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    DETECTION OF MYOCARDIAL ISCHEMIA FROM THE TIME SEQUENCE OF IMPLANTED SENSOR MEASUREMENTS
    1.
    发明申请
    DETECTION OF MYOCARDIAL ISCHEMIA FROM THE TIME SEQUENCE OF IMPLANTED SENSOR MEASUREMENTS 有权
    从插入式传感器测量的时间序列检测心肌梗塞

    公开(公告)号：US20070299356A1

    公开(公告)日：2007-12-27

    申请号：US11426835

    申请日：2006-06-27

    申请人： Ramesh Wariar ,  Veerichetty Kadhiresan ,  Richard Fogoros

    发明人： Ramesh Wariar ,  Veerichetty Kadhiresan ,  Richard Fogoros

    IPC分类号： A61B5/04

    CPC分类号： A61B5/02 ,  A61B5/0402 ,  A61B5/0535 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3702

    摘要： A system including a plurality of implantable sensors, a processor, and a response circuit. Each sensor produces an electrical sensor signal related to physiologic cardiovascular events of a subject. The processor includes an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of a subject and a decision module. The time-wise cascade includes at least first, second, and third physiologic cardiovascular events. The decision module declares whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events. The response circuit provides a specified response if the ischemic event is declared.

    摘要翻译： 一种包括多个可植入传感器，处理器和响应电路的系统。 每个传感器产生与受试者的生理心血管事件相关的电传感器信号。 该处理器包括事件序列检测器，以允许实时检测与受试者和决策模块的心肌缺血相关的生理心血管事件的时间顺序级联。 时间级联包括至少第一，第二和第三生理心血管事件。 决策模块声明是否使用至少应用于第一，第二和第三生理心血管事件的时间关系的规则来发生缺血事件。 如果声明缺血事件，则响应电路提供指定的响应。

    Detection of myocardial ischemia from the time sequence of implanted sensor measurements
    2.
    发明授权
    Detection of myocardial ischemia from the time sequence of implanted sensor measurements 有权
    从植入传感器测量的时间顺序检测心肌缺血

    公开(公告)号：US08000780B2

    公开(公告)日：2011-08-16

    申请号：US11426835

    申请日：2006-06-27

    申请人： Ramesh Wariar ,  Veerichetty Kadhiresan ,  Richard Fogoros

    发明人： Ramesh Wariar ,  Veerichetty Kadhiresan ,  Richard Fogoros

    IPC分类号： A61B5/04

    CPC分类号： A61B5/02 ,  A61B5/0402 ,  A61B5/0535 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3702

    摘要： A system including a plurality of implantable sensors, a processor, and a response circuit. Each sensor produces an electrical sensor signal related to physiologic cardiovascular events of a subject. The processor includes an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of a subject and a decision module. The time-wise cascade includes at least first, second, and third physiologic cardiovascular events. The decision module declares whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events. The response circuit provides a specified response if the ischemic event is declared.

    摘要翻译： 一种包括多个可植入传感器，处理器和响应电路的系统。 每个传感器产生与受试者的生理心血管事件相关的电传感器信号。 该处理器包括事件序列检测器，以允许实时检测与受试者和决策模块的心肌缺血相关的生理心血管事件的时间顺序级联。 时间级联包括至少第一，第二和第三生理心血管事件。 决策模块声明是否使用至少应用于第一，第二和第三生理心血管事件的时间关系的规则来发生缺血事件。 如果声明缺血事件，则响应电路提供指定的响应。

    Cardiac rehabilitation using patient monitoring devices
    4.
    发明授权
    Cardiac rehabilitation using patient monitoring devices 有权
    使用患者监护仪进行心脏康复

