公开(公告)号：US08309181B2

公开(公告)日：2012-11-13

申请号：US12868385

申请日：2010-08-25

申请人： Kenichi Ishizuka ,  Taisei Nishimi

发明人： Kenichi Ishizuka ,  Taisei Nishimi

IPC分类号： B05D3/02

CPC分类号： B05D7/24 ,  B82Y10/00 ,  C08J5/18 ,  C08J2353/00 ,  C08J2387/00 ,  G11B5/82

摘要： A method of manufacturing a polymer film having a microphase-separated morphology includes a film-forming step in which a solution containing a block copolymer having two or more types of polymer chains which are mutually incompatible and are bonded to each other, a first solvent and a second solvent having a higher boiling point by at least 15° C. than the first solvent is applied onto a substrate and the first solvent is removed to form a film; a heating step in which the film is heated at a temperature which is higher than the boiling point of the first solvent but is lower than the boiling point of the second solvent to make the film formed have a microphase-separated morphology; and a solvent removal step in which the second solvent is removed from the film having the microphase-separated morphology to form the polymer film having the microphase-separated morphology.

摘要翻译： 具有微相分离形态的聚合物膜的制造方法包括成膜步骤，其中含有具有两种或更多种彼此不相容并且彼此结合的聚合物链的嵌段共聚物的溶液，第一溶剂和 将具有比第一溶剂高沸点至少15℃的第二溶剂施加到基材上，并除去第一溶剂以形成膜; 加热步骤，其中所述膜在比所述第一溶剂的沸点高但低于所述第二溶剂的沸点的温度下加热以使所形成的膜具有微相分离的形态; 以及溶剂除去步骤，其中从具有微相分离形态的膜中除去第二溶剂以形成具有微相分离形态的聚合物膜。

公开(公告)号：US08303896B2

公开(公告)日：2012-11-06

申请号：US12848280

申请日：2010-08-02

申请人： Taisei Nishimi ,  Toshihide Ezoe

发明人： Taisei Nishimi ,  Toshihide Ezoe

IPC分类号： G01N33/53

CPC分类号： G01N33/553 ,  Y10T436/201666

摘要： An object of the present invention is to provide a biosensor and a method for immobilizing a physiologically active substance, by which preconcentration effects can be obtained at a pH that is equivalent to or higher than the isoelectric point of the physiologically active substance and the physiologically active substance can be covalently bound to the surface. The present invention provides a biosensor comprising a solid substrate to which a polymer having a primary or secondary amino group is bound, by which a physiologically active substance can be chemically immobilized following preconcentration of the substance at a pH that is equivalent to or higher than the isoelectric point of the substance.

摘要翻译： 本发明的目的是提供一种生物传感器和固定生物活性物质的方法，通过该生物传感器和生物活性物质的生理活性物质的等电点的pH值可以获得预浓缩效果， 物质可以共价结合到表面。 本发明提供了一种生物传感器，其包含具有伯或仲氨基的聚合物所固定的固体基质，通过该生物传感器，物理活性物质可以在相当于或高于 物质的等电点。

公开(公告)号：US20110020649A1

公开(公告)日：2011-01-27

申请号：US12934322

申请日：2009-03-13

申请人： Morihito Ikeda ,  Taisei Nishimi ,  Junichi Katada

发明人： Morihito Ikeda ,  Taisei Nishimi ,  Junichi Katada

IPC分类号： C07F7/02 ,  C08G63/91 ,  C07K2/00 ,  C07K14/76 ,  C07H99/00 ,  C07K14/78 ,  C08F120/10 ,  C08F120/06 ,  C08F20/56 ,  C08F226/10 ,  B32B5/16

CPC分类号： C07F7/1804 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/2991

摘要： An immobilization method for immobilizing a physiologically active substance on a solid phase carrier, the method including: bringing the solid phase carrier into contact with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I); and carrying out a process of binding of the physiologically active substance to the acid anhydride functional group while maintaining the solid phase carrier after the contact at a temperature within the range of 0° C. to 60° C.; a physiologically active substance-immobilized carrier, and a carrier for immobilization are provided. Further, a carrier including a porous material treated with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I), a blocking agent that is immobilized to the porous material; and a method for producing it is provided.

