公开(公告)号：US07922909B2

公开(公告)日：2011-04-12

申请号：US11932343

申请日：2007-10-31

申请人： Robert W. Allington ,  Shaofeng Xie ,  Tao Jiang ,  Mingcheng Xu

发明人： Robert W. Allington ,  Shaofeng Xie ,  Tao Jiang ,  Mingcheng Xu

IPC分类号： B01D15/08

CPC分类号： B01J20/3064 ,  B01D15/206 ,  B01J8/0005 ,  B01J19/0013 ,  B01J19/18 ,  B01J20/283 ,  B01J20/285 ,  B01J2219/00162 ,  B01J2220/54 ,  B01J2220/82 ,  G01N30/56 ,  G01N2030/522 ,  G01N2030/528 ,  G01N2030/567 ,  G01N30/30

摘要： Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.

摘要翻译： 在柱套管中制备可渗透的聚合物整体材料。 在一个实施方案中，可渗透的聚合物整体材料在通过具有与聚合混合物接触的平滑活塞头的活塞施加压力时聚合。 压力消除了墙壁效应并改变了柱子的结构。 类似地，一些在水溶液存在下具有溶胀倾向并在施加溶液时加压以防止膨胀和壁效应的柱。 此过程也会更改列中的结构。 分离有效开口的尺寸可以通过消除的压力和孔隙的量来控制。 通过用辐射而不是传导热来控制聚合来提高方向流动的均匀性。

公开(公告)号：US07922908B2

公开(公告)日：2011-04-12

申请号：US11337071

申请日：2006-01-19

申请人： Robert W. Allington ,  Shaofeng Xie ,  Tao Jiang ,  Mingcheng Xu

发明人： Robert W. Allington ,  Shaofeng Xie ,  Tao Jiang ,  Mingcheng Xu

IPC分类号： B01D15/08

CPC分类号： B01J20/3064 ,  B01D15/206 ,  B01J8/0005 ,  B01J19/0013 ,  B01J19/18 ,  B01J20/283 ,  B01J20/285 ,  B01J2219/00162 ,  B01J2220/54 ,  B01J2220/82 ,  G01N30/56 ,  G01N2030/522 ,  G01N2030/528 ,  G01N2030/567 ,  G01N30/30

摘要： Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.

公开(公告)号：US20080179773A1

公开(公告)日：2008-07-31

申请号：US11932343

申请日：2007-10-31

申请人： Robert W. Allington ,  Shaofeng Xie ,  Tao Jiang ,  Mingcheng Xu

发明人： Robert W. Allington ,  Shaofeng Xie ,  Tao Jiang ,  Mingcheng Xu

IPC分类号： B01D67/00

CPC分类号： B01J20/3064 ,  B01D15/206 ,  B01J8/0005 ,  B01J19/0013 ,  B01J19/18 ,  B01J20/283 ,  B01J20/285 ,  B01J2219/00162 ,  B01J2220/54 ,  B01J2220/82 ,  G01N30/56 ,  G01N2030/522 ,  G01N2030/528 ,  G01N2030/567 ,  G01N30/30

摘要： Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.

摘要翻译： 在柱套管中制备可渗透的聚合物整体材料。 在一个实施方案中，可渗透的聚合物整体材料在通过具有与聚合混合物接触的平滑活塞头的活塞施加压力时聚合。 压力消除了墙壁效应并改变了柱子的结构。 类似地，一些在水溶液存在下具有溶胀倾向并在施加溶液时加压以防止膨胀和壁效应的柱。 此过程也会更改列中的结构。 分离有效开口的尺寸可以通过消除的压力和孔隙的量来控制。 通过用辐射而不是传导热来控制聚合来提高方向流动的均匀性。

公开(公告)号：US07074331B2

公开(公告)日：2006-07-11

申请号：US10607080

申请日：2003-06-25

申请人： Robert W. Allington ,  Shaofeng Xie ,  Tao Jiang ,  Mingcheng Xu

发明人： Robert W. Allington ,  Shaofeng Xie ,  Tao Jiang ,  Mingcheng Xu

IPC分类号： B01D15/08

CPC分类号： B01J20/3064 ,  B01D15/206 ,  B01J8/0005 ,  B01J19/0013 ,  B01J19/18 ,  B01J20/283 ,  B01J20/285 ,  B01J2219/00162 ,  B01J2220/54 ,  B01J2220/82 ,  G01N30/56 ,  G01N2030/522 ,  G01N2030/528 ,  G01N2030/567 ,  G01N30/30