    公开(公告)号：US08905925B2

    公开(公告)日：2014-12-09

    申请号：US12482172

    申请日：2009-06-10

    申请人： Kenneth C. Beck ,  Ramesh Wariar ,  Viktoria A. Averina

    发明人： Kenneth C. Beck ,  Ramesh Wariar ,  Viktoria A. Averina

    IPC分类号： A61B5/00 ,  A61B5/22 ,  A61B5/0205 ,  A61N1/372 ,  A61N1/362 ,  A61N1/00 ,  G06F19/00

    CPC分类号： A61B5/222 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/4833 ,  A61N1/362 ,  A61N1/37247 ,  A63B2230/08 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3475 ,  G06F19/36 ,  G16H40/63 ,  G16H40/67 ,  G16H80/00 ,  Y10S482/902

    摘要： Systems and methods permit remotely-monitored rehabilitation of a patient. A system can comprise a patient monitor configured to monitor a patient's physiological data. The patient monitor can monitor using a first monitoring mode. A patient communication device can be configured to present, to the patient, an option to perform an exercise regimen, and to receive a response indicating whether the patient will perform the exercise regimen. A configuration module coupled to the patient communication device can be configured to activate a second monitoring mode when the response indicates that the patient will perform the exercise regimen. When the exercise regimen is complete, the first monitoring mode can be re-established. When the response indicates that the patient will not perform the exercise regimen, the response can be recorded as a negative response, and the option to perform the exercise regimen can be presented again.

    摘要翻译： 系统和方法允许远程监测患者的康复。 系统可以包括被配置为监视患者生理数据的患者监护仪。 患者监护仪可以使用第一监测模式进行监测。 患者通信装置可以被配置为向患者呈现执行运动方案的选项，并且接收指示患者是否将执行运动方案的响应。 耦合到患者通信设备的配置模块可以被配置为当响应指示患者将执行运动方案时激活第二监视模式。 运动方案完成后，可以重新建立第一种监测模式。 当反应表明患者不能进行运动方案时，可以将反应记录为阴性反应，并且可再次呈现执行运动方案的选择。

    PHYSIOLOGICAL STATUS INDICATOR APPARATUS AND METHOD
    5.
    发明申请
    PHYSIOLOGICAL STATUS INDICATOR APPARATUS AND METHOD 有权
    生理状态指示器和方法

    公开(公告)号：US20130165755A1

    公开(公告)日：2013-06-27

    申请号：US13725675

    申请日：2012-12-21

    申请人： Pramodsingh Hirasingh Thakur ,  John D. Hatlestad ,  Ramesh Wariar ,  Viktoria A. Averina ,  Lynne E. Swanson

    发明人： Pramodsingh Hirasingh Thakur ,  John D. Hatlestad ,  Ramesh Wariar ,  Viktoria A. Averina ,  Lynne E. Swanson

    IPC分类号： A61B5/0205 ,  A61N1/365 ,  A61B5/053

    CPC分类号： A61B5/053 ,  A61B5/686 ,  A61B5/72

    摘要： A processor circuit can be configured to obtain a first multidimensional vector. The first multidimensional vector can include dimensions corresponding to respective first conductivity characteristics obtained from different implantable electrode configurations associated with a subject. The processor circuit can also be configured to obtain a second multidimensional vector or vector space. The second multidimensional vector or vector space can include dimensions corresponding to respective second conductivity characteristics obtained from such different electrode configurations associated with the same or a different subject. The processor circuit can also provide a physiological status indicator that can be obtained at least in part by performing a vector comparison of the first multidimensional vector to the second multidimensional vector space or vector.

    摘要翻译： 处理器电路可以被配置为获得第一多维向量。 第一多维向量可以包括对应于从与对象相关联的不同可植入电极配置获得的各自的第一导电特性的尺寸。 处理器电路还可以被配置为获得第二多维向量或向量空间。 第二多维向量或向量空间可以包括对应于从与相同或不同对象相关联的这种不同电极配置获得的各自的第二导电特性的尺寸。 处理器电路还可以提供至少部分地通过执行第一多维向量与第二多维向量空间或向量的向量比较来获得的生理状态指示符。

    Systems and methods for monitoring pulmonary edema dynamics
    7.
    发明授权
    Systems and methods for monitoring pulmonary edema dynamics 有权
    用于监测肺水肿动态的系统和方法

