利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.036 秒)

    Sampling interface system for in-vivo estimation of tissue analyte concentration
    21.
    发明申请
    Sampling interface system for in-vivo estimation of tissue analyte concentration 审中-公开
    用于体内估计组织分析物浓度的采样界面系统

    公开(公告)号：US20050187439A1

    公开(公告)日：2005-08-25

    申请号：US11031103

    申请日：2005-01-06

    申请人： Thomas Blank ,  George Acosta ,  Stephen Monfre ,  Roxanne Abul-Haj ,  Kevin Hazen ,  Sedar Brown ,  Benjamin Richie ,  James Henderson ,  Barry Elliott ,  Josh Hope

    发明人： Thomas Blank ,  George Acosta ,  Stephen Monfre ,  Roxanne Abul-Haj ,  Kevin Hazen ,  Sedar Brown ,  Benjamin Richie ,  James Henderson ,  Barry Elliott ,  Josh Hope

    IPC分类号： A61B5/00 ,  G01N21/35

    CPC分类号： G01N21/359 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2562/146

    摘要： Sampling is controlled to enhance analyte concentration estimation derived from noninvasive sampling. Means of assuring that the same tissue sample volume is repeatably sampled are presented, thus minimizing sampling errors due to mechanical tissue distortion, specular reflectance, and probe placement. In a first embodiment of the invention, sampling is controlled using automated delivery of a coupling fluid to a region between a tip of a sample probe and a tissue measurement site in a manner requiring minimal user interaction. In a second embodiment of the invention, sampling is controlled by controlling temperature variations, preferably with a coupling fluid, at a region about the tip of a sample probe and a sample site. In a third embodiment, sampling is procedurally controlled via timing and location of coupling fluid delivery to a sample site.

    摘要翻译： 控制采样以增强从无创采样得到的分析物浓度估计。 呈现确保相同组织样本体积被重复采样的方法，从而最小化由于机械组织变形，镜面反射率和探针放置引起的采样误差。 在本发明的第一实施例中，采用自动化方式将耦合流体以需要最少用户相互作用的方式自动传送到样品探针的尖端和组织测量部位之间的区域进行控制。 在本发明的第二实施例中，通过在围绕样品探针的尖端的区域和样品位置处控制温度变化来控制采样，优选地通过耦合流体进行控制。 在第三实施例中，通过将流体输送到样品位置的定时和位置程序地控制采样。

    Apparatus and method for reproducibly modifying localized absorption and scattering coefficients at a tissue measurement site during optical sampling
    24.
    发明授权
    Apparatus and method for reproducibly modifying localized absorption and scattering coefficients at a tissue measurement site during optical sampling 失效
    在光学采样期间在组织测量部位可重复地修改局部吸收和散射系数的装置和方法

    公开(公告)号：US06534012B1

    公开(公告)日：2003-03-18

    申请号：US09631440

    申请日：2000-08-02

    申请人： Kevin H. Hazen ,  George Acosta ,  N. Alan Abul-Haj ,  Roxanne E. Abul-Haj

    发明人： Kevin H. Hazen ,  George Acosta ,  N. Alan Abul-Haj ,  Roxanne E. Abul-Haj

    IPC分类号： G01N2147

    CPC分类号： A61B5/0059 ,  A61B5/14552 ,  A61B5/6824 ,  A61B5/6843

    摘要： An apparatus for varying localized absorption and scattering coefficients at a tissue measurement site in a controlled and reproducible manner during optical sampling of a tissue volume by controlling the pressure applied to a tissue measurement site by a spectroscopic analyzer allows applied pressure to be maintained at a constant level, or the applied pressure may be varied in a controlled, reproducible manner as a function of time. A rest for receiving a body part holds the body part in a fixed position and at a fixed elevation. A mechanical system advances a fiber optic probe until it makes contact with the body part with a constant amount of pressure. The applied force is supplied by a counterweight on a single arm balance. A temperature control allows the temperature of the fiber optic probe to be equilibrated with the temperature in the immediate vicinity of the tissue measurement site. Alternate embodiments allow the fiber optic probe to be brought into direct contact with the tissue measurement site, and displaced a known distance into the tissue. The invention is also embodied as a method in which the absorption and scattering coefficients for successive spectral measurements are calculated to determine optimum depth of penetration for detection of a target analyte.