摘要： Permeable polymeric monolithic materials are prepared in a column casing. In one embodiment, the permeable polymeric monolithic materials are polymerized while pressure is applied through a piston having a smooth piston head in contact with the polymerization mixture. The pressure eliminates wall effect and changes the structure in the column. Similarly, some columns that have a tendency to swell in the presence of aqueous solutions and pressurized while the solution is applied to prevent swelling and wall effect. This procedure also changes the structure in the column. The size of the separation effective openings can be controlled by the amount of the pressure and pores eliminated. Uniformity in the direction flow is improved by controlling polymerization with radiation rather than with conducted heat.

公开(公告)号：US06241890B1

公开(公告)日：2001-06-05

申请号：US09332710

申请日：1999-06-14

申请人： Dale Lee Clay ,  Robert W. Allington ,  Philip Bernard Liescheski, III ,  Robin Randall Winter ,  Daniel Gene Jameson

发明人： Dale Lee Clay ,  Robert W. Allington ,  Philip Bernard Liescheski, III ,  Robin Randall Winter ,  Daniel Gene Jameson

IPC分类号： B01D1100

CPC分类号： B01D11/0203 ,  B01D11/0407 ,  F04B9/042 ,  F04B15/08 ,  F04B49/065 ,  F04B2205/03 ,  F04B2205/05 ,  F04B2205/09 ,  F05B2230/41 ,  F05C2201/0493 ,  F05C2253/12 ,  F16K15/183 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N2001/4033 ,  G01N2001/4061 ,  G01N2030/6013 ,  G01N2035/0441 ,  G21F5/015 ,  B01D15/40

摘要： To collect analyte from a supercritical fluid extractor, the collector lifts vials into place by a biasing means that guides the file up to the restrictor where it is sealed. The vial can be moved back down from the collecting mechanism even if frost forms on the vial while the restrictor means remains stationary. This vial is held in place by a guide that contains the seal for sealing the vial when it is raised in place.

摘要翻译： 为了从超临界流体提取器收集分析物，收集器通过偏压装置将小瓶提升到适当位置，该偏压装置将文件引导到限制器的密封位置。 即使在限制器装置保持静止的情况下，小瓶也可以从收集机构向后移回。 该小瓶通过包含用于密封小瓶的密封件的引导件保持在适当位置，当它被升高到适当位置时。

公开(公告)号：US5614089A

公开(公告)日：1997-03-25

申请号：US542683

申请日：1995-10-13

申请人： Robert W. Allington ,  Henry L. Walters ,  Daniel G. Jameson ,  Yoossef Tehrani

发明人： Robert W. Allington ,  Henry L. Walters ,  Daniel G. Jameson ,  Yoossef Tehrani

IPC分类号： B01D11/02 ,  B01D11/04 ,  F04B9/04 ,  F04B15/08 ,  F04B49/06 ,  F16K15/18 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N30/32 ,  G01N30/60 ,  G01N30/82 ,  G01N35/04 ,  G21F5/015 ,  B01D15/08

CPC分类号： B01D11/0407 ,  B01D11/0203 ,  F04B15/08 ,  F04B49/065 ,  F04B9/042 ,  F16K15/183 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/28 ,  G01N30/82 ,  G21F5/015 ,  F04B2205/03 ,  F04B2205/05 ,  F04B2205/09 ,  F05B2230/41 ,  F05C2201/0493 ,  F05C2253/12 ,  G01N2001/4033 ,  G01N2001/4061 ,  G01N2030/6008 ,  G01N2030/6013 ,  G01N2035/0441 ,  G01N30/02 ,  G01N30/32 ,  G01N30/60

摘要： A variable-orifice fluid restrictor for use with a supercritical extractor or chromatograph includes an inlet line for fluid at a pressure above its critical pressure, an extended tubular probe having an inner and an outer surface and a proximal and a distal end. The proximal end of the probe is disposed toward the inlet line. The distal end of the probe includes an adjustable orifice means adapted for metering the fluid and having first and second orifice members and an adjusting stem having first and second ends. The adjustable orifice means is adjacent to the outer surface of the probe and the orifice means is adjustable with the adjusting stem. The end of the adjusting stem is located at the distal end of the probe and is adapted for moving the first orifice member with respect to the second orifice member to control the adjustable orifice for varying the restriction of fluid passing through the adjustable orifice.

