公开(公告)号：US09026198B2

公开(公告)日：2015-05-05

申请号：US13155690

申请日：2011-06-08

申请人： Jie Lian ,  Dirk Muessig

发明人： Jie Lian ,  Dirk Muessig

IPC分类号： A61B5/04 ,  A61B5/0452 ,  A61B5/00

CPC分类号： A61B5/0452 ,  A61B5/7221 ,  Y10S128/901

摘要： A method for determining the signal quality of samples in a physiological signal, in particular an electrocardiogram (ECG) signal, is provided. A supra-threshold sample sum, a noise threshold crossing sum, or both are calculated in a noise detection window including the sample to be evaluated, and low signal quality is indicated if either or both of the sums exceed respective values. ECG beat detections can then be labeled as unreliable based on the determination of low signal quality for one or more samples between the detections.

摘要翻译： 提供了一种用于确定生理信号，特别是心电图（ECG）信号中的样本的信号质量的方法。 在包括要评估的样本的噪声检测窗口中计算超阈值采样和，噪声阈值交叉和或两者，并且如果这些和之一或两者都超过相应值，则指示低信号质量。 然后可以基于检测之间的一个或多个样本的低信号质量的确定，将ECG拍摄检测标记为不可靠。

公开(公告)号：US20120302904A1

公开(公告)日：2012-11-29

申请号：US13462134

申请日：2012-05-02

申请人： Jie Lian ,  J. Christopher Moulder ,  Dirk Muessig

发明人： Jie Lian ,  J. Christopher Moulder ,  Dirk Muessig

IPC分类号： A61N1/365 ,  A61B5/0452

CPC分类号： A61N1/3684 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/36578 ,  A61N1/36592 ,  A61N1/3682

摘要： Exemplary methods and apparatuses are disclosed that provide for determination of an atrio-ventricular delay on a beat-to-beat basis by determining a P-wave duration from electric signals corresponding to electric potentials in a heart, and determining the atrio-ventricular delay on a beat-to-beat basis such that the atrio-ventricular delay for an individual heart cycle depends on the P-wave duration of a same or an immediately preceding heart cycle.

摘要翻译： 公开了示例性方法和装置，其通过从对应于心脏中的电位的电信号确定P波持续时间来提供基于节拍的心室延迟的确定，并且确定心室上的心室延迟 以心跳为基础，使得个体心脏周期的心室延迟取决于相同或紧接在前的心脏周期的P波持续时间。

公开(公告)号：US08175709B2

公开(公告)日：2012-05-08

申请号：US11668491

申请日：2007-01-30

申请人： Jie Lian ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Jie Lian ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/362

CPC分类号： A61B5/04017 ,  A61B5/0402 ,  A61B5/04525 ,  A61B5/7232

摘要： A system for heart monitoring comprises an IEGM input for an intracardiac electrocardiogram (IEGM) that is connected to an active filtering stage that is adapted to transform an incoming IEGM into an output ECG signal. The active filtering stage is connected to a filter characterization stage that is adapted to process a recorded, patient specific IEGM template and a corresponding SECG template and to adapt the filter characteristics of said active filtering stage such that the filter characteristics best characterize the input-output relationship between the IEGM template and the corresponding SECG template. As a consequence, the active filtering stage is adapted to transform an incoming IEGM such that the output ECG signal closely resembles a morphology of a corresponding SECG.

摘要翻译： 用于心脏监测的系统包括用于心内心电图（IEGM）的IEGM输入，其连接到适用于将输入的IEGM变换为输出ECG信号的有源滤波级。 有源滤波级连接到滤波器表征阶段，其适于处理记录的，患者特异性IEGM模板和对应的SECG模板，并适应所述有源滤波级的滤波器特性，使得滤波器特性最好地表征输入 - 输出 IEGM模板与相应的SECG模板之间的关系。 因此，有源滤波阶段适于变换输入的IEGM，使得输出的ECG信号非常类似于对应的SECG的形态。

公开(公告)号：US07985185B2

公开(公告)日：2011-07-26

申请号：US12132477

申请日：2008-06-03

申请人： Christopher S. De Voir ,  Dirk Muessig ,  Sharon Lefkov ,  Michael V. Orlov

发明人： Christopher S. De Voir ,  Dirk Muessig ,  Sharon Lefkov ,  Michael V. Orlov

IPC分类号： A61B5/04 ,  A61B5/02

CPC分类号： A61B5/042 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/3682 ,  A61N1/3684

摘要： Heart monitoring apparatus with sensing stage connectable to intracardiac electrode picking up electric potentials and adapted to process electric signals representing a time course of said potentials, a mechanical action detection stage adapted to generate a geometry signal having a time course reflecting heart chamber's geometry change, an evaluation unit connected to sensing stage and impedance measuring stage and adapted to determine a first and second fiducial point in the time course of said potentials and geometry signal, respectively, both fiducial points belonging to same heart cycle, and to determine a measured time delay between said fiducial points. Evaluation unit adapted to repeat said determined time delay to determine plurality of measured time delays and variance thereof or divergence of the statistical properties of cycle times based on said time course of said electric potentials versus cycle times based on said time course reflecting a change of a heart chamber's geometry.

