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公开(公告)号：US20220411860A1
公开(公告)日：2022-12-29
申请号：US17373295
申请日：2021-07-12
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20
摘要： Disclosed herein, inter alfa, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
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22.发明申请公开(公告)号：US20170114403A1
公开(公告)日：2017-04-27
申请号：US15354531
申请日：2016-11-17
申请人： Jingyue Ju , Dae Hyun Kim , Lanrong Bi , Qinglin Meng , Xiaoxu Li
发明人： Jingyue Ju , Dae Hyun Kim , Lanrong Bi , Qinglin Meng , Xiaoxu Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6823 , C12Q2565/631 , C12Q2523/107 , C12Q2523/319
摘要： This invention provides a process for sequencing single-stranded DNA employing modified nucleotides.
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23.发明授权Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators 有权通过使用可切割荧光核苷酸可逆终止子的合成进行四色DNA测序公开(公告)号：US07883869B2
公开(公告)日：2011-02-08
申请号：US12312903
申请日：2007-11-30
申请人： Jingyue Ju , Dae Hyun Kim , Lanrong Bi , Qinglin Meng , Xiaoxu Li
发明人： Jingyue Ju , Dae Hyun Kim , Lanrong Bi , Qinglin Meng , Xiaoxu Li
CPC分类号： C12Q1/6869 , C12Q1/6823 , C12Q2565/631 , C12Q2523/107 , C12Q2523/319
摘要： This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.
摘要翻译： 本发明提供了使用修饰的核苷酸测序单链DNA的方法。
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24.发明授权公开(公告)号：US08204389B2
公开(公告)日：2012-06-19
申请号：US12351444
申请日：2009-01-09
申请人： Guifang Li , Eduardo Mateo , Likai Zhu , Xiaoxu Li , Gilad Goldfarb , Xin Chen , Inwoong Kim , Fatih Yaman
发明人： Guifang Li , Eduardo Mateo , Likai Zhu , Xiaoxu Li , Gilad Goldfarb , Xin Chen , Inwoong Kim , Fatih Yaman
IPC分类号： H04B10/06
CPC分类号： H04J14/02 , H04B10/2507 , H04B2210/252 , H04J14/06
摘要： Systems and method of compensating for transmission impairment are disclosed. One such method comprises: receiving an optical signal which has been distorted in the physical domain by an optical transmission channel; and propagating the distorted optical signal backward in the electronic domain in a corresponding virtual optical transmission channel.
摘要翻译： 公开了补偿传动损伤的系统和方法。 一种这样的方法包括：通过光传输信道接收已经在物理域中失真的光信号; 并在对应的虚拟光传输信道中的电子域中向后传播失真的光信号。
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25.发明申请Electronic Compensation of Nonlinear Effects of Semiconductor Optical Amplifiers 有权半导体光放大器非线性效应的电子补偿公开(公告)号：US20100239270A1
公开(公告)日：2010-09-23
申请号：US12728404
申请日：2010-03-22
申请人： Guifang Li , Xiaoxu Li
发明人： Guifang Li , Xiaoxu Li
CPC分类号： H04B10/2507 , H04B10/6971 , H04B2210/252
摘要： Systems and methods are disclosed for compensating for impairments caused by a semiconductor optical amplifier (SOA). One such method comprises receiving an optical signal which has been distorted in the physical domain by an SOA, and propagating the distorted optical signal backward in the electronic domain in a corresponding virtual SOA.
摘要翻译： 公开了用于补偿由半导体光放大器（SOA）引起的损伤的系统和方法。 一种这样的方法包括：接收在物理域中由SOA失真的光信号，并在对应的虚拟SOA中在电子域中向后传播失真的光信号。
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26.发明授权Electronic compensation of nonlinear effects of semiconductor optical amplifiers 有权半导体光放大器非线性效应的电子补偿公开(公告)号：US08452191B2
公开(公告)日：2013-05-28
申请号：US12728404
申请日：2010-03-22
申请人： Guifang Li , Xiaoxu Li
发明人： Guifang Li , Xiaoxu Li
IPC分类号： H04B10/06
CPC分类号： H04B10/2507 , H04B10/6971 , H04B2210/252
摘要： Systems and methods are disclosed for compensating for impairments caused by a semiconductor optical amplifier (SOA). One such method comprises receiving an optical signal which has been distorted in the physical domain by an SOA, and propagating the distorted optical signal backward in the electronic domain in a corresponding virtual SOA.