摘要翻译： 用于超临界萃取器或色谱仪的可变孔口流体限制器包括用于高于其临界压力的压力的流体的入口管线，具有内外表面和近端和远端的延伸管状探针。 探针的近端朝向入口线设置。 探针的远端包括适于计量流体并具有第一和第二孔口构件的调节孔口装置和具有第一和第二端部的调节杆。 可调整的孔口装置与探针的外表面相邻，孔口装置可用调节杆调节。 调节杆的端部位于探针的远端，并且适于相对于第二孔构件移动第一孔构件以控制可调节孔，以改变通过可调节孔的流体的限制。

公开(公告)号：US5198197A

公开(公告)日：1993-03-30

申请号：US908458

申请日：1992-07-06

申请人： Dale L. Clay ,  Robert W. Allington

发明人： Dale L. Clay ,  Robert W. Allington

IPC分类号： B01D11/02 ,  B01D11/04 ,  F04B9/04 ,  F04B15/08 ,  F04B49/06 ,  F16K15/18 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G01N30/02 ,  G01N30/28 ,  G01N30/60 ,  G01N35/04 ,  G21F5/015

CPC分类号： G01N30/28 ,  B01D11/0203 ,  B01D11/0407 ,  F04B15/08 ,  F04B49/065 ,  F04B9/042 ,  F16K15/183 ,  G01F1/34 ,  G01N1/34 ,  G01N1/40 ,  G21F5/015 ,  F04B2205/03 ,  F04B2205/05 ,  F04B2205/09 ,  F05B2230/41 ,  F05C2201/0493 ,  F05C2253/12 ,  G01N2001/4033 ,  G01N2001/4061 ,  G01N2030/6013 ,  G01N2035/0441 ,  G01N30/02

摘要： An apparatus for supercritical fluid extraction incorporates a removable extraction cartridge which in operation has insignificant pressure difference between its inside and outside walls. Because of the low pressure difference, the extraction cartridge need not have the strength to withstand significant pressure and can be made out of molded plastic for disposable use as well as stainless steel and/or machined plastic for reusability. The extraction cartridge can be removed and opened for sample access without the use of tools. The outside of the cartridge can be purged after it is installed in a heated high pressure vessel to remove contamination from its exterior. In one embodiment, the extractor includes a fraction collector for extractments, an automatic sample changer and an automatic carteidge transfer mechanism which provide completely automated extractions.

摘要翻译： 用于超临界流体萃取的装置包括可移除的提取筒，其在操作中在其内壁和外壁之间具有不显着的压力差。 由于低压差，提取筒不需要具有承受显着压力的强度，并且可以由用于一次性使用的模制塑料以及用于可重复使用的不锈钢和/或加工塑料制成。 提取盒可以拆卸和打开，无需使用工具进行样品通道。 在将其安装在加热的高压容器中以清除其外部的污染物之后，可将其清除。 在一个实施例中，提取器包括用于提取的馏分收集器，自动取样器和自动提升机输送机构，其提供完全自动提取。

公开(公告)号：US5135628A

公开(公告)日：1992-08-04

申请号：US348679

申请日：1989-05-05

申请人： Robert W. Allington

发明人： Robert W. Allington

IPC分类号： G01N27/447

CPC分类号： G01N27/44773

摘要： An electrophoresis apparatus 10 has a power supply 12, an electrophoresis gel system including the tank 85 and an adjustable switching means 42 connected together for controlling the electric field force, electric field angle and the pulse duration to resolve DNA molecules greater than 1,000 kb in length along straight, unbent lanes within a gel. The electrophoresis system 10 permits adjustment of the pulse durations through a range from generally one-tenth of a second to shorter ranges. It permits the adjustability of the electric field force, electric field angle and the pulse duration so that it may have: (1) pulse durations in a range that maintains the pulse durations shorter than one-tenth of a second; (2) an angle or angles of two fields up to 180 degrees with respect to each other; (3) a side range of intensities of the fields; and (4) any number of repetitions of pulses of the fields before changing the angle of the two fields with respect to each other.

