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32 条记录 (耗时 0.023 秒)

    Anionically copolymerized living random (meth)acrylic copolymers and copolymers prepared therefrom
    21.
    发明授权
    Anionically copolymerized living random (meth)acrylic copolymers and copolymers prepared therefrom 失效
    阴离子共聚的活性无规（甲基）丙烯酸共聚物和由其制备的共聚物

    公开(公告)号：US5977261A

    公开(公告)日：1999-11-02

    申请号：US98981

    申请日：1998-06-17

    申请人： Jin-shan Wang ,  Philippe Bayard ,  Philippe Teyssie ,  Bruno Vuillemin ,  Philippe Heim

    发明人： Jin-shan Wang ,  Philippe Bayard ,  Philippe Teyssie ,  Bruno Vuillemin ,  Philippe Heim

    IPC分类号： C08F20/12 ,  C08F220/12 ,  C08F297/02

    CPC分类号： C08F20/12 ,  C08F220/12

    摘要： Living random (meth)acrylic copolymers, facilely converted into random co(meth)acrylates and block copolymers thereof, comprise the anionic copolymerizates of at least one comonomer A with at least one comonomer B selected from among the (meth)acrylates and maleimides, at least one of the comonomers A and B comprising a (meth)acrylate, in the presence of (i) at least one alkali or alkaline earth metal, mono- or difunctional initiator and (ii) at least one ligand, for example a nonnitrogenous macrocyclic complexant, e.g., a crown ether, or an alkali metal alcoholate.

    摘要翻译： 活性无规（甲基）丙烯酸共聚物易于转化为无规共聚（甲基）丙烯酸酯及其嵌段共聚物，包含至少一种共聚单体A与至少一种选自（甲基）丙烯酸酯和马来酰亚胺的共聚单体B的阴离子共聚物， 在（i）至少一种碱金属或碱土金属，单 - 或双官能引发剂存在下，包含（甲基）丙烯酸酯的至少一种共聚单体A和B，和（ii）至少一种配体，例如非氮大环 络合剂，例如冠醚或碱金属醇化物。

    Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery
    22.
    发明授权
    Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery 失效
    生物相容性和可生物降解的纳米粒子设计用于蛋白质药物的吸收和输送

    公开(公告)号：US5962566A

    公开(公告)日：1999-10-05

    申请号：US973863

    申请日：1998-05-07

    申请人： Christian Grandfils ,  Robert Jerome ,  Nicole Nihant ,  Philippe Teyssie

    发明人： Christian Grandfils ,  Robert Jerome ,  Nicole Nihant ,  Philippe Teyssie

    IPC分类号： A61K9/51

    CPC分类号： A61K9/5153 ,  A61K9/5192 ,  Y10S977/773 ,  Y10S977/801

    摘要： The presently claimed invention comprises a biopolymer nanoparticle for drug delivery wherein the nanoparticle comprises a homogeneous blend of an aliphatic polyester polymer blended with a polyether, a lipophilic or polypeptide drug and a biocompatible cholesterol interacting agent for preserving the activity of the drug administered to the patient while at the same time controlling the release of the drug. Methods for making the homogeneous drug delivery nanoparticles are also disclosed.

    摘要翻译： PCT No.PCT / EP96 / 02878第 371日期1998年5月7日 102（e）日期1998年5月7日PCT PCT 1996年7月2日PCT公布。 出版物WO97 / 0202200 日本1997年1月23日本发明包括用于药物递送的生物聚合物纳米颗粒，其中纳米颗粒包含与聚醚共混的脂族聚酯聚合物，亲脂性或多肽药物和生物相容性胆固醇相互作用剂的均匀共混物，用于保持 同时施用于患者的药物同时控制药物的释放。 还公开了制备均匀药物递送纳米颗粒的方法。

    Process for controlled radical polymerization or copolymerization of (meth)acrylic and vinyl monomers and (co)polymers obtained
    24.
    发明授权
    Process for controlled radical polymerization or copolymerization of (meth)acrylic and vinyl monomers and (co)polymers obtained 失效
    获得的（甲基）丙烯酸和乙烯基单体和（共）聚合物的受控自由基聚合或共聚方法

