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    DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS
    21.
    发明申请
    DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS 有权
    指导性合成寡糖磷酸酯STEREOISOMERS

    公开(公告)号：US20140045719A1

    公开(公告)日：2014-02-13

    申请号：US14026936

    申请日：2013-09-13

    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

    Inventor： Dieter Heindl ,  Dirk Kessler ,  Angelika Roesler ,  Christoph Seidel ,  Wilma Thuer

    IPC: G01N33/53 ,  C07F9/655

    CPC classification number: G01N33/5308 ,  C07F9/6552 ,  C07F9/65586 ,  Y02P20/55

    Abstract: The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner.

    Abstract translation: 使化合物的三价磷原子与试剂反应，形成稳定的磷酸酯模拟物或说明物。 具有至少一个含有保护基团的羟基残基的磷原子的亚磷酰胺与该游离羟基反应：在第一个合成循环中，羟基通过可裂解或不可切割的方式与固体支持物连接 接头。 在进一步的合成循环中，通过从生长的低聚物中切割保护基而产生羟基。 这导致形成与叠氮化物反应的亚磷酸三酯。 通过选择具有定义的立体定构的合成合成单体，以立体控制的方式制备式1的化合物。

    BINDING AGENT
    24.
    发明申请
    BINDING AGENT 审中-公开

    公开(公告)号：US20200277406A1

    公开(公告)日：2020-09-03

    申请号：US16821537

    申请日：2020-03-17

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

    IPC: C07K19/00 ,  C07K16/32 ,  C07K16/18 ,  C07K16/28

    Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

    Process for producing magnetic monodisperse polymer particles
    25.
    发明授权
    Process for producing magnetic monodisperse polymer particles 有权

    公开(公告)号：US10573443B2

    公开(公告)日：2020-02-25

    申请号：US15170251

    申请日：2016-06-01

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Seidel ,  Jens Christian Bolle ,  Sandra Recklies

    IPC: H01F1/44 ,  C08F257/00 ,  C08K9/10

    Abstract: Disclosed is a simplified process for producing magnetic polymer particles. The process comprises: (a) providing a composition having a liquid monomer which is radical polymerizable, a radical initiator soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; and (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. The process forms monodisperse magnetic particles. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.

    PROCESS FOR PRODUCING MAGNETIC MONODISPERSE POLYMER PARTICLES
    26.
    发明申请
    PROCESS FOR PRODUCING MAGNETIC MONODISPERSE POLYMER PARTICLES 审中-公开
    生产磁性单体聚合物颗粒的方法

    公开(公告)号：US20160276080A1

    公开(公告)日：2016-09-22

    申请号：US15170251

    申请日：2016-06-01

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Christoph Seidel ,  Jens Christian Bolle ,  Sandra Recklies

    IPC: H01F1/44 ,  C08F257/00 ,  C08K9/10

    CPC classification number: H01F1/44 ,  C08F257/00 ,  C08K9/10 ,  C08K2201/01 ,  H01F1/0054 ,  C08F212/36 ,  C08F212/08 ,  C08F2/44

    Abstract: Disclosed is a simplified process for producing magnetic polymer particles. The process comprises: (a) providing a composition having a liquid monomer which is radical polymerizable, a radical initiator soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; and (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. The process forms monodisperse magnetic particles. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.

    Abstract translation: 公开了用于制备磁性聚合物颗粒的简化方法。 该方法包括：（a）提供具有可自由基聚合的液体单体的组合物，可溶于单体的自由基引发剂，空间稳定剂和包含表面活性剂涂覆的胶体磁性颗粒在载体流体中的铁磁流体，该载体流体可与 单体; （b）从与单体不混溶的极性溶剂和步骤（a）的组成制备乳液; （c）将种子聚合物颗粒加入到乳液中，混合形成接种的乳液，并孵育接种的乳液，从而使种子聚合物颗粒溶胀; 和（d）活化自由基引发剂并使单体在溶胀的种子聚合物颗粒中聚合; 从而产生磁性聚合物颗粒。 该过程形成单分散磁性颗粒。 颗粒的特征在于磁性材料的分布均匀，并且不存在磁铁矿渗出。

    BINDING AGENT
    27.
    发明申请
    BINDING AGENT 审中-公开
    绑定代理

    公开(公告)号：US20160194410A1

    公开(公告)日：2016-07-07

    申请号：US15079897

    申请日：2016-03-24

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Andreas Gallusser ,  Dieter Heindl ,  Michael Schraeml ,  Christoph Seidel ,  Herbert von der Eltz

    IPC: C07K19/00

    CPC classification number: C07K19/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/626 ,  C07K2317/92 ,  C07K2317/94

    Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.

    Abstract translation: 式Aa'的结合剂：aSb：b'-B：X（n），其中A和B是一价结合剂，a：a以及b：b'是一个结合对，其中a' 并且a不干扰b与b'的结合，反之亦然，S是长度至少为1nm的间隔物：X表示共价或通过结合对结合至至少一个“ ，a，b，b'或S，（n）为整数且至少为1， - 表示共价键，连接体aSb的长度为6〜100nm。 还公开了生产这种结合剂及其某些用途的方法。

    Directed synthesis of oligophosphoramidate stereoisomers
    28.
    发明授权
    Directed synthesis of oligophosphoramidate stereoisomers 有权
    导向合成寡聚氨基磷酸酯立体异构体

    公开(公告)号：US08853132B2

    公开(公告)日：2014-10-07

    申请号：US14026936

    申请日：2013-09-13

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Dieter Heindl ,  Dirk Kessler ,  Angelika Roesler ,  Christoph Seidel ,  Wilma Thuer

    IPC: C07F9/6558 ,  G01N33/53 ,  C07F9/655

    CPC classification number: G01N33/5308 ,  C07F9/6552 ,  C07F9/65586 ,  Y02P20/55

    Abstract: The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic or a specifier is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. By selecting suitable monomers for the synthesis which have a defined stereoconformation compounds of Formula 1 are produced in a stereocontrolled manner.

    Abstract translation: 使化合物的三价磷原子与试剂反应，形成稳定的磷酸酯模拟物或说明物。 具有至少一个含有保护基团的羟基残基的磷原子的亚磷酰胺与该游离羟基反应：在第一个合成循环中，羟基通过可裂解或不可切割的方式与固体支持物连接 接头。 在进一步的合成循环中，通过从生长的低聚物中切割保护基而产生羟基。 这导致形成与叠氮化物反应的亚磷酸三酯。 通过选择具有定义的立体定构的合成合成单体，以立体控制的方式制备式1的化合物。

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