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公开(公告)号：US20070288063A1
公开(公告)日：2007-12-13
申请号：US11451138
申请日：2006-06-12
申请人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
发明人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/00
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： The invention relates to heart stimulators and implantable atrial pacemakers which utilize a rhythm based atrial capture threshold test wherein in a ventricle based DDI mode a predetermined number of ventricle started atrial and ventricular escape intervals are triggered with an overdrive rate about 20% higher than an intrinsic heart rate. The number of atrial sense events during atrial capture threshold test is counted. Too high of a number of atrial sense events indicates loss of capture due to too small of a pulse strength of the atrial stimulation pulses.
摘要翻译： 本发明涉及心脏刺激器和可植入心房起搏器，其利用基于心律的心房采集阈值测试，其中在基于心室的DDI模式中，预定数量的心室开始心房和心室逃逸间隔被触发，超速率比内在的 心率。 在心房采集阈值测试期间心房感觉事件的数量被计数。 许多心房感觉事件的太高表示由于心房刺激脉冲的脉冲强度太小而导致的捕获损失。
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公开(公告)号：US07761163B2
公开(公告)日：2010-07-20
申请号：US11451138
申请日：2006-06-12
申请人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
发明人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/362
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： The invention relates to heart stimulators and implantable atrial pacemakers which utilize a rhythm based atrial capture threshold test wherein in a ventricle based DDI mode a predetermined number of ventricle started atrial and ventricular escape intervals are triggered with an overdrive rate about 20% higher than an intrinsic heart rate. The number of atrial sense events during atrial capture threshold test is counted. Too high of a number of atrial sense events indicates loss of capture due to too small of a pulse strength of the atrial stimulation pulses.
摘要翻译： 本发明涉及心脏刺激器和可植入心房起搏器，其利用基于心律的心房采集阈值测试，其中在基于心室的DDI模式中，预定数量的心室开始心房和心室逃逸间隔被触发，超速率比内在的 心率。 在心房采集阈值测试期间心房感觉事件的数量被计数。 许多心房感觉事件的太高表示由于心房刺激脉冲的脉冲强度太小而导致的捕获损失。
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公开(公告)号：US20080300504A1
公开(公告)日：2008-12-04
申请号：US11754973
申请日：2007-05-29
申请人： Sharon Lefkov , David F. Hastings , Christopher S. de Voir , Garth Garner , Dirk Muessig , Hannes Kraetschmer
发明人： Sharon Lefkov , David F. Hastings , Christopher S. de Voir , Garth Garner , Dirk Muessig , Hannes Kraetschmer
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0538 , A61B5/0809 , A61B5/4878 , A61B5/6846 , A61B5/7285 , A61N1/36521 , A61N1/36585
摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.
摘要翻译： 具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元 用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到 阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值 。
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公开(公告)号：US07970462B2
公开(公告)日：2011-06-28
申请号：US11754973
申请日：2007-05-29
申请人： Sharon Lefkov , David F. Hastings , Christopher S. de Voir , Garth Garner , Dirk Muessig , Hannes Kraetschmer
发明人： Sharon Lefkov , David F. Hastings , Christopher S. de Voir , Garth Garner , Dirk Muessig , Hannes Kraetschmer
CPC分类号： A61B5/053 , A61B5/0538 , A61B5/0809 , A61B5/4878 , A61B5/6846 , A61B5/7285 , A61N1/36521 , A61N1/36585
摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.
摘要翻译： 具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元 用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到 阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值 。
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5.发明授权Atrial overdrive pacing in non-atrial tracking mode while maintaining AV synchrony 失效心房超速起搏在非心房跟踪模式同时保持AV同步公开(公告)号：US07583996B2
公开(公告)日：2009-09-01
申请号：US11560099
申请日：2006-11-15
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3688
摘要： Heart stimulator that stimulates at least a heart's right atrium and ventricle in an atrium asynchronous stimulation mode with an overdrive stimulation rate. Interposes one resynchronization cycle after a sensed atrial event to regain AV synchrony during otherwise asynchronous stimulation mode. Allows for pacing mode that can pace the atrium with an overdrive stimulation rate in dual-chamber asynchronous mode while maintaining the AV synchrony and is called DDI(R)+. In DDI(R)+, pacemaker performs an atrial asynchronous (V synchronous) pacing mode such as DDI or DDI(R). The overdrive stimulation rate (OSR) is either a fixed rate (programmed by the external device) that is thought to be above the underlying intrinsic atrial rate, or is dynamically adjusted according to the measured atrial cycle length to be slightly above intrinsic atrial rate. The overdrive stimulation rate may be based on an intrinsic atrial rate or on hemodynamic need. DDI(R)+ timing may be ventricle-based.