    公开(公告)号：US08417463B2

    公开(公告)日：2013-04-09

    申请号：US12505926

    申请日：2009-07-20

    申请人： Ramesh Wariar ,  John D. Hatlestad ,  Kenneth C. Beck ,  Aaron Lewicke

    发明人： Ramesh Wariar ,  John D. Hatlestad ,  Kenneth C. Beck ,  Aaron Lewicke

    IPC分类号： A61B5/00 ,  A61B5/08 ,  A61B5/02 ,  A61B5/04 ,  A61N1/00 ,  G01N33/48 ,  G01N33/50

    CPC分类号： A61B5/03 ,  A61B5/021 ,  A61B5/0537 ,  A61B5/4878

    摘要： This document discusses, among other things, systems and methods for measuring the dynamics of pulmonary congestion in heart failure subjects over time to monitor the subjects susceptibility to pulmonary edema, including sensing and receiving information indicative of a bodily pressure and information indicative of pulmonary fluid, and using the transient responses of these measurements to compute parameters related to the dynamics of thoracic fluid accumulation, such as a critical pressure (Pc), a critical time (Tc), or a filtration index (Kfi).

    摘要翻译： 本文件尤其讨论了随着时间的推移，测量心力衰竭受试者的肺充血动力学的系统和方法，以监测受试者对肺水肿的易感性，包括感测和接收指示身体压力的信息和指示肺动脉的信息， 并且使用这些测量的瞬态响应来计算与胸腔积液的动力学相关的参数，例如临界压力（Pc），临界时间（Tc）或过滤指数（Kfi）。

    SENSING RATE OF CHANGE OF PRESSURE IN THE LEFT VENTRICLE WITH AN IMPLANTED DEVICE
    8.
    发明申请
    SENSING RATE OF CHANGE OF PRESSURE IN THE LEFT VENTRICLE WITH AN IMPLANTED DEVICE 有权
    在具有嵌入式装置的左心室中的压力变化率的感测率

    公开(公告)号：US20120330174A1

    公开(公告)日：2012-12-27

    申请号：US13605397

    申请日：2012-09-06

    申请人： Gerrard M. Carlson ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Marina Brockway

    发明人： Gerrard M. Carlson ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Marina Brockway

    IPC分类号： A61B7/04 ,  A61M5/168 ,  A61N1/365

    CPC分类号： A61B5/021 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/375

    摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.

    摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。

    MANAGING PRELOAD RESERVE BY TRACKING THE VENTRICULAR OPERATING POINT WITH HEART SOUNDS
    9.
    发明申请
    MANAGING PRELOAD RESERVE BY TRACKING THE VENTRICULAR OPERATING POINT WITH HEART SOUNDS 有权
    通过用心脏声音追踪心室操作点来管理前端保留

    公开(公告)号：US20120203116A1

    公开(公告)日：2012-08-09

    申请号：US13447506

    申请日：2012-04-16

    申请人： Gerrard M. Carlson ,  Ramesh Wariar ,  Krzysztof Z. Siejko

    发明人： Gerrard M. Carlson ,  Ramesh Wariar ,  Krzysztof Z. Siejko

    IPC分类号： A61N1/365 ,  A61B5/0205 ,  A61B5/021

    CPC分类号： A61N1/36585 ,  A61B5/021 ,  A61B5/0452 ,  A61B7/04 ,  A61M5/1723 ,  A61N1/37

    摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.

    摘要翻译： 一种用于管理预负荷储备并跟踪患者心脏的变力状态的系统和方法。 测量S1心音作为直接测量行程体积的代理。 可以将S3心音测量为用于直接测量预载水平的代理。 S1-S3对在Frank Starling曲线上产生一个点，并显示关于患者的心室手术点和变力状态的信息。 作为S3心音的测量或除了测量S3心音之外，也可以测量S4心音，或者为了确定患者的预压水平可以进行直接的压力测量。 上述测量可以由诸如起搏器或可植入除颤器的心律管理装置进行。