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1.发明授权
公开(公告)号：US4904247A
公开(公告)日：1990-02-27
申请号：US782848
申请日：1985-10-02
CPC分类号： A61K9/7084 , A61F13/0213 , A61F13/0253 , A61L15/58 , B32B7/02 , A61F2013/00604 , A61F2013/00748 , A61F2013/00757 , A61F2013/00765 , A61F2013/00846 , A61F2013/00906 , A61F2013/0091
摘要： The present invention describes a pressure-sensitive hydrophilic laminate composite comprising contiguous layers of a tacky pressure sensitive hydrophilic polymer blend, and a non-tacky hydrophilic polymer blend. Numerous variations in individual layer formulations allow for a multitude of hydrophilic blend laminate composite structures, which are readily utilizable as wound dressings, and/or transdermal and topical delivery systems incorporating a wide range of bioactive agents. The hydrophilic laminate composite structurese are characterized by ease of application, adhesiveness to skin, high tensile strength, mechanical integrity, transparency, fluid absorbency, and highly effective bacterial barrier properties, and permeability to water vapor, oxygen and drugs and/or bioactive agents. In the preferred embodiments, they are further characterized in their ability to inhibit severe maceration of the wound as well as underlying tissue destruction upon removal.
摘要翻译： 本发明描述了一种压敏亲水层压复合材料，其包含粘性压敏亲水性聚合物共混物的邻接层和非粘性亲水性聚合物共混物。 单独层制剂的许多变化允许多种亲水混合层压复合结构，其易于用作伤口敷料，和/或包含广泛生物活性剂的透皮和局部递送系统。 亲水性层压复合结构的特征在于易于使用，对皮肤的粘合性，高拉伸强度，机械完整性，透明度，流体吸收性和高效细菌屏障性能，以及对水蒸气，氧气和药物和/或生物活性剂的渗透性。 在优选的实施方案中，它们的进一步特征在于它们能够抑制伤口的严重浸渍以及去除时潜在的组织破坏。
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公开(公告)号：US4306039A
公开(公告)日：1981-12-15
申请号：US142986
申请日：1980-04-23
申请人： Kishore R. Shah , Samuel C. Temin
发明人： Kishore R. Shah , Samuel C. Temin
CPC分类号： F16J15/3284 , C08L33/064 , C09J133/08 , C09K3/10 , C08L39/00 , C09K2200/0615 , C09K2200/0622 , C09K2200/0625
摘要： A non-tacky thermoplastic elastomeric composition which is an optically clear blend of (A) a copolymer of ethyl or butyl acrylate or mixtures thereof with from 2 to 10% by weight of a copolymerizable ethylenic monomer containing an acid group and (B) from 2 to 15%, by weight of the blend, of a water-soluble homopolymer of a vinyl lactam having the structure ##STR1## in which X represents an alkylene bridge having three to five carbon atoms, or from 2 to 30%, by weight of the blend, of a copolymer of said lactam with from 1 to 80 mole percent of a copolymerizable monomer containing a polymerizable ethylenic unsaturation, the vinyl lactam polymer or copolymer having a glass transistion temperature from 20.degree. to 250.degree. C.
摘要翻译： 一种非粘性热塑性弹性体组合物，其是（A）丙烯酸乙酯或丁酯或其混合物与2-10重量％含有酸基团的可共聚乙烯单体和（B）的共聚物的光学透明共混物， 至15重量％的具有结构“IMAGE”的乙烯基内酰胺的水溶性均聚物，其中X表示具有3至5个碳原子的亚烷基桥，或2至30重量％ 所述内酰胺与1至80摩尔％的含可聚合烯属不饱和度的可共聚单体的共聚物的共混物，所述乙烯基内酰胺聚合物或共聚物的玻璃化转变温度为20-250℃。
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3.发明授权Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents 失效用于阴道内施用药理活性剂的亲水性聚苯乙烯接枝共聚物载体
公开(公告)号：US5814329A
公开(公告)日：1998-09-29
申请号：US746327
申请日：1996-11-12
申请人： Kishore R. Shah
发明人： Kishore R. Shah
CPC分类号： A61K47/32 , A61K9/0034 , Y10S514/967
摘要： This invention pertains to the vaginal delivery of pharmacologically active agents and to polymeric formulations that allow for a prolonged release of the active agents in the vaginal environment. More specically the invention pertains to compositions for the delivery of drugs intravaginally comprising a drug or a plurality of drugs to be delivered and a thermoplastic graft copolymer, said graft copolymer being the reaction product of a polystyrene macromonomer having an ethylenically unsaturated functional group and at least one hydrophilic monomer having an ethylenically unsaturated functional group.
