公开(公告)号：US08068523B2

公开(公告)日：2011-11-29

申请号：US12509090

申请日：2009-07-24

申请人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

发明人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

IPC分类号： H01S3/13 ,  H01S3/091 ,  H01S3/092 ,  H01S3/08

CPC分类号： H01S3/0604 ,  H01S3/025 ,  H01S3/0405 ,  H01S3/042 ,  H01S3/0612 ,  H01S3/0621 ,  H01S3/07 ,  H01S3/08 ,  H01S3/08072 ,  H01S3/08095 ,  H01S3/0813 ,  H01S3/09408 ,  H01S3/10061 ,  H01S3/1643 ,  H01S3/2316 ,  H01S3/2333

摘要： A laser gain medium includes an optical medium configured to transmit a laser beam and having an incident face, a first face, a second face opposing to the first face; and gain media configured to amplify the laser beam while reflecting the laser beam. At least one of the gain media is joined on a first face of the optical medium as a first face gain medium, and at least one of the remaining gain media is joined on a second face of the optical medium as a second face gain medium. The laser beam is incident into the optical medium, and is amplified by the first face gain medium and the second face gain medium while being alternately reflected by the first face gain medium and the second face gain medium.

摘要翻译： 激光增益介质包括配置为透射激光束并具有入射面，第一面，与第一面相对的第二面的光学介质; 并且增益介质配置成放大激光束同时反射激光束。 所述增益介质中的至少一个作为第一面增益介质连接在所述光介质的第一面上，并且所述剩余增益介质中的至少一个作为所述第二面增益介质连接在所述光介质的第二面上。 激光束入射到光学介质中，并且被第一面增益介质和第二面增益介质放大，同时被第一面增益介质和第二面增益介质交替反射。

公开(公告)号：US07773641B2

公开(公告)日：2010-08-10

申请号：US12003178

申请日：2007-12-20

申请人： Kenji Takeshita ,  Shinya Ishii

发明人： Kenji Takeshita ,  Shinya Ishii

IPC分类号： H01S3/30 ,  H01S3/07 ,  H01S3/08

CPC分类号： H01S3/09415 ,  H01S3/042 ,  H01S3/0604 ,  H01S3/0621 ,  H01S3/0627 ,  H01S3/0915 ,  H01S3/094038

摘要： An optically pumped disk type solid state laser oscillator includes: a cylindrical shape thin film laser gain medium having a through-hole; a ring mirror whose surface is opposing to a side surface of the thin film laser gain medium; a conical mirror arranged in the through-hole and reflects a light from the ring mirror to a direction perpendicular to the thin film laser gain medium where an output mirror is arranged. The ring mirror, the conical mirror and the output mirror compose a resonator for oscillating a laser beam to be outputted from the output mirror.

摘要翻译： 光泵式固态激光振荡器包括：具有通孔的圆柱形薄膜激光增益介质; 表面与薄膜激光增益介质的侧表面相对的环形镜; 布置在所述通孔中的圆锥镜，并将来自所述环形镜的光反射到与设置有输出镜的所述薄膜激光增益介质垂直的方向。 环形镜，锥形镜和输出镜组成用于振荡从输出镜输出的激光束的谐振器。

公开(公告)号：US20090161702A1

公开(公告)日：2009-06-25

申请号：US12003178

申请日：2007-12-20

申请人： Kenji Takeshita ,  Shinya Ishii

发明人： Kenji Takeshita ,  Shinya Ishii

IPC分类号： H01S5/30

CPC分类号： H01S3/09415 ,  H01S3/042 ,  H01S3/0604 ,  H01S3/0621 ,  H01S3/0627 ,  H01S3/0915 ,  H01S3/094038

摘要： An optically pumped disk type solid state laser oscillator includes: a cylindrical shape thin film laser gain medium having a through-hole; a ring mirror whose surface is opposing to a side surface of the thin film laser gain medium; a conical mirror arranged in the through-hole and reflects a light from the ring mirror to a direction perpendicular to the thin film laser gain medium where an output mirror is arranged. The ring mirror, the conical mirror and the output mirror compose a resonator for oscillating a laser beam to be outputted from the output mirror.

摘要翻译： 光泵式固态激光振荡器包括：具有通孔的圆柱形薄膜激光增益介质; 表面与薄膜激光增益介质的侧表面相对的环形镜; 布置在所述通孔中的圆锥镜，并将来自所述环形镜的光反射到与设置有输出镜的所述薄膜激光增益介质垂直的方向。 环形镜，锥形镜和输出镜组成用于振荡从输出镜输出的激光束的谐振器。

公开(公告)号：US08259763B2

公开(公告)日：2012-09-04

申请号：US13241740

申请日：2011-09-23

申请人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

发明人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

IPC分类号： H01S3/13

CPC分类号： H01S3/0604 ,  H01S3/025 ,  H01S3/0405 ,  H01S3/042 ,  H01S3/0612 ,  H01S3/0621 ,  H01S3/07 ,  H01S3/08 ,  H01S3/08072 ,  H01S3/08095 ,  H01S3/0813 ,  H01S3/09408 ,  H01S3/10061 ,  H01S3/1643 ,  H01S3/2316 ,  H01S3/2333

