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公开(公告)号：US20160089480A1
公开(公告)日：2016-03-31
申请号：US14860128
申请日：2015-09-21
Applicant: SurModics, Inc.
Inventor： Ralph A. Chappa , Nathan A. Lockwood , Joseph Schmidt McGonigle
CPC classification number: A61L29/14 , A61L29/049 , A61L29/085 , A61L31/041 , A61L31/10 , A61L31/14 , A61L2400/10 , A61L2420/06 , C08J3/203 , C08J2375/04 , C08J2429/10 , C08J2437/00 , C08L73/02 , C08L75/04
Abstract: Embodiments of the invention include medical device elements formed from polymers with lubricious properties. In an embodiment, a method of forming a medical device element is included. The method can include mixing a first polymeric component and a second polymeric component to form a polymer mixture. The method can further include forming the polymer mixture into the medical device element. The method can also include treating the polymer mixture with at least one of an acid or a base. In an embodiment, a medical device is included. The medical device can include a lubricious element, the lubricious element comprising a mixture of a first polymeric component and a second polymeric component. The second polymeric component can include a polymer that is treated with at least one of an acid or a base after formation of the element. Other embodiments are also included herein.
Abstract translation: 本发明的实施方案包括由具有光滑性质的聚合物形成的医疗装置元件。 在一个实施例中，包括形成医疗装置元件的方法。 该方法可以包括混合第一聚合物组分和第二聚合物组分以形成聚合物混合物。 该方法还可以包括将聚合物混合物形成到医疗装置元件中。 该方法还可以包括用酸或碱中的至少一种处理聚合物混合物。 在一个实施例中，包括医疗装置。 医疗装置可以包括润滑元件，润滑元件包括第一聚合物组分和第二聚合物组分的混合物。 第二聚合物组分可以包括在形成元素之后用至少一种酸或碱处理的聚合物。 本文还包括其它实施例。
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公开(公告)号：US11819590B2
公开(公告)日：2023-11-21
申请号：US15930128
申请日：2020-05-12
Applicant: Surmodics, Inc.
Inventor： Michael Militello , Ralph A. Chappa , Alvin A. Kucera
CPC classification number: A61L31/005 , B05C5/0216 , B05C21/00 , A61L2420/02 , B05C5/0241
Abstract: Aspects herein relate to apparatus and methods for coating medical devices. In an embodiment, a coating system is included having a two-part fluid applicator defining a central channel, the two-part fluid applicator can include a first part having a first degree of flexibility; and a second part having a second degree of flexibility. The system can further include a fluid supply conduit in fluid communication with the fluid applicator; and a fluid supply reservoir in fluid communication with the fluid supply conduit. Other embodiments are also included herein.
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公开(公告)号：US11090469B2
公开(公告)日：2021-08-17
申请号：US16363644
申请日：2019-03-25
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa , Mark F. Carlson
Abstract: A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.
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公开(公告)号：US11090468B2
公开(公告)日：2021-08-17
申请号：US14063113
申请日：2013-10-25
Applicant: SurModics, Inc.
Inventor： Ralph A. Chappa , Mark F. Carlson
Abstract: Embodiments of the invention include apparatus and methods for coating medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit including a fluid applicator; a first rotation mechanism and a second rotation mechanism; and a controller, wherein the controller causes the first rotation mechanism and the second rotation mechanism to rotate a medical device at substantially the same speed, wherein the speed is greater than 500 rotations per minute. In an embodiment, the invention includes a method of coating a medical device including rotating a medical device with a rotation mechanism at a speed of greater than 500 rotations per minute; contacting the medical device with a fluid applicator; and applying a coating solution to the device. In an embodiment, the invention includes a medical device. In some embodiments a surface of a shaft of the device comprises high points and low points.
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公开(公告)号：US10099041B2
公开(公告)日：2018-10-16
申请号：US15783554
申请日：2017-10-13
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa , Andrew G. Bach , Mark MacGregor
Abstract: Embodiments herein include apparatus and methods for coating medical devices. In an embodiment, a coating apparatus is included having a coating application unit including a movement restriction structure, a fluid applicator having a lengthwise major axis, a fluid distribution bar having a body angled with respect to the major lengthwise axis of the fluid applicator between 0 and 20 degrees, a rotation mechanism and an axial motion mechanism. The axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
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Patent Agency Ranking
公开(公告)号：US20180272040A1
公开(公告)日：2018-09-27
申请号：US15994263
申请日：2018-05-31
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa , Andrew G. Bach
CPC classification number: A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/60
Abstract: Embodiments of the invention include bioactive agent eluting devices. In an embodiment the invention includes a bioactive agent delivery device including a substrate, a hydrophilic polymer disposed on the substrate, and a substantially amorphous bioactive agent disposed on the surface of the hydrophilic polymer. In an embodiment, the invention includes a method of making a bioactive agent delivery device including depositing a hydrophilic polymer on a substrate forming a hydrophilic surface and depositing a substantially amorphous bioactive agent on the hydrophilic surface. In an embodiment, the invention includes a bioactive agent-eluting catheter including a catheter shaft and an expandable balloon disposed on the catheter shaft. Other embodiments are included herein.
