公开(公告)号：US20140079189A1

公开(公告)日：2014-03-20

申请号：US14114624

申请日：2012-01-24

申请人： Akihiro Miyamoto ,  Yuichiro Kamino ,  Shinya Ishii ,  Tatsufumi Aoi ,  Akira Watanabe

发明人： Akihiro Miyamoto ,  Yuichiro Kamino ,  Shinya Ishii ,  Tatsufumi Aoi ,  Akira Watanabe

IPC分类号： H01J35/02

CPC分类号： H01J35/025 ,  H01J35/116 ,  H01J35/14 ,  H05H9/044

摘要： An X-ray generating device (10) is provided with an electron gun (12) that generates an electron beam, a linear accelerator (14) that accelerates, by means of microwaves, the electron beam generated by the electron gun (12), an X-ray target (16) that generates X-rays by being irradiated with the electron beam accelerated by the linear accelerator (14), a microwave generating device that generates microwaves to be introduced into the linear accelerator (14), and a pulse modulator that controls the microwave generating device so as to change the power of the microwaves. Because the linear accelerator (14) includes a plurality of buncher cavities (40), even if there are electrons that are shifted out of the acceleration phase when the power of the microwaves is decreased, these electrons can be accelerated in the acceleration phase of the next time period; therefore, a decrease in the intensity of an electron beam to be emitted is suppressed even if the power of the microwaves is decreased.

摘要翻译： X射线产生装置（10）具有产生电子束的电子枪（12），通过微波加速由电子枪（12）产生的电子束的线性加速器（14） 通过用线性加速器（14）加速的电子束照射产生X射线的X射线靶（16），产生要引入线性加速器（14）的微波的微波产生装置，以及脉冲 调制器，其控制微波产生装置以改变微波的功率。 因为线性加速器（14）包括多个聚束空腔（40），所以即使在微波功率减小的情况下有电子从加速阶段移出，也可以在加速阶段加速 下一个时期 因此即使微波功率降低也抑制了要发射的电子束强度的降低。

公开(公告)号：US08623360B2

公开(公告)日：2014-01-07

申请号：US13595139

申请日：2012-08-27

申请人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Takashi Nakai

发明人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Takashi Nakai

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00

摘要： The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

公开(公告)号：US20120253016A1

公开(公告)日：2012-10-04

申请号：US13524528

申请日：2012-06-15

申请人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Mika Sakurai ,  Tetsuo Kojima ,  Tatsuhiko Tachibana ,  Hirotake Shiraiwa ,  Hiroyuki Tsunoda ,  Yoshinobu Higuchi

发明人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Mika Sakurai ,  Tetsuo Kojima ,  Tatsuhiko Tachibana ,  Hirotake Shiraiwa ,  Hiroyuki Tsunoda ,  Yoshinobu Higuchi

IPC分类号： C07K16/00 ,  C12N15/63 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12P21/02

CPC分类号： C07K16/2866 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/461 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

摘要翻译： 本发明通过改变作为人源化抗IL-6受体IgG1抗体的TOCILIZUMAB的可变区和恒定区的氨基酸序列来提供优于TOCILIZUMAB的第二代分子的药物组合物，以增强抗原 - 中和能力增强，药代动力学改善，治疗效果较差，免疫原性，安全性和物理化学性质（稳定性和均一性）均有改善。 本发明还提供了制备这些药物组合物的方法。 通过适当地组合CDR结构域，可变区和恒定区中的氨基酸序列改变，本发明人成功地生产出优于TOCILIZUMAB的第二代分子。

公开(公告)号：US08259763B2

公开(公告)日：2012-09-04

申请号：US13241740

申请日：2011-09-23

申请人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

发明人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

IPC分类号： H01S3/13

CPC分类号： H01S3/0604 ,  H01S3/025 ,  H01S3/0405 ,  H01S3/042 ,  H01S3/0612 ,  H01S3/0621 ,  H01S3/07 ,  H01S3/08 ,  H01S3/08072 ,  H01S3/08095 ,  H01S3/0813 ,  H01S3/09408 ,  H01S3/10061 ,  H01S3/1643 ,  H01S3/2316 ,  H01S3/2333

摘要： A laser gain medium includes an optical medium configured to transmit a laser beam and having an incident face, a first face, a second face opposing to the first face; and gain media configured to amplify the laser beam while reflecting the laser beam. At least one of the gain media is joined on a first face of the optical medium as a first face gain medium, and at least one of the remaining gain media is joined on a second face of the optical medium as a second face gain medium. The laser beam is incident into the optical medium, and is amplified by the first face gain medium and the second face gain medium while being alternately reflected by the first face gain medium and the second face gain medium.

