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21.发明授权Programming interface with a concentric axial view of a stimulation lead with complex electrode array geometry 有权具有复杂电极阵列几何形状的刺激引线的同心轴视图的编程界面公开(公告)号：US07848802B2
公开(公告)日：2010-12-07
申请号：US11591280
申请日：2006-10-31
IPC分类号： A61N1/08
CPC分类号： A61N1/37247 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/36185
摘要： The disclosure is directed to programming implantable stimulators to deliver stimulation energy via one or more implantable leads having complex electrode array geometries. The disclosure also contemplates guided programming to select electrode combinations and parameter values to support efficacy. The techniques may be applied to a programming interface associated with a clinician programmer, a patient programmer, or both. A user interface permits a user to view electrodes from different perspectives relative to the lead. For example, the user interface provides a side view of a lead and a concentric axial view of the lead. The user interface may include an axial control medium to select and/or view electrodes at different axial positions along the length of a lead, and a rotational control medium to select and/or view electrodes at different angular positions around a circumference of the lead.
摘要翻译： 本公开涉及编程可植入刺激器以通过具有复杂电极阵列几何形状的一个或多个可植入引线输送刺激能量。 本公开还考虑了引导编程以选择电极组合和参数值以支持功效。 这些技术可以应用于与临床医生程序员，患者程序员或两者相关联的编程接口。 用户界面允许用户从相对于铅的不同角度来观察电极。 例如，用户界面提供引线的侧视图和引线的同心轴向视图。 用户界面可以包括轴向控制介质，用于选择和/或查看沿引线长度的不同轴向位置处的电极;以及旋转控制介质，用于选择和/或查看围绕引线圆周的不同角位置处的电极。
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公开(公告)号：US07826902B2
公开(公告)日：2010-11-02
申请号：US11591178
申请日：2006-10-31
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/3605 , A61N1/36082 , A61N1/37247
摘要： The disclosure describes a method and system that allows a user to configure electrical stimulation therapy by defining a stimulation field. After a stimulation lead is implanted in a patient, a clinician manipulates a stimulation field on the display to encompass desired anatomical regions of the patient. In this manner, the clinician determines which anatomical regions to stimulate, and the system generates the necessary stimulation parameters. In some cases, a lead icon representing the implanted lead is displayed to show the clinician where the lead is relative to anatomical regions of the patient.
摘要翻译： 本公开描述了允许用户通过定义刺激场来配置电刺激治疗的方法和系统。 在刺激引线植入患者体内之后，临床医生操纵显示器上的刺激场以包围病人的所需解剖区域。 以这种方式，临床医生确定要刺激的解剖区域，并且系统产生必要的刺激参数。 在一些情况下，显示代表植入引线的引线图标，以显示临床医师，其中引线相对于患者的解剖区域。
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23.发明授权公开(公告)号：US07822483B2
公开(公告)日：2010-10-26
申请号：US11591299
申请日：2006-10-31
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/36082
摘要： The disclosure describes a method and system that generates an electrical field model of defined stimulation therapy and displays the electrical field model to a user via a user interface. The electrical field model is generated based upon a patient anatomy and stimulation parameters to illustrate which areas of a patient anatomical region will be covered by the electrical field during therapy. In addition, a neuron model may be applied to the electrical field model to generate an activation field model. The activation field model indicates which neurons will be activated by the electrical field in the anatomical region. These field models may be used by a clinician to determine effective therapy prior to stimulation delivery. In particular, the field models may be beneficial when programming non axi-symmetric, or three-dimensional (3D), leads which allow greater flexibility in creating stimulation fields.
摘要翻译： 本公开描述了一种产生定义的刺激疗法的电场模型并通过用户界面向用户显示电场模型的方法和系统。 基于患者解剖学和刺激参数产生电场模型，以说明在治疗期间患者解剖区域的哪些区域将被电场覆盖。 此外，神经元模型可以应用于电场模型以产生激活场模型。 激活场模型指示哪个神经元将被解剖区域中的电场激活。 临床医生可以使用这些现场模型来确定在刺激递送之前的有效治疗。 特别地，当编程非轴对称或三维（3D））引线时，场模型可能是有益的，这些引导允许在创建刺激场方面具有更大的灵活性。
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24.发明授权Stimulation templates for programming a stimulation lead with complex electrode array geometry 有权用于用复杂电极阵列几何编程刺激引线的刺激模板公开(公告)号：US07676273B2
公开(公告)日：2010-03-09
申请号：US11591189
申请日：2006-10-31
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/36082 , A61N1/36185
摘要： The disclosure is directed to programming implantable stimulators to deliver stimulation energy via one or more implantable leads having complex electrode array geometries. A user interface of a programmer allows a user to define stimulation therapy by interacting with one or more representations of the lead that delivers the therapy. The disclosure also contemplates selecting stimulation parameters to satisfy a user defined stimulation field by selecting one or more volumetric stimulation templates that best fit the stimulation field. The user interface may display the stimulation templates in relation to different perspectives of a lead and the stimulation field. Use of stimulation templates may simplify the determination of stimulation parameters in response to any of a variety of types of user definition of a stimulation field.
