公开(公告)号：US08552037B2

公开(公告)日：2013-10-08

申请号：US13657956

申请日：2012-10-23

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Osamu Uchikawa ,  Tatsuki Koike ,  Yasutaka Hoashi ,  Takafumi Takai

IPC: A61K31/428 ,  A61K31/423 ,  C07D277/60 ,  C07D263/52

CPC classification number: A61K31/428 ,  A61K31/423 ,  C07D263/52 ,  C07D277/60 ,  C07D277/62 ,  C07D413/06

Abstract: The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.

Abstract translation: 本发明提供下式表示的化合物，其可用作预防或治疗与褪黑激素或其盐等有关的疾病的药剂。

公开(公告)号：US12091410B2

公开(公告)日：2024-09-17

申请号：US17413473

申请日：2019-12-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuichi Kajita ,  Yuhei Miyanohana ,  Tatsuki Koike ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Norihito Tokunaga ,  Tsuneo Oda ,  Tohru Miyazaki ,  Dilhumar Uyghur ,  Yoshiteru Ito ,  Kohei Takeuchi ,  Keisuke Imamura ,  Takahiro Sugimoto ,  Koichiro Fukuda ,  Yasuhisa Kohara ,  Rei Okamoto ,  Taiichi Ohra ,  Naoki Miyamoto ,  Yoshito Terao ,  Masanori Kawasaki

IPC: C07D471/04 ,  C07D215/38 ,  C07D231/56 ,  C07D277/64 ,  C07D401/14

CPC classification number: C07D471/04 ,  C07D215/38 ,  C07D231/56 ,  C07D277/64 ,  C07D401/14

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US12071434B2

公开(公告)日：2024-08-27

申请号：US17413469

申请日：2019-12-11

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuhei Miyanohana ,  Yuichi Kajita ,  Tatsuki Koike ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Norihito Tokunaga ,  Tsuneo Oda ,  Tohru Miyazaki ,  Dilhumar Uyghur ,  Yoshiteru Ito ,  Kohei Takeuchi ,  Keisuke Imamura ,  Takahiro Sugimoto ,  Koichiro Fukuda ,  Yasuhisa Kohara ,  Rei Okamoto ,  Taiichi Ohra ,  Naoki Miyamoto ,  Jun Chiba ,  Yoshito Terao ,  Masanori Kawasaki

IPC: C07D455/02 ,  A61P25/26 ,  C07D217/24 ,  C07D237/32 ,  C07D239/90 ,  C07D401/06 ,  C07D401/10 ,  C07D403/10 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04

CPC classification number: C07D455/02 ,  A61P25/26 ,  C07D217/24 ,  C07D237/32 ,  C07D239/90 ,  C07D401/06 ,  C07D401/10 ,  C07D403/10 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  C07B2200/05

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the description, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US11987586B1

公开(公告)日：2024-05-21

申请号：US18497602

申请日：2023-10-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Yasushi Hattori ,  Marilena Pira ,  Yoshiteru Ito ,  Kohei Takeuchi ,  Eiji Kimura ,  Norihito Tokunaga ,  Shuhei Ikeda ,  Martin Alexander Pawliczek ,  Noriyuki Tezuka ,  Yasutaka Hoashi ,  Yuhei Miyanohana ,  Yuichi Kajita ,  Tatsuki Koike

IPC: C07D487/04 ,  A61P25/00 ,  C07D413/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61P25/00 ,  C07D413/04 ,  C07D519/00

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US11655241B2

公开(公告)日：2023-05-23

申请号：US16973320

申请日：2019-06-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tsuneo Oda ,  Yoshiteru Ito ,  Tohru Miyazaki ,  Kohei Takeuchi ,  Norihito Tokunaga ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Keisuke Imamura ,  Yuichi Kajita ,  Yuhei Miyanohana ,  Takahiro Sugimoto ,  Tatsuki Koike ,  Dilhumar Uyghur

IPC: C07D405/12 ,  C07D207/14 ,  C07D211/56 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D417/06 ,  C07D417/14

CPC classification number: C07D405/12 ,  C07D207/14 ,  C07D211/56 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.
A compound represented by the formula (I):




wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US11174272B2

公开(公告)日：2021-11-16

申请号：US16933092

申请日：2020-07-20

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby

IPC: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.
The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US10584097B2

公开(公告)日：2020-03-10

申请号：US16577449

申请日：2019-09-20

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Yuichi Kajita ,  Yuhei Miyanohana ,  Tatsuki Koike ,  Kohei Takeuchi ,  Yoshiteru Ito ,  Norihito Tokunaga ,  Takahiro Sugimoto ,  Tohru Miyazaki ,  Tsuneo Oda ,  Yasutaka Hoashi ,  Yasushi Hattori ,  Keisuke Imamura

IPC: C07D211/56 ,  C07D405/06 ,  C07D205/04 ,  C07D207/14 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/06 ,  C07D405/10 ,  C07D405/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14 ,  C07D211/36 ,  A61P25/00

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：US10112956B2

公开(公告)日：2018-10-30

申请号：US15467548

申请日：2017-03-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Yuichi Kajita ,  Masato Yoshikawa ,  Shuhei Ikeda ,  Eiji Kimura ,  Tomoaki Hasui ,  Toshiya Nishi ,  Hiromi Fukuda

IPC: C07D498/08 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D471/10 ,  C07D405/14 ,  C07D213/74 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D487/18 ,  C07D401/12 ,  C07D413/04 ,  C07D417/04 ,  C07D451/02 ,  C07D451/04 ,  C07D487/10 ,  C07D491/18 ,  C07D403/12 ,  C07D491/08 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D213/12 ,  A61K9/20 ,  A61K9/48 ,  C07D213/72 ,  C07D487/08 ,  C12N9/99

Abstract: An object of the present invention is to provide a compound having a superior CH24H inhibitory action, which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09586930B2

公开(公告)日：2017-03-07

申请号：US15221761

申请日：2016-07-28

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby ,  Toshiya Nishi

IPC: C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D498/08

CPC classification number: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供可用作预防或治疗神经变性疾病等的药剂或其盐。 本发明涉及由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

公开(公告)号：US09193709B2

公开(公告)日：2015-11-24

申请号：US14349201

申请日：2012-10-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby

IPC: C07D413/10 ,  C07D417/14 ,  C07D498/08 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/10

CPC classification number: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供可用作预防或治疗神经变性疾病等的药剂或其盐。 本发明涉及由式（I）表示的化合物，其中每个符号如说明书中所定义，或其盐。