摘要： A laser gain medium includes an optical medium configured to transmit a laser beam and having an incident face, a first face, a second face opposing to the first face; and gain media configured to amplify the laser beam while reflecting the laser beam. At least one of the gain media is joined on a first face of the optical medium as a first face gain medium, and at least one of the remaining gain media is joined on a second face of the optical medium as a second face gain medium. The laser beam is incident into the optical medium, and is amplified by the first face gain medium and the second face gain medium while being alternately reflected by the first face gain medium and the second face gain medium.

摘要翻译： 激光增益介质包括配置为透射激光束并具有入射面，第一面，与第一面相对的第二面的光学介质; 并且增益介质配置成放大激光束同时反射激光束。 所述增益介质中的至少一个作为第一面增益介质连接在所述光介质的第一面上，并且所述剩余增益介质中的至少一个作为所述第二面增益介质连接在所述光介质的第二面上。 激光束入射到光学介质中，并且被第一面增益介质和第二面增益介质放大，同时被第一面增益介质和第二面增益介质交替反射。

公开(公告)号：US20100111121A1

公开(公告)日：2010-05-06

申请号：US12509090

申请日：2009-07-24

申请人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

发明人： Kenji Takeshita ,  Shinya Ishii ,  Tomoko Saito ,  Junji Kawanaka ,  Noriaki Miyanaga ,  Kazuo Imazaki ,  Taku Saiki ,  Hiroaki Furuse

IPC分类号： H01S3/13

CPC分类号： H01S3/0604 ,  H01S3/025 ,  H01S3/0405 ,  H01S3/042 ,  H01S3/0612 ,  H01S3/0621 ,  H01S3/07 ,  H01S3/08 ,  H01S3/08072 ,  H01S3/08095 ,  H01S3/0813 ,  H01S3/09408 ,  H01S3/10061 ,  H01S3/1643 ,  H01S3/2316 ,  H01S3/2333

摘要： A laser gain medium includes an optical medium configured to transmit a laser beam and having an incident face, a first face, a second face opposing to the first face; and gain media configured to amplify the laser beam while reflecting the laser beam. At least one of the gain media is joined on a first face of the optical medium as a first face gain medium, and at least one of the remaining gain media is joined on a second face of the optical medium as a second face gain medium. The laser beam is incident into the optical medium, and is amplified by the first face gain medium and the second face gain medium while being alternately reflected by the first face gain medium and the second face gain medium.

摘要翻译： 激光增益介质包括配置为透射激光束并具有入射面，第一面，与第一面相对的第二面的光学介质; 并且增益介质配置成放大激光束同时反射激光束。 所述增益介质中的至少一个作为第一面增益介质连接在所述光介质的第一面上，并且所述剩余增益介质中的至少一个作为所述第二面增益介质连接在所述光介质的第二面上。 激光束入射到光学介质中，并且被第一面增益介质和第二面增益介质放大，同时被第一面增益介质和第二面增益介质交替反射。

公开(公告)号：US08562991B2

公开(公告)日：2013-10-22

申请号：US12680087

申请日：2009-09-25

申请人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Mika Sakurai ,  Tetsuo Kojima ,  Tatsuhiko Tachibana ,  Hirotake Shiraiwa ,  Hiroyuki Tsunoda ,  Yoshinobu Higuchi

发明人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Mika Sakurai ,  Tetsuo Kojima ,  Tatsuhiko Tachibana ,  Hirotake Shiraiwa ,  Hiroyuki Tsunoda ,  Yoshinobu Higuchi

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/461 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions.

摘要翻译： 本发明通过改变作为人源化抗IL-6受体IgG1抗体的TOCILIZUMAB的可变区和恒定区的氨基酸序列来提供优于TOCILIZUMAB的第二代分子的药物组合物，以增强抗原 - 中和能力增强，药代动力学改善，治疗效果较差，免疫原性，安全性和物理化学性质（稳定性和均一性）均有改善。 本发明还提供了制备这些药物组合物的方法。 通过适当地组合CDR结构域，可变区和恒定区中的氨基酸序列改变，本发明人成功地生产出优于TOCILIZUMAB的第二代分子。

公开(公告)号：US20110111406A1

公开(公告)日：2011-05-12

申请号：US12936587

申请日：2009-04-10

申请人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Takashi Nakai

发明人： Tomoyuki Igawa ,  Shinya Ishii ,  Atsuhiko Maeda ,  Takashi Nakai

IPC分类号： C12Q1/68 ,  C07K16/00 ,  C07K16/44 ,  C12N5/071 ,  G01N33/53 ,  C12P21/02

CPC分类号： C12N15/1037 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/505 ,  A61K2039/544 ,  A61K2039/545 ,  A61K2039/552 ,  C07K16/244 ,  C07K16/248 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C12N2760/16111 ,  C12N2760/16134 ,  C12N2770/20071 ,  G01N33/6854 ,  G01N2500/00