摘要翻译： 一种用于将生理活性物质固定在固相载体上的固定方法，所述方法包括：使固相载体与由下式（I）表示的含酸酐官能团的硅烷偶联剂接触; 并且在0℃至60℃的范围内的温度下，将生理活性物质与酸酐官能团结合，同时保持接触后的固相载体; 提供生理活性物质固定化载体和用于固定的载体。 此外，包括用下述通式（I）表示的含酸酐官能团的硅烷偶联剂处理的多孔材料的载体，固定在多孔材料上的封端剂; 并提供其制造方法。

公开(公告)号：US07348458B2

公开(公告)日：2008-03-25

申请号：US10807163

申请日：2004-03-24

申请人： Taisei Nishimi ,  Koki Nakamura

发明人： Taisei Nishimi ,  Koki Nakamura

IPC分类号： C07F9/54

CPC分类号： C01B33/44 ,  C07F9/5407

摘要： A tetraalkylphosphonium salt having at least one branched alkyl chain containing 9 to 100 carbon atoms in total, an organically modified layered silicate containing the tetraalkylphosphonium salt having at least one branched alkyl chain containing 9 to 100 carbon atoms in total between layers of a layered silicate and a composition comprising the organically modified layered silicate and an organic solvent or a thermoplastic resin. There are provided a tetraalkylphosphonium salt for a layered silicate having thermal stability and dispersibility superior to those of conventional organophilized layered silicates, an organically modified layered silicate containing the tetraalkylphosphonium salt and a composition thereof.

摘要翻译： 一种具有至少一个总共含有9至100个碳原子的支链烷基链的四烷基鏻盐，含有四烷基鏻盐的有机改性层状硅酸盐，其具有至少一个在层状硅酸盐的层之间总共含有9至100个碳原子的支链烷基链， 包含有机改性层状硅酸盐和有机溶剂或热塑性树脂的组合物。 提供了一种具有热稳定性和分散性优于常规有机硅化层状硅酸盐的层状硅酸盐的四烷基鏻盐，含有四烷基鏻盐的有机改性层状硅酸盐及其组合物。

公开(公告)号：US20060257933A1

公开(公告)日：2006-11-16

申请号：US11378380

申请日：2006-03-20

申请人： Taisei Nishimi ,  Toshiaki Kubo ,  Toshihide Ezoe

发明人： Taisei Nishimi ,  Toshiaki Kubo ,  Toshihide Ezoe

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N33/54373

摘要： It is an object of the present invention to provide a biosensor used to easily produce a hydrogel capable of immobilizing a physically active substance, using safe materials; and a method for producing the same. The present invention provides a biosensor which comprises a substrate having a metal layer on the surface thereof, wherein an acetoacetyl group-containing hydrophilic polymer is bound to said metal layer directly or via an intermediate layer.

摘要翻译： 本发明的目的是提供一种用于容易地生产能够使用安全的材料固定活性物质的水凝胶的生物传感器。 及其制造方法。 本发明提供一种生物传感器，其包括其表面具有金属层的基板，其中含有乙酰乙酰基的亲水性聚合物直接或经由中间层与所述金属层结合。

公开(公告)号：US20060240478A1

公开(公告)日：2006-10-26

申请号：US11358107

申请日：2006-02-22

申请人： Taisei Nishimi ,  Toshihide Ezoe ,  Toshiaki Kubo ,  Hidetoshi Tomita

发明人： Taisei Nishimi ,  Toshihide Ezoe ,  Toshiaki Kubo ,  Hidetoshi Tomita

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N33/54353 ,  G01N33/54373

摘要： One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on its surface, wherein a hydrophilic polymer having a reactive functional group capable of reacting with a hydroxyl group or an amino group of a physiologically active substance is bound to the metal layer directly or indirectly via an intermediate layer.

公开(公告)号：US20050214556A1

公开(公告)日：2005-09-29

申请号：US11061478

申请日：2005-02-22

申请人： Taisei Nishimi ,  Hiroshi Iwanaga ,  Hiroshi Arakatsu ,  Seiya Sakurai

发明人： Taisei Nishimi ,  Hiroshi Iwanaga ,  Hiroshi Arakatsu ,  Seiya Sakurai

IPC分类号： B32B27/00 ,  C08G63/193 ,  C08G64/04 ,  C08K3/00

CPC分类号： C08K3/01 ,  C08G63/193 ,  C08G64/04 ,  C08K2201/008 ,  Y10T428/31855

摘要： In a gas barrier laminate film comprising a base material film containing an inorganic compound and at least one set of inorganic layer and organic layer formed on the base material film, the base material film is formed with a resin having a glass transition temperature of 250° C. or higher. A gas barrier laminate film that has superior durability, heat resistance and gas barrier performance, shows a small difference in coefficient of linear expansion relative to an contiguous layer and can maintain superior gas barrier property even if it is bent is provided.

