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    Product removal process for use in a biofermentation system
    22.
    发明申请
    Product removal process for use in a biofermentation system 失效
    用于生物发酵系统的产品去除过程

    公开(公告)号：US20050208615A1

    公开(公告)日：2005-09-22

    申请号：US10860221

    申请日：2004-06-03

    申请人： Antoinette Wilkins ,  David Lowe

    发明人： Antoinette Wilkins ,  David Lowe

    IPC分类号： C12M1/00 ,  B01D15/08 ,  C12M1/12 ,  C12M1/26 ,  C12N1/38 ,  C12P7/18 ,  C12P1/00 ,  C12P21/06

    CPC分类号： C12M47/12 ,  B01D15/1814 ,  B01D15/426 ,  C12M29/02 ,  C12M33/14 ,  C12M47/10 ,  C12N1/38 ,  C12P7/18

    摘要： This invention relates to a bioprocess engineering solution for a product removal process for use in a biofermentation. The invention discloses a process for withdrawing an aliquot of broth from a biofermentation vessel during at least a portion of the biofermentation, removing biocatalyst and water, chromatographically separating biofermentation products from the withdrawn broth using water as an eluent, and returning the remaining components of the broth back to the biofermentation vessel. Process chromatography permits highly selective separation of the target molecule, preventing feedback inhibition of the biofermentation.

    摘要翻译： 本发明涉及用于在生物发酵中使用的产品去除方法的生物过程工程解决方案。 本发明公开了一种在至少一部分生物发酵过程中从生物发酵容器中取出等份的肉汤的方法，除去生物催化剂和水，使用水作为洗脱剂，使生物发酵产物与取出的肉汤色谱分离，并返回剩余组分 肉汤回到生物发酵罐。 过程色谱法允许目标分子的高度选择性分离，防止反应抑制生物发酵。

    Transgenic flies expressing Abeta42-Italian
    23.
    发明申请
    Transgenic flies expressing Abeta42-Italian 审中-公开

    公开(公告)号：US20050132425A1

    公开(公告)日：2005-06-16

    申请号：US10970189

    申请日：2004-10-21

    申请人： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

    发明人： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

    IPC分类号： A01K67/033

    CPC分类号： A01K67/0333 ,  A01K67/0339 ,  A01K2267/0312

    摘要： The present invention discloses a transgenic fly that expresses the Italian mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Italian peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

    Transgenic flies expressing Abeta42-Flemish
    24.
    发明申请
    Transgenic flies expressing Abeta42-Flemish 审中-公开
    表达Abeta42-Flemish的转基因苍蝇

    公开(公告)号：US20050132423A1

    公开(公告)日：2005-06-16

    申请号：US10969895

    申请日：2004-10-21

    申请人： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

    发明人： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

    IPC分类号： A01K67/033 ,  C12N15/85

    CPC分类号： A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/0312 ,  C12N15/8509

    摘要： The present invention discloses a transgenic fly that expresses the Flemish mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Flemish peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

    摘要翻译： 本发明公开了一种表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的佛兰芒突变体型的转基因飞行物，以及表达Tau蛋白和人类Abeta42前体蛋白（APP）的双转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

    Transgenic flies expressing Abeta42-Arctic
    25.
    发明申请
    Transgenic flies expressing Abeta42-Arctic 审中-公开
    表达Abeta42-北极的转基因苍蝇

    公开(公告)号：US20050132421A1

    公开(公告)日：2005-06-16

    申请号：US10969893

    申请日：2004-10-21

    申请人： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

    发明人： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

    IPC分类号： A01K67/00 ,  A01K67/033 ,  C12N15/85 ,  G01N33/00

    CPC分类号： A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/0312 ,  C12N15/8509

    摘要： The present invention discloses a transgenic fly that expresses the Arctic mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Arctic peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

    摘要翻译： 本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的北极突变体版本的转基因飞行物，以及表达Tau蛋白质和人Abeta42二极体的双重转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

    Endoprosthesis having foot extensions
    26.
    发明申请
    Endoprosthesis having foot extensions 有权
    具有脚伸展的内假体

    公开(公告)号：US20050107865A1

    公开(公告)日：2005-05-19

    申请号：US10992976

    申请日：2004-11-19

    申请人： Anton Clifford ,  Kevin Kang ,  David Lowe ,  Jeff Pappas ,  Erik Eli ,  Howard Huang ,  Lisa Weldon ,  Ketan Muni ,  Eugene Young

    发明人： Anton Clifford ,  Kevin Kang ,  David Lowe ,  Jeff Pappas ,  Erik Eli ,  Howard Huang ,  Lisa Weldon ,  Ketan Muni ,  Eugene Young

    IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/90

    CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2250/0098 ,  Y10T29/49826 ,  Y10T29/49908

    摘要： Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations. Preferably, each connection location includes a foot extension, such as by an overlapping pattern between the longitudinally-adjacent annular elements or by a connector extending therebetween.