摘要翻译： 公开了用于补偿由半导体光放大器（SOA）引起的损伤的系统和方法。 一种这样的方法包括：接收在物理域中由SOA失真的光信号，并在对应的虚拟SOA中在电子域中向后传播失真的光信号。
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27.发明申请公开(公告)号：US20090214215A1
公开(公告)日：2009-08-27
申请号：US12351444
申请日：2009-01-09
申请人： Guifang Li , Eduardo Mateo , Likai Zhu , Xiaoxu Li , Gilad Goldfarb , Xin Chen , Inwoong Kim , Fatih Yaman
发明人： Guifang Li , Eduardo Mateo , Likai Zhu , Xiaoxu Li , Gilad Goldfarb , Xin Chen , Inwoong Kim , Fatih Yaman
CPC分类号： H04J14/02 , H04B10/2507 , H04B2210/252 , H04J14/06
摘要： Systems and method of compensating for transmission impairment are disclosed. One such method comprises: receiving an optical signal which has been distorted in the physical domain by an optical transmission channel; and propagating the distorted optical signal backward in the electronic domain in a corresponding virtual optical transmission channel.
摘要翻译： 公开了补偿传动损伤的系统和方法。 一种这样的方法包括：通过光传输信道接收已经在物理域中失真的光信号; 并在对应的虚拟光传输信道中的电子域中向后传播失真的光信号。
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28.发明申请Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids ("PNAs") with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer 有权具有独特表达或过表达的mRNA靶向序列的壳交联睾丸（SCK）和肽核酸（“PNA”）的细胞可渗透纳米缀合物用于癌症的早期诊断和治疗公开(公告)号：US20060159619A1
公开(公告)日：2006-07-20
申请号：US11250830
申请日：2005-10-14
申请人： Matthew Becker , Huafeng Fang , Xiaoxu Li , Dipanjan Pan , Raffaella Rossin , Xiankai Sun , John-Stephen Taylor , Jeffrey Turner , Michael Welch , Karen Wooley
发明人： Matthew Becker , Huafeng Fang , Xiaoxu Li , Dipanjan Pan , Raffaella Rossin , Xiankai Sun , John-Stephen Taylor , Jeffrey Turner , Michael Welch , Karen Wooley
CPC分类号： A61K31/7088 , A61K51/1251 , B82Y5/00 , B82Y30/00 , C01P2004/64 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3513 , C12N2310/3517 , C12N2320/10 , C12N2320/31 , C12N2310/3525
摘要： A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
摘要翻译： 用于诊断和治疗癌症作为生物体的功能性生物活性粒子缀合物包含具有与其相关联的细胞内靶向配体的纳米级粒子，其包含PNA或另一种核酸酶抗性寡核苷酸类似物，例如MOE-mRNA（2'-甲氧基乙基mRNA）或LNA （锁定的核酸），其具有与活的哺乳动物中癌症或疾病状态特异性的独特表达或过表达的mRNA的选择性结合的序列。 在一个方面，针对癌症或疾病状态特异性的唯一过表达的靶是可以由反义序列PNA50靶向的unr mRNA。
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29.发明授权Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (“PNAs”) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer 有权具有独特表达或过表达的mRNA靶向序列的壳交联睾丸（SCK）和肽核酸（PNA）的细胞可渗透纳米缀合物用于癌症的早期诊断和治疗公开(公告)号：US08354093B2
公开(公告)日：2013-01-15
申请号：US11250830
申请日：2005-10-14
申请人： Matthew L. Becker , Huafeng Fang , Xiaoxu Li , Dipanjan Pan , Raffaella Rossin , Xiankai Sun , John-Stephen Taylor , Jeffrey L. Turner , Michael John Welch , Karen L. Wooley
发明人： Matthew L. Becker , Huafeng Fang , Xiaoxu Li , Dipanjan Pan , Raffaella Rossin , Xiankai Sun , John-Stephen Taylor , Jeffrey L. Turner , Michael John Welch , Karen L. Wooley
CPC分类号： A61K31/7088 , A61K51/1251 , B82Y5/00 , B82Y30/00 , C01P2004/64 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3513 , C12N2310/3517 , C12N2320/10 , C12N2320/31 , C12N2310/3525
摘要： A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
摘要翻译： 用于诊断和治疗癌症作为生物体的功能性生物活性粒子缀合物包含具有与其相关联的细胞内靶向配体的纳米级粒子，其包含PNA或另一种核酸酶抗性寡核苷酸类似物，例如MOE-mRNA（2'-甲氧基乙基mRNA）或LNA （锁定的核酸），其具有与活的哺乳动物中癌症或疾病状态特异性的独特表达或过表达的mRNA的选择性结合的序列。 在一个方面，针对癌症或疾病状态特异性的唯一过表达的靶是可以由反义序列PNA50靶向的unr mRNA。
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