摘要翻译： 激光增益介质包括配置为透射激光束并具有入射面，第一面，与第一面相对的第二面的光学介质; 并且增益介质配置成放大激光束同时反射激光束。 所述增益介质中的至少一个作为第一面增益介质连接在所述光介质的第一面上，并且所述剩余增益介质中的至少一个作为所述第二面增益介质连接在所述光介质的第二面上。 激光束入射到光学介质中，并且被第一面增益介质和第二面增益介质放大，同时被第一面增益介质和第二面增益介质交替反射。

公开(公告)号：US07898595B2

公开(公告)日：2011-03-01

申请号：US10542639

申请日：2003-12-19

申请人： Tsutomu Kume ,  Shinya Ishii ,  Tokuichiro Yamada ,  Yoshinori Tomita

发明人： Tsutomu Kume ,  Shinya Ishii ,  Tokuichiro Yamada ,  Yoshinori Tomita

IPC分类号： H04N7/01 ,  H04N11/20

CPC分类号： H04N7/0135

摘要： A method for converting frames that can display smooth moving images is provided. A memory (16) to which image data of frames in the NTSC format is written is provided. A memory controller (14) for retrieving image data of an odd field and an even field from the memory (16) every odd field period and even field period in the frame period of the PAL format is provided. An interpolating circuit (76) is provided. The interpolating circuit (76) mixes the image data of the odd field retrieved by the memory controller (14) and image data of a next odd field at a predetermined ratio to output as image data of an odd field in the frame period of the PAL format, and mixes the retrieved image data of the even field and image data of a next even field at a predetermined ratio to output as image data of an even field in the frame period of the PAL format. A coefficient-generating circuit (73) for changing the mixing ratios in the interpolating circuit (76) every field period of the PAL format is provided.

摘要翻译： 提供了一种用于转换可显示平滑运动图像的帧的方法。 提供了写入NTSC格式的帧的图像数据的存储器（16）。 提供一种存储器控制器（14），用于在PAL格式的帧周期中每隔奇数场周期和偶数场周期从存储器（16）中检索奇数场和偶数场的图像数据。 提供内插电路（76）。 内插电路（76）将由存储器控制器（14）检索到的奇数场的图像数据和预定比率的下一个奇数场的图像数据混合，作为PAL帧的帧周期中的奇数场的图像数据输出 格式化，并且将检索到的偶数场的图像数据和下一个偶数场的图像数据以预定比率混合，作为PAL格式的帧周期中的偶数场的图像数据输出。 提供了用于在PAL格式的每个场周期改变内插电路（76）中的混合比的系数产生电路（73）。

公开(公告)号：US20100111121A1

公开(公告)日：2010-05-06

申请号：US12509090

申请日：2009-07-24

申请人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

发明人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

IPC分类号： H01S3/13

CPC分类号： H01S3/0604 ,  H01S3/025 ,  H01S3/0405 ,  H01S3/042 ,  H01S3/0612 ,  H01S3/0621 ,  H01S3/07 ,  H01S3/08 ,  H01S3/08072 ,  H01S3/08095 ,  H01S3/0813 ,  H01S3/09408 ,  H01S3/10061 ,  H01S3/1643 ,  H01S3/2316 ,  H01S3/2333

摘要： A laser gain medium includes an optical medium configured to transmit a laser beam and having an incident face, a first face, a second face opposing to the first face; and gain media configured to amplify the laser beam while reflecting the laser beam. At least one of the gain media is joined on a first face of the optical medium as a first face gain medium, and at least one of the remaining gain media is joined on a second face of the optical medium as a second face gain medium. The laser beam is incident into the optical medium, and is amplified by the first face gain medium and the second face gain medium while being alternately reflected by the first face gain medium and the second face gain medium.

摘要翻译： 激光增益介质包括配置为透射激光束并具有入射面，第一面，与第一面相对的第二面的光学介质; 并且增益介质配置成放大激光束同时反射激光束。 所述增益介质中的至少一个作为第一面增益介质连接在所述光介质的第一面上，并且所述剩余增益介质中的至少一个作为所述第二面增益介质连接在所述光介质的第二面上。 激光束入射到光学介质中，并且被第一面增益介质和第二面增益介质放大，同时被第一面增益介质和第二面增益介质交替反射。

公开(公告)号：US06375918B1

公开(公告)日：2002-04-23

申请号：US09424303

申请日：1999-11-22

申请人： Masahiro Ota ,  Yasushi Mitsuyama ,  Masaharu Nishimura ,  Shinya Ishii ,  Naohiko Matsuda ,  Ichirou Yamashita

发明人： Masahiro Ota ,  Yasushi Mitsuyama ,  Masaharu Nishimura ,  Shinya Ishii ,  Naohiko Matsuda ,  Ichirou Yamashita

IPC分类号： C01B3104

CPC分类号： H05B6/78 ,  C01B32/20 ,  H05B6/784 ,  Y02P20/124

摘要： A process for the continuous firing of powdered carbon which comprises firing powdered carbon continuously by feeding powdered carbon into a firing tube and applying microwaves to the top surface of a deposited layer of the powdered carbon so as to form a high-temperature fired layer within the deposited layer, and an apparatus therefor.