    公开(公告)号：US5767210A

    公开(公告)日：1998-06-16

    申请号：US827386

    申请日：1997-03-27

    申请人： Philippe Lecomte ,  Philippe Dubois ,  Robert Jerome ,  Philippe Teyssie ,  Thierry Senninger

    发明人： Philippe Lecomte ,  Philippe Dubois ,  Robert Jerome ,  Philippe Teyssie ,  Thierry Senninger

    IPC分类号： C08F2/24 ,  C08F2/02 ,  C08F2/38 ,  C08F4/00 ,  C08F4/04 ,  C08F4/26 ,  C08F4/28 ,  C08F4/72 ,  C08F4/80 ,  C08F20/00 ,  C08F20/14 ,  C08F2/00 ,  C08F20/06

    CPC分类号： C08F4/00 ,  C08F4/80

    摘要： This process is characterized by the fact that at least one of the said monomers is polymerized or copolymerized in bulk, solution, emulsion or suspension, at a temperature that can be as low as 0.degree. C., in the presence of an initiation system including: at least one compound generating radicals, other than bromofluorene, and at least one catalyst consisting of a complex of palladium in the 0 oxidation state, denoted by the following formula (I): Pd(0)L.sup.1 L.sup.2 L.sup.3 L.sup.4 in which each of L.sup.1, L.sup.2, L.sup.3 and L.sup.4, which are identical or different, denotes a ligand which may be a chiral ligand, which is chosen from PRR'R", P(OR)(OR')(OR"), NRR'R", ORR', SRR', SeRR', AsRR'R", SbRR'R", where each of R, R' and R" independently denotes a C.sub.1 -C.sub.14 alkyl group, optionally substituted, or an optionally substituted aromatic group, it being possible for at least two of these ligands to be joined to one another by one or more divalent radicals.

    摘要翻译： 该方法的特征在于，在起始系统存在下，至少一种所述单体在本体，溶液，乳液或悬浮液中在可低至0℃的温度下聚合或共聚，包括 ：除了溴芴之外，至少一种产生自由基的化合物和至少一种由O型氧化态的钯络合物组成的催化剂，由下式（I）表示：Pd（0）L1L2L3L4，其中L1，L2 表示可以是手性配体的配体，其选自PRR'R“，P（OR）（OR'）（OR”）（OR“），NRR'R” ，ORR'，SRR'，SeRR'，AsRR'R“，SbRR'R”，其中R，R'和R“各自独立地表示任选取代的C 1 -C 14烷基或任选取代的芳族 这些配体中的至少两个可能通过一个或多个二价基团彼此连接。

    Anionic polymerization of alkyl (meth)acrylate monomers
    25.
    发明授权
    Anionic polymerization of alkyl (meth)acrylate monomers 失效
    （甲基）丙烯酸烷基酯单体的阴离子聚合

    公开(公告)号：US5681909A

    公开(公告)日：1997-10-28

    申请号：US589371

    申请日：1996-01-22

    申请人： Bruno Vuillemin ,  Philippe Teyssie ,  Jinshan Wang

    发明人： Bruno Vuillemin ,  Philippe Teyssie ,  Jinshan Wang

    IPC分类号： C08F4/08 ,  C08F4/06 ,  C08F4/48 ,  C08F20/10 ,  C08F20/12 ,  C08F293/00

    CPC分类号： C08F20/12

    摘要： Poly(alkyl (meth)acrylates) are inexpensively prepared, even on an industrial scale, by anionically polymerizing at least one alkyl (meth)acrylate monomer in the presence of a lithium-based initiator and in a liquid solvent medium in which the solubility parameter .delta. is less than 20, said initiator comprising an alcoholate having the formula ROLi, wherein R has the formula R.sup.1 (OR.sup.2).sub.m, in which R.sup.1 is a linear or branched alkyl radical having from 2 to 4 carbon atoms, R.sup.2 is a linear or branched alkylene radical having from 2 to 4 carbon atoms, and m is 1, 2 or 3.