摘要翻译： 本公开涉及编程可植入刺激器以通过具有复杂电极阵列几何形状的一个或多个可植入引线输送刺激能量。 程序员的用户界面允许用户通过与递送治疗的引线的一个或多个表示相互作用来定义刺激治疗。 本公开还考虑通过选择最适合刺激场的一个或多个体积刺激模板来选择刺激参数以满足用户定义的刺激场。 用户界面可以显示与铅和刺激场的不同观点相关的刺激模板。 刺激模板的使用可以响应于刺激场的各种类型的用户定义中的任一种来简化刺激参数的确定。
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公开(公告)号：US07422030B2
公开(公告)日：2008-09-09
申请号：US11182635
申请日：2005-07-15
申请人： Richard T. Stone
发明人： Richard T. Stone
CPC分类号： F16K15/08 , Y10T137/7897 , Y10T137/7913 , Y10T137/7918
摘要： A one directional flow valve assembly for a fluid system. The valve assembly is comprised of a valve body having an internal valve chamber in communication with the ambient environment and a valve seat arrangement. The assembly further has a cap structure with means to position and align a sealing member with respect to the valve seat. A flexible elastomeric sealing diaphragm may be utilized and which is under tension when the sealing diaphragm is in a sealing configuration. The sealing member has a peripheral deflection shield to direct ambient fluid through the valve body. A carrier plate structure may be provided to position the sealing member and deflection shield with respect to the valve seat arrangement to operate the valve assembly.
摘要翻译： 一种用于流体系统的单向流量阀组件。 阀组件包括具有与周围环境连通的内部阀室的阀体和阀座装置。 组件还具有盖结构，其具有相对于阀座定位和对准密封构件的装置。 当密封隔膜处于密封构造时，可以使用柔性弹性体密封隔膜并且处于张力下。 密封构件具有外围偏转屏蔽件，以将环境流体引导通过阀体。 可以提供承载板结构以将密封构件和偏转屏蔽件相对于阀座装置定位以操作阀组件。
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公开(公告)号：US06557825B2
公开(公告)日：2003-05-06
申请号：US09821951
申请日：2001-03-30
申请人： Richard T. Stone , Raun A. Kopp
发明人： Richard T. Stone , Raun A. Kopp
IPC分类号： F16L2900
CPC分类号： F16L55/1108 , F16J15/064 , F16L55/1141
摘要： A connector assembly for a plumbing appliance and for sealingly attaching an air admittance valve in a vent pipe. The connector assembly has an elastomeric sealing gasket with an interior threaded bore which is expanded by a rigid bottom portion of an air admittance valve. The bottom portion of the valve body has exterior threads and an expander portion which cooperates with the lower sealing ring of the sealing gasket to compress the elastomeric body of the sealing gasket against the interior of the vent pipe.
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公开(公告)号：US5971023A
公开(公告)日：1999-10-26
申请号：US800904
申请日：1997-02-12
申请人： Cynthia T. Clague , Frank D. Dorman , Robert C. Hamlen , Donald W. Hegeman, III , Timothy A. Miller , Joseph E. Poissant , Richard T. Stone , Michael P. Sullivan
发明人： Cynthia T. Clague , Frank D. Dorman , Robert C. Hamlen , Donald W. Hegeman, III , Timothy A. Miller , Joseph E. Poissant , Richard T. Stone , Michael P. Sullivan
CPC分类号： A61M39/10 , F04D29/428 , A61M1/101 , A61M2202/0413 , A61M2206/10 , Y10S415/90 , Y10T137/2104 , Y10T137/2109 , Y10T137/2115
摘要： A biological fluid transport device comprises a cutwater at the junction of at least two blood flow paths. The cutwater is substantially straight, substantially vertical, or both. At least one of the fluid paths may be tubular, and in some embodiments all of the fluid paths are tubular. The shear sensitive fluid may be, without limitation, blood, blood-based combinations, cell culture media, cell suspensions, proteins, and microcapsule suspensions. The device may be part of an extracorporeal circuit (e.g., blood during heart-lung bypass procedures or blood processing), but it need not be. Preferred embodiments of the device include, without limitation, kinetic pumps, mass transfer devices, filters, reservoirs, and heat exchangers.