    摘要翻译： 内置假体，例如支架，包括至少一个环形元件，所述至少一个环形元件由第一组支柱构件限定，所述第一组撑杆构件互相连接以限定靠近所述环形元件相对侧的顶点。 环形元件还包括在至少一对周向相邻的支柱构件之间延伸的脚延伸部。 脚部延伸部具有从周向相邻的支柱构件的对应端部周向延伸的第一和第二脚部，并且具有轮廓以提供至少两个弯曲区域。 第一和第二脚部在脚延伸部的脚趾部分处连接，并且在一对周向相邻的支柱构件之间限定圆周方向的顶点。 优选地，提供至少一个或多个另外的环形元件，每个环形元件由互连的支柱构件限定。 环形元件通常在输送配置和展开配置之间可扩展。 环形元件在连接位置处纵向对齐并连接。 优选地，每个连接位置包括脚部延伸部，例如通过在纵向相邻的环形元件之间的重叠图案，或者通过在它们之间延伸的连接器。

    Stent crimping system and method
    28.
    发明授权
    Stent crimping system and method 有权
    支架压接系统及方法

    公开(公告)号：US08544160B2

    公开(公告)日：2013-10-01

    申请号：US13543591

    申请日：2012-07-06

    申请人： Arkady Kokish ,  David Lowe ,  Dan Shumer ,  Scott Baron

    发明人： Arkady Kokish ,  David Lowe ,  Dan Shumer ,  Scott Baron

    IPC分类号： B23P11/02

    CPC分类号： B25B27/10 ,  A61F2/95 ,  A61F2002/9522

    摘要： A stent crimping assembly is provided for crimping a stent from a first diameter to a reduced second diameter. The crimping assembly includes a plurality of movable wedges disposed about a rotational axis to form a wedge assembly. Each wedge includes a respective first side and a second side converging to form a tip portion. The tip portions are arranged to collectively form an iris about the rotational axis thereof. The iris defines a crimp aperture about which the movable wedges are disposed. A control unit is electronically programmed to control the mechanical components. A method of calibrating the control unit includes inserting a quill of known diameter into the iris and reducing the diameter of the iris onto the quill.

    摘要翻译： 提供一种用于将支架从第一直径压缩到减小的第二直径的支架压接组件。 压接组件包括围绕旋转轴线设置的多个可动楔形件以形成楔形组件。 每个楔子包括相应的第一侧​​和第二侧，该第二侧会聚以形成尖端部分。 尖端部分被布置为围绕其旋转轴线共同形成虹膜。 虹膜限定了压接孔，可动楔设置在该开口处。 电子编程的控制单元用于控制机械部件。 校准控制单元的方法包括将已知直径的芯线插入虹膜并将虹膜的直径减小到套筒上。

    Filling, identifying, validating, and servicing tip for fluid-ejection device
    29.
    发明授权
    Filling, identifying, validating, and servicing tip for fluid-ejection device 有权
    填充，识别，验证和维护流体喷射装置的末端

    公开(公告)号：US08002371B2

    公开(公告)日：2011-08-23

    申请号：US12501451

    申请日：2009-07-12

    申请人： Blair M. Kent ,  James P. Axtell ,  Trudy Benjamin ,  David Lowe ,  Preston Seu

    发明人： Blair M. Kent ,  James P. Axtell ,  Trudy Benjamin ,  David Lowe ,  Preston Seu

    IPC分类号： B41J29/38

    CPC分类号： B41J2/17506 ,  B41J3/36 ,  B41J3/407

    摘要： A tip to be placed on a fluid-ejection device is filled with fluid. The fluid may be introduced into a substantially hollow body of the tip at a first end of the body. The body of the tip has a second end at which a fluid-ejection mechanism is disposed to eject the fluid as controlled by the fluid-ejection device. The fluid may be introduced into the substantially hollow body of the tip through of the fluid-ejection mechanism disposed at the second end of the body of the tip. The tip may further be identified and/or serviced, and the tip and/or the fluid-ejection device may further be validated.

    摘要翻译： 放置在流体喷射装置上的尖端填充有流体。 流体可以在身体的第一端被引入到尖端的基本上中空的主体中。 尖端的主体具有第二端，在该第二端处设置有流体喷射机构，以便由流体喷射装置控制地喷射流体。 流体可以通过设置在尖端的主体的第二端处的流体排出机构引入尖端的基本上中空的主体。 尖端还可以被识别和/或维修，并且可以进一步验证尖端和/或流体喷射装置。