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公开(公告)号：US20160256668A1
公开(公告)日：2016-09-08
申请号：US15061234
申请日：2016-03-04
Applicant: SurModics, Inc.
Inventor： Ralph A. Chappa , Andrew G. Bach , Mark MacGregor
IPC: A61M25/10
CPC classification number: A61M25/1029 , A61L29/08 , A61M25/1027 , A61M2025/1031 , A61M2025/105 , B05B13/0442
Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
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公开(公告)号：US20140328998A1
公开(公告)日：2014-11-06
申请号：US14272204
申请日：2014-05-07
Applicant: SurModics, Inc.
Inventor： Ralph A. Chappa , Andrew G. Bach , Mark MacGregor
IPC: A61M25/10
CPC classification number: A61M25/1029 , A61M2025/1031 , B05B13/0442
Abstract: Embodiments of the invention include apparatus and methods for coating drug eluting medical devices. In an embodiment, the invention includes a coating apparatus including a coating application unit comprising a movement restriction structure; a fluid applicator; and an air nozzle. The apparatus can further include a rotation mechanism and an axial motion mechanism, the axial motion mechanism configured to cause movement of at least one of the coating application unit and the rotation mechanism with respect to one another. Other embodiments are also included herein.
Abstract translation: 本发明的实施方案包括用于涂敷药物洗脱医学装置的装置和方法。 在一个实施例中，本发明包括涂覆装置，其包括包括运动限制结构的涂布施加单元; 流体施加器; 和空气喷嘴。 该装置还可包括旋转机构和轴向运动机构，所述轴向运动机构构造成使涂层施加单元和旋转机构中的至少一个相对于彼此移动。 本文还包括其它实施例。
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公开(公告)号：US20140161964A1
公开(公告)日：2014-06-12
申请号：US14063124
申请日：2013-10-25
Applicant: SurModics, Inc.
Inventor： Ralph A. Chappa , Timothy M. Kloke
IPC: A61M25/00
CPC classification number: A61M25/0009 , A61M25/1029 , A61M2025/1031 , B05C1/00 , B05C1/06 , B05C13/02 , Y10S901/43
Abstract: Embodiments of the invention include coating apparatuses and related methods. In an embodiment, the invention includes a coating apparatus. The coating apparatus can include a motor, a rotating contact member, a fluid applicator, a fluid pump, and a base member. The fluid applicator can include an orifice. The rotating contact member can be configured to rotate around a device to be coated that does not rotate. The rotating contact member can be configured to move along the lengthwise axis of a device to be coated. In an embodiment, the invention includes a method of coating a medical device. The method of coating a medical device can include a rotating a contact member around the outer diameter of a non-rotating medical device, applying a coating solution to the outer diameter of the non-rotating medical device at a position adjacent to the contact member, and moving at least one of the contact member and the non-rotating medical device with respect to one another so that the contact member moves with respect to the lengthwise axis of the non-rotating medical device. Other embodiments are also included herein.
Abstract translation: 本发明的实施例包括涂覆装置和相关方法。 在一个实施例中，本发明包括涂覆装置。 涂布装置可以包括马达，旋转接触构件，流体施加器，流体泵和基座构件。 流体施加器可以包括孔口。 旋转接触构件可以构造成围绕不旋转的待涂覆装置旋转。 旋转接触构件可以构造成沿待涂覆的装置的纵向轴线移动。 在一个实施例中，本发明包括涂覆医疗装置的方法。 医疗装置的涂敷方法可以包括使非旋转医疗装置的外径附近的接触部件旋转，在与所述接触部件相邻的位置向所述非旋转医疗装置的外径施加涂布溶液， 并且相对于彼此移动所述接触构件和所述非旋转医疗装置中的至少一个，使得所述接触构件相对于所述非旋转医疗装置的纵向轴线移动。 本文还包括其它实施例。
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公开(公告)号：US11478815B2
公开(公告)日：2022-10-25
申请号：US17149390
申请日：2021-01-14
Applicant: Surmodics, Inc.
Inventor： Ralph A. Chappa , Michael Militello
Abstract: Aspects herein relate to coating apparatus and methods for coating medical devices. In an embodiment, a coating system is included having a valve, a fluid supply reservoir in fluid communication with the valve, a reciprocating positive displacement pump in fluid communication with the valve, and a fluid applicator in fluid communication with the three-way valve. The valve can be configured to assume a first fluid transport state and a second fluid transport state, wherein the valve provides fluid communication between the fluid supply reservoir and the reciprocating positive displacement pump when in the first fluid transport state for filling of the reciprocating positive displacement pump, and wherein the valve provides fluid communication between the reciprocating positive displacement pump and the fluid applicator when in the second fluid transport state for applying a coating suspension to a medical device surface. Other embodiments are also included herein.
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