摘要翻译： 心脏监测装置，其具有可连接到心内电极的感测级，其拾取电位并且适于处理表示所述电位的时间过程的电信号;适于产生具有反映心室几何变化的时间过程的几何信号的机械动作检测阶段， 评估单元连接到感测级和阻抗测量级，并且适于在所述电位和几何信号的时间过程中分别确定属于同一心脏周期的基准点的第一和第二基准点，并且确定 说的基准点。 评估单元，适于重复所述确定的时间延迟，以基于所述时间过程，基于所述电位相对于周期时间，基于所述时间过程来确定多个测量的时间延迟及其方差或周期时间的统计特性的发散， 心室的几何。

公开(公告)号：US20100099996A1

公开(公告)日：2010-04-22

申请号：US12579305

申请日：2009-10-14

申请人： Indra B. NIGAM ,  Dirk Muessig

发明人： Indra B. NIGAM ,  Dirk Muessig

IPC分类号： A61B5/0402

CPC分类号： A61N1/3704 ,  A61B5/042 ,  A61B5/046 ,  A61B5/0468 ,  A61B5/6846 ,  A61N1/395

摘要： Method for detecting cardiac events, e.g., Atrial Fibrillation (AF) or termination of AF. Based on analysis of the instability observed in heart rate, caused by irregular conduction from the atrium during AF. Change in heart interval is monitored on beat-to-beat basis to recognize instability that indicates presence of AF or Atrial Flutter. A packet of a number of consecutive intervals is evaluated, whether the length of an interval is stable compared with the length of the preceding interval, or whether the length of the subsequent interval has changed. After detection of an instability, instability counter is incremented. The result of the stability test for a packet of intervals is represented by the value of the instability counter. Depending upon whether or not an AF already declared, (indicated by AF status flag), different “X-out-of-Y” criterion are applied. AF status flag set/cleared when declaring AF/termination of AF.

摘要翻译： 用于检测心脏事件的方法，例如心房颤动（AF）或AF终止。 基于AF期间心房不规则传导引起的心率不稳定性分析。 以搏动为基础监测心脏间隔的变化，以识别指示存在AF或心房扑动的不稳定性。 评估多个连续间隔的分组，间隔的长度是否与先前间隔的长度相比是稳定的，还是后续间隔的长度是否已经改变。 检测不稳定后，不稳定计数器增加。 一段时间间隔的稳定性测试结果由不稳定性计数器的值表示。 根据AF已经声明的（AF状态标志）是否适用不同的“X-out-of-Y”标准。 声明自动对焦/终止AF时AF状态标志置1 /清除。

公开(公告)号：US20080125823A1

公开(公告)日：2008-05-29

申请号：US11563279

申请日：2006-11-27

申请人： Dirk Muessig ,  Kurt Swenson

发明人： Dirk Muessig ,  Kurt Swenson

IPC分类号： A61N1/362

CPC分类号： A61N1/3706 ,  A61N1/365

摘要： A heart stimulator for stimulating a chamber of a heart by way of electrical stimulation pulses, said pacemaker comprises a sensing stage connected or being connectable to an electrode lead comprising an electrode for picking up electric potentials inside a heart chamber, said sensing stage being adapted to sense an excitation of a heart chamber by way of picked up electric potentials, a stimulation pulse generator adapted to generate electric stimulation pulses and being connected or being connectable to an electrode lead comprising a stimulation electrode for delivering electric stimulation pulses to said chamber of a heart, and a control unit being connected to said sensing stage and to said stimulation pulse generator and being adapted to trigger stimulation pulses to be generated by the stimulation pulse generator and to be delivered via said electrode lead, said stimulation pulses being triggered with a controlled stimulation rate controlled by the control unit. For preventing too high a stimulation rate for too long a period of time a monitoring stage is provided that connected to the control unit and being adapted to monitor said controlled stimulation rate and override the controlled stimulation rate by a fixed stimulation rate for a predetermined period of time if the average controlled stimulation rate exceeds a predetermined maximum rate.

摘要翻译： 一种用于通过电刺激脉冲刺激心脏室的心脏刺激器，所述起搏器包括连接或可连接到电极引线的感测级，电极引线包括用于拾取心室内的电位的电极，所述感测级适于 通过拾取电位感测心室的激发，刺激脉冲发生器，其适于产生电刺激脉冲并且被连接或可连接到电极引线，该电极引线包括用于将电刺激脉冲传送到心脏的所述腔室的刺激电极 以及控制单元，其连接到所述感测级和所述刺激脉冲发生器，并且适于触发由所述刺激脉冲发生器产生的刺激脉冲并经由所述电极引线传送，所述刺激脉冲由受控刺激触发 速率由控制单元控制。 为了防止太高的刺激速率持续太长时间，提供了连接到控制单元并且适于监测所述受控刺激速率并且将受控刺激速率以固定刺激速率超过预定时间段的监测阶段 如果平均受控刺激速率超过预定的最大速率，则为时间。

