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114 条记录 (耗时 0.033 秒)

    Expandable fluoropolymer device for delivery of therapeutic agents and method of making
    26.
    发明授权
    Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
    用于递送治疗剂的可扩展含氟聚合物装置和制备方法

    公开(公告)号：US06955661B1

    公开(公告)日：2005-10-18

    申请号：US09411797

    申请日：1999-10-01

    申请人： Steve A. Herweck ,  Peter H. Gingras ,  Paul Martakos ,  Theodore Karwoski

    发明人： Steve A. Herweck ,  Peter H. Gingras ,  Paul Martakos ,  Theodore Karwoski

    IPC分类号： A61F2/958 ,  A61L29/04 ,  B29C47/00 ,  B29C55/24 ,  A61M5/00

    CPC分类号： A61M25/1029 ,  A61L29/041 ,  A61M25/10 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1075 ,  B29C47/00 ,  B29C47/0023 ,  B29C55/24 ,  B29C2049/465 ,  B29K2027/18 ,  B29L2022/022 ,  B29L2031/753 ,  B32B2305/026 ,  C08L27/18

    摘要： A radially expandable fluid delivery device for delivering a fluid to a treatment site within the body is disclosed. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device. The fluid delivery device includes a tubular member defined by a wall having a thickness transverse to the longitudinal axis of the tubular member and extending between an inner and an outer surface. The wall is characterized by a microstructure of nodes interconnected by fibrils. The tubular member is deployable from a first, reduced diameter configuration to a second, increased diameter configuration upon the introduction of a pressurized fluid to the lumen. The tubular member includes at least one microporous portion having a porosity sufficient for the pressurized fluid to permeate through the wall. Substantially all of the nodes within the microporous portion are oriented such that spaces between the nodes form micro-channels extending from the inner surface-to the outer surface of the wall.

    摘要翻译： 公开了一种用于将流体输送到体内的治疗部位的可径向扩张的流体输送装置。 流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的 设备的墙壁。 流体输送装置包括由壁限定的管状构件，其具有横向于管状构件的纵向轴线并在内表面和外表面之间延伸的厚度。 壁的特征在于通过纤维互连的节点的微结构。 当将加压流体引入内腔时，管状构件可从第一缩径直径构型展开至第二增大直径构型。 管状构件包括具有足以使加压流体渗透通过壁的孔隙的至少一个微孔部分。 基本上微孔部分内的所有节点被定向成使得节点之间的空间形成从壁的内表面延伸到外表面的微通道。

    Vascular endoprosthesis and method
    27.
    发明授权
    Vascular endoprosthesis and method 有权
    血管内假体和方法

    公开(公告)号：US06423089B1

    公开(公告)日：2002-07-23

    申请号：US09296349

    申请日：1999-04-22

    申请人： Peter Gingras ,  Paul Martakos ,  Theodore Karwoski ,  Steve A. Herweck

    发明人： Peter Gingras ,  Paul Martakos ,  Theodore Karwoski ,  Steve A. Herweck

    IPC分类号： A61F206

    CPC分类号： A61F2/82 ,  A61F2/07 ,  A61F2/90 ,  A61F2/958 ,  A61L31/048 ,  C08L27/18

    摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.

    摘要翻译： 血管内假体由具有连续表面并且直径小于预期血管的直径的管状衬垫预制件形成。 将衬垫插入到处理部位，并且其片材经历径向膨胀至适合容器的最终尺寸。 使用导管组件实现插入和原位扩张，其中内部支架例如刚性丝状螺旋编织管或可膨胀气囊将衬垫预制件向外压靠在容器的内壁上。 支架或一个或多个简单的内部卡环将扩张的衬垫固定就位。 膨胀的衬垫是多孔的，或在膨胀期间变得更多孔，并且其孔隙率的一个或多个方面是针对固定化处理材料，分离细胞或允许所选材料的受控渗透的预期治疗目标。

    Multi-stage prosthesis
    28.
    发明授权
    Multi-stage prosthesis 有权
    多期假体

    公开(公告)号：US06287337B1

    公开(公告)日：2001-09-11

    申请号：US09246312

    申请日：1999-02-08

    申请人： Paul Martakos ,  Peter Gingras ,  Theodore Karwoski ,  Steve A. Herweck

    发明人： Paul Martakos ,  Peter Gingras ,  Theodore Karwoski ,  Steve A. Herweck

    IPC分类号： A61F206

    CPC分类号： A61F2/07 ,  A61F2/06 ,  A61F2/105 ,  A61F2/2412 ,  A61F2/88 ,  A61F2002/072 ,  A61F2240/001 ,  A61L27/16 ,  A61L27/34 ,  A61L27/507 ,  C08L27/18

    摘要： A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls are found with radial zones of differing porosity are described.

    摘要翻译： 公开了适合用作血管​​移植假体的多孔管及其制造方法。 它具有多孔聚四氟乙烯的结构，其具有连接节点的节点和纤维的纤维结构，以及与可变孔隙度区域相邻的整体的内部周向支撑。 本发明提供一种多孔形式的聚四氟乙烯聚合物，其用作例如血管旁路，血管通路和血管内假体的人造内脏。 发现PTFE壁具有不同孔隙率的径向区域。

    DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY
    30.
    发明申请
    DRUG DELIVERY COATING FOR USE WITH A MEDICAL DEVICE AND METHODS OF TREATING VASCULAR INJURY 审中-公开
    用于医疗设备的药物输送涂料和治疗血管损伤的方法

    公开(公告)号：US20100004738A1

    公开(公告)日：2010-01-07

    申请号：US11919315

    申请日：2006-04-28

    申请人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61F2/82 ,  A61F2/00 ,  A61K31/439 ,  A61M25/00 ,  A61B17/03

    CPC分类号： A61K31/436 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/434 ,  A61L2300/45

    摘要： The present inventions provide various embodiments of methods for one or more of treating vascular injury, neointima proliferation and/or local inflammation in a mammal by locally administering therapeutic compound comprising a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the therapeutic compound comprises a bio-absorbable carrier component carrier component at least partially formed of a cellular uptake inhibitor and a cellular uptake enhancer, a mTOR targeting compound and a calcineurin inhibitor. In various aspects, the present invention provides for controlled delivery, which is at least partially characterized by total and relative amounts of a cellular uptake inhibitor and cellular uptake enhancer in a bio-absorbable carrier component.

    摘要翻译： 本发明提供了通过局部施用包含mTOR靶向化合物和钙调磷酸酶抑制剂的治疗化合物来治疗哺乳动物血管损伤，新内膜增生和/或局部炎症中的一种或多种的方法的各种实施方案。 在各个方面，治疗化合物包括至少部分由细胞摄取抑制剂和细胞吸收增强剂，mTOR靶向化合物和钙调磷酸酶抑制剂形成的生物可吸收载体组分载体组分。 在各个方面，本发明提供受控递送，其至少部分地表征为生物可吸收载体组分中的细胞摄取抑制剂和细胞摄取增强剂的总量和相对量。