摘要翻译： 在包含含有无机化合物的基材膜和在基材膜上形成的至少一组无机层和有机层的阻气性层压膜中，基材膜由玻璃化转变温度为250°的树脂形成 C.或更高。 具有优异的耐久性，耐热性和阻气性的阻气性层压膜显示相对于邻接层的线性膨胀系数的小差异，并且即使设置弯曲也能保持优异的阻气性。

公开(公告)号：US08404621B2

公开(公告)日：2013-03-26

申请号：US12934322

申请日：2009-03-13

申请人： Morihito Ikeda ,  Taisei Nishimi ,  Junichi Katada

发明人： Morihito Ikeda ,  Taisei Nishimi ,  Junichi Katada

IPC分类号： C40B60/00

CPC分类号： C07F7/1804 ,  G01N33/54353 ,  G01N33/54393 ,  Y10T428/2991

摘要： An immobilization method for immobilizing a physiologically active substance on a solid phase carrier, the method including: bringing the solid phase carrier into contact with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I); and carrying out a process of binding of the physiologically active substance to the acid anhydride functional group while maintaining the solid phase carrier after the contact at a temperature within the range of 0° C. to 60° C.; a physiologically active substance-immobilized carrier, and a carrier for immobilization are provided. Further, a carrier including a porous material treated with an acid anhydride functional group-containing silane coupling agent represented by the following Formula (I), a blocking agent that is immobilized to the porous material; and a method for producing it is provided.

摘要翻译： 一种用于将生理活性物质固定在固相载体上的固定方法，所述方法包括：使固相载体与由下式（I）表示的含酸酐官能团的硅烷偶联剂接触; 并且在0℃至60℃的范围内的温度下，将生理活性物质与酸酐官能团结合，同时保持接触后的固相载体; 提供生理活性物质固定化载体和用于固定的载体。 此外，包括用下述通式（I）表示的含酸酐官能团的硅烷偶联剂处理的多孔材料的载体，固定在多孔材料上的封端剂; 并提供其制造方法。

公开(公告)号：US08119248B2

公开(公告)日：2012-02-21

申请号：US12433512

申请日：2009-04-30

申请人： Makoto Sawada ,  Taisei Nishimi ,  Jiro Tsukahara ,  Shuuji Kanayama ,  Ritsuko Morita

发明人： Makoto Sawada ,  Taisei Nishimi ,  Jiro Tsukahara ,  Shuuji Kanayama ,  Ritsuko Morita

IPC分类号： B05D3/00

CPC分类号： B01D67/0079 ,  Y10T428/31855

摘要： A free standing film having excellent mechanical strength and flexibility as well as sufficient area is provided. The organic-inorganic hybrid free standing film includes an organic polymer having a constitutional repeating unit derived from a monomer represented by general formula (1) and a hydrolytic condensate of a metal alkoxide.

摘要翻译： 提供了具有优异的机械强度和柔韧性以及足够面积的自立式膜。 有机 - 无机混合自立膜包括具有来自由通式（1）表示的单体的构成重复单元和金属醇盐的水解缩合物的有机聚合物。

公开(公告)号：US07674633B2

公开(公告)日：2010-03-09

申请号：US11524303

申请日：2006-09-21

申请人： Taisei Nishimi ,  Toshihide Ezoe

发明人： Taisei Nishimi ,  Toshihide Ezoe

IPC分类号： G01N33/553

CPC分类号： G01N33/54393 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/553

摘要： It is an object of the present invention to provide a technique of conserving a functional group used for binding a physiologically active substance in the form of an inactive ester, and converting it to an activated ester by simple operations immediately before formation of an amide bond. The present invention provides a biosensor which comprises a substrate that has been modified with a phenyl ester group having a substituent whose electron-withdrawing ability is increased as a result of a chemical reaction.

摘要翻译： 本发明的目的是提供一种保护用于结合无活性酯形式的生理活性物质的官能团的技术，并且在形成酰胺键之前通过简单的操作将其转化为活化的酯。 本发明提供了一种生物传感器，其包括由具有吸电子性能的化合物反应性增加的具有取代基的苯基酯基改性的基板。