摘要翻译： 本发明涉及药物活性剂的阴道递送和允许活性剂在阴道环境中延长释放的聚合物制剂。 更具体地说，本发明涉及阴道内递送包含药物或多种待递送药物的药物和热塑性接枝共聚物的组合物，所述接枝共聚物是具有烯属不饱和官能团的聚苯乙烯大分子单体和至少具有烯属不饱和官能团的反应产物 一种具有烯键式不饱和官能团的亲水单体。
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4.发明授权Microphase separated hydrogels for controlled release of bioactive materials 失效用于微生物分离的水凝胶用于控制释放生物活性物质
公开(公告)号：US4693887A
公开(公告)日：1987-09-15
申请号：US606794
申请日：1984-05-03
申请人： Kishore R. Shah
发明人： Kishore R. Shah
CPC分类号： C08L39/06 , A61K47/32 , A61K9/2027 , A61K9/2031 , C08L57/00
摘要： Novel hydrogel compositions, comprised of a blend of two thermoplastic uncrosslinked polymers, one of which is hydrophobic, and the other hydrophilic, and having a microphase separated morphology are described. These hydrogel compositions are useful as devices for controlling the release rate of bioactive agents, such as therapeutic drugs, antimicrobials, contraceptive agents, or the like, in a biological environment. Depending upon the chemical nature of the agent to be released, its rate of release can be controlled by appropriate selection of the polymeric components of the blend and their relative ratios.
摘要翻译： 描述了由两种热塑性未交联聚合物的共混物组成的新型水凝胶组合物，其中一种是疏水的，另一种是亲水的，并且具有微相分离的形态。 这些水凝胶组合物可用作在生物环境中控制生物活性剂如治疗药物，抗微生物剂，避孕剂等的释放速率的装置。 取决于要释放的试剂的化学性质，其释放速率可以通过适当选择共混物的聚合物组分及其相对比例来控制。
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公开(公告)号：US4369229A
公开(公告)日：1983-01-18
申请号：US229653
申请日：1981-01-29
申请人： Kishore R. Shah
发明人： Kishore R. Shah
CPC分类号： G02B1/043 , B29D11/0073 , B32B27/08 , Y10T428/31507 , Y10T428/3154 , Y10T428/31884 , Y10T428/31909 , Y10T428/31928
摘要： Polymer blends capable of forming hydrogels upon immersion in water are bonded by heat and pressure alone to water-resistant polymer compositions compatible with vinyl lactam polymers to form laminates. Bonding can also be achieved by casting on the surface of the polymer composition a solution of the blend in a solvent inert to the polymer composition and evaporating the solvent. The blends are optically clear blends of vinyl lactam polymers or copolymers with water insoluble copolymers of a hydrophobic water-insoluble ethylenically unsaturated monomer, an ethylenically unsaturated monomer containing an acid group, and optionally a hydrophilic ethylenically unsaturated monomer free from acidic groups.
摘要翻译： 能够在浸入水中形成水凝胶的聚合物共混物通过热和压力单独粘合到与乙烯基内酰胺聚合物相容的耐水性聚合物组合物中以形成层压体。 粘合也可以通过在聚合物组合物的表面上浇铸共混物在对聚合物组合物惰性且溶剂蒸发的溶剂中的溶液来实现。 共混物是乙烯基内酰胺聚合物或共聚物与疏水性不溶于水的烯键式不饱和单体的水不溶性共聚物，含有酸基的烯属不饱和单体和任选的不含酸性基团的亲水性烯属不饱和单体的光学透明共混物。
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公开(公告)号：US6068852A
公开(公告)日：2000-05-30
申请号：US988742
申请日：1997-12-11
申请人： Kishore R. Shah
发明人： Kishore R. Shah
CPC分类号： A61F5/443 , A61L24/043 , A61L28/0026 , A61L2400/14
摘要： A two part, polymerizable, skin sealant or shield which cures in situ to form a custom made, solid, shaped, skin friendly barrier which absorbs aqueous fluids without disintegrating.
