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公开(公告)号：US11085076B2
公开(公告)日：2021-08-10
申请号：US15763364
申请日：2016-09-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
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公开(公告)号：US11999999B2
公开(公告)日：2024-06-04
申请号：US17373295
申请日：2021-07-12
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869 , C12Q2525/117 , C12Q2563/107
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
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公开(公告)号：US20220411860A1
公开(公告)日：2022-12-29
申请号：US17373295
申请日：2021-07-12
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20
摘要： Disclosed herein, inter alfa, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
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4.发明申请公开(公告)号：US20180274024A1
公开(公告)日：2018-09-27
申请号：US15763364
申请日：2016-09-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/6869 , C07H19/20 , C07H19/10 , C07H19/14
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q2525/117 , C12Q2563/107
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
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5.发明申请公开(公告)号：US20180327828A1
公开(公告)日：2018-11-15
申请号：US15777416
申请日：2016-11-18
申请人： Jingyue Ju , Xiaoxu Li , Zengmin Li , Shiv Kumar , Xin Chen , Cheng Guo , Shundi Shi , Jianyi Ren , Chuanjuan Tao , Minchen Chien , James J. Russo , Lin Yu
发明人： Jingyue Ju , Xiaoxu Li , Zengmin Li , Shiv Kumar , Xin Chen , Cheng Guo , Shundi Shi , Jianyi Ren , Chuanjuan Tao , Minchen Chien , James J. Russo , Lin Yu
IPC分类号： C12Q1/6869
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20 , C12Q2525/101 , C12Q2527/119 , C12Q2565/607
摘要： This disclosure is related to a method for determining the identity of a nucleotide residue of a single-stranded DNA or RNA, or sequencing DNA or RNA, in a solution using an ion-sensing field effect transistor and reversible nucleotide terminators.
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公开(公告)号：US11499186B2
公开(公告)日：2022-11-15
申请号：US16653278
申请日：2019-10-15
申请人： Jingyue Ju , Shiv Kumar , Zengmin Li , Chuanjuan Tao , Minchen Chien , James J. Russo , Sergey Kalachikov , Ken Shepard , Jacob Karl Rosenstein
发明人： Jingyue Ju , Shiv Kumar , Zengmin Li , Chuanjuan Tao , Minchen Chien , James J. Russo , Sergey Kalachikov , Ken Shepard , Jacob Karl Rosenstein
IPC分类号： C12Q1/68 , C12Q1/6869 , C07H19/10 , C07H21/00 , G01N33/487
摘要： This disclosure is related to a method of sequencing a single-stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.
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公开(公告)号：US10443096B2
公开(公告)日：2019-10-15
申请号：US13994431
申请日：2011-12-16
申请人： Jingyue Ju , Shiv Kumar , Zengmin Li , Chuanjuan Tao , Minchen Chien , James J. Russo , Sergey Kalachikov , Ken Shepard , Jacob Karl Rosenstein
发明人： Jingyue Ju , Shiv Kumar , Zengmin Li , Chuanjuan Tao , Minchen Chien , James J. Russo , Sergey Kalachikov , Ken Shepard , Jacob Karl Rosenstein
IPC分类号： C12Q1/68 , C12Q1/6869 , C07H19/10 , C07H21/00 , G01N33/487
摘要： This disclosure is related to a method of sequencing a single-stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.
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8.发明申请DNA SEQUENCING BY SYNTHESIS USING MODIFIED NUCLEOTIDES AND NANOPORE DETECTION 审中-公开通过使用修饰的核苷酸和纳米RNA检测合成DNA公开(公告)号：US20130264207A1
公开(公告)日：2013-10-10
申请号：US13994431
申请日：2011-12-16
申请人： Jingyue Ju , Shiv Kumar , Zengmin Li , Chuanjuan Tao , Minchen Chien , James J. Russo , Sergey Kalachikov , Ken Shepard , Jacob Karl Rosenstein
发明人： Jingyue Ju , Shiv Kumar , Zengmin Li , Chuanjuan Tao , Minchen Chien , James J. Russo , Sergey Kalachikov , Ken Shepard , Jacob Karl Rosenstein
CPC分类号： C12Q1/6869 , C07H19/10 , C07H21/00 , G01N33/48721 , C12Q2525/113 , C12Q2525/117 , C12Q2565/518 , C12Q2565/631
摘要： This disclosure is related to a method of sequencing a single-stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.
摘要翻译： 本公开涉及使用脱氧核苷酸多磷酸酯类似物测序单链DNA并通过纳米孔从掺入的脱氧核苷酸多磷酸酯类似物转运标签的方法。
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公开(公告)号：US10662463B2
公开(公告)日：2020-05-26
申请号：US15560820
申请日：2016-03-22
申请人： Jingyue Ju , Youngjin Cho , Shiv Kumar , Sergey Kalachikov , Chuanjuan Tao , Minchen Chien , James J. Russo
发明人： Jingyue Ju , Youngjin Cho , Shiv Kumar , Sergey Kalachikov , Chuanjuan Tao , Minchen Chien , James J. Russo
IPC分类号： C12Q1/6827 , C12Q1/6869 , G01N33/487
摘要： This invention provides methods of using labeled nucleotide polyphosphate analogues to detect the identity or presence of a nucleotide at certain positions in nucleic acid sequences with single molecule sensitivity using nanopore detection, nucleotides and primer-conjugated nanopore proteins for use in such methods, and processes for producing such nucleotides and primer-conjugated nanopore proteins.
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公开(公告)号：US20180112257A1
公开(公告)日：2018-04-26
申请号：US15560820
申请日：2016-03-22
申请人： Jingyue Ju , Youngjin Cho , Shiv Kumar , Sergey Kalachikov , Chuanjuan Tao , Minchen Chien , James J. Russo
发明人： Jingyue Ju , Youngjin Cho , Shiv Kumar , Sergey Kalachikov , Chuanjuan Tao , Minchen Chien , James J. Russo
IPC分类号： C12Q1/6827 , C12Q1/6869 , G01N33/487
摘要： This invention provides methods of using labeled nucleotide polyphosphate analogues to detect the identity or presence of a nucleotide at certain positions in nucleic acid sequences with single molecule sensitivity using nanopore detection, nucleotides and primer-conjugated nanopore proteins for use in such methods, and processes for producing such nucleotides and primer-conjugated nanopore proteins.
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