hopper ,  Richard Fogoros ,  Lemont Baker

发明人： Veerichetty Kadhiresan ,  Donald Hopper ,  Richard Fogoros ,  Lemont Baker

IPC分类号： A61N1/362

CPC分类号： A61N1/365 ,  A61B5/0205 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3702

摘要： An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's heart rate response. Such evaluation may be performed by computing a heart rate response slope, defined as the ratio of an incremental change in intrinsic heart rate to an incremental change in measured activity level. The heart rate response slope may then be compared with a normal range to assess the patient's functional status.

摘要翻译： 可植入心脏装置被配置和编程以通过评估患者的心率响应来评估患者的心肺功能。 可以通过计算定义为内在心率的增量变化与测量的活动水平的增量变化的比率的心率响应斜率来执行这种评估。 然后将心率反应斜率与正常范围进行比较以评估患者的功能状态。

公开(公告)号：US20060282000A1

公开(公告)日：2006-12-14

申请号：US11148107

申请日：2005-06-08

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Siejko

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

公开(公告)号：US08628471B2

公开(公告)日：2014-01-14

申请号：US12827985

申请日：2010-06-30

申请人： Scott T. Mazar ,  Richard Fogoros ,  Yatheendhar D. Manicka ,  Bruce H. KenKnight ,  Michael J. Pederson

发明人： Scott T. Mazar ,  Richard Fogoros ,  Yatheendhar D. Manicka ,  Bruce H. KenKnight ,  Michael J. Pederson

IPC分类号： A61B5/0452 ,  A61B5/026 ,  A61B5/0205 ,  A61B5/053

CPC分类号： A61B5/14546 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/0456 ,  A61B5/0464 ,  A61B5/0809 ,  A61B5/11 ,  A61B5/14532 ,  A61B2562/0219

摘要： Systems and Methods for predicting patient health and patient relative well-being within a patient management system are disclosed. A preferred embodiment utilizes an implantable medical device comprising an analysis component and a sensing component further comprising a three-dimensional accelerometer, a transthoracic impedance sensor, a cardio-activity sensor, an oxygen saturation sensor and a blood glucose sensor. Some embodiments of a system disclosed herein also can be configured as an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.

摘要翻译： 公开了用于预测患者健康状况和患者管理系统内患者相对健康的系统和方法。 优选实施例利用包括分析部件和感测部件的可植入医疗装置，其进一步包括三维加速度计，经胸阻抗传感器，心脏活动传感器，氧饱和度传感器和血糖传感器。 本文公开的系统的一些实施例还可以被配置为有助于更好地监测，预测和管理慢性疾病的高级患者管理系统。