    摘要翻译： 聚（（甲基）丙烯酸烷基酯）通过在锂基引发剂的存在下，通过阴离子聚合至少一种（甲基）丙烯酸烷基酯单体，在工业规模上廉价地制备，其中溶解度参数 所述引发剂包括具有式ROLi的醇化物，其中R具有式R 1（OR 2）m，其中R 1是具有2至4个碳原子的直链或支链烷基，R 2是直链或 具有2至4个碳原子的支链亚烷基，m为1,2或3。

    Process for the controlled polymerization or copolymerization of (meth)acrylic and vinyl monomers and products thus obtained
    28.
    发明授权
    Process for the controlled polymerization or copolymerization of (meth)acrylic and vinyl monomers and products thus obtained 失效
    （甲基）丙烯酸和乙烯基单体和由此获得的产物的受控聚合或共聚方法

    公开(公告)号：US5869583A

    公开(公告)日：1999-02-09

    申请号：US821873

    申请日：1997-03-21

    申请人： Claude Granel ,  Philippe Teyssie ,  Robert Jerome ,  Pascal Nicol

    发明人： Claude Granel ,  Philippe Teyssie ,  Robert Jerome ,  Pascal Nicol

    IPC分类号： C08F4/80 ,  C08F2/00 ,  C08F2/38 ,  C08F4/40 ,  C08F4/42 ,  C08F20/00 ,  C08F293/00 ,  C08F4/00 ,  C08F210/00

    CPC分类号： C08F293/00 ,  C08F4/40

    摘要： The process for the controlled radical (co)polymerization of (meth)acrylic and/or vinyl monomers is characterized in that the bulk, solution, emulsion or suspension polymerization or copolymerization is carried out, at a temperature at which can fall to 0.degree. C., of at least one of the said monomers in the presence of an initiating system comprising a radical-generating compound and at least one catalyst composed of a metal complex containing a ligand of the type�4-R.sup.3 -2,6-(CH.sub.2 NR.sup.1 R.sup.2).sub.2 C.sub.6 H.sub.2 !--(I)in which: R.sup.1 and R.sup.2, which are identical or different, represent a branched or unbranched C.sub.1 -C.sub.4 alkyl group or a phenyl group or alternatively R.sup.1 and R.sup.2 form, with the nitrogen atom to which they are connected, a cyclic amine or alternatively the two R.sup.2 groups, taken together, form a polymethylene bridge and R.sup.3 represents a hydrogen atom, an alkyl or benzyl group or an electron-donating or electron-withdrawing functional group.

    摘要翻译： （甲基）丙烯酸和/或乙烯基单体的受控自由基（共）聚合的方法的特征在于，在可以降至0℃的温度下进行本体，溶液，乳液或悬浮液的聚合或共聚 在包含自由基产生化合物的起始系统存在下的至少一种所述单体，和至少一种由含有[4-R3-2,6-（CH2NR1R2 ）2C 6 H 2] - （I）其中：相同或不同的R 1和R 2表示支链或非支链C 1 -C 4烷基或苯基，或者R 1和R 2与它们连接的氮原子形成 环状胺或两个R2基团一起形成多亚甲基桥，R 3表示氢原子，烷基或苄基或给电子或吸电子官能团。

    Process for the controlled radical (CO) polymerization of (Meth) acrylic vinyl vinylidene and diene monomers in the presence of an Rh Co OR Ir
    29.
    发明授权
    Process for the controlled radical (CO) polymerization of (Meth) acrylic vinyl vinylidene and diene monomers in the presence of an Rh Co OR Ir 失效
    （甲基）丙烯酸乙烯基亚乙烯基和二烯单体在Rh Co OR Ir存在下的受控自由基（CO）聚合方法

    公开(公告)号：US5811500A

    公开(公告)日：1998-09-22

    申请号：US884219

    申请日：1997-06-27

    申请人： Philippe Dubois ,  Georges Moineau ,  Philippe Teyssie ,  Robert Jerome ,  Thierry Senninger

    发明人： Philippe Dubois ,  Georges Moineau ,  Philippe Teyssie ,  Robert Jerome ,  Thierry Senninger