摘要翻译： 心脏刺激器，可以刺激至少一个心脏异位刺激模式的心脏和心室，具有超速刺激速率。 在感应到的心房事件之后插入一个再同步循环，以在其他异步刺激模式下重新获得AV同步。 允许起搏模式，可以在双室异步模式下以过驱动刺激速率调节心房，同时保持AV同步，称为DDI（R）+。 在DDI（R）+中，起搏器执行心房异步（V同步）起搏模式，如DDI或DDI（R）。 超速刺激速率（OSR）是被认为高于潜在固有心房率的固定比率（由外部设备编程），或根据测量的心房周期长度动态调整为略高于固有心房率。 超速刺激速率可以基于固有心房率或血液动力学需要。 DDI（R）+时间可能是基于心室的。
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公开(公告)号：US20080114409A1
公开(公告)日：2008-05-15
申请号：US11560099
申请日：2006-11-15
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3688
摘要： Heart stimulator that stimulates at least a heart's right atrium and ventricle in an atrium asynchronous stimulation mode with an overdrive stimulation rate. Interposes one resynchronization cycle after a sensed atrial event to regain AV synchrony during otherwise asynchronous stimulation mode. Allows for pacing mode that can pace the atrium with an overdrive stimulation rate in dual-chamber asynchronous mode while maintaining the AV synchrony and is called DDI(R)+. In DDI(R)+, pacemaker performs an atrial asynchronous (V synchronous) pacing mode such as DDI or DDI(R). The overdrive stimulation rate (OSR) is either a fixed rate (programmed by the external device) that is thought to be above the underlying intrinsic atrial rate, or is dynamically adjusted according to the measured atrial cycle length to be slightly above intrinsic atrial rate. The overdrive stimulation rate may be based on an intrinsic atrial rate or on hemodynamic need. DDI(R)+ timing may be ventricle-based.
摘要翻译： 心脏刺激器，可以刺激至少一个心脏异位刺激模式的心脏和心室，具有超速刺激速率。 在感应到的心房事件之后插入一个再同步循环，以在其他异步刺激模式下重新获得AV同步。 允许起搏模式，可以在双室异步模式下以过驱动刺激速率调节心房，同时保持AV同步，称为DDI（R）+。 在DDI（R）+中，起搏器执行心房异步（V同步）起搏模式，如DDI或DDI（R）。 超速刺激速率（OSR）是被认为高于潜在固有心房率的固定比率（由外部设备编程），或根据测量的心房周期长度动态调整为略高于固有心房率。 超速刺激速率可以基于固有心房率或血液动力学需要。 DDI（R）+时间可能是基于心室的。
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7.发明授权Method and apparatus for reducing far-field interchamber interference in an implanted medical device 有权用于减少植入式医疗装置中的远场车间干扰的方法和装置公开(公告)号：US07822475B2
公开(公告)日：2010-10-26
申请号：US11015561
申请日：2004-12-17
IPC分类号： A61N1/365
CPC分类号： A61N1/3702
摘要： An implantable medical device comprises at least two sensing channels for receiving sensed first and second location electrical signals originating from two different locations of a heart. A control unit is connected to the sensing channels and is adapted to process sensed electrical signals originating from first and second locations of the heart. The control unit incorporates an adaptive filter compensator adapted to generate an estimate signal for compensating a far-field contribution of the second location signal to the first location signal, thereby generating an output signal representing a near field signal originating from the first location. A gate is connected to the second location sensing channel and is adapted to enable the adaptive filter compensator only if a predetermined signal is sensed via the second location sensing channel.