公开(公告)号：US20070288063A1

公开(公告)日：2007-12-13

申请号：US11451138

申请日：2006-06-12

申请人： Christopher S. de Voir ,  Jie Lian ,  Richard A. Schomburg ,  Duane Patterson ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Christopher S. de Voir ,  Jie Lian ,  Richard A. Schomburg ,  Duane Patterson ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/00

CPC分类号： A61N1/3712 ,  A61N1/3622 ,  A61N1/3714

摘要： The invention relates to heart stimulators and implantable atrial pacemakers which utilize a rhythm based atrial capture threshold test wherein in a ventricle based DDI mode a predetermined number of ventricle started atrial and ventricular escape intervals are triggered with an overdrive rate about 20% higher than an intrinsic heart rate. The number of atrial sense events during atrial capture threshold test is counted. Too high of a number of atrial sense events indicates loss of capture due to too small of a pulse strength of the atrial stimulation pulses.

摘要翻译： 本发明涉及心脏刺激器和可植入心房起搏器，其利用基于心律的心房采集阈值测试，其中在基于心室的DDI模式中，预定数量的心室开始心房和心室逃逸间隔被触发，超速率比内在的 心率。 在心房采集阈值测试期间心房感觉事件的数量被计数。 许多心房感觉事件的太高表示由于心房刺激脉冲的脉冲强度太小而导致的捕获损失。

公开(公告)号：US08718750B2

公开(公告)日：2014-05-06

申请号：US13462134

申请日：2012-05-02

申请人： Jie Lian ,  J. Christopher Moulder ,  Dirk Muessig

发明人： Jie Lian ,  J. Christopher Moulder ,  Dirk Muessig

IPC分类号： A61B5/04

CPC分类号： A61N1/3684 ,  A61N1/3627 ,  A61N1/36521 ,  A61N1/36578 ,  A61N1/36592 ,  A61N1/3682

摘要： Exemplary methods and apparatuses are disclosed that provide for determination of an atrio-ventricular delay on a beat-to-beat basis by determining a P-wave duration from electric signals corresponding to electric potentials in a heart, and determining the atrio-ventricular delay on a beat-to-beat basis such that the atrio-ventricular delay for an individual heart cycle depends on the P-wave duration of a same or an immediately preceding heart cycle.

摘要翻译： 公开了示例性方法和装置，其通过从对应于心脏中的电位的电信号确定P波持续时间来提供基于节拍的心房延迟的确定，并且确定心室上的心室延迟 以心跳为基础，使得个体心脏周期的心室延迟取决于相同或紧接在前的心脏周期的P波持续时间。

公开(公告)号：US08064998B2

公开(公告)日：2011-11-22

申请号：US11863375

申请日：2007-09-28

申请人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/00

CPC分类号： A61N1/3702 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/145 ,  A61N1/368 ,  A61N1/3682

摘要： Heart stimulating system for stimulating at least a ventricle of a heart including: stimulation pulse generator adapted to generate stimulation pulses and connected to a ventricular stimulation electrode for delivering stimulation pulses, atrial sensing stage connected to an electrode for picking up potentials inside an atrium and adapted to sense an excitation or contraction of atrial myocardium, ventricular sensing stage connected to an electrode for picking up potentials inside a ventricle and adapted to sense an excitation or contraction of ventricular myocardium, memory for AV-delay values, a control unit adapted to trigger said stimulation pulse generator to generate ventricular stimulation pulses timed based on AV-delay values stored in said memory and to acquire atrioventricular interval samples, and atrioventricular interval timing analyzing unit for receiving atrioventricular interval samples from said control unit and adapted to generate at least one histogram based on said atrioventricular interval samples and analyze said histograms.

摘要翻译： 用于刺激至少一个心脏心室的心脏刺激系统，包括：刺激脉冲发生器，其适于产生刺激脉冲并连接到心室刺激电极以传递刺激脉冲，心房感测级连接到电极，用于拾取心房内的电位并适应 感测心房心肌的激发或收缩，心室感测阶段连接到电极，用于拾取心室内的电位并且适于感测心室心肌的激发或收缩，用于AV延迟值的记忆，适于触发所述 刺激脉冲发生器，以产生基于存储在所述存储器中的AV延迟值定时并获取房室间隔样本的心室刺激脉冲，以及房室间隔定时分析单元，用于从所述控制单元接收房室间隔样本，并适于生成至少一个基于直方图 就说 房室间隔采样并分析所述直方图。

公开(公告)号：US07970462B2

公开(公告)日：2011-06-28

申请号：US11754973

申请日：2007-05-29

申请人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61B5/02 ,  A61B5/08 ,  A61B5/05 ,  A61N1/00

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/4878 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36521 ,  A61N1/36585

摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.

摘要翻译： 具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元 用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到 阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值 。