摘要翻译： 两部分可聚合的皮肤密封剂或护套，其可原位固化以形成定制的，固体的，形状的，皮肤友好的屏障，其吸收含水流体而不分解。
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公开(公告)号：US5322695A
公开(公告)日：1994-06-21
申请号：US932747
申请日：1992-08-25
CPC分类号： A61K9/7084 , A61L15/44 , A61L15/58 , A61L2300/202 , A61L2300/206 , A61L2300/222 , A61L2300/404 , A61L2300/408
摘要： Described is a moisture-vapor-permeable and oxygen-permeable adhesive dressing for use in supplying a topical medicament to human skin in a controlled release manner, which dressing is unaffected by and impermeable to water in the liquid phase, which dressing when in use on human skin consists essentially of:(i) a polymeric backing material lamina having two surfaces, a first substantially planar surface and a second substantially planar surface;(ii) adhering to said first planar surface of said backing material a medication reservoir lamina having two surfaces, a first substantially planar surface and a second substantially planar surface, consisting essentially of an intimate mixture of:(a) a polyvinyl chloride polymer;(b) a polymeric plasticizer intimately admixed with said polyvinyl chloride and compatible with said polyvinyl chloride; and(c) a topical medicament compatible with said polyvinyl chloride and said plasticizer;said first substantially planar surface of said medication reservoir lamina adhering to said first substantially planar surface of said backing material in a continuous or discontinuous manner; and(iii) adhering to said second substantially planar surface of said medication reservoir lamina, a pressure-sensitive adhesive which is permeable to oxygen and moisture vapor but is unaffected by liquid water.
摘要翻译： 描述了一种用于以控制释放的方式向人体皮肤供应局部药物的透湿透湿粘合剂，该敷料不受液相中的水的影响，并且不透水。 人体皮肤基本上由以下部分组成：（i）具有两个表面的聚合物背衬材料层，第一基本上平坦的表面和第二基本平坦的表面; （ii）粘附在所述背衬材料的所述第一平坦表面上，具有两个表面的药物储存器层，第一基本上平坦的表面和第二基本平坦的表面，其基本上由以下组成的紧密混合物组成：（a）聚氯乙烯聚合物; （b）与所述聚氯乙烯密切混合并与所述聚氯乙烯相容的聚合物增塑剂; 和（c）与所述聚氯乙烯和所述增塑剂相容的局部药物; 所述药物储存器层的所述第一基本上平坦的表面以连续或不连续的方式粘附到所述背衬材料的所述第一基本上平坦的表面; 和（iii）粘附到所述药物储存器层的所述第二基本上平坦的表面，压敏粘合剂，其可渗透氧气和水汽，但不受液态水影响。
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8.发明授权
公开(公告)号：US4758434A
公开(公告)日：1988-07-19
申请号：US847635
申请日：1986-04-03
申请人： Agis Kydonieus , Kishore R. Shah , Bret Berner
发明人： Agis Kydonieus , Kishore R. Shah , Bret Berner
CPC分类号： A61K9/703 , A61K31/21 , A61K9/7084 , A61M31/002
摘要： Described is an article of manufacture useful for administration of pharmacologically-active substances, transdermally, orally or by means of subdermal implant comprising a solid vinyl plastisol layer for contacting a patient's tissue, internally or externally, the layer containing from about 20 up to about 70% by weight of a polyvinyl chloride resin or a polyvinyl chloride-polyvinyl acetate copolymer containing a minor proportion of vinyl acetate; from about 20-70% plasticizer composition; from abotu 0.5 up to 35% of pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, glyceryl trinitrate and prostaglandin and optionally excipients. Also described is the novel plasticizer-polyvinyl chloride composition of matter comprising 1-dodecylhexahydro-2H-azepin-2-one and polyvinyl chloride resin taken together with a pharmacologically-active substance whereint he 1-dodecylhexahydro-2H-azepin-2-one not only acts as a plasticizer but also acts as a penetration enhancer (through tissue) for the pharmacologically-active substance.