摘要翻译： 可植入医疗装置包括用于接收源自心脏两个不同位置的感测的第一和第二位置电信号的至少两个感测通道。 控制单元连接到感测通道并且适于处理源自心脏的第一和第二位置的感测的电信号。 所述控制单元包括自适应滤波器补偿器，所述自适应滤波器补偿器适于产生用于补偿所述第二位置信号对所述第一位置信号的远场贡献的估计信号，由此产生表示源自所述第一位置的近场信号的输出信号。 门连接到第二位置感测通道，并且仅当经由第二位置感测通道感测到预定信号时才适于启用自适应滤波器补偿器。
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公开(公告)号：US20090312649A1
公开(公告)日：2009-12-17
申请号：US12476164
申请日：2009-06-01
IPC分类号： A61B5/0205 , A61B5/085
CPC分类号： A61B5/0809 , A61B5/0538 , A61N1/36521 , A61N1/36585 , A61N1/36592
摘要： The invention refers to a monitoring device for monitoring and analyzing physiological signals. The monitoring device comprises a transthoracic impedance measurement unit and an evaluation unit connected to the transthoracic impedance measurement unit. The transthoracic impedance measurement unit is adapted to conduct a transthoracic impedance measurement and to generate a transthoracic impedance signal representing a measured transthoracic impedance at consecutive points in time. The evaluation unit being configured to process the transthoracic impedance signal received from the transthoracic impedance measurement unit and to thus generate a respiration signal and to generate therefrom an evaluation signal reflecting at least a diurnal pattern of the respiration rate.
摘要翻译： 本发明涉及用于监测和分析生理信号的监测装置。 监测装置包括经胸阻抗测量单元和连接到经胸阻抗测量单元的评估单元。 经胸阻抗测量单元适于进行经胸阻抗测量，并产生表示连续时间点测量的经胸阻抗的经胸阻抗信号。 评估单元被配置为处理从经胸阻抗测量单元接收的经胸阻抗信号，并因此产生呼吸信号，并从其产生反映呼吸速率的至少昼夜模式的评估信号。
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公开(公告)号：US08394029B2
公开(公告)日：2013-03-12
申请号：US12476164
申请日：2009-06-01
IPC分类号： A61B5/08
CPC分类号： A61B5/0809 , A61B5/0538 , A61N1/36521 , A61N1/36585 , A61N1/36592
摘要： The invention refers to a monitoring device for monitoring and analyzing physiological signals. The monitoring device comprises a transthoracic impedance measurement unit and an evaluation unit connected to the transthoracic impedance measurement unit. The transthoracic impedance measurement unit is adapted to conduct a transthoracic impedance measurement and to generate a transthoracic impedance signal representing a measured transthoracic impedance at consecutive points in time. The evaluation unit being configured to process the transthoracic impedance signal received from the transthoracic impedance measurement unit and to thus generate a respiration signal and to generate therefrom an evaluation signal reflecting at least a diurnal pattern of the respiration rate.
摘要翻译： 本发明涉及用于监测和分析生理信号的监测装置。 监测装置包括经胸阻抗测量单元和连接到经胸阻抗测量单元的评估单元。 经胸阻抗测量单元适于进行经胸阻抗测量，并产生表示连续时间点测量的经胸阻抗的经胸阻抗信号。 评估单元被配置为处理从经胸阻抗测量单元接收的经胸阻抗信号，并因此产生呼吸信号，并从其产生反映呼吸速率的至少昼夜模式的评估信号。
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公开(公告)号：US07596535B2
公开(公告)日：2009-09-29
申请号：US10674270
申请日：2003-09-29
CPC分类号： G06K9/00536 , A61B5/04525 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B5/7264 , G16H50/20
摘要： An apparatus according to the invention for the classification of physiological events has a signal input for the input of a physiological signal representing or constituting a physiological event and a classification unit 1 for classifying the physiological signal on the basis of its signal shape. The classification unit 1 includes a transformation unit 3 which is designed to carry out transformation of the physiological signal in such a way that as the output signal it outputs a number of values representing the physiological signal and based on the transformation; and a probabilistic neural network which is connected to the transformation unit 3 to receive the values and which contains a number of event classes which represent physiological events and which in turn are each represented by a set of comparative values, which probabilistic neural network is adapted on the basis of the comparison of the values with the comparative values to effect an association of the physiological signal represented by the values with one of the event classes.
摘要翻译： 根据本发明的用于分类生理事件的装置具有用于输入表示或构成生理事件的生理信号的信号输入和用于基于其信号形状分类生理信号的分类单元1。 分类单元1包括变换单元3，其被设计为以这样的方式执行生理信号的变换，使得输出信号输出表示生理信号的数值并基于该变换; 以及概率神经网络，其连接到变换单元3以接收值并且包含表示生理事件的多个事件类别，其又由一组比较值表示，该概率神经网络适应于 将值与比较值进行比较的基础，以实现由值表示的生理信号与事件类之一的关联。
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