公开(公告)号：US20130096438A1

公开(公告)日：2013-04-18

申请号：US13805205

申请日：2011-05-11

Applicant: Jens Fehre ,  Ralf Nanke

Inventor： Jens Fehre ,  Ralf Nanke

IPC: A61B1/04

CPC classification number: A61B1/043 ,  A61B1/041 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4205 ,  G01N21/6408 ,  G01N21/6486 ,  G06K9/00147 ,  G06K2209/053

Abstract: In a method and apparatus for detecting tumorous cell tissue in a gastrointestinal tract, electromagnetic radiation is emitted in a locally defined manner from an endoscope onto cell tissue and, after deactivation of the radiation, the decay of the inherent fluorescence intensity of the irradiated cell tissue, excited by the electromagnetic radiation, is detected, with temporal and spectral resolution and with a known scanning rate for at least one wavelength. From the intensity measurement values obtained in this manner, the difference autocorrelation function of the intensity decay is determined, from which a fractal dimension for the irradiated cell tissue is determined. The value of the fractal dimension is used to classify the irradiated cell tissue as to a degree to which the cell tissue is tumorous.

Abstract translation: 在用于检测胃肠道中的肿瘤细胞组织的方法和装置中，电磁辐射以局部限定的方式从内窥镜发射到细胞组织上，并且在辐射失活之后辐射细胞组织的固有荧光强度的衰减 被电磁辐射激发，被检测到，具有时间和光谱分辨率，并具有用于至少一个波长的已知扫描速率。 根据以这种方式获得的强度测量值，确定强度衰减的差分自相关函数，确定照射的细胞组织的分形维数。 分形维数的值用于将照射的细胞组织分类为细胞组织肿瘤程度。

公开(公告)号：US08386012B2

公开(公告)日：2013-02-26

申请号：US12671643

申请日：2008-07-31

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61B5/05

CPC classification number: G01R33/1269 ,  A61B5/06 ,  A61B5/4381 ,  A61K49/00 ,  A61K49/0004

Abstract: In a screening test method, and a device for implementing the screening test method, a diagnostic substance is provided that contains at least one biomarker connected with at least one ferromagnetic particle, the biomarker binding specifically to a target molecule that is formed by specific pathological prostrate tissue. The diagnostic substance is administered to the blood stream of a patient. A magnetometer is used to detect enrichment of the ferromagnetic particle in the prostrate, as an indicator of a level of the specific pathological prostrate tissue.

Abstract translation: 在筛选试验方法以及实施筛选试验方法的装置中，提供了含有至少一种与至少一个铁磁性粒子连接的生物标志物的诊断物质，特异性结合由特异性病理性前列腺素形成的靶分子的生物标志物 组织。 将诊断物质施用于患者的血液流。 磁力计用于检测前列腺中铁磁颗粒的富集，作为特定病理性pro层组织水平的指标。

公开(公告)号：US07942575B2

公开(公告)日：2011-05-17

申请号：US11943786

申请日：2007-11-21

Applicant: Jens Fehre ,  Ralf Nanke ,  Monika Schwarz

Inventor： Jens Fehre ,  Ralf Nanke ,  Monika Schwarz

IPC: H05G1/02

CPC classification number: A61B6/4429 ,  A61B6/587

Abstract: A urological x-ray workstation has an x-ray source and an x-ray receiver that are respectively supported on device retainers of a device carrier located at the longitudinal side of a patient positioning table such that they can be positioned opposite one another and independently of one another in various positions on an orbit proceeding around a common center in a working plane oriented perpendicular to the longitudinal axis.

Abstract translation: 泌尿x射线工作站具有分别支撑在位于患者定位台的纵向侧的装置载体的装置保持器上的x射线源和x射线接收器，使得它们可以彼此相对定位并且独立地定位 在垂直于纵向轴线定向的工作平面中的公共中心周围的轨道上的各种位置。

公开(公告)号：US20100286517A1

公开(公告)日：2010-11-11

申请号：US12774798

申请日：2010-05-06

Applicant: Ali Kamen ,  Wolfgang Wein ,  Parmeshwar Khurd ,  Mamadou Diallo ,  Ralf Nanke ,  Jens Fehre ,  Berthold Kiefer ,  Martin Requardt ,  Clifford Weiss

Inventor： Ali Kamen ,  Wolfgang Wein ,  Parmeshwar Khurd ,  Mamadou Diallo ,  Ralf Nanke ,  Jens Fehre ,  Berthold Kiefer ,  Martin Requardt ,  Clifford Weiss