    摘要翻译： 一种用于通过控制通过光谱分析仪施加到组织测量部位的压力而在组织体积的光学取样期间以受控和可再现的方式在组织测量部位处改变局部吸收和散射系数的装置，使施加的压力保持恒定 水平或施加的压力可以以受控的，可再生的方式随时间变化。 用于接收身体部分的休息部将身体部分保持在固定位置并且固定高度。 机械系统推进光纤探针，直到其与身体部分以恒定的压力接触。 施加的力由一个平衡臂上的配重提供。 温度控制允许光纤探针的温度与组织测量位置附近的温度平衡。 替代实施例允许光纤探针与组织测量部位直接接触，并将已知距离移位到组织中。 本发明还被体现为其中计算连续光谱测量的吸收和散射系数以确定用于检测目标分析物的最佳穿透深度的方法。

    Implantable venous valve
    26.
    发明申请
    Implantable venous valve 有权
    植入式静脉瓣

    公开(公告)号：US20060247762A1

    公开(公告)日：2006-11-02

    申请号：US11217648

    申请日：2005-09-01

    申请人： George Acosta ,  George Kick

    发明人： George Acosta ,  George Kick

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2475 ,  A61F2/2412 ,  A61F2/2418

    摘要： A venous valve prosthesis includes a hollow conduit (40) defining a central passageway through which blood may flow. Opposing, pliable leaflet members (30) are located within the conduit and move back and forth between a first, open position, whereby blood may flow through the central passageway in a first direction, and a second, closed position, whereby blood is prevented from backflowing through the central passageway in a second direction which is opposite the first direction. A hollow and generally cylindrical support member (10, 20) retains the leaflet members and is coaxially disposed within the conduit. The support member includes opposing cutaway regions (18) defining two axially extending struts (16) supporting the leaflet members. The cutaway regions, in cooperation with the struts, allow the leaflet members to collapse inwardly to the closed position.

    摘要翻译： 静脉瓣膜假体包括限定中心通道的中空导管（40），血液可以通过该中心通道流动。 相对的，柔韧的小叶构件（30）位于导管内并且在第一打开位置之间来回移动，由此血液可以沿着第一方向流过中央通道，并且第二闭合位置被阻止 在与第一方向相反的第二方向上回流通过中央通道。 中空的和大致圆柱形的支撑构件（10,20）保持叶片构件并同轴地设置在导管内。 支撑构件包括限定支撑叶片构件的两个轴向延伸的支柱（16）的相对的切口区域（18）。 与支柱协作的切口区域允许小叶构件向内折叠到关闭位置。

    Oscillating mechanism driven monochromator
    27.
    发明授权
    Oscillating mechanism driven monochromator 失效
    振荡机构驱动单色仪

    公开(公告)号：US06587196B1

    公开(公告)日：2003-07-01

    申请号：US09491350

    申请日：2000-01-26

    申请人： Tim Stippick ,  George Acosta ,  Ken Meissner

    发明人： Tim Stippick ,  George Acosta ,  Ken Meissner

    IPC分类号： G01J306

    CPC分类号： G01J3/06

    摘要： The invention provides a mechanism for oscillating the spectral grating of a monochromator. The mechanism couples the spectral grating of the monochromator to an oscillating spatial linkage mechanism which accepts a rotational input and converts it into an oscillatory motion. A monochromator according to the invention comprises an oscillating grating that is oscillated by such spacial linkage mechanism drive.

    摘要翻译： 本发明提供一种用于振荡单色仪的光谱光栅的机构。 该机构将单色仪的光谱光栅耦合到接受旋转输入并将其转换为振荡运动的振荡空间连杆机构。 根据本发明的单色仪包括通过这种空间连杆机构驱动振荡的振荡光栅。