摘要： The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

摘要翻译： 本发明人发现，与血浆pH值相比，在早期内体体内具有较弱抗原结合活性的抗体能够用单一抗体分子与多个抗原分子结合，血浆半衰期长 改善其与抗原结合的时间持续时间。

公开(公告)号：US20080075712A1

公开(公告)日：2008-03-27

申请号：US10575905

申请日：2003-10-14

申请人： Kunihiro Hattori ,  Tetsuo Kojima ,  Taro Miyazaki ,  Tetsuhiro Soeda ,  Chiaki Senoo ,  Osamu Natori ,  Keiko Kasutani ,  Shinya Ishii

发明人： Kunihiro Hattori ,  Tetsuo Kojima ,  Taro Miyazaki ,  Tetsuhiro Soeda ,  Chiaki Senoo ,  Osamu Natori ,  Keiko Kasutani ,  Shinya Ishii

IPC分类号： A61K39/395 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P7/00 ,  C07K16/00 ,  C07K16/36

CPC分类号： C07K16/36 ,  C07K16/2866 ,  C07K2317/31 ,  C07K2317/622

摘要： The present inventors succeeded in separating bispecific antibodies that functionally substitute for ligands of type I interferon receptors comprising two types of molecules: AR1 chain and AR2 chain. Furthermore, the present inventors succeeded in producing bispecific antibodies that substitute for the enzyme reaction-accelerating function of blood coagulation factor VIII/activated blood coagulation factor VIII, which bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X.

摘要翻译： 本发明人成功地分离了功能上代替包含两种类型的分子：AR1链和AR2链的I型干扰素受体的配体的双特异性抗体。 此外，本发明人成功地制备了代替凝血因子VIII /活化凝血因子VIII的酶反应促进功能的双特异性抗体，其结合凝血因子IX /活化凝血因子IX和凝血因子X 。

公开(公告)号：US06753932B2

公开(公告)日：2004-06-22

申请号：US09859275

申请日：2001-05-17

申请人： Shinya Ishii ,  Nobuo Yamazaki

发明人： Shinya Ishii ,  Nobuo Yamazaki

IPC分类号： H04N322

CPC分类号： H04N9/28 ,  H04N3/2335 ,  H04N17/045

摘要： An image processing apparatus is disclosed by which correction of convergence and correction of distortion of an image can be performed with a high degree of accuracy. Correction data to be used for correction of position errors of the three colors of red, green and blue obtained by an adjustment apparatus in advance are stored in a storage section. The stored correction data are outputted to a correction waveform outputting section through a control circuit when necessary. The correction waveform outputting section produces correction waveforms based on the correction data inputted thereto and outputs the correction waveforms to a clock signal generation circuit. The clock signal generation circuit generates clocks, and the video data of red, green and blue stored in the memory are read out in response to the clock signals.

摘要翻译： 公开了一种图像处理装置，通过该图像处理装置可以高精度地执行图像的收敛和失真校正。 用于校正由调节装置预先获得的红色，绿色和蓝色三种颜色的位置误差的校正数据被存储在存储部分中。 存储的校正数据在必要时通过控制电路输出到校正波形输出部。 校正波形输出部根据输入的校正数据生成校正波形，并将校正波形输出到时钟信号生成电路。 时钟信号产生电路产生时钟，并且响应于时钟信号读出存储在存储器中的红色，绿色和蓝色的视频数据。

公开(公告)号：US06395104B1

公开(公告)日：2002-05-28

申请号：US09202511

申请日：1998-12-15

申请人： Kenji Kosuge ,  Kishio Mochinaga ,  Eiichi Nanba ,  Nobuo Tachibana ,  Shinya Ishii ,  Naoki Yagi

发明人： Kenji Kosuge ,  Kishio Mochinaga ,  Eiichi Nanba ,  Nobuo Tachibana ,  Shinya Ishii ,  Naoki Yagi

IPC分类号： C21D176

CPC分类号： C21D8/1283 ,  C21D3/04 ,  C21D8/1244 ,  C21D8/1272 ,  C23C8/18 ,  C23C28/00 ,  H01F1/14783

摘要： A process for producing a grain-oriented electrical steel sheet wherein during the decarburization annealing step, the steel sheet is first rapidly heated in a rapid heating chamber and the PH2O/PH2 ratio in the rapid heating chamber is more than the PH2O/PH2 ratio in the decarburization annealing furnace so as to provide improved oxide film adhesion.

摘要翻译： 一种方向性电磁钢板的制造方法，其中在脱碳退火工序中，钢板首先在快速加热室中快速加热，并且快速加热室中的PH 2 O / PH 2比大于PH 2 O / PH 2比 脱碳退火炉，以提供改善的氧化膜附着力。