IPC: A61B8/14 ,  A61B8/00

CPC classification number: A61B10/0241 ,  A61B8/4254 ,  A61B34/20 ,  A61B2017/00274 ,  A61B2017/00694 ,  A61B2017/3413 ,  A61B2018/00547 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/367 ,  A61B2090/374 ,  A61B2090/378

Abstract: In a method for image guided prostate cancer needle biopsy, a first registration is performed to match a first image of a prostate to a second image of the prostate. Third images of the prostate are acquired and compounded into a three-dimensional (3D) image. The prostate in the compounded 3D image is segmented to show its border. A second registration and then a third registration different from the second registration is performed on distance maps generated from the prostate borders of the first image and the compounded 3D image, wherein the first and second registrations are based on a biomechanical property of the prostate. A region of interest in the first image is mapped to the compounded 3D image or a fourth image of the prostate acquired with the second modality.

Abstract translation: 在用于图像引导的前列腺癌针活检的方法中，首先进行配准以将前列腺的第一图像与前列腺的第二图像相匹配。 获取前列腺的第三图像并将其复合成三维（3D）图像。 复合3D图像中的前列腺被分割以显示其边界。 在从第一图像和复合3D图像的前列腺边界产生的距离图上执行与第二登记不同的第二登记，然后第三登记，其中第一和第二登记基于前列腺的生物力学性质。 将第一图像中的感兴趣区域映射到复合3D图像或用第二模态获取的前列腺的第四图像。

公开(公告)号：US20090131789A1

公开(公告)日：2009-05-21

申请号：US12094933

申请日：2006-09-28

Applicant: Jens Fehre ,  Bernd Granz ,  Markus Lanski ,  Ralf Nanke

Inventor： Jens Fehre ,  Bernd Granz ,  Markus Lanski ,  Ralf Nanke

IPC: A61B8/00 ,  A61N5/10

CPC classification number: A61B8/12 ,  A61N5/1002 ,  A61N5/1027 ,  A61N5/1048 ,  A61N5/1049 ,  A61N2005/1058

Abstract: In a method and a device for x-ray brachytherapy, a probe is inserted into the interior of the body of a subject, the probe carrying at its distal end an x-ray source that radiates x-rays into an exposure area in the body of the subject outside of the probe. The probe also contains an x-ray array that generates an ultrasound image representing at least a portion of the exposure area. A display device displays the ultrasound image to allow identification of the exposure area in the ultrasound image.

Abstract translation: 在用于x射线近距离放射治疗的方法和装置中，将探针插入到受试者的身体的内部，探针在其远端处携带x射线源，将x射线辐射到体内的暴露区域 的探头外。 探针还包含产生表示曝光区域的至少一部分的超声波图像的X射线阵列。 显示装置显示超声图像以允许识别超声图像中的曝光区域。

公开(公告)号：US20090060844A1

公开(公告)日：2009-03-05

申请号：US12203201

申请日：2008-09-03

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61K49/18

CPC classification number: A61K49/1866 ,  A61K49/16 ,  A61K49/1875 ,  B82Y5/00

Abstract: In a method for imaging a prostate tumor in which a contrast agent that can be distributed via the circulatory system is administered to the patient, the contrast agent contains at least one type of biomarkers which are bound to a ferromagnetic particle and specifically bind to a target molecule typical of the tumor and formed within the tumor or in a tissue adjacent to the tumor. The imaging ensues with the use of magnetic resonance tomography.

Abstract translation: 在用于对可以通过循环系统分布的造影剂给予患者的前列腺肿瘤成像方法中，造影剂含有至少一种类型的结合于铁磁颗粒并特异性结合靶的生物标志物 典型的肿瘤分子，并在肿瘤内或与肿瘤相邻的组织中形成。 使用磁共振断层扫描成像。

公开(公告)号：US07281429B2

公开(公告)日：2007-10-16

申请号：US10535804

申请日：2003-10-07

Applicant: Bernd Granz ,  Ralf Nanke

Inventor： Bernd Granz ,  Ralf Nanke

IPC: G01D5/32

CPC classification number: A61B17/22029 ,  A61B17/22 ,  G01H9/00

Abstract: An optical hydrophone for measurement of the acoustic pressure distribution in a fluid medium has a light source that illuminates an area of a boundary region between an optically transparent body and the fluid medium. A light receiver measures the intensity of the light reflected from the illuminated area as a measurement of acoustic pressure, due to changes in the index of refraction of the fluid medium that are caused by the acoustic pressure. The illuminated area is smaller than the boundary surface formed between the optically transparent body and the fluid medium, thereby giving the hydrophone a longer service light and a high spatial resolution capacity.