摘要翻译： 描述了可用于施用药理学活性物质，经皮，口服或通过皮下植入的制剂，其包括固体乙烯基增塑溶胶层，用于在内部或外部将患者组织接触含有约20至约70的层 重量百分比的聚氯乙烯树脂或含有少量醋酸乙烯酯的聚氯乙烯 - 聚乙酸乙烯酯共聚物; 约20-70％的增塑剂组成; 来自abotu 0.5至35％的药理活性物质如硝酸异山梨酯，尼古丁，可乐定，胍法西林，吲哚美辛，三硝酸甘油酯和前列腺素以及任选的赋形剂。 还描述了包含1-十二烷基六氢-2H-氮杂-2-酮和聚氯乙烯树脂与药物活性物质一起的新型增塑剂 - 聚氯乙烯组合物，其中1-十二烷基六氢-2H-氮杂-2-酮不包括 仅用作增塑剂，但也用作药理活性物质的渗透促进剂（通过组织）。
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公开(公告)号：US4370380A
公开(公告)日：1983-01-25
申请号：US367256
申请日：1982-04-12
申请人： Kishore R. Shah
发明人： Kishore R. Shah
IPC分类号： A61L29/14 , C01B21/26 , C08L39/04 , C08L39/06 , C09J7/02 , C09J133/06 , C09J139/06 , C08L35/00
CPC分类号： C09J133/064 , A61L29/145 , C01B21/26 , C09J139/06 , C09J7/0207 , C08L39/04 , C08L39/06 , C09J2201/606 , Y10T428/28 , Y10T428/2887 , Y10T428/31797 , Y10T428/31928 , Y10T428/31935
摘要： An optically clear blend of (1) a water-soluble polymer of a vinyl lactam having the structure ##STR1## in which X represents an alkylene bridge having three to five carbon atoms or a copolymer thereof with 1 to 80 mole percent of a copolymerizable monomer containing a polymerizable ethylenic unsaturation; and (2) a tacky water-insoluble copolymer of (A) an ester or a mixture of esters having the structure ##STR2## in which R' represents hydrogen or methyl and R.sub.1 represents alkyl having from 1 to 14 carbon atoms and (B) from 1 to 12% by weight, based on the copolymer, of an ethylenic monomer containing an acid group, the vinyl lactam polymer or copolymer being present in an amount from 1 to 30% by weight of the blend and having a glass transition temperature from 20.degree. to 150.degree. C., and the tacky copolymer having a glass transition temperature below 0.degree. C. and being present in an amount from 70 to 99% by weight of the blend and having a viscosity less than 50,000 cp at 350.degree. F. The blend is useful as a pressure-sensitive adhesive composition.
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公开(公告)号：US08257719B2
公开(公告)日：2012-09-04
申请号：US12043743
申请日：2008-03-06
CPC分类号： A61K8/87 , A61K8/8176 , A61K8/86 , A61Q11/00 , A61Q11/02
摘要： An oral care composition including a hydrophilic, aliphatic, polyether-based thermoplastic polyurethane, a glycol polymer, and a poly(N-vinyl lactam). These components form a tacky film having a thickness of about 1 mils to about 50 mils. A whitening agent, such as a peroxide, can be absorbed into the tacky film, and adapted to desorb from the tacky film to whiten teeth to which the film is joined. A method is also provided in which the components are extruded through a twin screw extruder and output to a die to produce the film. The whitening agent can be deposited on the film and absorbed by the film to form a relatively stable oral care composition including the whitening agent.
摘要翻译： 一种口腔护理组合物，其包含亲水性，脂肪族，聚醚类热塑性聚氨酯，二醇聚合物和聚（N-乙烯基内酰胺）。 这些组分形成厚度为约1密耳至约50密耳的粘性薄膜。 美白剂如过氧化物可以被吸收到粘性膜中，并且适于从粘性膜解吸，以使与该膜接合的牙齿变白。 还提供了一种方法，其中组分通过双螺杆挤出机挤出并输出到模具以制备膜。 增白剂可以沉积在薄膜上并被薄膜吸收以形成包含增白剂的相对稳定的口腔护理组合物。
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