Vesicles for active macromolecule delivery
    24.
    发明申请
    Vesicles for active macromolecule delivery 审中-公开
    用于活性大分子递送的囊泡

    公开(公告)号:US20080312134A1

    公开(公告)日:2008-12-18

    申请号:US12157042

    申请日:2008-06-06

    申请人: Thomas Hirt Zhihua Lu

    发明人: Thomas Hirt Zhihua Lu

    摘要: Vesicles for delivery of active macromolecules, such as oligoaminoacids, oligonucleotides, microRNA, siRNA, dsRNA, single stranded oligonucleotides, DNA, peptide nucleic acids, peptides, proteins, and some synthetic organic drugs which are made from amphiphilic segmented copolymers where one segment contains the active macromolecule. In one preferred embodiment, the active macromolecule is contained in the hydrophilic C segment of an amphiphilic ABC segmented copolymer.

    摘要翻译: 用于递送活性大分子的囊泡,例如寡氨基酸,寡核苷酸,微RNA,siRNA,dsRNA,单链寡核苷酸,DNA,肽核酸,肽,蛋白质和由两亲性分段共聚物制成的一些合成有机药物,其中一个部分含有 活性高分子。 在一个优选的实施方案中,活性大分子包含在两亲性ABC分段共聚物的亲水性C链段中。