公开(公告)号：US4306039A

公开(公告)日：1981-12-15

申请号：US142986

申请日：1980-04-23

申请人： Kishore R. Shah ,  Samuel C. Temin

发明人： Kishore R. Shah ,  Samuel C. Temin

IPC分类号： C08L33/06 ,  C08L33/08 ,  C08L39/00 ,  C09J133/08 ,  C09K3/10 ,  F16J15/32 ,  C08L39/06

CPC分类号： F16J15/3284 ,  C08L33/064 ,  C09J133/08 ,  C09K3/10 ,  C08L39/00 ,  C09K2200/0615 ,  C09K2200/0622 ,  C09K2200/0625

摘要： A non-tacky thermoplastic elastomeric composition which is an optically clear blend of (A) a copolymer of ethyl or butyl acrylate or mixtures thereof with from 2 to 10% by weight of a copolymerizable ethylenic monomer containing an acid group and (B) from 2 to 15%, by weight of the blend, of a water-soluble homopolymer of a vinyl lactam having the structure ##STR1## in which X represents an alkylene bridge having three to five carbon atoms, or from 2 to 30%, by weight of the blend, of a copolymer of said lactam with from 1 to 80 mole percent of a copolymerizable monomer containing a polymerizable ethylenic unsaturation, the vinyl lactam polymer or copolymer having a glass transistion temperature from 20.degree. to 250.degree. C.

摘要翻译： 一种非粘性热塑性弹性体组合物，其是（A）丙烯酸乙酯或丁酯或其混合物与2-10重量％含有酸基团的可共聚乙烯单体和（B）的共聚物的光学透明共混物， 至15重量％的具有结构“IMAGE”的乙烯基内酰胺的水溶性均聚物，其中X表示具有3至5个碳原子的亚烷基桥，或2至30重量％ 所述内酰胺与1至80摩尔％的含可聚合烯属不饱和度的可共聚单体的共聚物的共混物，所述乙烯基内酰胺聚合物或共聚物的玻璃化转变温度为20-250℃。

公开(公告)号：US4300820A

公开(公告)日：1981-11-17

申请号：US201349

申请日：1980-10-27

申请人： Kishore R. Shah

发明人： Kishore R. Shah

IPC分类号： A61L15/58 ,  A61L17/14 ,  A61L29/08 ,  A61L29/14 ,  C01B21/26 ,  C08L39/04 ,  C08L39/06 ,  C09J133/06 ,  C09J139/06 ,  C08L45/00 ,  G02C7/04

CPC分类号： C09J133/064 ,  A61L15/585 ,  A61L17/145 ,  A61L29/085 ,  A61L29/145 ,  C01B21/26 ,  C08L39/06 ,  C09J139/06 ,  G02B1/04 ,  G02B1/043 ,  C08L39/04 ,  C09J2201/606

摘要： A composition capable of absorbing more than 45% of its weight of water without dissolution at room temperature to form a hydrogel is made by blending (1) 40 to 98% by weight of water-soluble polymer of a vinyl lactam having the structure ##STR1## in which X represents an alkylene bridge having three to five carbon atoms or a copolymer thereof with 1 to 90 mole percent of a copolymerizable monomer containing a polymerizable ethylenic unsaturation; and (2) 2 to 60% by weight of a water-insoluble copolymer formed of 50% to 90% by weight based on the total copolymer of a hydrophobic water-insoluble ethylenically unsaturated monomer, 2 to 12% by weight of an ethylenically unsaturated monomer containing an acid group, and 0 to 50% by weight of a hydrophilic ethylenically unsaturated monomer free from acidic groups.

摘要翻译： 通过混合（1）40至98重量％的具有结构其中X表示具有3-5个碳原子的亚烷基桥基或其与1至90摩尔％的含可聚合烯属不饱和度的可共聚单体的共聚物; 和（2）2至60重量％的基于疏水性不溶于水的烯键式不饱和单体的总共共聚物的50重量％至90重量％形成的水不溶性共聚物，2至12重量％的烯键式不饱和单体 含有酸基的单体和0〜50重量％的不含酸性基团的亲水性烯属不饱和单体。

公开(公告)号：US5942243A

公开(公告)日：1999-08-24

申请号：US76216

申请日：1998-05-12

申请人： Kishore R. Shah

发明人： Kishore R. Shah

IPC分类号： A61K9/02 ,  A61K9/00 ,  A61K9/70 ,  A61K31/085 ,  A61K31/4164 ,  A61K31/565 ,  A61K38/00 ,  A61K45/00 ,  A61K47/32 ,  A61P15/16 ,  A61P31/10

CPC分类号： A61K9/0036 ,  A61K47/32 ,  A61K9/0034 ,  A61K9/006 ,  A61K9/06 ,  A61K9/7007

摘要： This invention pertains to mucoadhesive compositions for the delivery of pharmacologically active agents, and to polymeric formulations that allow for a prolonged, sustained release of the active agents. More specically the invention pertains to compositions for the delivery of drugs to mucosal tissue, said composition comprising a drug or a plurality of drugs to be delivered and a thermoplastic graft copolymer, said graft copolymer being the reaction product of a polystyrene macromonomer having an ethylenically unsaturated functional group, and at least one acidic hydrophilic monomer having an ethylenically unsaturated functional group.

摘要翻译： 本发明涉及用于递送药理活性剂的粘膜粘附组合物，以及允许活性剂延长，持续释放的聚合制剂。 更具体地说，本发明涉及用于将药物递送至粘膜组织的组合物，所述组合物包含药物或多种待递送药物和热塑性接枝共聚物，所述接枝共聚物是具有烯属不饱和的聚苯乙烯大分子单体的反应产物 官能团和至少一种具有烯属不饱和官能团的酸性亲水单体。

公开(公告)号：US4510197A

公开(公告)日：1985-04-09

申请号：US481509

申请日：1983-04-01

申请人： Kishore R. Shah

发明人： Kishore R. Shah

IPC分类号： A61L15/58 ,  C08F220/18 ,  C09J7/02 ,  C09J133/08 ,  C09J139/06 ,  C08F226/10

CPC分类号： C09J139/06 ,  A61L15/42 ,  A61L15/58 ,  C08F220/18 ,  C09J133/08 ,  C09J7/0217 ,  C09J2201/606

摘要： The present invention comprises a water vapor permeable, pressure-sensitive adhesive composition useful for surgical and medical bandage applications, and incorporating modified copolymers of butyl acrylate containing N-vinyl 2-pyrrolidone and acrylic acid. The present pressure-sensitive adhesive composition results in enhanced water vapor transmission rates, which may lead to a concomittant reduction in skin lesions that were previously attendant upon the accumulation of water under conventional inadequately permeable pressure-sensitive adhesive-coated surgical and medical dressings.

摘要翻译： 本发明包括可用于手术和医用绷带应用的水蒸汽可渗透的压敏粘合剂组合物，并且包含含有N-乙烯基2-吡咯烷酮和丙烯酸的丙烯酸丁酯的改性共聚物。 本发明的压敏粘合剂组合物导致增加的水蒸汽透过率，这可能导致伴随着传统的不充分渗透压敏粘合剂涂覆的外科手术和医用敷料在水中累积的皮肤病变的伴随减少。