摘要翻译： 生物流体输送装置包括在至少两个血流路径的交界处的切割水。 切割水基本上是直的，基本垂直的，或两者都是。 流体路径中的至少一个可以是管状的，并且在一些实施例中，所有流体路径都是管状的。 剪切敏感流体可以是但不限于血液，基于血液的组合，细胞培养基，细胞悬浮液，蛋白质和微胶囊悬浮液。 该装置可以是体外循环的一部分（例如在心肺旁路手术或血液处理期间的血液），但是不需要。 装置的优选实施例包括但不限于动力泵，传质装置，过滤器，储存器和热交换器。
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28.发明授权Apparatus and method for preventing defects during the lamination of materials 失效用于在层压材料期间防止缺陷的装置和方法
公开(公告)号：US5641374A
公开(公告)日：1997-06-24
申请号：US405531
申请日：1995-03-16
申请人： John A. Peterson , Richard T. Stone
发明人： John A. Peterson , Richard T. Stone
CPC分类号： B32B38/1866 , B65H23/26 , B65H23/34 , Y10T156/1741
摘要： An apparatus thermally laminates at least two materials together while minimizing wrinkles, ripples, curl, and color density loss in the laminate applying heat and pressure to the materials, by turning the laminate in a first direction away from a hotter laminating member causing a curvature of the laminate, and by turning the laminate in a second direction which reverses the curvature of the laminate.
摘要翻译： 一种设备将至少两种材料热层压在一起，同时通过将层压体沿着第一方向转动离开较热的层压构件，使层压体向材料施加热和压力使皱纹，波纹，卷曲和颜色密度损失最小化， 层叠体，并且通过在层叠体的曲率的第二方向上转动层压体。
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公开(公告)号：US08612024B2
公开(公告)日：2013-12-17
申请号：US11591281
申请日：2006-10-31
IPC分类号： A61N1/08
CPC分类号： A61N1/37247 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/3605 , A61N1/3606 , A61N1/36082 , A61N1/36125 , A61N1/36146 , A61N1/36153 , A61N1/36157 , A61N1/36192 , G06F3/04815 , G06F3/04817 , G06F3/0482 , G06F19/00 , G06F19/321 , G06F19/325 , G16H50/50
摘要： The disclosure describes a method and system that allows a user to configure electrical stimulation therapy by defining a three-dimensional (3D) stimulation field. After a stimulation lead is implanted in a patient, a clinician manipulates the 3D stimulation field in a 3D environment to encompass desired anatomical regions of the patient. In this manner, the clinician determines which anatomical regions to stimulate, and the system generates the necessary stimulation parameters. In some cases, a lead icon representing the implanted lead is displayed to show the clinician where the lead is relative to the 3D anatomical regions of the patient.
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30.发明申请PHYSIOLOGICAL CONDITION DETERMINATION BASED ON PRESSURE WAVE PRODUCED BY AN IMPLANTABLE MEDICAL DEVICE HOUSING 审中-公开基于由可植入医疗器械住房产生的压力波的生理条件确定公开(公告)号：US20130310706A1
公开(公告)日：2013-11-21
申请号：US13982159
申请日：2012-01-24
申请人： Richard T. Stone , Xuan Wei
发明人： Richard T. Stone , Xuan Wei
摘要： A physiological state of a patient is detected by at least producing and detecting pressure waves with a free wall of an implantable medical device (IMD) housing. An actuator element may contact the free wall, e.g., a portion of the IMD housing, and cause movement of the free wall that produces a pressure wave within the fluid and tissue of the patient. A detector element contacting the free wall may in turn detect reflected pressure waves received by the free wall. An acoustic module within the IMD may then determine a physiological condition of the patient, e.g., a bladder fullness state, based on the time delay between the transmitted and reflected pressure waves. In some examples in which the IMD also delivers stimulation therapy to the patient, e.g., incontinence therapy, the IMD may also automatically adjust stimulation therapy based on the determined physiological condition.
摘要翻译： 通过至少用可植入医疗装置（IMD）壳体的自由壁产生和检测压力波来检测患者的生理状态。 致动器元件可以接触自由壁，例如IMD壳体的一部分，并引起在患者的流体和组织内产生压力波的游离壁的移动。 接触自由壁的检测器元件又可以检测由游离壁接收的反射压力波。 IMD内的声学模块然后可以基于发射和反射的压力波之间的时间延迟来确定患者的生理状况，例如膀胱充盈状态。 在其中IMD还向患者提供刺激疗法（例如，失禁治疗）的一些实例中，IMD还可以基于所确定的生理状况自动调整刺激疗法。
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