Abstract translation: 用于测量流体介质中的声压分布的光学水听器具有照亮光学透明体和流体介质之间的边界区域的区域的光源。 由于由声压引起的流体介质的折射率的变化，光接收器测量从照明区域反射的光的强度作为声压的测量值。 照明区域小于在光学透明体和流体介质之间形成的边界面，从而使水听器具有更长的使用光和高的空间分辨能力。

公开(公告)号：US10674979B2

公开(公告)日：2020-06-09

申请号：US15764558

申请日：2016-08-09

Applicant: Jens Fehre ,  Alexander Gemmel ,  Andreas Limmer ,  Ralf Nanke

Inventor： Jens Fehre ,  Alexander Gemmel ,  Andreas Limmer ,  Ralf Nanke

IPC: A61B6/00

Abstract: The invention relates to a mobile C-arm system (C1), at least comprising at least three wheels, at least two wheels each having an electric motor, wherein the electric motor has a stator (S) and a rotor (R), the stator (S) being connected to a wheel suspension (T) of the wheel and the rotor (R) being surrounded peripherally by a running wheel (L).

公开(公告)号：US08981317B2

公开(公告)日：2015-03-17

申请号：US13320610

申请日：2010-05-12

Applicant: Juergen Schreiber ,  Joerg Opitz ,  Carola Gerich ,  Jens Fehre ,  Georg Salomon ,  Ralf Nanke

Inventor： Juergen Schreiber ,  Joerg Opitz ,  Carola Gerich ,  Jens Fehre ,  Georg Salomon ,  Ralf Nanke

IPC: G01N21/64 ,  A61B5/00

CPC classification number: G01N21/6486 ,  A61B5/0059 ,  G01N21/6408

Abstract: The invention relates to a method and to an apparatus for recognizing tumorous living cell tissue. It furthermore relates to a method and to an apparatus for recognizing tumorous cell tissue at collected living cell tissue samples. In the method, electromagnetic radiation is emitted with local definition onto cell tissue by a radiation source and, after deactivation of the radiation source, the decay behavior of the inherent fluorescence intensity of the cell tissue excited by the electromagnetic radiation is detected at the cell tissue in a time resolved and spectrally resolved manner at known sampling rate(s) for at least one wavelength using a detector. The difference autocorrelation function C(t) of the intensity decay behavior is determined using the determined measured intensity values, the fractal dimension DF for the respective irradiated cell tissue is calculated from this and the value of the fractal dimension DF is used for a classification with respect to a presence of a tumor in the respective irradiated cell tissue.

Abstract translation: 本发明涉及用于识别肿瘤活细胞组织的方法和装置。 此外，本发明还涉及用于在收集的活细胞组织样品处识别肿瘤细胞组织的方法和装置。 在该方法中，电磁辐射通过辐射源以局部定义发射到细胞组织上，并且在放射源失活之后，在细胞组织处检测由电磁辐射激发的细胞组织的固有荧光强度的衰变行为 以使用检测器的至少一个波长的已知采样速率以时间分辨和频谱分辨的方式。 使用确定的测量强度值确定强度衰减行为的差分自相关函数C（t），并从其计算相应的照射细胞组织的分形维数DF，并且使用分形维数DF的值进行分类， 相对于各自照射的细胞组织中肿瘤的存在。

公开(公告)号：US20110230752A1

公开(公告)日：2011-09-22

申请号：US12671643

申请日：2008-07-31

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61B5/05

CPC classification number: G01R33/1269 ,  A61B5/06 ,  A61B5/4381 ,  A61K49/00 ,  A61K49/0004

Abstract: In a screening test method, and a device for implementing the screening test method, a diagnostic substance is provided that contains at least one biomarker connected with at least one ferromagnetic particle, the biomarker binding specifically to a target molecule that is formed by specific pathological prostrate tissue. The diagnostic substance is administered to the blood stream of a patient. A magnetometer is used to detect enrichment of the ferromagnetic particle in the prostrate, as an indicator of a level of the specific pathological prostrate tissue.

Abstract translation: 在筛选试验方法以及实施筛选试验方法的装置中，提供了含有至少一种与至少一个铁磁性粒子连接的生物标志物的诊断物质，特异性结合由特异性病理性前列腺素形成的靶分子的生物标志物 组织。 将诊断物质施用于患者的血液流。 磁力计用于检测前列腺中铁磁颗粒的富集，作为特定病理性pro层组织水平的指标。