    IPC分类号： C08F2/24 ,  C08F2/38 ,  C08F4/00 ,  C08F4/04 ,  C08F4/28 ,  C08F4/60 ,  C08F4/72 ,  C08F4/80 ,  C08F12/08 ,  C08F14/00 ,  C08F18/08 ,  C08F20/10 ,  C08F20/14 ,  C08F297/06 ,  C08F4/06

    CPC分类号： C08F4/00

    摘要： This process is characterized in that at least one of the said monomers is polymerized or copolymerized in bulk, solution, emulsion or suspension, at a temperature which may be as low as 0.degree. C., in the presence of an initiator system comprising at least one non-peroxy radical-generator compound and at least one catalyst consisting of a metal complex represented by formula Ma.sub.a (L).sub.n in which M represents Rh, Co or Ir; A represents, a halogen or a pseudohalogen; the groups L, which may be identical or different, each represent a ligand which may be a chiral ligand, which is chosen from cyclooctadiene, PRR'R", P(OR) (OR') (OR"), NRR'R", ORR', SRR', SeRR', AsRR'R", SbRR'R", each radical R, R' and R" independently representing an optionally substituted C.sub.1 -C.sub.14 alkyl group or an optionally substituted aromatic group, it being possible for at least two of these ligands to be joined together by one or more divalent radicals; a is an integer such that 1.ltoreq.a.ltoreq.3 ; n is an integer such that 1.ltoreq.n.ltoreq.5, and in the absence of activator.

    摘要翻译： 该方法的特征在于，至少一种所述单体在本体，溶液，乳液或悬浮液中，在可能低至0℃的温度下，在至少包含至少 一种非过氧自由基产生剂化合物和至少一种由式Ma（L）n表示的金属配合物组成的催化剂，其中M表示Rh，Co或Ir; A表示卤素或假卤素; 可以相同或不同的基团L各自表示可以是手性配体的配体，其选自环辛二烯，PRR'R“，P（OR）（OR'）（OR”），NRR' R“，ORR'，SRR'，SeRR'，AsRR'R”，SbRR'R“，每个基团R，R'和R”独立地表示任选取代的C 1 -C 14烷基或任选取代的芳族 这些配体中的至少两个可能通过一个或多个二价基团连接在一起; a是整数，使得1

    Highly syndiotactic PMMA polymers
    30.
    发明授权
    Highly syndiotactic PMMA polymers 失效
    高度间同立构的PMMA聚合物

    公开(公告)号：US5656704A

    公开(公告)日：1997-08-12

    申请号：US466126

    申请日：1995-06-06

    申请人： Jinshan Wang ,  Philippe Teyssie ,  Philippe Heim ,  Bruno Vuillemin

    发明人： Jinshan Wang ,  Philippe Teyssie ,  Philippe Heim ,  Bruno Vuillemin

    IPC分类号： C08F4/48 ,  C08F4/80 ,  C08F20/10 ,  C08F20/14 ,  C08F120/14 ,  C08F4/52 ,  C08F4/46

    CPC分类号： C08F20/14

    摘要： Mechanically strong; heat-resistant and transparent PMMA polymers having a high content of syndiotactic triads, a number average molecular weight ranging from 5,000 to 500,000 and a polydispersity index ranging from 1.01 to 1.5, are prepared by anionically polymerizing methyl methacrylate, characteristically at a temperature of at least 0.degree. C., in the presence of (a) at least one organolithium or organosodium initiator and (b) at least one AlR.sup.1 R.sup.2 R.sup.3 ligand, for example at least one di- or tri-phenoxy alkyl aluminum compound.

    摘要翻译： 机械强 通过阴离子聚合甲基丙烯酸甲酯制备具有高含量的间同立构三单元组，数均分子量为5,000至500,000和多分散指数为1.01至1.5的耐热和透明的PMMA聚合物，特征在于至少 在（a）至少一种有机锂或有机钠引发剂存在下，和（b）至少一种AlR1R2R3配体，例如至少一种二 - 或三 - 苯氧基烷基铝化合物。