摘要翻译： 电泳装置10具有电源12，电泳凝胶体系，其包括容器85和连接在一起的可调开关装置42，用于控制电场力，电场角和脉冲持续时间，以解析长度大于1000kb的DNA分子 沿着凝胶内的直线，未穿过的泳道。 电泳系统10允许脉冲持续时间的调整范围通常在十分之一到更短的范围内。 它允许电场力，电场角和脉冲持续时间的可调性，使得它可以具有：（1）在保持脉冲持续时间短于十分之一秒的范围内的脉冲持续时间; （2）相对于彼此高达180度的两个场的角度或角度; （3）场的强度的侧面范围; 和（4）在改变两个场相对于彼此的角度之间的任意数量的场的脉冲重复。

公开(公告)号：US5080785A

公开(公告)日：1992-01-14

申请号：US523475

申请日：1990-05-15

申请人： Robert W. Allington ,  John N. Jones

发明人： Robert W. Allington ,  John N. Jones

IPC分类号： G01N30/34

CPC分类号： G01N30/34

摘要： To prevent the solvents forming a gradient from mixing at the wrong place and to provide for accurate composition at start of the gradient in spite of solvent pressure variations, a microliquid or supercritical fluid chromatograph includes a combined mixer and pressure detector in which equal pressures of the two solvents in the gradient are detected by displacement of a ferromagnetic poppet in the mixing chamber. The poppet serves as a stop for the final solvent until the pressures are substantially equal and then its movement is detected by a circuit related to a linear variable differential transformer. The signal energizes a circuit which drives one of the sensing coils to drive the poppet during the gradient to provide mixing.

摘要翻译： 为了防止形成梯度的溶剂在错误的地方混合，并且尽管有溶剂压力变化而在梯度开始时提供精确的组成，但微液体或超临界流体色谱仪包括组合的混合器和压力检测器，其中相同的压力 梯度中的两种溶剂通过在混合室中的铁磁提升阀的位移来检测。 提升阀作为最终溶剂的停止点，直到压力基本相等，然后通过与线性可变差动变压器相关的电路检测其运动。 该信号激励驱动其中一个感测线圈的电路，以在梯度期间驱动提升阀以提供混合。

公开(公告)号：US4964533A

公开(公告)日：1990-10-23

申请号：US713328

申请日：1985-03-18

申请人： Robert W. Allington ,  Jon L. Curran ,  Jerold B. Schmidt

发明人： Robert W. Allington ,  Jon L. Curran ,  Jerold B. Schmidt

IPC分类号： F04B7/06 ,  F04B49/20

CPC分类号： F04B49/20 ,  F04B7/06

摘要： To control with precision and repeatability the amount of fluid dispensed or aspirated by a pumping system, a volume disk rotates with the output shaft of a DC motor that drives a reciprocating dispensing pump. A sensor detects indicia on the disk and provides periodic signals spaced-apart in time by an amount: (1) an amount proportional to the volume of fluid pumped; (2) proportional to the angle between indicia; (3) less than one-third of the length of the total stroke of the piston as the piston moves linearly in its working portion of a cycle; (4) necessary for the piston to sweep out a volume of less than five milliliters. The speed of the pump is controlled by a second disk having equally spaced indicia that are sensed to provide signals proportional to the motor speed. During dispensing or aspirating large volumes, the motor speed is increased to a high speed, run at the high speed and then decreased before stopping and during dispensing smaller volumes, it is maintained at a constant lower speed.

摘要翻译： 为了以精确和可重复的方式控制由泵送系统分配或吸入的流体的量，体积盘与驱动往复式分配泵的直流电动机的输出轴一起旋转。 传感器检测盘上的标记，并提供周期性信号，时间间隔一定量：（1）与泵送的流体体积成比例的量; （2）与标记之间的角度成比例; （3）当活塞在其循环的工作部分中线性移动时，其活塞的总冲程长度的三分之一以下; （4）活塞排出的体积必须少于5毫升。 泵的速度由具有等间隔的标记的第二盘控制，该标记被感测以提供与电动机速度成比例的信号。 在分配或抽吸大量时，电机速度提高到高速，高速运行，然后在停止之前和分配较小的体积期间减少，它保持在恒定的较低速度。