摘要翻译： 一种粉末状碳的连续焙烧的方法，其特征在于，通过将粉末碳进料到烧成管中，并将微波施加到所述粉末状碳的沉积层的上表面，连续地烧成碳粉，从而在所述粉末碳的内部形成高温烧成层 沉积层及其装置。

公开(公告)号：US07839405B2

公开(公告)日：2010-11-23

申请号：US11732485

申请日：2007-04-03

申请人： Shinya Ishii ,  Takashi Kitao

发明人： Shinya Ishii ,  Takashi Kitao

IPC分类号： G06T15/20

CPC分类号： G09B29/12 ,  G06T3/0031

摘要： Disclosed herein is a display control apparatus which may include an image conversion unit, a display unit, a point specifying unit, and a visual-point position setting unit.

摘要翻译： 这里公开了一种显示控制装置，其可以包括图像转换单元，显示单元，点指定单元和视点位置设置单元。

公开(公告)号：US20090161702A1

公开(公告)日：2009-06-25

申请号：US12003178

申请日：2007-12-20

申请人： Kenji Takeshita ,  Shinya Ishii

发明人： Kenji Takeshita ,  Shinya Ishii

IPC分类号： H01S5/30

CPC分类号： H01S3/09415 ,  H01S3/042 ,  H01S3/0604 ,  H01S3/0621 ,  H01S3/0627 ,  H01S3/0915 ,  H01S3/094038

摘要： An optically pumped disk type solid state laser oscillator includes: a cylindrical shape thin film laser gain medium having a through-hole; a ring mirror whose surface is opposing to a side surface of the thin film laser gain medium; a conical mirror arranged in the through-hole and reflects a light from the ring mirror to a direction perpendicular to the thin film laser gain medium where an output mirror is arranged. The ring mirror, the conical mirror and the output mirror compose a resonator for oscillating a laser beam to be outputted from the output mirror.

摘要翻译： 光泵式固态激光振荡器包括：具有通孔的圆柱形薄膜激光增益介质; 表面与薄膜激光增益介质的侧表面相对的环形镜; 布置在所述通孔中的圆锥镜，并将来自所述环形镜的光反射到与设置有输出镜的所述薄膜激光增益介质垂直的方向。 环形镜，锥形镜和输出镜组成用于振荡从输出镜输出的激光束的谐振器。

公开(公告)号：US07411617B2

公开(公告)日：2008-08-12

申请号：US10642925

申请日：2003-08-18

申请人： Tsutomu Kume ,  Shinya Ishii ,  Tokuichiro Yamada

发明人： Tsutomu Kume ,  Shinya Ishii ,  Tokuichiro Yamada

IPC分类号： H04N7/01

CPC分类号： H04N7/01

摘要： In image-data recording processing performed when a video output conforms to the PAL system, a display-signal processing section receives image data having a frame rate of 30 Hz recorded in a memory, through a bus, converts the image data to image data having an NTSC frame rate of 29.97 Hz by a frame-rate conversion method in which thinning out is performed according to the ratio of frame rates, and outputs it to a display section and a codec-IC interface. The display-signal processing section also converts to image data having a PAL frame rate of 25 Hz, and outputs it to a video-output interface. In other words, image data is processed at a frame rate not related to the output, and then converted to image data having a frame rate suited for the output, and output. This invention can be used in digital cameras.

摘要翻译： 在视频输出符合PAL制度的图像数据记录处理中，显示信号处理部通过总线接收记录在存储器中的帧频为30Hz的图像数据，将图像数据转换成具有 通过帧率转换方法，根据帧速率的比率执行稀疏化，并将其输出到显示部分和编解码器 - IC接口，NTSC帧速率为29.97Hz。 显示信号处理部分也转换成PAL帧速率为25Hz的图像数据，并将其输出到视频输出接口。 换句话说，图像数据以与输出不相关的帧速率被处理，然后被转换成具有适合于输出的帧速率的图像数据，并输出。 本发明可用于数码相机。